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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedChou R, Gore JL, Buckley D
Urinary biomarkers for diagnosis of bladder cancer: a systematic review and meta-analysis.
The authors systematically reviewed the evidence on the accuracy of urinary biomarkers for diagnosis of bladder cancer in adults who have signs or symptoms of the disease or are undergoing surveillance for recurrent disease. Their review concluded that urinary biomarkers miss a substantial proportion of patients with bladder cancer and are subject to false-positive results in others.
AHRQ-funded; 290201200014I.
Citation: Chou R, Gore JL, Buckley D .
Urinary biomarkers for diagnosis of bladder cancer: a systematic review and meta-analysis.
Ann Intern Med 2015 Dec 15;163(12):922-31. doi: 10.7326/m15-0997.
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Keywords: Cancer, Comparative Effectiveness, Diagnostic Safety and Quality
Gallego CJ, Shirts BH, Bennette CS
Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: a cost-effectiveness analysis.
The researchers evaluated the cost effectiveness of next-generation sequencing (NGS) panels for the diagnosis of colorectal cancer and polyposis (CRCP) syndromes in patients referred to cancer genetics clinics. They concluded that the use of an NGS panel that includes genes associated with highly penetrant CRCP syndromes in addition to Lynch syndrome genes as a first-line test is likely to provide meaningful clinical benefits in a cost-effective manner.
AHRQ-funded; HS021686.
Citation: Gallego CJ, Shirts BH, Bennette CS .
Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: a cost-effectiveness analysis.
J Clin Oncol 2015 Jun 20;33(18):2084-91. doi: 10.1200/jco.2014.59.3665..
Keywords: Cancer, Cancer: Colorectal Cancer, Shared Decision Making, Diagnostic Safety and Quality, Genetics, Healthcare Costs, Screening
Chou R, Cuevas C, Fu R
Imaging techniques for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.
This review evaluated the test performance of ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of hepatocellular carcinoma (HCC). It concluded that CT and MRI are associated with higher sensitivity than ultrasonography without contrast for detection of HCC. For detection of focal liver lesions, the sensitivities of all three techniques are similar.
AHRQ-funded; 290200710057I
Citation: Chou R, Cuevas C, Fu R .
Imaging techniques for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.
Ann Intern Med. 2015 May 19;162(10):697-711. doi: 10.7326/m14-2509..
Keywords: Cancer, Comparative Effectiveness, Diagnostic Safety and Quality, Imaging
Patel N, Yopp AC, Singal AG
Diagnostic delays are common among patients with hepatocellular carcinoma.
The primary goals of this study were to quantify diagnostic delays among patients diagnosed with HCC and identify factors associated with delays in follow-up testing. It found that 1 in 5 patients experienced significant diagnostic delays, allowing for interval tumor growth. Delays in diagnosis are particularly common among patients who present as an outpatient, being present in more than one-third of cases.
AHRQ-funded; HS022418.
Citation: Patel N, Yopp AC, Singal AG .
Diagnostic delays are common among patients with hepatocellular carcinoma.
J Natl Compr Canc Netw 2015 May;13(5):543-9..
Keywords: Cancer, Diagnostic Safety and Quality, Imaging
Lyratzopoulos G, Vedsted P, Singh H
Understanding missed opportunities for more timely diagnosis of cancer in symptomatic patients after presentation.
The authors highlight factors involved in missed opportunities to diagnose cancer more promptly in symptomatic patients and discuss responsible mechanisms and potential strategies to shorten intervals from presentation to diagnosis. They also provide a conceptual foundation for the development of future interventions to minimize the occurrence of missed opportunities in cancer diagnosis.
AHRQ-funded; HS022087.
Citation: Lyratzopoulos G, Vedsted P, Singh H .
Understanding missed opportunities for more timely diagnosis of cancer in symptomatic patients after presentation.
Br J Cancer 2015 Mar 31;112 Suppl 1:S84-91. doi: 10.1038/bjc.2015.47..
Keywords: Cancer, Diagnostic Safety and Quality, Quality of Care
Carter JL, Coletti RJ, Harris RP
Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.
The authors conducted a systematic review to identify and evaluate the methods that have been used for measuring overdiagnosis of cancer. Their systematic review highlights the high potential for bias and the reliance on unproven assumptions in modeling studies and studies that quantify overdiagnosis using pathological or imaging characteristics.
AHRQ-funded; HS021133.
Citation: Carter JL, Coletti RJ, Harris RP .
Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.
BMJ 2015 Jan 7;350:g7773. doi: 10.1136/bmj.g7773..
Keywords: Cancer, Diagnostic Safety and Quality, Imaging, Screening