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AHRQ Research Studies Date
Topics
- Ambulatory Care and Surgery (2)
- (-) Antibiotics (31)
- Antimicrobial Stewardship (14)
- Care Management (1)
- Case Study (1)
- Children/Adolescents (6)
- Clinical Decision Support (CDS) (2)
- Clostridium difficile Infections (2)
- Community-Acquired Infections (2)
- Comparative Effectiveness (2)
- Critical Care (1)
- Digestive Disease and Health (1)
- Education: Continuing Medical Education (1)
- Elderly (4)
- Emergency Department (1)
- Evidence-Based Practice (3)
- Guidelines (2)
- Healthcare-Associated Infections (HAIs) (8)
- Healthcare Costs (2)
- Healthcare Utilization (1)
- Health Services Research (HSR) (1)
- Home Healthcare (1)
- Hospital Discharge (1)
- Hospitalization (1)
- Hospital Readmissions (1)
- Hospitals (2)
- Human Immunodeficiency Virus (HIV) (1)
- Imaging (2)
- Infectious Diseases (8)
- Long-Term Care (3)
- Medication (18)
- Methicillin-Resistant Staphylococcus aureus (MRSA) (2)
- Newborns/Infants (1)
- Nursing Homes (2)
- Outcomes (1)
- Palliative Care (1)
- Patient-Centered Outcomes Research (1)
- Patient Safety (6)
- Pneumonia (2)
- Practice Patterns (5)
- Pregnancy (1)
- Prevention (4)
- Primary Care: Models of Care (1)
- Sepsis (1)
- Shared Decision Making (2)
- Sickle Cell Disease (1)
- Skin Conditions (1)
- Surgery (3)
- Urinary Tract Infection (UTI) (3)
- Women (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 31 Research Studies DisplayedAnesi JA, Lautenbach E, Nachamkin I
Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae.
In this retrospective cohort study, the investigators sought to determine the clinical outcomes associated with community-onset ESC-resistant (ESC-R) EB urinary tract infections (UTIs) in a US health system. The authors found that community-onset UTI due to an ESC-R EB organism was significantly associated with clinical failure, which may be due in part to inappropriate initial antibiotic therapy. They indicate that further studies are needed to determine which patients in the community are at high risk for drug-resistant infection to help inform prompt diagnosis and appropriate antibiotic prescribing for ESC-R EB.
AHRQ-funded; HS020002.
Citation: Anesi JA, Lautenbach E, Nachamkin I .
Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae.
Infect Control Hosp Epidemiol 2018 Dec;39(12):1431-35. doi: 10.1017/ice.2018.254..
Keywords: Antibiotics, Community-Acquired Infections, Medication, Outcomes, Patient Safety, Urinary Tract Infection (UTI)
Frush JM, Zhu Y, Edwards KM
Prevalence of staphylococcus aureus and use of antistaphylococcal therapy in children hospitalized with pneumonia.
In a studied group of children hospitalized with community-acquired pneumonia, staphylococcal pneumonia was rare but associated with adverse in-hospital outcomes. Despite this low prevalence, use of antistaphylococcal antibiotics was common. The authors recommended efforts to minimize overuse of antistaphylococcal antibiotics while also ensuring adequate treatment for pathogen-specific diseases.
AHRQ-funded; HS022342.
Citation: Frush JM, Zhu Y, Edwards KM .
Prevalence of staphylococcus aureus and use of antistaphylococcal therapy in children hospitalized with pneumonia.
J Hosp Med 2018 Dec;13(12):848-52. doi: 10.12788/jhm.3093..
Keywords: Children/Adolescents, Infectious Diseases, Pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA), Community-Acquired Infections, Hospitalization, Antibiotics, Medication
Varda BK, Finkelstein JB, Wang HH
The association between continuous antibiotic prophylaxis and UTI from birth until initial postnatal imaging evaluation among newborns with antenatal hydronephrosis.
This study examined whether the routine use of continuous antibiotic prophylaxis (CAP) before initial postnatal imaging is effective to prevent urinary tract infection (UTI) in infants with a history of antenatal urinary tract dilation (AUTD). A single-institution, retrospective cohort study of infants with a history of AUTD was conducted. A random sample of 500 infants was selected with six excluded for other congenital anomalies. Of the 494 remaining, 157 (32%) received CAP. There was no difference found in UTI incidence among those treated with CAP and those who were not.
AHRQ-funded; HS000063.
Citation: Varda BK, Finkelstein JB, Wang HH .
The association between continuous antibiotic prophylaxis and UTI from birth until initial postnatal imaging evaluation among newborns with antenatal hydronephrosis.
J Pediatr Urol 2018 Dec;14(6):539.e1-39.e6. doi: 10.1016/j.jpurol.2018.04.022..
Keywords: Antibiotics, Antimicrobial Stewardship, Urinary Tract Infection (UTI), Newborns/Infants, Imaging, Medication, Prevention
D'Agata EMC, Lindberg CC, Lindberg CM
The positive effects of an antimicrobial stewardship program targeting outpatient hemodialysis facilities.
The purpose of this study was to quantify the effect of an antimicrobial stewardship program in reducing antimicrobial prescribing. Implementation of the antimicrobial stewardship program was associated with a 6% monthly reduction in antimicrobial doses per 100 patient months during the intervention period (P=.02). The investigators found that within 6 hemodialysis facilities, implementation of an antimicrobial stewardship was associated with a decline in antimicrobial prescribing with no negative effects.
AHRQ-funded; HS021666.
Citation: D'Agata EMC, Lindberg CC, Lindberg CM .
The positive effects of an antimicrobial stewardship program targeting outpatient hemodialysis facilities.
Infect Control Hosp Epidemiol 2018 Dec;39(12):1400-05. doi: 10.1017/ice.2018.237..
Keywords: Antibiotics, Antimicrobial Stewardship, Prevention, Medication, Medication
Mundkur ML, Franklin J, Huybrechts KF
Changes in outpatient use of antibiotics by adults in the United States, 2006-2015.
The two goals of this observational study were to describe general trends in outpatient antibiotic use among adults from 2006 to 2015, and to identify rapid shifts in use during this time period as potential indicators for key events. Patients aged 18 years and older were selected from the Optum Clinformatics Datamart, a commercial insurance claims database; linear regression was used to identify trends in use over multiple years, and change-point regression was used to identify rapid shifts in use within individual years. Outpatient use of antibiotics from 2006 to 2015 decreased substantially among adults. Rapid shifts in use occurring in 2008 and 2013 may reflect the presence of key drivers of change.
AHRQ-funded; HS024930; 233201500020I.
Citation: Mundkur ML, Franklin J, Huybrechts KF .
Changes in outpatient use of antibiotics by adults in the United States, 2006-2015.
Drug Saf 2018 Dec;41(12):1333-42. doi: 10.1007/s40264-018-0697-4..
Keywords: Antibiotics, Healthcare Utilization, Medication, Practice Patterns
Kline SE, Sanstead EC, Johnson JR
Cost-effectiveness of pre-operative Staphylococcus aureus screening and decolonization.
In this study, the investigators developed a decision analytic model to evaluate the impact of a preoperative Staphylococcus aureus decolonization bundle on surgical site infections (SSIs), health-care-associated costs (HCACs), and deaths due to SSI. The investigators predict that the treat-all strategy would be the most effective and cost-saving strategy for preventing SSIs. However, they concluded that because this strategy might select more extensively for mupirocin-resistant S. aureus and cause more medication adverse effects than the test-and-treat approach or the SOC, additional studies are needed to define its comparative benefits and harms.
AHRQ-funded; HS022912.
Citation: Kline SE, Sanstead EC, Johnson JR .
Cost-effectiveness of pre-operative Staphylococcus aureus screening and decolonization.
Infect Control Hosp Epidemiol 2018 Nov;39(11):1340-46. doi: 10.1017/ice.2018.228..
Keywords: Surgery, Antibiotics, Antimicrobial Stewardship, Healthcare-Associated Infections (HAIs), Infectious Diseases, Patient Safety, Prevention, Healthcare Costs
Kadri SS, Adjemian J, Lai YL
Difficult-to-treat resistance in gram-negative bacteremia at 173 US hospitals: retrospective cohort analysis of prevalence, predictors, and outcome of resistance to all first-line agents.
Resistance to all first-line antibiotics necessitates the use of less effective or more toxic "reserve" agents. In this study, the Premier Database was analyzed for inpatients with select Gram-negative bloodstream infections (GNBSIs). Prevalence and aminoglycoside resistance of difficult-to-treat resistance (DTR) episodes were compared with carbapenem-resistant, extended-spectrum cephalosporin-resistant, and fluoroquinolone-resistant episodes using CDC definitions. The investigators concluded that nonsusceptibility to first-line antibiotics was associated with decreased survival in GNBSIs. They suggest that DSR is a simple bedside prognostic measure of treatment-limiting coresistance.
AHRQ-funded; HS025008.
Citation: Kadri SS, Adjemian J, Lai YL .
Difficult-to-treat resistance in gram-negative bacteremia at 173 US hospitals: retrospective cohort analysis of prevalence, predictors, and outcome of resistance to all first-line agents.
Clin Infect Dis 2018 Nov 28;67(12):1803-14. doi: 10.1093/cid/ciy378..
Keywords: Antibiotics, Antimicrobial Stewardship, Infectious Diseases
D'Agata EMC, Varu A, Geffert SF
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
This nested case-control study was conducted among 137 nursing home residents who did not receive antimicrobials, with 44 acquiring a multi-drug resistant organism. Risk factors identified included receiving gastrointestinal medication that affected the gut microbiome, the number of visits from healthcare workers, pressure ulcers, and not residing in a dementia unit.
AHRQ-funded; HS021666.
Citation: D'Agata EMC, Varu A, Geffert SF .
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
Clin Infect Dis 2018 Oct 15;67(9):1437-40. doi: 10.1093/cid/ciy358..
Keywords: Antimicrobial Stewardship, Antibiotics, Medication, Nursing Homes, Long-Term Care, Elderly, Digestive Disease and Health, Case Study
Pulia MS, Schwei RJ, Patterson BW
Effectiveness of outpatient antibiotics after surgical drainage of abscesses in reducing treatment failure.
The objective of this retrospective observational study was to evaluate the real-world effectiveness of outpatient antibiotic prescribing after surgical drainage of cutaneous abscesses on reducing treatment failure. The investigators found that this real-world, comparative effectiveness analysis did not demonstrate any significant reduction in treatment failure with the use of antibiotics after drainage of abscesses in the emergency department.
AHRQ-funded; HS024558; HS024342.
Citation: Pulia MS, Schwei RJ, Patterson BW .
Effectiveness of outpatient antibiotics after surgical drainage of abscesses in reducing treatment failure.
J Emerg Med 2018 Oct;55(4):512-21. doi: 10.1016/j.jemermed.2018.06.036..
Keywords: Antibiotics, Comparative Effectiveness, Patient-Centered Outcomes Research, Surgery
Doernberg SB, Aboo LM, Burdette SD
Essential resources and strategies for antibiotic stewardship programs in the acute care setting.
This study measured the success of antibiotic stewardship programs to rates of antibiotic resistant disease. A survey was conducted of US stewardship programs using a cross-section of members of 3 infectious diseases subspecialty societies. Two-hundred forty-four respondents from a variety of acute care settings filled out the survey. Eighty-five percent of surveyed programs demonstrated at least 1 improved outcome in the prior 2 years. Every 0.50 increase in pharmacist and physician full-time equivalent (FTE) support predicted a 1.48-fold increase in demonstration effectiveness.
AHRQ-funded; HS023866.
Citation: Doernberg SB, Aboo LM, Burdette SD .
Essential resources and strategies for antibiotic stewardship programs in the acute care setting.
Clin Infect Dis 2018 Sep 28;67(8):1168-74. doi: 10.1093/cid/ciy255..
Keywords: Antimicrobial Stewardship, Antibiotics, Critical Care, Medication
Michener A, Heath B, Crnich CJ
Infections in older adults: a case-based discussion series emphasizing antibiotic stewardship.
This article describes the results of a series of 1-hour case-based discussions on recognition, diagnosis, and infections common in older adults, including those living in long-term care settings, and antibiotic stewardship that were developed by the authors. This series of five discussions was held at 15 Veterans Affairs medical centers in their skilled nursing centers. There were participants from an array of disciplines who completed an evaluation as well as pre- and post-course knowledge assessment. Total participants numbered from 68 to 108 per center. There were positive assessments, with many participants saying they were likely to make changes to help combat health associated infections.
AHRQ-funded; HS023866.
Citation: Michener A, Heath B, Crnich CJ .
Infections in older adults: a case-based discussion series emphasizing antibiotic stewardship.
MedEdPORTAL 2018 Sep 21;14:10754. doi: 10.15766/mep_2374-8265.10754..
Keywords: Antimicrobial Stewardship, Antibiotics, Medication, Elderly, Infectious Diseases
D'Agata EMC, Tran D, Bautista J
Clinical and economic benefits of antimicrobial stewardship programs in hemodialysis facilities: a decision analytic model.
In this study, the authors developed a decision analytic model of antimicrobial use on the clinical and economic consequences of implementing a nationwide antimicrobial stewardship program in outpatient dialysis facilities. The authors found that the model suggested that implementation of antimicrobial stewardship programs in outpatient dialysis facilities would result in substantial reductions in infections caused by multidrug-resistant organisms and C. difficile, infection-related deaths, and costs.
AHRQ-funded; R18 HS021666.
Citation: D'Agata EMC, Tran D, Bautista J .
Clinical and economic benefits of antimicrobial stewardship programs in hemodialysis facilities: a decision analytic model.
Clin J Am Soc Nephrol 2018 Sep 7;13(9):1389-97. doi: 10.2215/cjn.12521117..
Keywords: Antimicrobial Stewardship, Shared Decision Making, Antibiotics, Medication, Healthcare Costs, Clostridium difficile Infections, Healthcare-Associated Infections (HAIs)
Morgan JR, Barlam TF, Drainoni ML
A qualitative study of the real-world experiences of infectious diseases fellows regarding antibiotic stewardship.
A qualitative study was performed to explore infectious disease (ID) fellows' experiences and perspectives regarding their antibiotic stewardship training and their role as future antibiotic stewards. The investigators concluded that ID fellowship training was not successfully conveying the public health importance of antibiotic stewardship or the role of ID physicians as leaders of antibiotic stewardship programs. They noted that fellows were more focused on concrete tasks related to stewardship.
AHRQ-funded; HS022242.
Citation: Morgan JR, Barlam TF, Drainoni ML .
A qualitative study of the real-world experiences of infectious diseases fellows regarding antibiotic stewardship.
Open Forum Infect Dis 2018 Sep;5(9):ofy102. doi: 10.1093/ofid/ofy102..
Keywords: Antibiotics, Antimicrobial Stewardship, Education: Continuing Medical Education, Infectious Diseases
Durkin MJ, Keller M, Butler AM
An assessment of inappropriate antibiotic use and guideline adherence for uncomplicated urinary tract infections.
In 2011, The Infectious Diseases Society of America released a clinical practice guideline (CPG) that recommended short-course antibiotic therapy and avoidance of fluoroquinolones for uncomplicated urinary tract infections (UTIs). This study assessed whether the CPG had an impact on national antibiotic prescribing practices. The study found that CPG was not associated with a clinically meaningful change in national antibiotic prescribing practices for UTIs.
AHRQ-funded; HS019455.
Citation: Durkin MJ, Keller M, Butler AM .
An assessment of inappropriate antibiotic use and guideline adherence for uncomplicated urinary tract infections.
Open Forum Infect Dis 2018 Sep;5(9):ofy198. doi: 10.1093/ofid/ofy198..
Keywords: Antibiotics, Shared Decision Making, Guidelines, Practice Patterns, Urinary Tract Infection (UTI)
Hume PS, Varon J, Englert JA
Trends in "usual care" for septic shock.
The investigators examined changes in treatment patterns for septic shock in the emergency department (ED) of a large academic hospital. The investigators observed, from 2003 to 2013, significant reductions in time to antibiotics and fluids for patients with septic shock in the ED, underscoring the evolution of “usual care” over time. These findings may explain why early goal-directed therapy is not beneficial in the current era and may help inform ongoing deliberations regarding best practices for sepsis care.
AHRQ-funded; HS025008.
Citation: Hume PS, Varon J, Englert JA .
Trends in "usual care" for septic shock.
Infect Control Hosp Epidemiol 2018 Sep;39(9):1125-26. doi: 10.1017/ice.2018.154..
Keywords: Antibiotics, Emergency Department, Practice Patterns, Sepsis
Patterson ES, Dewart CM, Stevenson K
A mixed methods approach to tailoring evidence-based guidance for antibiotic stewardship to one medical system.
The purpose of the study is to operationalize a novel antibiotic advisor, called the personalized weighted incidence syndromic combination antibiogram (pWISCA), intended to help physicians with initial antibiotic choice in hospitals. This paper presents findings from applying a mixed methods approach to identifying and prioritizing antibiotic medications and associated contextual data to display in a clinical decision support tailored to the local hospital.
AHRQ-funded; HS024379.
Citation: Patterson ES, Dewart CM, Stevenson K .
A mixed methods approach to tailoring evidence-based guidance for antibiotic stewardship to one medical system.
Proc Int Symp Hum Factors Ergon Healthc 2018 Jun;7(1):224-31. doi: 10.1177/2327857918071053..
Keywords: Antibiotics, Clinical Decision Support (CDS), Evidence-Based Practice, Health Services Research (HSR), Hospitals
Hostler CJ, Moehring RW, Ashley ESD
Feasibility and value of developing a regional antibiogram for community hospitals.
The purpose of this study was to determine the feasibility and value of developing a regional antibiogram for community hospitals. The investigators concluded that small community hospitals frequently cannot develop an accurate antibiogram due to a paucity of local data. They suggest that a regional antibiogram is likely to provide clinically useful information to community hospitals for low-prevalence pathogens.
AHRQ-funded; HS023866.
Citation: Hostler CJ, Moehring RW, Ashley ESD .
Feasibility and value of developing a regional antibiogram for community hospitals.
Infect Control Hosp Epidemiol 2018 Jun;39(6):718-22. doi: 10.1017/ice.2018.71..
Keywords: Antibiotics, Hospitals, Medication
Murray MT, Johnson CL, Cohen B
Use of antibiotics in paediatric long-term care facilities.
The authors sought to describe antibiotic use in three pediatric long-term care (LTC) facilities and to describe the factors associated with use. They found that the use of antibiotics in pediatric LTC facilities is widespread. They recommended further assessment of antibiotic use in pediatric LTC facilities.
AHRQ-funded; HS021470.
Citation: Murray MT, Johnson CL, Cohen B .
Use of antibiotics in paediatric long-term care facilities.
J Hosp Infect 2018 Jun;99(2):139-44. doi: 10.1016/j.jhin.2017.10.019.
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Keywords: Antibiotics, Children/Adolescents, Healthcare-Associated Infections (HAIs), Long-Term Care, Practice Patterns
Hersh AL, Olson J, Stockmann C
Impact of antimicrobial stewardship for pediatric outpatient parenteral antibiotic therapy.
In this study, the investigators developed an outpatient parenteral antibiotic therapy (OPAT) stewardship program in a freestanding children's hospital to improve the appropriateness of OPAT prescribing.
AHRQ-funded; HS023320.
Citation: Hersh AL, Olson J, Stockmann C .
Impact of antimicrobial stewardship for pediatric outpatient parenteral antibiotic therapy.
J Pediatric Infect Dis Soc 2018 May 15;7(2):e34-e36. doi: 10.1093/jpids/pix038..
Keywords: Antibiotics, Antimicrobial Stewardship, Children/Adolescents, Ambulatory Care and Surgery
McBride S, Thurm C, Gouripeddi R
Comparison of empiric antibiotics for acute osteomyelitis in children.
Broad-spectrum antibiotics are commonly used for the empiric treatment of acute hematogenous osteomyelitis and often target methicillin-resistant Staphylococcus aureus (MRSA) with medication-associated risk and unknown treatment benefit. In this study, the investigators aimed to compare clinical outcomes among patients with osteomyelitis who did and did not receive initial antibiotics used to target MRSA. The investigators found that, early antibiotic treatment used to target MRSA was associated with a higher rate of repeat MRI.
AHRQ-funded; HS019862.
Citation: McBride S, Thurm C, Gouripeddi R .
Comparison of empiric antibiotics for acute osteomyelitis in children.
Hosp Pediatr 2018 May;8(5):280-87. doi: 10.1542/hpeds.2017-0079..
Keywords: Children/Adolescents, Antibiotics, Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Medication, Imaging, Patient Safety
Spellberg B
The maturing antibiotic mantra: "Shorter is still better."
The proper duration of antibiotic therapy for various infections is a matter of long-standing consternation. This article discusses the evidence supporting the idea that shorter courses of antibiotic therapy are as effective as longer courses. It asserts that shorter courses are better due to reduced exposure which intrinsically reduces the risk of adverse events and of selective pressure that drives resistance in our microbiomes.
AHRQ-funded; HS025690.
Citation: Spellberg B .
The maturing antibiotic mantra: "Shorter is still better."
J Hosp Med 2018 May;13(5):361.62. doi: 10.12788/jhm.2904.
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Keywords: Antibiotics, Care Management, Medication
Keller SC, Tamma PD, Cosgrove SE
AHRQ Author: Miller MA
Ambulatory antibiotic stewardship through a human factors engineering approach: a systematic review.
The authors conducted a systematic review to identify controlled interventions and qualitative studies of ambulatory antibiotic stewardship (AS) interventions and determine whether and how they incorporated principles from a human factors engineering model, the Systems Engineering Initiative for Patient Safety 2.0 model. They concluded that studies have not focused on clinic-wide approaches to AS.
AHRQ-authored; AHRQ-funded; 233201500020I.
Citation: Keller SC, Tamma PD, Cosgrove SE .
Ambulatory antibiotic stewardship through a human factors engineering approach: a systematic review.
J Am Board Fam Med 2018 May-Jun;31(3):417-30. doi: 10.3122/jabfm.2018.03.170225.
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Keywords: Antibiotics, Clinical Decision Support (CDS), Primary Care: Models of Care, Ambulatory Care and Surgery, Patient Safety
Johnson SP, Zhong L, Chung KC
Perioperative antibiotics for clean hand surgery: a national study.
This research is a national study on the use of prophylactic antibiotics in soft tissue hand surgery when antimicrobials are not indicated. Insurance claims from the Truven MarketScan Databases were used to identify patients who had 1 of 5 outpatient surgery procedures including: open or endoscopic carpal tunnel release; trigger finger release; de Ouervain release, and wrist ganglion excision between 2009 and 2015. An increase of 72.5% in prophylactic intravenous antibiotics was shown from 2009 to 2015. Patients with a younger age, male sex, lower income, or obesity had higher odds of receiving antibiotics. Total charge for these antibiotics equaled $1.6 million.
AHRQ-funded; HS023313.
Citation: Johnson SP, Zhong L, Chung KC .
Perioperative antibiotics for clean hand surgery: a national study.
J Hand Surg Am 2018 May;43(5):407-16.e1. doi: 10.1016/j.jhsa.2017.11.018..
Keywords: Antibiotics, Antimicrobial Stewardship, Healthcare-Associated Infections (HAIs), Infectious Diseases, Medication, Patient Safety, Surgery
Wynn A, Ramogola-Masire D, Gaolebale P
Prevalence and treatment outcomes of routine Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis testing during antenatal care, Gaborone, Botswana.
AHRQ-funded; HS000046.
Citation: Wynn A, Ramogola-Masire D, Gaolebale P .
Prevalence and treatment outcomes of routine Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis testing during antenatal care, Gaborone, Botswana.
Sex Transm Infect 2018 May;94(3):230-35. doi: 10.1136/sextrans-2017-053134..
Keywords: Antibiotics, Human Immunodeficiency Virus (HIV), Infectious Diseases, Pregnancy, Women
Wald-Dickler N, Holtom P, Spellberg B
Busting the myth of "static vs cidal": a systemic literature review.
This study compared the effectiveness of bactericidal antibiotics versus bacteriostatic agents. A systematic literature review was conducted of published, randomized, controlled trials that were comparison studies. Of the 56 identified trials published since 1985, 49 found no significant difference in effectiveness between the two types of antibiotics. Only 1 trial found the bactericidal agent was superior.
AHRQ-funded; HS025690.
Citation: Wald-Dickler N, Holtom P, Spellberg B .
Busting the myth of "static vs cidal": a systemic literature review.
Clin Infect Dis 2018 Apr 17;66(9):1470-74. doi: 10.1093/cid/cix1127..
Keywords: Antibiotics, Medication, Comparative Effectiveness, Evidence-Based Practice