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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedIglesia EGA, Kwan M, Virkud YV
Management of food allergies and food-related anaphylaxis.
This paper discusses the management of IgE-mediated food-protein allergies that may cause anaphylaxis and death in addition to the allergic response to the food-carbohydrate galactose-α-1,3-galactose (alpha-gal) in mammalian meat. In the United States, 9 foods account for more than 90% of IgE-mediated food allergies: crustacean shellfish, dairy, peanut, tree nuts, fin fish, egg, wheat, soy, and sesame. Peanut allergies are the leading food-related cause of fatal and near-fatal anaphylaxis in the US, followed by tree nuts and shellfish. The estimated fatality rate from anaphylaxis is estimated to be 0.04 per million per year. Alpha-gal syndrome has been rising with a seroprevalence of 20% to 31% in the southeastern US. While avoidance of the culprit food is the main management strategy, if there is exposure use of the self-injectable epinephrine pen is the first-line treatment for food-related anaphylaxis. The FDA has just approved an oral immunotherapy product for treatment of peanut allergy, with other immunotherapies currently in development to desensitive one or more foods.
AHRQ-funded; HS026395.
Citation: Iglesia EGA, Kwan M, Virkud YV .
Management of food allergies and food-related anaphylaxis.
JAMA 2024 Feb 13; 331(6):510-21. doi: 10.1001/jama.2023.26857.
Keywords: Care Management