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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedShah SC, Tepler A, Peek RM
Association between Helicobacter pylori exposure and decreased odds of eosinophilic esophagitis-a systematic review and meta-analysis.
Previous or current infection with Helicobacter pylori (exposure) has been reported to protect against eosinophilic esophagitis (EoE), perhaps owing to H pylori-induced immunomodulation. However, findings vary. In this study the investigators performed a systematic review and meta-analysis of comparative studies to define the association between H pylori exposure and EoE more clearly. The investigators found evidence for a significant association between H pylori exposure and reduced odds of EoE.
AHRQ-funded; HS026395.
Citation: Shah SC, Tepler A, Peek RM .
Association between Helicobacter pylori exposure and decreased odds of eosinophilic esophagitis-a systematic review and meta-analysis.
Clin Gastroenterol Hepatol 2019 Oct;17(11):2185-98.e3. doi: 10.1016/j.cgh.2019.01.013..
Keywords: Digestive Disease and Health, Evidence-Based Practice
Tepler A, Narula N, Peek RM
Systematic review with meta-analysis: association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease.
Accumulating data support a protective role of Helicobacter pylori against inflammatory bowel diseases (IBD), which might be mediated by strain-specific constituents, specifically cagA expression. The aim of this study was to perform a systematic review and meta-analysis to more clearly define the association between CagA seropositivity and IBD. The investigators found evidence for a significant association between CagA seropositive H pylori exposure and reduced odds of IBD, particularly CD, but not for CagA seronegative H pylori exposure.
AHRQ-funded; HS026395.
Citation: Tepler A, Narula N, Peek RM .
Systematic review with meta-analysis: association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease.
Aliment Pharmacol Ther 2019 Jul;50(2):121-31. doi: 10.1111/apt.15306..
Keywords: Digestive Disease and Health, Evidence-Based Practice