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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedSchmajuk G, Jafri K, Evans M
Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs.
This study examined the use of prophylactic drugs used to prevent Pneumocystis jirovecii pneumonia (PJP), a rare condition sometimes caused by use of high risk immunosuppressants. This disease has a high rate of mortality. The study authors followed 316 patients for about 1-2 years who had high risk conditions such as vasculitis, myositis, or systemic lupus erythematosus. Overall, 39% of patients received prophylactic antibiotics. However, at least 25% of the patients with the highest risk conditions (vasculitis) or highest risk for immunosuppressants did not receive PJP prophylaxis. During the study period, no cases of PJP ever occurred among any of the study group.
AHRQ-funded; HS023558; HS024412.
Citation: Schmajuk G, Jafri K, Evans M .
Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs.
Semin Arthritis Rheum 2019 Jun;48(6):1087-92. doi: 10.1016/j.semarthrit.2018.10.018..
Keywords: Antibiotics, Medication, Prevention, Risk
Olsen MA, Nickel KB, Fraser VJ
Prevalence and predictors of postdischarge antibiotic use following mastectomy.
This study determined utilization, predictors, and outcomes of postdischarge prophylactic antibiotics after mastectomy with or without immediate breast reconstruction. The study conclude that prophylactic postdischarge antibiotics are commonly prescribed after mastectomy; immediate reconstruction is the strongest predictor. The authors recommended stewardship efforts in this population to limit continuation of prophylactic antibiotics after discharge are needed to limit antimicrobial resistance.
AHRQ-funded; HS019455.
Citation: Olsen MA, Nickel KB, Fraser VJ .
Prevalence and predictors of postdischarge antibiotic use following mastectomy.
Infect Control Hosp Epidemiol 2017 Sep;38(9):1048-54. doi: 10.1017/ice.2017.128.
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Keywords: Antibiotics, Healthcare-Associated Infections (HAIs), Medication, Patient Safety, Surgery, Injuries and Wounds, Prevention, Adverse Events, Risk