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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedMaloney MH, Payne SR, Herrin J
Risk of systemic adverse events after intravitreal bevacizumab, ranibizumab, and aflibercept in routine clinical practice.
Intravitreal anti-vascular endothelial growth factor (VEGF) pharmacotherapy plays a central role in the management of neovascular age-related macular degeneration (nAMD), diabetic retinal disease (DRD), and retinal venous occlusive disease (RVO). The goal of this study was to compare the systemic safety of intravitreal bevacizumab, ranibizumab, and aflibercept in real-world practice. The investigators observed no differences in the risk of acute MI, CVD, major bleeding, or all-cause hospitalization after treatment initiation with intravitreal bevacizumab, ranibizumab, or aflibercept during routine clinical practice.
AHRQ-funded; HS024075; HS025164; HS025402; HS025517; HS026379.
Citation: Maloney MH, Payne SR, Herrin J .
Risk of systemic adverse events after intravitreal bevacizumab, ranibizumab, and aflibercept in routine clinical practice.
Ophthalmology 2021 Mar;128(3):417-24. doi: 10.1016/j.ophtha.2020.07.062..
Keywords: Eye Disease and Health, Medication, Risk, Adverse Drug Events (ADE), Adverse Events
Gopal AD, Wallach JD, Shah SA
On-label and off-label clinical studies of FDA-approved ophthalmic therapeutics.
The authors characterized the frequency, accrual, and quality of on-label and off-label prospective studies of novel FDA-approved ophthalmic therapeutics. They concluded that ophthalmologists should recognize that, for some therapeutics, prospective data guiding off-label use may be limited; expanding post-approval evaluation of FDA-approved and off-label indications may mitigate uncertainties and aid ophthalmologists in optimally assessing the decision to adopt approved therapeutics for off-label use.
AHRQ-funded; HS025164; HS022882.
Citation: Gopal AD, Wallach JD, Shah SA .
On-label and off-label clinical studies of FDA-approved ophthalmic therapeutics.
Ophthalmology 2021 Feb;128(2):332-34. doi: 10.1016/j.ophtha.2020.07.028..
Keywords: Medication, Eye Disease and Health
Jiramongkolchai P, Lander DP, Kallogjeri D
Trend of surgery for orbital cellulitis: an analysis of state inpatient databases.
This study examined trends in surgery for orbital cellulitis from 2008 to 2015. Retrospective data was extracted from AHRQ’s State Inpatient Databases (SIDs) and patients with an ICD9-CM diagnosis code for orbital cellulitis were identified from Arkansas, Florida, Iowa, Maryland, Nebraska, New York and Wisconsin. The number of hospitalizations declined from a high of 1,574 down to 865 in 2014. The number of surgeries ranged from 103 to 154 from 2008 to 2015. For children, surgery was associated with age, ophthalmologic cormobidity, and conjunctival edema. For adults - male gender, private insurance, optic neuritis, and cranial nervs III/VI/VI palsy were associated with surgery.
AHRQ-funded; HS019455.
Citation: Jiramongkolchai P, Lander DP, Kallogjeri D .
Trend of surgery for orbital cellulitis: an analysis of state inpatient databases.
Laryngoscope 2020 Mar;130(3):567-74. doi: 10.1002/lary.28050..
Keywords: Healthcare Cost and Utilization Project (HCUP), Eye Disease and Health, Surgery, Hospitalization