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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedGoodman KE, Simner PJ, Klein EY
Predicting probability of perirectal colonization with carbapenem-resistant Enterobacteriaceae (CRE) and other carbapenem-resistant organisms (CROs) at hospital unit admission.
This study measured the prevalence of carbapenem-resistant organisms (CROs), including carbapenem-resistant Enterobacteriaceae (CRE) and carbapenemase-production organisms (CPOs) in the perirectal area in all patients admitted to the medical intensive care unit or solid organ transplant unit at Johns Hopkins Hospital between July 1, 2016 and July 1, 2017. The data was then used to develop models to predict colonization probabilities using decision tree learning. While overall, decision tree models poorly predicted CRO and CPO colonization; for patients with recent CRO-positive cultures who use proton-pump inhibitors the decision tree did accurately identify patients with CRO-positive cultures.
AHRQ-funded; HS025089.
Citation: Goodman KE, Simner PJ, Klein EY .
Predicting probability of perirectal colonization with carbapenem-resistant Enterobacteriaceae (CRE) and other carbapenem-resistant organisms (CROs) at hospital unit admission.
Infect Control Hosp Epidemiol 2019 May;40(5):541-50. doi: 10.1017/ice.2019.42..
Keywords: Healthcare-Associated Infections (HAIs), Hospitals, Hospitalization, Infectious Diseases
Khamash DF, Mongodin EF, White JR
The association between the developing nasal microbiota of hospitalized neonates and Staphylococcus aureus colonization.
This research studied the association between hospitalized neonates who develop Staphylococcus aureus infections and nasal microbiota populations that preceded infection. Nares samples were obtained for neonates who were screened weekly for S. aureus. DNA was extracted and DNA of the bacterias were sequenced. It was found that controls and treated cases had a higher abundance of genes that contributed to the synthesis of natural antimicrobial compounds from several commensal bacterial types.
AHRQ-funded; HS022872.
Citation: Khamash DF, Mongodin EF, White JR .
The association between the developing nasal microbiota of hospitalized neonates and Staphylococcus aureus colonization.
Open Forum Infect Dis 2019 Apr;6(4):ofz062. doi: 10.1093/ofid/ofz062..
Keywords: Healthcare-Associated Infections (HAIs), Hospitalization, Hospitals, Infectious Diseases, Newborns/Infants
Leeman H, Cosgrove SE, Williams D
Assessing burden of central line-associated bloodstream infections present on hospital admission.
Investigators described patients presenting to an academic medical center with central line-associated bloodstream infection present on hospital admission over 1 year. Of the 130 admissions, they found that about half presented from home infusion, followed by oncology clinic, hemodialysis, and skilled nursing facility. They concluded that efforts to reduce such infections should address patients across the entire health care system.
AHRQ-funded; HS025782.
Citation: Leeman H, Cosgrove SE, Williams D .
Assessing burden of central line-associated bloodstream infections present on hospital admission.
Am J Infect Control 2020 Feb;48(2):216-18. doi: 10.1016/j.ajic.2019.08.010..
Keywords: Central Line-Associated Bloodstream Infections (CLABSI), Healthcare-Associated Infections (HAIs), Hospitalization, Home Healthcare, Hospitals, Infectious Diseases