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Search All Research Studies
Topics
- Adverse Drug Events (ADE) (1)
- Adverse Events (1)
- (-) Behavioral Health (6)
- Brain Injury (1)
- Comparative Effectiveness (2)
- Depression (1)
- Elderly (1)
- Emergency Department (2)
- Evidence-Based Practice (2)
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- (-) Hospitalization (6)
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- Labor and Delivery (1)
- (-) Medication (6)
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- Patient-Centered Outcomes Research (2)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedGuglielminotti J, Li G
Exposure to general anesthesia for cesarean delivery and odds of severe postpartum depression requiring hospitalization.
This retrospective cohort study evaluated the risk of general anesthesia use in cesarean delivery versus neuraxial anesthesia on maternal mental health. Cesarean deliveries performed in New York State hospitals between 2006 and 2013 were included. Exclusion criteria included having more than 1 cesarean delivery during the study period, residing outside of New York State, and having a general anesthetic for other surgery or delivery in the year before or after the index case. The primary outcome looked at was severe postpartum depression (PPD), and secondary outcomes were suicidal ideation, anxiety disorders, and posttraumatic stress disorder (PTSD). The majority of cesareans used neuraxial anesthesia and only 8% (34,356) had general anesthesia. Severe PPD requiring hospitalization occurred in 1158 women with 60% identified during readmission. General anesthesia was found to be associated with a 54% increased odds of PPD, and a 91% increased odds of suicidal ideation or self-inflicted injury. There was insufficient evidence for increased risk of anxiety orders.
AHRQ-funded; HS025787.
Citation: Guglielminotti J, Li G .
Exposure to general anesthesia for cesarean delivery and odds of severe postpartum depression requiring hospitalization.
Anesth Analg 2020 Nov;131(5):1421-29. doi: 10.1213/ane.0000000000004663..
Keywords: Labor and Delivery, Pregnancy, Women, Depression, Behavioral Health, Surgery, Risk, Hospitalization, Medication, Adverse Drug Events (ADE), Adverse Events
Oh ES, Needham DM, Nikooie R
Antipsychotics for preventing delirium in hospitalized adults: a systematic review.
The purpose of this study was to conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults. Results showed that there was little evidence demonstrating neurologic harms associated with short-term use of antipsychotics for treating delirium in adult inpatients, but potentially harmful cardiac effects tended to occur more frequently. Current evidence does not support routine use of haloperidol or second-generation antipsychotics to treat delirium in adult inpatients.
AHRQ-funded; 290201500006I.
Citation: Oh ES, Needham DM, Nikooie R .
Antipsychotics for preventing delirium in hospitalized adults: a systematic review.
Ann Intern Med 2019 Oct 1;171(7):474-84. doi: 10.7326/m19-1859..
Keywords: Neurological Disorders, Medication, Hospitalization, Inpatient Care, Patient-Centered Outcomes Research, Outcomes, Evidence-Based Practice, Comparative Effectiveness, Behavioral Health, Prevention
Nikooie R, Neufeld KJ, Oh ES
Antipsychotics for treating delirium in hospitalized adults: a systematic review.
The purpose of this study was to conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults. Results showed that there was little evidence demonstrating neurologic harms associated with short-term use of antipsychotics for treating delirium in adult inpatients, but potentially harmful cardiac effects tended to occur more frequently. Current evidence does not support routine use of haloperidol or second-generation antipsychotics to treat delirium in adult inpatients.
AHRQ-funded; 290201500006I.
Citation: Nikooie R, Neufeld KJ, Oh ES .
Antipsychotics for treating delirium in hospitalized adults: a systematic review.
Ann Intern Med 2019 Oct 1;171(7):485-95. doi: 10.7326/m19-1860.
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Keywords: Neurological Disorders, Medication, Hospitalization, Inpatient Care, Patient-Centered Outcomes Research, Outcomes, Evidence-Based Practice, Comparative Effectiveness, Behavioral Health
Albrecht JS, Mullins DC, Smith GS
Psychotropic medication use among Medicare beneficiaries following traumatic brain injury.
The researchers characterized psychotropic medication use before and after traumatic brain injury (TBI) hospitalization among older adults. They found that average monthly prevalence of psychotropic medication use among all patients hospitalized for TBI was 44.8 percent; antidepressants constituted 73 percent. Following TBI, psychotropic medication use increased slightly.
AHRQ-funded; HS024560.
Citation: Albrecht JS, Mullins DC, Smith GS .
Psychotropic medication use among Medicare beneficiaries following traumatic brain injury.
Am J Geriatr Psychiatry 2017 Apr;25(4):415-24. doi: 10.1016/j.jagp.2016.11.018.
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Keywords: Brain Injury, Elderly, Hospitalization, Medication, Behavioral Health
Olfson M
Surveillance of adverse psychiatric medication events.
This article estimates the numbers and rates of adverse drug event (ADE) emergency department (ED) visits involving psychiatric medications among US adults between January 1, 2009, and December 31, 2011. The author finds that there were an estimated 89,094 psychiatric medication ADE emergency department visits annually, with 19.3 percent resulting in hospitalization and 49.4 percent involving patients aged 19 to 44.
AHRQ-funded; HS021112.
Citation: Olfson M .
Surveillance of adverse psychiatric medication events.
JAMA 2015 Mar 24-31;313(12):1256-7. doi: 10.1001/jama.2014.15743..
Keywords: Emergency Department, Behavioral Health, Hospitalization, Medication
Morrato EH, Parks J, Campagna EJ
Comparative effectiveness of injectable paliperidone palmitate versus oral atypical antipsychotics: early postmarketing evidence.
The researchers compared the likelihood of hospitalization and emergency department visits in Medicaid patients from the state of Missouri starting paliperidone palmitate versus oral atypical (also known as second-generation) antipsychotics. They found that paliperidone palmitate treatment resulted in a statistically significant 37 percent reduction in the adjusted likelihood of an all-cause emergency department visit. There was no statistically significant reduction in hospitalization.
AHRQ-funded; HS019464.
Citation: Morrato EH, Parks J, Campagna EJ .
Comparative effectiveness of injectable paliperidone palmitate versus oral atypical antipsychotics: early postmarketing evidence.
J Comp Eff Res 2015 Mar-Apr;4(2):89-99. doi: 10.2217/cer.14.50..
Keywords: Medication, Hospitalization, Behavioral Health, Emergency Department, Healthcare Utilization