National Healthcare Quality and Disparities Report
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Topics
- Access to Care (2)
- Ambulatory Care and Surgery (2)
- Anxiety (2)
- Behavioral Health (24)
- Blood Pressure (1)
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- Care Management (1)
- Case Study (1)
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- Comparative Effectiveness (4)
- Complementary and Alternative Medicine (2)
- (-) Depression (50)
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- Elderly (4)
- Electronic Health Records (EHRs) (2)
- Evidence-Based Practice (4)
- Falls (1)
- Family Health and History (1)
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- Healthcare Costs (1)
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- Human Immunodeficiency Virus (HIV) (1)
- Implementation (1)
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- Research Methodologies (2)
- Respiratory Conditions (3)
- Risk (4)
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- Sex Factors (1)
- Sickle Cell Disease (2)
- Social Determinants of Health (6)
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- Social Stigma (1)
- Stress (4)
- Stroke (1)
- Teams (1)
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- Vulnerable Populations (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 50 Research Studies DisplayedCarson NJ, Progovac AM, Wang Y
A decline in depression treatment following FDA antidepressant warnings largely explains racial/ethnic disparities in prescription fills.
The Food and Drug Administration's 2004 antidepressant warning was followed by decreases in antidepressant prescribing for youth. Little is known about how antidepressant prescribing patterns varied by race/ethnicity. This study analyzed Medicaid claims data from four U.S. states (2002-2009) for youth ages 5-17. The authors found that antidepressant prescription fills declined most post-warning for White youth, suggesting that risk information may have diffused less rapidly to prescribers or caregivers of minorities.
AHRQ-funded; HS021486.
Citation: Carson NJ, Progovac AM, Wang Y .
A decline in depression treatment following FDA antidepressant warnings largely explains racial/ethnic disparities in prescription fills.
Depress Anxiety 2017 Dec;34(12):1147-56. doi: 10.1002/da.22681..
Keywords: Medication, Children/Adolescents, Depression, Guidelines, Racial and Ethnic Minorities
Beck A, Davidson AJ, Xu S
A multilevel analysis of individual, health system, and neighborhood factors associated with depression within a large metropolitan area.
This study geocoded depression diagnosis and demographic data from electronic health records to obtain both individual and neighborhood factors related to depression. The researchers found higher depression rates associated with greater age, female gender, white race, medical comorbidities, and with lower rates of home owner occupancy, residential stability, and higher educational attainment, but not with economic disadvantage. Among the cohort, higher depression rates were associated with higher crime rates and a lower percent of foreign born residents and single mother households.
AHRQ-funded; HS022143.
Citation: Beck A, Davidson AJ, Xu S .
A multilevel analysis of individual, health system, and neighborhood factors associated with depression within a large metropolitan area.
J Urban Health 2017 Dec;94(6):780-90. doi: 10.1007/s11524-017-0190-x..
Keywords: Depression, Electronic Health Records (EHRs), Social Determinants of Health, Urban Health
Mistry KB, Forrest CB
AHRQ Author: Mistry KB
Applying evidence from clinical trials: need for pediatric learning health system research.
The authors argue that to fill the many gaps in the understanding of major depressive disorder management (and more generally, the pediatric knowledge base), a new approach for augmenting the conventional randomized controlled trial is needed. They believe that the emerging field of learning health system research addresses this need.
AHRQ-authored.
Citation: Mistry KB, Forrest CB .
Applying evidence from clinical trials: need for pediatric learning health system research.
Pediatrics 2017 Dec;140(6). doi: 10.1542/peds.2017-3098.
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Keywords: Depression, Evidence-Based Practice, Health Systems, Children/Adolescents
Asher GN, Gartlehner G, Gaynes BN
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
The objective of this study was to report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). The investigators indicated that although they found little difference in the comparative efficacy of most CAM therapies or exercise and SGAs, the overall poor quality of the available evidence base tempers any conclusions that they might draw from those trials.
AHRQ-funded; 290201200008I.
Citation: Asher GN, Gartlehner G, Gaynes BN .
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
Journal Altern Complement Med 2017 Dec;23(12):907-19. doi: 10.1089/acm.2016.0261..
Keywords: Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Evidence-Based Practice, Behavioral Health
Cosgrove L, Krimsky S, Wheeler EE
Conflict of interest policies and industry relationships of guideline development group members: A cross-sectional study of clinical practice guidelines for depression.
The purpose of the present study was to assess a) the disclosure requirements of guideline development groups in a cross-section of guidelines for major depression; and, b) the extent and type of conflicts of panel members. It found that most of the guidelines were developed by panels that had members with industry financial ties to drug companies that manufacture antidepressant medication.
AHRQ-funded; HS022940.
Citation: Cosgrove L, Krimsky S, Wheeler EE .
Conflict of interest policies and industry relationships of guideline development group members: A cross-sectional study of clinical practice guidelines for depression.
Account Res 2017;24(2):99-115. doi: 10.1080/08989621.2016.1251319.
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Keywords: Medication, Depression, Guidelines, Behavioral Health, Research Methodologies
Hong S, Burnett-Zeigler I
The frequency of PTSD and subthreshold PTSD among African-American women with depressive symptoms in a disadvantaged urban neighborhood: pilot study.
This report examined the frequency of a post-traumatic stress disorder (PTSD) diagnosis and subthreshold PTSD among 72 female participants with depressive symptoms in a mindfulness-based intervention for depression at an urban federally qualified health center. The authors reported the high frequency of PTSD diagnosis and subthreshold PTSD among underserved women with depressive symptoms.
AHRQ-funded; HS023011.
Citation: Hong S, Burnett-Zeigler I .
The frequency of PTSD and subthreshold PTSD among African-American women with depressive symptoms in a disadvantaged urban neighborhood: pilot study.
J Racial Ethn Health Disparities 2017 Dec;4(6):1069-73. doi: 10.1007/s40615-016-0311-3.
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Keywords: Depression, Behavioral Health, Racial and Ethnic Minorities, Urban Health, Vulnerable Populations
Adam SS, Flahiff CM, Kamble S
Depression, quality of life, and medical resource utilization in sickle cell disease.
Researchers performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with sickle cell disease and its association with health-related quality of life (HRQoL) and medical resource utilization. They found that depression was associated with worse physical and mental HRQoL scores and during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients.
AHRQ-funded; HS017645.
Citation: Adam SS, Flahiff CM, Kamble S .
Depression, quality of life, and medical resource utilization in sickle cell disease.
Blood Adv 2017 Oct 12;1(23):1983-92. doi: 10.1182/bloodadvances.2017006940.
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Keywords: Depression, Healthcare Costs, Healthcare Utilization, Quality of Life, Sickle Cell Disease
McBride NM, Johnco C, Salloum A
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
This study examined the incidence of suicidal thoughts and behaviors in youth with anxiety before initiating cognitive behavioral therapy, as well as the emergence of suicidal thoughts and behaviors during treatment. Findings suggest that the assessment of suicidality at a single time-point and from one informant is not sufficient to identify at-risk youth. Ongoing assessment of suicidal risk during treatment is important in this population.
AHRQ-funded; HS018665.
Citation: McBride NM, Johnco C, Salloum A .
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
Child Psychiatry Hum Dev 2017 Oct;48(5):705-13. doi: 10.1007/s10578-016-0696-6..
Keywords: Anxiety, Behavioral Health, Children/Adolescents, Depression
Wang S, Mosher C, Gao S
Antidepressant use and depressive symptoms in intensive care unit survivors.
Nearly 30% of intensive care unit (ICU) survivors have depressive symptoms 2-12 months after hospital discharge. In this study, the investigators examined the prevalence of depressive symptoms and risk factors for depressive symptoms in 204 patients at their initial evaluation in the Critical Care Recovery Center (CCRC), an ICU survivor clinic based at Eskenazi Hospital in Indianapolis, Indiana.
AHRQ-funded; HS024384.
Citation: Wang S, Mosher C, Gao S .
Antidepressant use and depressive symptoms in intensive care unit survivors.
J Hosp Med 2017 Sep;12(9):731-34. doi: 10.12788/jhm.2814..
Keywords: Medication, Depression, Intensive Care Unit (ICU), Behavioral Health
Albrecht JS, Khokhar B, Huang TY
Adherence and healthcare utilization among older adults with COPD and depression.
The researchers quantified the independent effects of adherence to antidepressants and chronic obstructive pulmonary disease (COPD) maintenance medications on healthcare utilization among individuals co-diagnosed with COPD and depression. They found that, compared to no use,higher levels of adherence to COPD maintenance medications were associated with decreased risk of ED visits and hospitalizations. Similarly, higher levels of adherence to antidepressants resulted in decreased risk of ED visits and hospitalization.
AHRQ-funded; HS024560.
Citation: Albrecht JS, Khokhar B, Huang TY .
Adherence and healthcare utilization among older adults with COPD and depression.
Respir Med 2017 Aug;129:53-58. doi: 10.1016/j.rmed.2017.06.002.
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Keywords: Elderly, Healthcare Utilization, Respiratory Conditions, Depression, Patient Adherence/Compliance
McClintock HF, Bogner HR
Incorporating patients' social determinants of health into hypertension and depression care: a pilot randomized controlled trial.
The objective of this study was to carry out a randomized controlled pilot trial to test the effectiveness of an integrated intervention for hypertension and depression incorporating patients' social determinants of health (enhanced intervention) versus an integrated intervention alone (basic intervention). The pilot trial results indicate integrated care management that addresses the social determinants of health for patients with hypertension and depression may be effective.
AHRQ-funded; HS023445.
Citation: McClintock HF, Bogner HR .
Incorporating patients' social determinants of health into hypertension and depression care: a pilot randomized controlled trial.
Community Ment Health J 2017 Aug;53(6):703-10. doi: 10.1007/s10597-017-0131-x.
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Keywords: Depression, Behavioral Health, Blood Pressure, Social Determinants of Health, Patient-Centered Healthcare, Healthcare Delivery
Goldmann E, Roberts ET, Parikh NS
Chronic physical illness burden and suicidal ideation among Dominicans in New York City.
This study used data from a community survey of 2753 Dominican adults in New York City to investigate the association between chronic illness and suicidal ideation. The investigators concluded that the association of interest did not differ significantly between younger and older adults. They suggest that screening for SI in health care practice, particularly among Dominican men with multiple chronic health conditions, may be warranted.
AHRQ-funded; HS022961.
Citation: Goldmann E, Roberts ET, Parikh NS .
Chronic physical illness burden and suicidal ideation among Dominicans in New York City.
J Immigr Minor Health 2017 Jun;19(3):616-22. doi: 10.1007/s10903-016-0477-0..
Keywords: Chronic Conditions, Depression, Behavioral Health, Racial and Ethnic Minorities, Risk
Crits-Christoph P, Gallop R, Diehl CK
Mechanisms of change in cognitive therapy for major depressive disorder in the community mental health setting.
This study examined the relation of change in theory-relevant cognitive variables to depressive symptom change over the course of cognitive therapy, as well as the specificity of change mechanisms to cognitive therapy as compared with dynamic therapy. Its results provide support for the compensatory skills model of cognitive therapy within a community mental health setting.
AHRQ-funded; HS018440.
Citation: Crits-Christoph P, Gallop R, Diehl CK .
Mechanisms of change in cognitive therapy for major depressive disorder in the community mental health setting.
J Consult Clin Psychol 2017 Jun;85(6):550-61. doi: 10.1037/ccp0000198.
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Keywords: Behavioral Health, Depression
Cosgrove L, Shaughnessy AF, Peters SM
Conflicts of interest and the presence of methodologists on guideline development panels: a cross-sectional study of clinical practice guidelines for major depressive disorder.
The authors aimed to review treatment guidelines for major depressive disorder and assess the relationship between endorsement of antidepressants for mild depression as a first-line intervention and financial conflicts of interest of guideline panel members. They concluded that ensuring that guideline development groups are free of commercial ties and include individuals with methodological expertise provides an important safeguard – that an evidence-based review is applied at every stage, from the framing of the questions for review, to searching, evaluating, and synthesizing the evidence.
AHRQ-funded; HS022940.
Citation: Cosgrove L, Shaughnessy AF, Peters SM .
Conflicts of interest and the presence of methodologists on guideline development panels: a cross-sectional study of clinical practice guidelines for major depressive disorder.
Psychother Psychosom 2017;86(3):168-70. doi: 10.1159/000458727.
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Keywords: Depression, Evidence-Based Practice, Guidelines, Research Methodologies
Heerman WJ, Taylor JL, Wallston KA
Parenting self-efficacy, parent depression, and healthy childhood behaviors in a low-income minority population: a cross-sectional analysis.
The study’s objective was to measure the associations between parenting self-efficacy, parent depressive symptoms, and preschool child behaviors that support healthy growth. It found that in this minority population, higher parenting self-efficacy was associated with longer child sleep and fewer meals in front of the TV, but parent depressive symptoms mitigated that protective effect for child sleep duration.
AHRQ-funded; HS022990.
Citation: Heerman WJ, Taylor JL, Wallston KA .
Parenting self-efficacy, parent depression, and healthy childhood behaviors in a low-income minority population: a cross-sectional analysis.
Matern Child Health J 2017 May;21(5):1156-65. doi: 10.1007/s10995-016-2214-7.
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Keywords: Children/Adolescents, Family Health and History, Depression, Racial and Ethnic Minorities, Low-Income
Hoffman GJ, Hays RD, Wallace SP
Depressive symptomatology and fall risk among community-dwelling older adults.
The directionality of observed relationship between falls and depressive symptoms (DS) is in need of elaboration given that cross-sectional study designs can yield biased estimates of the DS-falls relationship. This study found that the DS-falls relationship was not significant when use of psychiatric medications, which was positively associated with falls, was included in the model.
AHRQ-funded; HS000046.
Citation: Hoffman GJ, Hays RD, Wallace SP .
Depressive symptomatology and fall risk among community-dwelling older adults.
Soc Sci Med 2017 Apr;178:206-13. doi: 10.1016/j.socscimed.2017.02.020.
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Keywords: Depression, Elderly, Falls, Patient Safety, Risk
Gallo KP, Olin SS, Storfer-Isser A
Parent burden in accessing outpatient psychiatric services for adolescent depression in a large state system.
This study examined barriers facing parents who seek outpatient psychiatric care in a large state system for adolescents with depression. It found that virtually all clinics required at least one intake or therapy appointment before receipt of a psychiatry appointment. Parental burden did not differ by region, urbanicity, clinic type, seasonality (spring or summer), or insurance status.
AHRQ-funded; HS020503.
Citation: Gallo KP, Olin SS, Storfer-Isser A .
Parent burden in accessing outpatient psychiatric services for adolescent depression in a large state system.
Psychiatr Serv 2017 Apr;68(4):411-14. doi: 10.1176/appi.ps.201600111.
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Keywords: Access to Care, Children/Adolescents, Depression, Behavioral Health, Ambulatory Care and Surgery
Tak YR, Brunwasser SM, Lichtwarck-Aschoff A
The prospective associations between self-efficacy and depressive symptoms from early to middle adolescence: a cross-lagged model.
This study investigated the bidirectional and prospective associations between depressive symptoms and academic, social and emotional self-efficacy from early to mid adolescence in a cross-lagged path model. It found that depressive symptoms predicted subsequent levels of academic and emotional self-efficacy on all time points, and social self-efficacy on one time point. Self-efficacy did not predict subsequent levels of depressive symptoms.
AHRQ-funded; HS022990.
Citation: Tak YR, Brunwasser SM, Lichtwarck-Aschoff A .
The prospective associations between self-efficacy and depressive symptoms from early to middle adolescence: a cross-lagged model.
J Youth Adolesc 2017 Apr;46(4):744-56. doi: 10.1007/s10964-016-0614-z.
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Keywords: Depression, Children/Adolescents, Health Status, Behavioral Health
Radovic A, Gmelin T, Stein BD
Depressed adolescents' positive and negative use of social media.
This qualitative study examined descriptions of social media use among 23 adolescents (18 female, 5 male) who were diagnosed with depression to explore how social media use may influence and be influenced by psychological distress. Adolescents described both positive and negative use of social media. ." In the context of treatment, these adolescents shifted their social media use patterns from what they perceived as negative to more positive use.
AHRQ-funded; HS022989.
Citation: Radovic A, Gmelin T, Stein BD .
Depressed adolescents' positive and negative use of social media.
J Adolesc 2017 Feb;55:5-15. doi: 10.1016/j.adolescence.2016.12.002.
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Keywords: Children/Adolescents, Depression, Behavioral Health
Zullo MD, Gathright EC, Dolansky MA
Influence of depression on utilization of cardiac rehabilitation postmyocardial infarction: A study of 158 991 Medicare beneficiaries.
The purpose of this study was to examine the association between depression diagnosis and participation in cardiac rehabilitation (CR) in a large sample of Medicare beneficiaries with recent myocardial infarction (MI). It concluded that diagnosis of depression in Medicare beneficiaries was strongly associated with attending CR and attending more sessions of CR compared with those without depression. Depression is not a barrier to CR participation after MI in Medicare beneficiaries.
AHRQ-funded; HS019795.
Citation: Zullo MD, Gathright EC, Dolansky MA .
Influence of depression on utilization of cardiac rehabilitation postmyocardial infarction: A study of 158 991 Medicare beneficiaries.
J Cardiopulm Rehabil Prev 2017 Jan;37(1):22-29. doi: 10.1097/hcr.0000000000000222.
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Keywords: Heart Disease and Health, Depression, Medicare, Patient Adherence/Compliance, Comparative Effectiveness
Hopkins AL, Moore-Monroy M, Wilkinson-Lee AM
It's complicated: negotiating between traditional research and community-based participatory research in a translational study.
The authors focused on the challenges, solutions, and lessons learned in applying the Interactive Systems Framework (ISF) to their translational research project. They identified challenges in the areas of research design, and in the ISF systems of prevention synthesis and translation, prevention support, and prevention delivery. They negotiated solutions between the scientific and local community that resulted in acceptable compromises for both groups. They concluded that although the model presented by the ISF is difficult to achieve, they offered concrete solutions to community members and scientists to move toward that ideal.
AHRQ-funded; HS022016.
Citation: Hopkins AL, Moore-Monroy M, Wilkinson-Lee AM .
It's complicated: negotiating between traditional research and community-based participatory research in a translational study.
Prog Community Health Partnersh 2016;10(3):425-33. doi: 10.1353/cpr.2016.0049.
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Keywords: Education: Patient and Caregiver, Depression, Prevention, Racial and Ethnic Minorities, Implementation
Earnshaw VA, Rosenthal L, Lang SM
Stigma, activism, and well-being among people living with HIV.
The researchers examined associations between experiences of HIV stigma and HIV activism, and test whether HIV activists benefit from greater well-being than non-activists. Their results suggest that HIV activists reported greater social network integration, greater social well-being, greater engagement in active coping with discrimination, and greater meaning in life than non-activists.
AHRQ-funded; HS022986.
Citation: Earnshaw VA, Rosenthal L, Lang SM .
Stigma, activism, and well-being among people living with HIV.
AIDS Care 2016;28(6):717-21. doi: 10.1080/09540121.2015.1124978.
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Keywords: Human Immunodeficiency Virus (HIV), Quality of Life, Depression, Social Determinants of Health, Social Stigma
Brunwasser SM, Garber J
Programs for the prevention of youth depression: evaluation of efficacy, effectiveness, and readiness for dissemination.
This study used the Society for Prevention Research's Standards of Evidence to evaluate the degree to which existing depression prevention programs have established intervention efficacy, effectiveness, and readiness for dissemination. The authors concluded that although several programs have demonstrated promise in terms of efficacy, no depression prevention program for children or adolescents has garnered sufficient evidence of effectiveness under real-world conditions to warrant widespread dissemination.
AHRQ-funded; HS022990.
Citation: Brunwasser SM, Garber J .
Programs for the prevention of youth depression: evaluation of efficacy, effectiveness, and readiness for dissemination.
J Clin Child Adolesc Psychol 2016 Nov-Dec;45(6):763-83. doi: 10.1080/15374416.2015.1020541.
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Keywords: Children/Adolescents, Depression, Evidence-Based Practice, Patient-Centered Outcomes Research
Sumner JA, Khodneva Y, Muntner P
Effects of concurrent depressive symptoms and perceived stress on cardiovascular risk in low- and high-income participants: findings from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study.
Using data from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study, the authors examined associations among depressive symptoms and stress, alone and in combination, and incident cardiovascular disease (CVD) and all-cause mortality as a function of socioeconomic status. They found that screening for a combination of elevated depressive symptoms and stress in low-income persons may help identify those at increased risk of incident CVD and mortality.
AHRQ-funded; HS023009.
Citation: Sumner JA, Khodneva Y, Muntner P .
Effects of concurrent depressive symptoms and perceived stress on cardiovascular risk in low- and high-income participants: findings from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study.
J Am Heart Assoc 2016 Oct 10;5(10). doi: 10.1161/jaha.116.003930.
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Keywords: Cardiovascular Conditions, Depression, Social Determinants of Health, Stress, Stroke
Garber J, Brunwasser SM, Zerr AA
Treatment and prevention of depression and anxiety in youth: test of cross-over effects.
The present meta-analytic review examined whether interventions for children and adolescents that explicitly targeted either anxiety or depression showed treatment specificity or also impacted the other outcome (i.e. cross-over effects). Anxiety prevention studies (n = 14) significantly affected anxious, but not depressive symptoms, indicating no cross-over effect of anxiety prevention trials on depression. For depression prevention studies (n = 15), the effects were not significant for either depressive or anxiety symptoms, although the effect was significantly larger for depressive than for anxious symptoms.
AHRQ-funded; HS022990.
Citation: Garber J, Brunwasser SM, Zerr AA .
Treatment and prevention of depression and anxiety in youth: test of cross-over effects.
Depress Anxiety 2016 Oct;33(10):939-59. doi: 10.1002/da.22519.
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Keywords: Anxiety, Children/Adolescents, Depression, Patient-Centered Outcomes Research