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AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (6)
- Adverse Events (1)
- Blood Clots (1)
- Blood Thinners (1)
- Chronic Conditions (2)
- Clinical Decision Support (CDS) (1)
- Elderly (3)
- Electronic Health Records (EHRs) (2)
- Falls (1)
- Health Information Technology (HIT) (1)
- Injuries and Wounds (1)
- Inpatient Care (1)
- Medical Errors (1)
- (-) Medication (15)
- Medication: Safety (8)
- Neurological Disorders (1)
- Nursing Homes (1)
- Opioids (2)
- Pain (1)
- (-) Patient Safety (15)
- Practice-Based Research Network (PBRN) (1)
- Primary Care (1)
- Provider: Pharmacist (3)
- Risk (1)
- Substance Abuse (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 15 of 15 Research Studies DisplayedNaples JG, Kotlarczyk MP, Perera S
Non-tricyclic and non-selective serotonin reuptake inhibitor antidepressants and recurrent falls in frail older women.
This study determined the risk of recurrent falls associated with antidepressants other than tricyclics (TCAs) and selective serotonin reuptake inhibitors (SSRIs) among frail older women. At least 15 percent of women experienced recurrent falls between 0-6 and 6-12 months. At baseline and 6 months, 18.2 percent and 6.9 percent had a non-TCA/non-SSRI antidepressant, respectively. It concluded that non-TCA/non-SSRI antidepressant exposure significantly increased the risk of recurrent falls.
AHRQ-funded; HS023779.
Citation: Naples JG, Kotlarczyk MP, Perera S .
Non-tricyclic and non-selective serotonin reuptake inhibitor antidepressants and recurrent falls in frail older women.
Am J Geriatr Psychiatry 2016 Dec;24(12):1221-27. doi: 10.1016/j.jagp.2016.08.008.
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Keywords: Medication, Elderly, Falls, Patient Safety
Gagne JJ, Han X, Hennessy S
Successful comparison of US Food and Drug Administration sentinel analysis tools to traditional approaches in quantifying a known drug-adverse event association.
The authors assessed the extent to which the newly developed, semiautomated Sentinel Propensity Score Matching tool could produce the same results as a customized protocol-driven assessment. They found initial evidence that Sentinel analytic tools can produce findings similar to those produced by a highly customized protocol-driven assessment.
AHRQ-funded; HS022193.
Citation: Gagne JJ, Han X, Hennessy S .
Successful comparison of US Food and Drug Administration sentinel analysis tools to traditional approaches in quantifying a known drug-adverse event association.
Clin Pharmacol Ther 2016 Nov;100(5):558-64. doi: 10.1002/cpt.429.
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Keywords: Adverse Drug Events (ADE), Medication, Medication: Safety, Patient Safety
Naples JG, Gellad WF, Hanlon JT
The role of opioid analgesics in geriatric pain management.
This article reviews the epidemiology of opioid use and their effectiveness for chronic noncancer pain (CNCP) in older adults and summarizes important age-related changes in opioid pharmacokinetics and pharmacodynamics that increase the risks of adverse effects in the elderly. Finally, to assist clinicians with selecting appropriate therapy, the article concludes with an evidence-based approach to optimize opioid prescribing in older adults with CNCP.
AHRQ-funded; HS023779.
Citation: Naples JG, Gellad WF, Hanlon JT .
The role of opioid analgesics in geriatric pain management.
Clin Geriatr Med 2016 Nov;32(4):725-35. doi: 10.1016/j.cger.2016.06.006.
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Keywords: Chronic Conditions, Elderly, Medication, Opioids, Pain, Patient Safety
Kesselheim AS, Bykov K, Gagne JJ
Switching generic antiepileptic drug manufacturer not linked to seizures: a case-crossover study.
The researchers estimated the risk of seizure-related events associated with refilling antiepileptic drugs (AED) with generic AEDs and the effect of switching between different manufacturers of the same generic drug. They found that among patients on a generic AED, refilling the same AED was associated with an elevated risk of seizure-related event; however, there was no additional risk from switching during that refill to a different manufacturer.
AHRQ-funded; HS022193.
Citation: Kesselheim AS, Bykov K, Gagne JJ .
Switching generic antiepileptic drug manufacturer not linked to seizures: a case-crossover study.
Neurology 2016 Oct 25;87(17):1796-801. doi: 10.1212/wnl.0000000000003259.
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Keywords: Adverse Drug Events (ADE), Adverse Events, Medication, Medication: Safety, Neurological Disorders, Patient Safety, Risk
Green TC, Gilbert M
Counterfeit medications and fentanyl.
In this invited commentary, the authors discuss counterfeit medications and fentanyl, including a research letter in the same issue by Arens et al., which reports on a case series of counterfeit Xanax tablets containing fentanyl and etizolam. They include malice, accident, obfuscation, and economic considerations as reasons why someone would press fentanyl into the shape of a Xanax tablet.
AHRQ-funded; HS024021.
Citation: Green TC, Gilbert M .
Counterfeit medications and fentanyl.
JAMA Intern Med 2016 Oct;176(10):1555-57. doi: 10.1001/jamainternmed.2016.4310.
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Keywords: Medication: Safety, Medication, Patient Safety
Her QL, Amato MG, Seger DL
The frequency of inappropriate nonformulary medication alert overrides in the inpatient setting.
The purpose of this study was to quantify the frequency of inappropriate nonformulary medication (NFM) alert overrides in the inpatient setting and provide insight on how the design of formulary alerts could be improved. The study found that approximately 1 in 5 NFM alert overrides are overridden inappropriately.
AHRQ-funded; HS021094.
Citation: Her QL, Amato MG, Seger DL .
The frequency of inappropriate nonformulary medication alert overrides in the inpatient setting.
J Am Med Inform Assoc 2016 Sep;23(5):924-33. doi: 10.1093/jamia/ocv181..
Keywords: Clinical Decision Support (CDS), Health Information Technology (HIT), Inpatient Care, Medication, Patient Safety
Pevnick JM, Shane R, Schnipper JL
The problem with medication reconciliation.
The authors discussed medication reconciliation and the issue that benefits reaped by organizations focused on interventions have not generalized easily to other institutions. They specified that medication reconciliation interventions need to be carefully matched to organizational strengths, workflows, and goals based on institutional priorities, and that there are several broad recommendations that can be targeted to organizational leaders, clinicians and investigators.
AHRQ-funded; HS019598; HS023757.
Citation: Pevnick JM, Shane R, Schnipper JL .
The problem with medication reconciliation.
BMJ Qual Saf 2016 Sep;25(9):726-30. doi: 10.1136/bmjqs-2015-004734.
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Keywords: Electronic Health Records (EHRs), Medication, Patient Safety, Provider: Pharmacist
Walley AY, Green TC
Mainstreaming naloxone through coprescription to patients receiving long-term opioid therapy for chronic pain.
This editorial comments on the Coffin and colleagues' report of the Naloxone for Opioid Safety Evaluation (NOSE) study. The authors concluded that the NOSE study is a substantial step forward in demonstrating the feasibility of coprescription of rescue kits in primary care settings. (Coffin et al., Ann Intern Med. 2016 Aug 16;165(4):245-52.)
AHRQ-funded; HS024021.
Citation: Walley AY, Green TC .
Mainstreaming naloxone through coprescription to patients receiving long-term opioid therapy for chronic pain.
Ann Intern Med 2016 Aug 16;165(4):292-3. doi: 10.7326/m16-1348.
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Keywords: Chronic Conditions, Medication, Patient Safety, Primary Care
Bali V, Chatterjee S, Johnson ML
Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors.
The researchers evaluated comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures. They found no differential risk of hip fractures between paroxetine and other SSRIs.
AHRQ-funded; HS021264.
Citation: Bali V, Chatterjee S, Johnson ML .
Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors.
J Comp Eff Res 2016 Aug;5(5):461-73. doi: 10.2217/cer-2016-0009.
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Keywords: Medication, Elderly, Injuries and Wounds, Nursing Homes, Patient Safety
Kennedy-Hendricks A, Gielen A, McDonald E
Medication sharing, storage, and disposal practices for opioid medications among US adults.
The authors conducted a national survey among US adults with recent opioid medication use to examine the pervasiveness of sharing opioid medications, medication storage and disposal practices, and the sources of information received. Their findings suggested that current practices related to sharing, storing, and disposing of opioid medications, as well as communication of information on these topics, are suboptimal. They recommended that more research is needed to identify effective strategies to advance safer practices related to opioid medication sharing, storage, and disposal.
AHRQ-funded; HS000029.
Citation: Kennedy-Hendricks A, Gielen A, McDonald E .
Medication sharing, storage, and disposal practices for opioid medications among US adults.
JAMA Intern Med 2016 Jul;176(7):1027-9. doi: 10.1001/jamainternmed.2016.2543.
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Keywords: Medication: Safety, Medication, Opioids, Patient Safety, Substance Abuse
Wang SV, Franklin JM, Glynn RJ
Prediction of rates of thromboembolic and major bleeding outcomes with dabigatran or warfarin among patients with atrial fibrillation: new initiator cohort study.
The authors compared stratified event rates from randomized controlled trials with predicted event rates from models developed in observational data and assessed their ability to accurately capture observed rates of thromboembolism and major bleeding for patients treated with dabigatran or warfarin as part of routine care. They found that estimated rates of thromboembolism under dabigatran or warfarin treatment in randomized controlled trials were close to observed rates in routine care patients, but that rates of major bleeding were underestimated. They concluded that models developed in routine care patients can provide accurate, tailored estimates of risk and benefit under alternative treatment to enhance patient centered care.
AHRQ-funded; HS022193.
Citation: Wang SV, Franklin JM, Glynn RJ .
Prediction of rates of thromboembolic and major bleeding outcomes with dabigatran or warfarin among patients with atrial fibrillation: new initiator cohort study.
BMJ 2016 May 24;353:i2607. doi: 10.1136/bmj.i2607.
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Keywords: Blood Thinners, Adverse Drug Events (ADE), Blood Clots, Patient Safety, Medication
Topaz M, Seger DL, Slight SP
Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience.
The authors aimed to explore the common drug allergy alerts over the last 10 years and the reasons why providers tend to override these alerts. They found that alarmingly, alerts for immune mediated and life threatening reactions with definite allergen and prescribed medication matches were overridden 72.8 percent and 74.1 percent of the time, respectively.
AHRQ-funded; HS022728.
Citation: Topaz M, Seger DL, Slight SP .
Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience.
J Am Med Inform Assoc 2016 May;23(3):601-8. doi: 10.1093/jamia/ocv143.
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Keywords: Electronic Health Records (EHRs), Adverse Drug Events (ADE), Medication, Medication: Safety, Patient Safety
Zhong W, Feinstein JA, Patel NS
Tall Man lettering and potential prescription errors: a time series analysis of 42 children's hospitals in the USA over 9 years.
This paper evaluated rates of potential look-alike sound-alike (LA-SA) drug errors in the drug management process through to the point of dispensing before and after implementation of Tall Man lettering in 2007. The authors found no statistically significant change in error rate for each of the 11 drug pairs studied. Also, no downward trend in potential LA-SA drug error rates was evident over any time period 2004 onwards. They concluded that implementation of Tall Man lettering was not associated with a reduction in the potential LA-SA error rate.
AHRQ-funded; HS018425.
Citation: Zhong W, Feinstein JA, Patel NS .
Tall Man lettering and potential prescription errors: a time series analysis of 42 children's hospitals in the USA over 9 years.
BMJ Qual Saf 2016 Apr;25(4):233-40. doi: 10.1136/bmjqs-2015-004562.
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Keywords: Adverse Drug Events (ADE), Medication, Medication: Safety, Medical Errors, Patient Safety
Kennelty KA, Witry MJ, Gehring M
A four-phase approach for systematically collecting data and measuring medication discrepancies when patients transition between health care settings.
This article proposes a four-phase approach for systematically collecting medication data and measuring medication discrepancies between a hospital and community pharmacies. Using this phase-based approach, the study team successfully identified and reported medication discrepancies between a hospital and community pharmacies at the patient, medication, and community pharmacy units of analyses.
AHRQ-funded; HS021984.
Citation: Kennelty KA, Witry MJ, Gehring M .
A four-phase approach for systematically collecting data and measuring medication discrepancies when patients transition between health care settings.
Res Social Adm Pharm 2016 Jul-Aug;12(4):548-58. doi: 10.1016/j.sapharm.2015.09.001..
Keywords: Medication, Medication: Safety, Adverse Drug Events (ADE), Patient Safety, Provider: Pharmacist
Kozak MA, Melton JR, Gernant SA
A needs assessment of unused and expired medication disposal practices: a study from the Medication Safety Research Network of Indiana.
The investigators sought to describe the extent of the unused and expired medication (UEM) issue in Indiana, identify patient beliefs about UEM, and determine any association between those beliefs and various personal and demographic characteristics. They concluded that there remains a need for more disposal locations for both non-controlled and controlled medication.
AHRQ-funded; HS022119.
Citation: Kozak MA, Melton JR, Gernant SA .
A needs assessment of unused and expired medication disposal practices: a study from the Medication Safety Research Network of Indiana.
Res Social Adm Pharm 2016 Mar-Apr;12(2):336-40. doi: 10.1016/j.sapharm.2015.05.013.
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Keywords: Medication: Safety, Medication, Patient Safety, Provider: Pharmacist, Practice-Based Research Network (PBRN)