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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 7 of 7 Research Studies DisplayedCaballero ML, Krantz MS, Quirce S
Hidden dangers: recognizing excipients as potential causes of drug and vaccine hypersensitivity reactions.
In this paper, the authors provided a review of the evidence-based literature outlining epidemiology and mechanisms of excipient reactions and provided strategies for heightened recognition and allergy testing.
AHRQ-funded; HS026395.
Citation: Caballero ML, Krantz MS, Quirce S .
Hidden dangers: recognizing excipients as potential causes of drug and vaccine hypersensitivity reactions.
J Allergy Clin Immunol Pract 2021 Aug;9(8):2968-82. doi: 10.1016/j.jaip.2021.03.002..
Keywords: Adverse Drug Events (ADE), Adverse Events, Medication, Medication: Safety, Vaccination, Patient Safety
Feldman AG, Curtis DJ, Moore SL
Under-immunization of pediatric transplant recipients: a call to action for the pediatric community.
This article is a call to action for pediatric solid organ transplant recipients to receive their recommended immunizations. Vaccine-preventable infections (VIPs) occur in 1 in 6 pediatric transplant recipients and these hospitalizations result in significant morbidity, mortality, graft injury, and cost. There has been an increase in the overall population in non-medical vaccine exemptions, which reduces herd immunity and creates greater risk for patients undergoing or already having received transplants.
AHRQ-funded; HS026510.
Citation: Feldman AG, Curtis DJ, Moore SL .
Under-immunization of pediatric transplant recipients: a call to action for the pediatric community.
Pediatr Res 2020 Jan;87(2):277-81. doi: 10.1038/s41390-019-0507-4..
Keywords: Children/Adolescents, Transplantation, Vaccination, Adverse Events, Patient Safety
Blumenthal KG, Topaz M, Zhou L
Mining social media data to assess the risk of skin and soft tissue infections from allergen immunotherapy.
This study examined large social media databases including Facebook, Twitter, and Reddit to identify postings of rare incidents of contamination or infection from extracts for allergen immunotherapy (AIT). They used natural language processing (NLP) related to AIT from 2012 to 2016. They compared posts on adverse events for AIT compared to influenza vaccinations. The results showed that both types of posts are rare events.
AHRQ-funded; HS025375.
Citation: Blumenthal KG, Topaz M, Zhou L .
Mining social media data to assess the risk of skin and soft tissue infections from allergen immunotherapy.
J Allergy Clin Immunol 2019 Jul;144(1):129-34. doi: 10.1016/j.jaci.2019.01.029..
Keywords: Social Media, Skin Conditions, Adverse Events, Patient Safety, Vaccination, Risk
Daley MF, Narwaney KJ, Shoup JA
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Successful strategies are needed to address parental vaccine hesitancy, a significant public health issue. The study objective was to assess whether an Internet-based platform with vaccine information and interactive social media components improved parents' vaccine-related attitudes. The authors concluded that among vaccine-hesitant parents, an Internet-based intervention improved parents' attitudes about vaccines.
AHRQ-funded; HS021492.
Citation: Daley MF, Narwaney KJ, Shoup JA .
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Am J Prev Med 2018 Jul;55(1):44-54. doi: 10.1016/j.amepre.2018.04.010..
Keywords: Caregiving, Patient Safety, Social Media, Vaccination, Web-Based
Wang SV, Abdurrob A, Spoendlin J
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addressed a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination.
AHRQ-funded; HS022193.
Citation: Wang SV, Abdurrob A, Spoendlin J .
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
Pharmacoepidemiol Drug Saf 2018 Apr;27(4):405-12. doi: 10.1002/pds.4399..
Keywords: Adverse Drug Events (ADE), Adverse Events, Children/Adolescents, Patient Safety, Vaccination
Bilinski AM, Fitzpatrick MC, Rupprecht CE
Optimal frequency of rabies vaccination campaigns in Sub-Saharan Africa.
The purpose of this paper was to evaluate the cost-effectiveness of rabies canine vaccination campaigns at varying coverage and frequency. The researchers, studying two districts of northwest Tanzania, found that optimal vaccination strategies were every 2 years, at 80% coverage in Ngorongoro and annually at 70% coverage in Serengeti. They further found that coordinated campaigns may provide monetary savings in addition to public health benefits. They concluded that frequency and coverage of canine vaccination campaigns should be evaluated simultaneously and tailored to local canine ecology as well as to the risk of disease reintroduction from surrounding regions.
AHRQ-funded; HS000055.
Citation: Bilinski AM, Fitzpatrick MC, Rupprecht CE .
Optimal frequency of rabies vaccination campaigns in Sub-Saharan Africa.
Proc Biol Sci 2016 Nov 16;283(1842). doi: 10.1098/rspb.2016.1211.
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Keywords: Patient Safety, Prevention, Vaccination
Feemster KA
Remembering the benefits of vaccination.
This commentary discussed the issue of vaccination and tightening exemptions for school entry. The author pointed out that events show that the success of vaccines can be fragile, as the measles cases associated with Disneyland were preceded by 644 cases in 2014. And 2012 saw more than 40,000 cases of pertussis, the largest number since 1960. These events provided a dramatic reminder that vaccines remain an important and necessary public health tool.
AHRQ-funded; HS020939.
Citation: Feemster KA .
Remembering the benefits of vaccination.
JAMA Pediatr 2015 Jul;169(7):624-6. doi: 10.1001/jamapediatrics.2015.0647.
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Keywords: Children/Adolescents, Infectious Diseases, Patient Safety, Policy, Vaccination