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Topics
- Arthritis (1)
- Behavioral Health (2)
- Blood Thinners (1)
- Cardiovascular Conditions (6)
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- Comparative Effectiveness (1)
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- Disparities (3)
- Elderly (2)
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- Human Immunodeficiency Virus (HIV) (1)
- Imaging (1)
- Medical Devices (1)
- Medication (2)
- Outcomes (1)
- Pain (1)
- Patient-Centered Outcomes Research (4)
- Patient Safety (1)
- Racial and Ethnic Minorities (9)
- Respiratory Conditions (1)
- Risk (2)
- (-) Sex Factors (19)
- Stroke (2)
- Substance Abuse (2)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 19 of 19 Research Studies DisplayedMcQuillan J, Andersen JA, Berdahl TA
AHRQ Author: Berdahl TA
Associations of rheumatoid arthritis and depressive symptoms over time: are there differences by education, race/ethnicity, and gender?
The objective of this study was to examine associations between changes in Rheumatoid Arthritis symptoms and depressive symptoms and to test if these associations differed by education, or gender, or race/ethnicity. Data was taken from the National Rheumatoid Arthritis Study, 1988-98. The results indicated that people with Rheumatoid Arthritis experienced increases in depressive symptoms as well as pain, functional disability, and household work disability over the study period. There was no difference noted in the rate of change in depressive symptoms by education, gender, nor race/ethnicity, but the association of functional disability with depressive symptoms was stronger for men than women. The researchers concluded that it is important to monitor and treat both mental and physical health symptoms, and that future research should focus on the collection of data that reflects the educational, gender, and racial/ethnic diversity of people with Rheumatoid Arthritis.
AHRQ-authored.
Citation: McQuillan J, Andersen JA, Berdahl TA .
Associations of rheumatoid arthritis and depressive symptoms over time: are there differences by education, race/ethnicity, and gender?
Arthritis Care Res 2022 Dec;74(12):2050-58. doi: 10.1002/acr.24730..
Keywords: Arthritis, Depression, Behavioral Health, Racial and Ethnic Minorities, Sex Factors, Chronic Conditions
Marcaccio CL, Patel PB, de Guerre L
Disparities in 5-year outcomes and imaging surveillance following elective endovascular repair of abdominal aortic aneurysm by sex, race, and ethnicity.
The purpose of this study was to identify variations in 5-year outcomes and imaging surveillance after elective endovascular aortic aneurysm repair (EVAR) by sex, race, and ethnicity and to examine possible mechanisms contributing to these variations. The primary outcome was 5-year aneurysm rupture. Secondary outcomes were 5-year reintervention and mortality, and having no aortic imaging follow-up from 6 to 24 months after EVAR. The study found that among 16,040 patients, 73% were White males, 18% were White females, 2.6% were Black males, 1.1% were Black females, 0.9% were Asian males, 0.2% were Asian females, 1.7% were Hispanic males, and 0.4% were Hispanic females. At 5 years, Black females had the highest rupture rates at 6.4% and white males had the lowest at 2.3%. Compared with White males, rupture rates were higher in White females, Black females, and Asian females. Among other groups, Black males had higher reintervention and both Black and Hispanic males had higher rates of no imaging follow-up. In adjusted analyses, White, Black, and Asian females remained at significantly higher risk for 5-year rupture. The researchers concluded that Black females had higher 5-year aneurysm rupture, reintervention, and mortality rates after elective EVAR as compared with White male patients, whereas White females had higher rupture, mortality and loss-to-imaging-follow-up compared to White male patients. Black males had higher reintervention and no imaging follow-up, and Asian females had higher rupture rates.
AHRQ-funded; HS027285.
Citation: Marcaccio CL, Patel PB, de Guerre L .
Disparities in 5-year outcomes and imaging surveillance following elective endovascular repair of abdominal aortic aneurysm by sex, race, and ethnicity.
J Vasc Surg 2022 Nov;76(5):1205-15.e4. doi: 10.1016/j.jvs.2022.03.886..
Keywords: Disparities, Racial and Ethnic Minorities, Sex Factors, Outcomes, Imaging, Heart Disease and Health, Cardiovascular Conditions
Marcaccio CL, O'Donnell TFX, Dansey KD
Disparities in reporting and representation by sex, race, and ethnicity in endovascular aortic device trials.
The purpose of this study was to examine the demographics of patients enrolled in critical U.S. endovascular aortic device trials to explore the representation of vulnerable populations, including women and racial and ethnic minorities. The primary outcomes included the percentage of trials reporting participant sex, race, and ethnicity and the percentage of participants across sex, racial, and ethnic groups. The study found that the Food and Drug Administration (FDA) provided 29 approvals from 29 trials of 24 devices with a total of 4046 patients: 52% (15) were EVAR devices, 41% (12) were TEVAR devices, and 3.4% (1) was a FEVAR device, with 1 dissection stent (3.4%). Fifty-two percent of the trials reported the three most common racial groups (White, Black, Asian), and 48% reported Hispanic ethnicity. The TEVAR trials were the most likely to report all three racial groups and Hispanic ethnicity (92% and 75%, respectively), while the EVAR trials had the lowest reporting rates (13% and 20%, respectively). The median female enrollment was 21%, with the EVAR trials having the lowest female enrollment compared with 41% in the TEVAR trials, 21% in the FEVAR trial, and 34% in the dissection stent trial. The study concluded that in critical aortic device trials that led to FDA approval, female patients were underrepresented, especially for EVAR, and racial and ethnic minority groups were under-represented and underreported.
AHRQ-funded; HS027285.
Citation: Marcaccio CL, O'Donnell TFX, Dansey KD .
Disparities in reporting and representation by sex, race, and ethnicity in endovascular aortic device trials.
J Vasc Surg 2022 Nov;76(5):1244-52.e2. doi: 10.1016/j.jvs.2022.05.003..
Keywords: Disparities, Racial and Ethnic Minorities, Heart Disease and Health, Cardiovascular Conditions, Medical Devices, Sex Factors
Rich KM, Zubiago J, Murphy M
The association of gender with receptive and distributive needle sharing among individuals who inject drugs.
The authors sought to assess the relationship between gender and needle sharing with injection drug use. Using data from the 2010-2019 National Survey on Drug Use and Health (NSDUH) datasets, they found that women were more likely in comparison with men to share needles both through receptive and distributive means. They concluded that expansion of interventions, including syringe service programs, to increase access to sterile injection equipment, is of great importance.
AHRQ-funded; HS026008.
Citation: Rich KM, Zubiago J, Murphy M .
The association of gender with receptive and distributive needle sharing among individuals who inject drugs.
Harm Reduct J 2022 Sep 30;19(1):108. doi: 10.1186/s12954-022-00689-3..
Keywords: Human Immunodeficiency Virus (HIV), Substance Abuse, Behavioral Health, Sex Factors
Windgassen SS, Sutherland S, Finn MTM
Gender differences in the experience of interstitial cystitis/bladder pain syndrome.
This study assessed gender differences in a debilitating urologic pain condition, interstitial cystitis/bladder pain syndrome (IC/BPS). Findings indicated that women reported greater pain intensity and extent, but not significantly greater impairment from pain. The duration between time of pain symptom onset and time to diagnosis was significantly greater for women than men. Men emphasized needing more physiological treatment options whilst women emphasized needing more social and emotional support. While men reported feeling supported and involved in treatment decisions, women reported feeling dismissed and disbelieved.
AHRQ-funded; HS022990.
Citation: Windgassen SS, Sutherland S, Finn MTM .
Gender differences in the experience of interstitial cystitis/bladder pain syndrome.
Front Pain Res 2022 Aug 11;3:954967. doi: 10.3389/fpain.2022.954967..
Keywords: Pain, Sex Factors, Women
Patel PB, De Guerre L, Marcaccio CL
Sex-specific criteria for repair should be utilized in patients undergoing aortic aneurysm repair.
This study’s goal was determine if identifying inherent anatomic differences between sexes, aortic size index (ASI) and aortic height index (AHI) may provide an additional method for guiding treatment for abdominal aortic aneurysm (AAA) surgery. Females are more likely to undergo repair at smaller aortic diameter compared with male patients. The authors identified all patients who underwent AAA repair between 2003 and 2019 in the Vascular Quality Initiative database. The Dubois and Dubois formula was used to calculate body surface area; aortic diameter was divided by body surface area to calculate ASI, and aortic diameter was divided by height to calculate AHI. They identified 55,647 patients, of whom 12,664 were female (20%). For both types of repairs (intact and rupture), female patients were older, less likely to undergo endovascular aneurysm repair, and more likely to have comorbid conditions. Female patients underwent repair at smaller median aortic diameter compared with male patients for intact (5.4 vs 5.5 cm) and rupture repair (6.7 vs 7.7 cm). When they analyzed the cumulative distribution of rupture repair in male patients, they found that 12% of rupture repairs were performed at an aortic diameter below 5.5 cm, but to achieve the same proportion of rupture repair in female patients, the repair diameter was only 4.9 cm. When both ASI and AHI were used, female and male patients both reached 12% of rupture repair at an ASI of 2.7 cm/m(2) and an AHI of 3.0 cm/m.
AHRQ-funded; HS027285.
Citation: Patel PB, De Guerre L, Marcaccio CL .
Sex-specific criteria for repair should be utilized in patients undergoing aortic aneurysm repair.
J Vasc Surg 2022 Feb; 75(2):515-25. doi: 10.1016/j.jvs.2021.08.060..
Keywords: Sex Factors, Cardiovascular Conditions, Surgery
Acker WW, Plasek JM, Blumenthal KG
Prevalence of food allergies and intolerances documented in electronic health records.
The researchers sought to determine the prevalence of food allergy and intolerance documented in the EHR allergy module. Among 2.7 million patients, they identified 97,482 patients (3.6 percent) with 1 or more food allergies or intolerances. The prevalence of food allergy and intolerance was higher in females (4.2 percent vs 2.9 percent) and Asians (4.3 percent vs 3.6 percent).
AHRQ-funded; HS022728.
Citation: Acker WW, Plasek JM, Blumenthal KG .
Prevalence of food allergies and intolerances documented in electronic health records.
J Allergy Clin Immunol 2017 Dec;140(6):1587-91.e1. doi: 10.1016/j.jaci.2017.04.006.
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Keywords: Electronic Health Records (EHRs), Patient Safety, Racial and Ethnic Minorities, Sex Factors
Goto T, Faridi MK, Gibo K
Sex and racial/ethnic differences in the reason for 30-day readmission after COPD hospitalization.
This retrospective cohort study used 2006-2012 data from the State Inpatient Database of eight geographically-diverse US states (Arkansas, California, Florida, Iowa, Nebraska, New York, Utah, and Washington) to examine 30-day readmissions in patients hospitalized for chronic obstructive pulmonary disease (COPD). In their analysis of all-payer population-based data, the authors found sex and racial/ethnic differences in the reason for 30-day readmission in patients hospitalized for COPD.
AHRQ-funded; HS023305.
Citation: Goto T, Faridi MK, Gibo K .
Sex and racial/ethnic differences in the reason for 30-day readmission after COPD hospitalization.
Respir Med 2017 Oct;131:6-10. doi: 10.1016/j.rmed.2017.07.056..
Keywords: Respiratory Conditions, Healthcare Cost and Utilization Project (HCUP), Racial and Ethnic Minorities, Hospital Readmissions, Sex Factors
Bucholz EM, Strait KM, Dreyer RP
Sex differences in young patients with acute myocardial infarction: a VIRGO study analysis.
This study sought to compare young women and men at the time of acute myocardial infarction (AMI) on six domains of demographic and clinical factors in order to determine whether they have distinct profiles. The authors concluded that young women with AMI represent a distinct, higher-risk population that is different from young men.
AHRQ-funded; HS023000.
Citation: Bucholz EM, Strait KM, Dreyer RP .
Sex differences in young patients with acute myocardial infarction: a VIRGO study analysis.
Eur Heart J Acute Cardiovasc Care 2017 Oct;6(7):610-22. doi: 10.1177/2048872616661847..
Keywords: Heart Disease and Health, Patient-Centered Outcomes Research, Risk, Sex Factors
Boehme AK, Carr BG, Kasner SE
Sex differences in rt-PA utilization at hospitals treating stroke: the National Inpatient Sample.
The researchers sought to explore sex and race differences in the utilization of recombinant tissue plasminogen activator (rt-PA) at primary stroke centers (PSCs) compared to non-PSCs across the US. They found that women are less likely to receive rt-PA than men at both PSCs and non-PSCs. Absolute treatment rates are lowest in black women.
AHRQ-funded; HS17960; HS018362; HS013852.
Citation: Boehme AK, Carr BG, Kasner SE .
Sex differences in rt-PA utilization at hospitals treating stroke: the National Inpatient Sample.
Front Neurol 2017 Sep 27;8:500. Original Research. doi: 10.3389/fneur.2017.00500.
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Keywords: Healthcare Delivery, Healthcare Cost and Utilization Project (HCUP), Racial and Ethnic Minorities, Sex Factors, Stroke
Albright KC, Howard VJ, Howard G
Age and sex disparities in discharge statin prescribing in the stroke belt: evidence from the reasons for geographic and racial differences in stroke study.
This study analyzed discharge medications for participants hospitalized for an ischemic stroke during follow-up of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. It found that statin discharge prescribing may differ among Stroke Belt and non-Stroke Belt residents, particularly in older Americans and men.
AHRQ-funded; HS023009; HS013852.
Citation: Albright KC, Howard VJ, Howard G .
Age and sex disparities in discharge statin prescribing in the stroke belt: evidence from the reasons for geographic and racial differences in stroke study.
J Am Heart Assoc 2017 Aug 2;6(8). doi: 10.1161/jaha.117.005523.
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Keywords: Disparities, Medication, Stroke, Elderly, Sex Factors
Bersamira CS, Lin YA, Park K
Drug use among Asian Americans: Differentiating use by acculturation status and gender.
This study examined past-year drug use among Asian Americans with respect to ethnic subgroup, acculturation, and gender differences. Survey data were collected during the National Latino and Asian American Survey, a national epidemiological household survey of behavioral health prevalence and service utilization rates. The investigators indicate that findings suggest the need to better understand the heterogeneous character of Asian American drug use when considering the provision of culturally competent and linguistically appropriate prevention and treatment services.
AHRQ-funded; HS000084.
Citation: Bersamira CS, Lin YA, Park K .
Drug use among Asian Americans: Differentiating use by acculturation status and gender.
J Subst Abuse Treat 2017 Aug;79:76-81. doi: 10.1016/j.jsat.2017.06.002..
Keywords: Racial and Ethnic Minorities, Sex Factors, Substance Abuse
Vouri SM, Olsen MA, Theodoro D
Treated-and-released urinary catheterization in the emergency department by sex.
The prevalence of conditions associated with urinary catheterization (UC) visits in men and women were identified. The rate of UC in treated-and-released ED visits was higher in men than women, and UC rate increased with age. The heterogeneity of conditions coded in UC visits in women compared with men may suggest more potentially avoidable UC in women in the treated-and-released ED population.
AHRQ-funded; HS019455.
Citation: Vouri SM, Olsen MA, Theodoro D .
Treated-and-released urinary catheterization in the emergency department by sex.
Am J Infect Control 2017 Aug;45(8):905-10. doi: 10.1016/j.ajic.2017.02.025.
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Keywords: Emergency Department, Healthcare Cost and Utilization Project (HCUP), Sex Factors
Pietrowicz M, Hasegawa-Johnson M, Karahalios KG
Acoustic correlates for perceived effort levels in male and female acted voices.
To begin to study selected elements of vocal expression in acted speech, the investigators curated corpora from male actors' Hamlet and female actresses' Lady Macbeth soliloquy performances. Perception-grounded male and female acoustic feature sets which tracked the actors' expressive effort levels through the continuum of whispered, breathy, modal, and resonant speech were presented and validated via multiple models.
AHRQ-funded; HS022948.
Citation: Pietrowicz M, Hasegawa-Johnson M, Karahalios KG .
Acoustic correlates for perceived effort levels in male and female acted voices.
J Acoust Soc Am 2017 Aug;142(2):792. doi: 10.1121/1.4997189..
Keywords: Sex Factors
Stepanikova I, Oates GR, Bateman LB
Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender.
This study investigated the associations of body mass index (BMI) and waist circumference (WC) with markers of systemic inflammation in midlife by race and gender. Compared to White men, Black women have higher BMI and higher levels of all four inflammation markers; White women have lower BMI, lower WC, and lower E-selectin and fibrinogen but higher C-reactive protein, and Black men have higher fibrinogen.
AHRQ-funded; HS023009.
Citation: Stepanikova I, Oates GR, Bateman LB .
Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender.
Ethn Health 2017 Apr;22(2):169-83. doi: 10.1080/13557858.2016.1235681.
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Keywords: Health Status, Racial and Ethnic Minorities, Risk, Sex Factors
Palamaner Subash Shantha G, Bhave PD, Girotra S
Sex-specific comparative effectiveness of oral anticoagulants in elderly patients with newly diagnosed atrial fibrillation.
This study assessed the sex-specific, comparative effectiveness of direct oral anticoagulants (rivaroxaban and dabigatran), compared to each other and to warfarin among patients with atrial fibrillation. It concluded that the reduced risk of ischemic stroke in patients taking rivaroxaban, compared with dabigatran and warfarin, seems to be limited to men, whereas the higher risk of bleeding seems to be limited to women.
AHRQ-funded; HS023104.
Citation: Palamaner Subash Shantha G, Bhave PD, Girotra S .
Sex-specific comparative effectiveness of oral anticoagulants in elderly patients with newly diagnosed atrial fibrillation.
Circ Cardiovasc Qual Outcomes 2017 Apr;10(4). doi: 10.1161/circoutcomes.116.003418.
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Keywords: Elderly, Heart Disease and Health, Blood Thinners, Medication, Comparative Effectiveness, Cardiovascular Conditions, Sex Factors, Patient-Centered Outcomes Research, Evidence-Based Practice
Musey PI, Jr., Kline JA
Do gender and race make a difference in acute coronary syndrome pretest probabilities in the emergency department?
The objective was to test for significant differences in subjective and objective pretest probabilities for acute coronary syndrome (ACS) in chest pain patients. Despite consistently estimating the risk for ACS to be lower for both females and minorities concordantly with calculated objective pretest assessments, there does not appear to have been any significant decrease in subsequent evaluation of these perceived lower-risk groups when radiation exposure and costs are taken into account.
AHRQ-funded; HS018519.
Citation: Musey PI, Jr., Kline JA .
Do gender and race make a difference in acute coronary syndrome pretest probabilities in the emergency department?
Acad Emerg Med 2017 Feb;24(2):142-51. doi: 10.1111/acem.13131.
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Keywords: Sex Factors, Racial and Ethnic Minorities, Cardiovascular Conditions, Emergency Medical Services (EMS)
Lu Y, Zhou S, Dreyer RP
Sex differences in inflammatory markers and health status among young adults with acute myocardial infarction: results from the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study.
This study assessed sex differences in post-acute myocardial infarction (AMI) inflammatory markers and whether such differences account for sex differences in 12-month health status, using data from 2219 adults with AMI, 18 to 55 years of age, in the United States. Overall, women had higher levels of inflammatory markers after AMI compared with men, and this remained statistically significant after multivariable adjustment.
AHRQ-funded; HS023000.
Citation: Lu Y, Zhou S, Dreyer RP .
Sex differences in inflammatory markers and health status among young adults with acute myocardial infarction: results from the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study.
Circ Cardiovasc Qual Outcomes 2017 Feb;10(2):e003470. doi: 10.1161/circoutcomes.116.003470.
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Keywords: Cardiovascular Conditions, Health Status, Heart Disease and Health, Patient-Centered Outcomes Research, Sex Factors
Lu Y, Zhou S, Dreyer RP
Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: results from the VIRGO study.
This study characterized sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction (AMI). Young women with AMI had slightly favorable lipid and lipoprotein profiles compared with men, suggesting that difference in lipid and lipoprotein may not be a major contributor to sex differences in outcomes after AMI.
AHRQ-funded; HS023000.
Citation: Lu Y, Zhou S, Dreyer RP .
Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: results from the VIRGO study.
Am Heart J 2017 Jan;183:74-84. doi: 10.1016/j.ahj.2016.09.012.
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Keywords: Sex Factors, Heart Disease and Health, Healthcare Utilization, Women, Patient-Centered Outcomes Research