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AHRQ Research Studies Date
Topics
- Access to Care (1)
- Adverse Drug Events (ADE) (2)
- Adverse Events (2)
- Ambulatory Care and Surgery (1)
- Arthritis (3)
- Back Health and Pain (2)
- Behavioral Health (1)
- Blood Pressure (1)
- Blood Thinners (1)
- Cancer (1)
- Cancer: Lung Cancer (1)
- Cardiovascular Conditions (4)
- Children/Adolescents (3)
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- Comparative Effectiveness (12)
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- Healthcare Delivery (1)
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- Medicare (1)
- (-) Medication (31)
- Men's Health (1)
- Neurological Disorders (1)
- Newborns/Infants (1)
- Opioids (1)
- Osteoporosis (1)
- Outcomes (2)
- Pain (1)
- Palliative Care (1)
- (-) Patient-Centered Outcomes Research (31)
- Patient Adherence/Compliance (3)
- Patient Experience (1)
- Patient Safety (1)
- Practice Patterns (2)
- Pregnancy (1)
- Provider (1)
- Provider: Pharmacist (2)
- Quality Improvement (1)
- Racial and Ethnic Minorities (3)
- Registries (1)
- Respiratory Conditions (1)
- Risk (1)
- Shared Decision Making (1)
- Stroke (1)
- Substance Abuse (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 31 Research Studies DisplayedMcCoy RG, Van Houten HK, Ross JS
HbA1c overtesting and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study.
The researchers sought to determine the extent and effect of excessive testing for glycated hemoglobin (HbA1c) among adults with controlled type 2 diabetes. They found that in a US cohort of adults with stable and controlled type 2 diabetes, more than 60% received too many HbA1c tests, a practice associated with potential overtreatment with hypoglycemic drugs.
AHRQ-funded; HS018339.
Citation: McCoy RG, Van Houten HK, Ross JS .
HbA1c overtesting and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study.
BMJ 2015 Dec 8;351:h6138. doi: 10.1136/bmj.h6138..
Keywords: Chronic Conditions, Diabetes, Healthcare Utilization, Medication, Patient-Centered Outcomes Research
Stockmann C, Ampofo K, Pavia AT
Comparative effectiveness of oral versus outpatient parenteral antibiotic therapy for empyema.
This study compared outcomes between oral therapy and (outpatient parenteral antibiotic therapy (OPAT) for pediatric parapneumonic empyema (PPE) . The frequency of complications was similar with oral therapy and OPAT for children with PPE. Oral antibiotics may be considered safe and effective for children with PPE who will be discharged to complete therapy in the outpatient setting.
AHRQ-funded; HS023320.
Citation: Stockmann C, Ampofo K, Pavia AT .
Comparative effectiveness of oral versus outpatient parenteral antibiotic therapy for empyema.
Hosp Pediatr 2015 Dec;5(12):605-12. doi: 10.1542/hpeds.2015-0100.
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Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Medication, Hospitalization, Children/Adolescents
Du XL, Parikh RC, Lairson DR
Racial and geographic disparities in the patterns of care and costs at the end of life for patients with lung cancer in 2007-2010 after the 2006 introduction of bevacizumab.
The authors examined racial/ethnic and geographical disparities in cancer care and costs during the last 6 months of life for lung cancer decedents after the FDA's approval of bevacizumab. They found that there were substantial racial/ethnic and geographic disparities in the types of cancer care and costs in the last 6 months of life among lung cancer decedents, regardless of the length of survival times and hospice care status.
AHRQ-funded; HS018956.
Citation: Du XL, Parikh RC, Lairson DR .
Racial and geographic disparities in the patterns of care and costs at the end of life for patients with lung cancer in 2007-2010 after the 2006 introduction of bevacizumab.
Lung Cancer 2015 Dec;90(3):442-50. doi: 10.1016/j.lungcan.2015.09.017.
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Keywords: Cancer, Cancer: Lung Cancer, Disparities, Healthcare Costs, Medication, Palliative Care, Patient-Centered Outcomes Research, Practice Patterns, Racial and Ethnic Minorities
Strope SA, Vetter J, Elliott S
Use of medical therapy and success of laser surgery and transurethral resection of the prostate for benign prostatic hyperplasia.
To assess the impact of surgery for benign prostatic hyperplasia (BPH) on use of medication (5-alpha reductase inhibitors, alpha blockers, antispasmodics), the researchers assessed preoperative and postoperative medication utilization among surgically treated men. They found that most patients experience durable improvement after surgical intervention for BPH. However, their results show a need for effective patient counseling about continued or new use of medical therapy after laser and TURP procedures.
AHRQ-funded; HS019455.
Citation: Strope SA, Vetter J, Elliott S .
Use of medical therapy and success of laser surgery and transurethral resection of the prostate for benign prostatic hyperplasia.
Urology 2015 Dec;86(6):1115-22. doi: 10.1016/j.urology.2015.07.019..
Keywords: Surgery, Medication, Patient-Centered Outcomes Research, Men's Health
Goyal A, de Lemos JA, Peng SA
Association of patient enrollment in Medicare Part D with outcomes after acute myocardial infarction.
The researchers investigated whether enrollment versus nonenrollment in Medicare's prescription drug plan (Part D) is associated with better outcomes after acute myocardial infarction (AMI). They found that only half of Medicare-insured patients with AMI were enrolled in Part D by hospital discharge, and their 30-day and 1-year adjusted outcomes did not differ substantially from nonenrollees.
AHRQ-funded; HS021092.
Citation: Goyal A, de Lemos JA, Peng SA .
Association of patient enrollment in Medicare Part D with outcomes after acute myocardial infarction.
Circ Cardiovasc Qual Outcomes 2015 Nov;8(6):567-75. doi: 10.1161/circoutcomes.115.001650.
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Keywords: Heart Disease and Health, Medicare, Patient-Centered Outcomes Research, Medication, Patient Adherence/Compliance
Turner JA, Comstock BA, Standaert CJ
Can patient characteristics predict benefit from epidural corticosteroid injections for lumbar spinal stenosis symptoms?
The study’s aim was to identify patient characteristics associated with benefits from epidural injections of corticosteroid with lidocaine versus epidural injections of lidocaine only for lumbar spinal stenosis symptoms. It found that among 21 baseline patient characteristics examined, none, including clinician rated spinal stenosis severity, were consistent predictors of benefit from epidural injections of lidocain corticosteroid versus lidocaine only.
AHRQ-funded; HS019222; HS022972.
Citation: Turner JA, Comstock BA, Standaert CJ .
Can patient characteristics predict benefit from epidural corticosteroid injections for lumbar spinal stenosis symptoms?
Spine J 2015 Nov;15(11):2319-31. doi: 10.1016/j.spinee.2015.06.050..
Keywords: Patient-Centered Outcomes Research, Shared Decision Making, Medication, Back Health and Pain, Chronic Conditions
Bangalore S, Ogedegbe G, Gyamfi J
Outcomes with angiotensin-converting enzyme inhibitors vs other antihypertensive agents in hypertensive blacks.
The study’s objective was to evaluate the effectiveness of angiotensin-converting enzyme inhibitors when compared with other antihypertensive agents in hypertensive blacks. It found that in a large cohort of hypertensive blacks, angiotensin-converting enzyme inhibitors were associated with less benefit when compared with calcium channel blockers or thiazide diuretics.
AHRQ-funded; HS018589.
Citation: Bangalore S, Ogedegbe G, Gyamfi J .
Outcomes with angiotensin-converting enzyme inhibitors vs other antihypertensive agents in hypertensive blacks.
Am J Med 2015 Nov;128(11):1195-203. doi: 10.1016/j.amjmed.2015.04.034..
Keywords: Blood Pressure, Racial and Ethnic Minorities, Medication, Outcomes, Cardiovascular Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice, Comparative Effectiveness
Patorno E, Wang SV, Schneeweiss S
Patterns of beta-blocker initiation in patients undergoing intermediate to high-risk noncardiac surgery.
The objective of this study is to examine patterns of β-Blocker initiation among patients undergoing noncardiac elective surgery in the US. It concluded that after a period of a rapidly increasing trend, perioperative β-Blocker initiation decreased sharply in the second half of 2008 and continued to decrease afterwards.
AHRQ-funded; HS022193.
Citation: Patorno E, Wang SV, Schneeweiss S .
Patterns of beta-blocker initiation in patients undergoing intermediate to high-risk noncardiac surgery.
Am Heart J 2015 Oct;170(4):812-20.e6. doi: 10.1016/j.ahj.2015.06.028..
Keywords: Surgery, Patient-Centered Outcomes Research, Patient Safety, Medication
Desai NR, Sabatine MS
PCSK9 inhibition in patients with hypercholesterolemia.
The authors specified that large, cardiovascular outcomes trials are underway to assess definitively the efficacy and safety of 3 monoclonal antibodies (evolocumab, alirocumab, and bococizumab), while additional non-monoclonal antibody approaches to inhibit PCSK9 continue in the early-phase development.
AHRQ-funded; HS023000.
Citation: Desai NR, Sabatine MS .
PCSK9 inhibition in patients with hypercholesterolemia.
Trends Cardiovasc Med 2015 Oct;25(7):567-74. doi: 10.1016/j.tcm.2015.01.009.
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Keywords: Adverse Drug Events (ADE), Heart Disease and Health, Evidence-Based Practice, Medication, Patient-Centered Outcomes Research
Ogedegbe G, Shah NR, Phillips C
Comparative effectiveness of angiotensin-converting enzyme inhibitor-based treatment on cardiovascular outcomes in hypertensive Blacks versus Whites.
This study evaluated the comparative effectiveness of an ACE inhibitor–based regimen on a composite outcome of all-cause mortality, stroke, and acute myocardial infarction (AMI) in hypertensive blacks compared with whites. ACE inhibitor–based therapy was associated with poorer cardiovascular outcomes in hypertensive blacks but not in whites.
AHRQ-funded; HS018589.
Citation: Ogedegbe G, Shah NR, Phillips C .
Comparative effectiveness of angiotensin-converting enzyme inhibitor-based treatment on cardiovascular outcomes in hypertensive Blacks versus Whites.
J Am Coll Cardiol 2015 Sep 15;66(11):1224-33. doi: 10.1016/j.jacc.2015.07.021..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Cardiovascular Conditions, Racial and Ethnic Minorities, Medication
Wiener ES, Mullins CD, Pincus KJ
A framework for pharmacist-assisted medication adherence in hard-to-reach patients.
This study aimed to create a model for use in patient-centered, pharmacist-led interactions to improve medication adherence. The Health Action Process Approach (HAPA), a behavioral change framework, was adapted to known barriers of medication adherence. The study concluded that the newly developed framework provides a patient centered approach to facilitate and improve pharmacist-patient conversations regarding medication adherence.
AHRQ-funded; HS022135.
Citation: Wiener ES, Mullins CD, Pincus KJ .
A framework for pharmacist-assisted medication adherence in hard-to-reach patients.
Res Social Adm Pharm 2015 Sep-Oct;11(5):595-601. doi: 10.1016/j.sapharm.2014.11.0.
Keywords: Medication, Patient Adherence/Compliance, Patient-Centered Outcomes Research, Access to Care, Provider: Pharmacist
Michelson KA, Monuteaux MC, Neuman MI
Glucocorticoids and hospital length of stay for children with anaphylaxis: a retrospective study.
The objective of this study was to evaluate whether glucocorticoid administration is associated with improved outcomes in children with anaphylaxis. The investigators found that the use of glucocorticoids was inversely associated with prolonged length of stay among children hospitalized with anaphylaxis, but was not associated with 3-day emergency department revisits among discharged children, thus supporting the use of glucocorticoids in children hospitalized with anaphylaxis.
AHRQ-funded; HS000063.
Citation: Michelson KA, Monuteaux MC, Neuman MI .
Glucocorticoids and hospital length of stay for children with anaphylaxis: a retrospective study.
J Pediatr 2015 Sep;167(3):719-24.e1-3. doi: 10.1016/j.jpeds.2015.05.033.
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Keywords: Children/Adolescents, Medication, Respiratory Conditions, Respiratory Conditions, Patient-Centered Outcomes Research
Suri P, Pashova H, Heagerty PJ
Short-term improvements in disability mediate patient satisfaction after epidural corticosteroid injections for symptomatic lumbar spinal stenosis.
The researchers sought to identify mediators of the effect of lumbar epidural injections of corticosteroid plus lidocaine on patient satisfaction at 6 weeks postinjection in patients with lumbar spinal stenosis. Three-week change in disability was a significant mediator of the effects of lumbar epidural corticosteroid injections on patient satisfaction at 6 weeks, explaining 48 percent to 60 percent of the treatment effect on satisfaction.
AHRQ-funded; HS019222; HS022972.
Citation: Suri P, Pashova H, Heagerty PJ .
Short-term improvements in disability mediate patient satisfaction after epidural corticosteroid injections for symptomatic lumbar spinal stenosis.
Spine 2015 Sep 01;40(17):1363-70. doi: 10.1097/brs.0000000000001000.
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Keywords: Medication, Patient-Centered Outcomes Research, Back Health and Pain, Patient Experience
Bateman BT, Huybrechts KF, Maeda A
Calcium channel blocker exposure in late pregnancy and the risk of neonatal seizures.
This study assessed whether maternal calcium channel blocker exposure during late pregnancy is independently associated with neonatal seizures after carefully controlling for confounding factors. It found no significant increase in the risk of neonatal seizures in neonates attributable to maternal calcium channel blocker exposure in late pregnancy.
AHRQ-funded; HS018533.
Citation: Bateman BT, Huybrechts KF, Maeda A .
Calcium channel blocker exposure in late pregnancy and the risk of neonatal seizures.
Obstet Gynecol 2015 Aug;126(2):271-8. doi: 10.1097/aog.0000000000000908..
Keywords: Pregnancy, Adverse Events, Medication, Patient-Centered Outcomes Research, Newborns/Infants
Singh JA, Cameron C, Noorbaloochi S
Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis.
The researchers sought to determine whether biological drugs are associated with an increased risk of serious infection compared with traditional disease-modifying antirheumatic drugs (DMARDs). They found that standard-dose and high-dose biological drugs, with or without traditional DMARDs, are associated with an increase in serious infections in rheumatoid arthritis compared with traditional DMARDs, although low-dose biological drugs are not.
AHRQ-funded; HS021110.
Citation: Singh JA, Cameron C, Noorbaloochi S .
Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis.
Lancet 2015 Jul 18;386(9990):258-65. doi: 10.1016/s0140-6736(14)61704-9.
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Keywords: Comparative Effectiveness, Medication, Arthritis, Patient-Centered Outcomes Research
Lin CB, Cox M, Olson DM
Perception versus actual performance in timely tissue plasminogen activation administration in the management of acute ischemic stroke.
The purpose of this study was to compare stroke teams’ perceptions of their performance against known metrics associated with tPA administration. It found that less than one-third (29.1 percent) of staff accurately identified their door-to-needle performance It concluded that hospitals often overestimate their ability to deliver timely tPA to treated patients.
AHRQ-funded; HS016964.
Citation: Lin CB, Cox M, Olson DM .
Perception versus actual performance in timely tissue plasminogen activation administration in the management of acute ischemic stroke.
J Am Heart Assoc 2015 Jul;4(7). doi: 10.1161/jaha.114.001298..
Keywords: Stroke, Comparative Effectiveness, Patient-Centered Outcomes Research, Medication
Kavanaugh A, Lee SJ, Curtis JR
Discontinuation of tumour necrosis factor inhibitors in patients with rheumatoid arthritis in low-disease activity: persistent benefits. Data from the Corrona registry.
There is increasing interest in discontinuing biological therapies for patients with rheumatoid arthritis achieving good clinical responses, provided patients maintain clinical benefit. Using data from the Corrona registry, the investigators found that discontinuation of a first course of tumour necrosis factor inhibitor may be associated with persistent clinical benefit. Half of the registry patients included in the study maintained response through 20 months.
AHRQ-funded; HS018517.
Citation: Kavanaugh A, Lee SJ, Curtis JR .
Discontinuation of tumour necrosis factor inhibitors in patients with rheumatoid arthritis in low-disease activity: persistent benefits. Data from the Corrona registry.
Ann Rheum Dis 2015 Jun;74(6):1150-5. doi: 10.1136/annrheumdis-2014-206435.
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Keywords: Medication, Patient-Centered Outcomes Research, Registries, Arthritis
Khalil D, Boktor M, Mortensen EM
Comparison of frequency of inflammatory bowel disease and noninfectious gastroenteritis among statin users versus nonusers.
The objective of this study was to examine the association of statin use on the prevalence of IBD and noninfectious gastroenteritis (NI-GE) in a cohort of patients who were followed longitudinally in a military health care system, where patients had similar access and availability of health care. It found that statin use was not associated with either an increased or decreased risk of IBD or NI-GE diagnoses.
AHRQ-funded; HS022418.
Citation: Khalil D, Boktor M, Mortensen EM .
Comparison of frequency of inflammatory bowel disease and noninfectious gastroenteritis among statin users versus nonusers.
Am J Cardiol 2015 May 15;115(10):1396-401. doi: 10.1016/j.amjcard.2015.02.035..
Keywords: Digestive Disease and Health, Patient-Centered Outcomes Research, Risk, Medication, Cardiovascular Conditions
Singh JA, Akhras KS, Shiozawa A
Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort.
The researchers sought to assess the comparative effectiveness of febuxostat and allopurinol in reducing serum urate (sUA) levels in a real-world U.S. managed care setting. It concluded that febuxostat was more effective than allopurinol at the currently used doses in lowering sUA in gout patients as demonstrated by post-index mean sUA level, the likelihood of and the time to achieving sUA goals.
AHRQ-funded; HS021110.
Citation: Singh JA, Akhras KS, Shiozawa A .
Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort.
Arthritis Res Ther 2015 May 12;17(1):120. doi: 10.1186/s13075-015-0624-3..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Evidence-Based Practice, Medication, Treatments
O'Brien EC, Kim S, Hess PL
Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation.
Researchers assessed the potential effect of a new guideline for atrial fibrillation (AF) by comparing the proportion of patients with AF recommended for oral anticoagulation (OAC) under the 2011 and 2014 guidelines. They found that two-thirds of patients with AF who were previously not recommended for OAC are newly recommended under the 2014 guideline. They advised future studies evaluating longitudinal changes in anticoagulation treatment patterns and outcomes among patients reclassified by the new guidelines.
AHRQ-funded; HS021092.
Citation: O'Brien EC, Kim S, Hess PL .
Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation.
JAMA Intern Med 2015 May;175(5):848-50. doi: 10.1001/jamainternmed.2015.13.
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Keywords: Heart Disease and Health, Blood Thinners, Guidelines, Medication, Cardiovascular Conditions, Evidence-Based Practice, Patient-Centered Outcomes Research
Westover AN, Nakonezny PA, Barlow CE
Exercise outcomes in prevalent users of stimulant medications.
This study compared prevalent stimulant medication users to matched nonusers undergoing a maximal treadmill test for differences in peak systolic blood pressure, average rise in SBP during exercise, peak heart rate (HR), and aerobic exercise capacity. It found that stimulant use was associated with a decreased peak HR as well as an increased risk of chronotropic incompetence.
AHRQ-funded; HS022418.
Citation: Westover AN, Nakonezny PA, Barlow CE .
Exercise outcomes in prevalent users of stimulant medications.
J Psychiatr Res 2015 May;64:32-9. doi: 10.1016/j.jpsychires.2015.03.011.
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Keywords: Medication, Substance Abuse, Patient-Centered Outcomes Research
Yun H, Delzell E, Saag KG
Fractures and mortality in relation to different osteoporosis treatments.
The researchers aimed to determine if fracture and mortality rates vary among patients initiating different osteoporosis medications. They found that IV ibandronate and calcitonin were associated with higher rates of some types of fracture when compared to IV zolendronic acid. The relatively high mortality associated with use of calcitonin may reflect the poorer health of users of this agent.
AHRQ-funded; HS018517.
Citation: Yun H, Delzell E, Saag KG .
Fractures and mortality in relation to different osteoporosis treatments.
Clin Exp Rheumatol 2015 May-Jun;33(3):302-9..
Keywords: Osteoporosis, Medication, Comparative Effectiveness, Patient-Centered Outcomes Research
De Martino RR, Hoel AW, Beck AW
Participation in the Vascular Quality Initiative is associated with improved perioperative medication use, which is associated with longer patient survival.
The researchers analyzed the effect of Vascular Quality Initiative (VQI) participation on perioperative (preoperative and postoperative) medical management (MM) use over time and the effect of discharge MM on patient survival. They demonstrated that MM is associated with improved survival after a number of vascular procedures, and that VQI participation improves the use of MM, demonstrating that involvement in an organized quality effort can affect patient outcomes.
AHRQ-funded; HS021581.
Citation: De Martino RR, Hoel AW, Beck AW .
Participation in the Vascular Quality Initiative is associated with improved perioperative medication use, which is associated with longer patient survival.
J Vasc Surg 2015 Apr;61(4):1010-9. doi: 10.1016/j.jvs.2014.11.073.
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Keywords: Medication, Quality Improvement, Patient-Centered Outcomes Research, Practice Patterns
Ott BR, Daiello LA, Dahabreh IJ
Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials.
The researchers aimed to synthesize randomized clinical trial (RCTs) evidence on the association between statin therapy and cognitive outcomes. Their meta-analysis of cognitive test data from 14 studies failed to show significant adverse effects of statins on all tests of cognition in either cognitively normal subjects or Alzheimer’s disease subjects.
AHRQ-funded; HS017735.
Citation: Ott BR, Daiello LA, Dahabreh IJ .
Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials.
J Gen Intern Med 2015 Mar;30(3):348-58. doi: 10.1007/s11606-014-3115-3..
Keywords: Adverse Drug Events (ADE), Adverse Events, Medication, Neurological Disorders, Patient-Centered Outcomes Research
Rashid N, Coburn BW, Wu YL
Modifiable factors associated with allopurinol adherence and outcomes among patients with gout in an integrated healthcare system.
The investigators identified modifiable patient and provider factors associated with allopurinol adherence and the achievement of a serum urate acid (SUA) goal in gout. They found that among patients with gout initiating allopurinol in their study, 68% did not reach the SUA goal and 57% were nonadherent. They concluded that modifiable factors, including allopurinol dose escalation, treatment adherence, rheumatology referral, and concomitant medication use, could be important factors to consider in efforts aimed at optimizing gout treatment outcomes.
AHRQ-funded; HS018517.
Citation: Rashid N, Coburn BW, Wu YL .
Modifiable factors associated with allopurinol adherence and outcomes among patients with gout in an integrated healthcare system.
J Rheumatol 2015 Mar;42(3):504-12. doi: 10.3899/jrheum.140588.
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Keywords: Healthcare Delivery, Healthcare Utilization, Medication, Patient Adherence/Compliance, Patient-Centered Outcomes Research