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- (-) Transplantation (30)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 30 Research Studies DisplayedStrauss AT, Sidoti CN, Purnell TS
Multicenter study of racial and ethnic inequities in liver transplantation evaluation: understanding mechanisms and identifying solutions.
This multicenter study examined racial and ethnic inequities in liver transplantation. The authors recruited participants from the liver transplantation (LT) teams including coordinators, advanced practice providers, physicians, social workers, dieticians, pharmacists, leadership at 2 major LT centers. They conducted 54 interviews and had 49 observation hours. They created a conceptual framework describing how transplant work system characteristics and other external factors may improve equity in the LT evaluation process. They proposed transplant center-level solutions (i.e., including but not limited to training of staff on health equity) to modifiable barriers in the clinical work system that could help patient navigation, reduce disparities, and improve access to care. Their findings call for an urgent need for transplant centers, national societies, and policy makers to focus efforts on improving equity (tailored, patient-centered resources) using the science of human factors and systems engineering.
AHRQ-funded; HS024600.
Citation: Strauss AT, Sidoti CN, Purnell TS .
Multicenter study of racial and ethnic inequities in liver transplantation evaluation: understanding mechanisms and identifying solutions.
Liver Transpl 2022 Dec;28(12):1841-56. doi: 10.1002/lt.26532..
Keywords: Racial and Ethnic Minorities, Transplantation, Disparities, Access to Care
Qin CX, Auerbach SR, Charnaya O
Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients.
The purpose of this observational cohort study was to assess whether a third SARS-CoV-2 vaccine would improve immunogenicity in adolescent solid organ transplant recipients (SOTRs), and to report the antibody response and safety of a third mRNA vaccine dose (D3) in adolescent SOTRs. Forty-two participants received three BNT162b2 doses and one received three mRNA-1273 doses. Participants were 6-13 years from transplant (median 10 [IQR]), and heart transplant was the most common procedure, in 41.9% of the participants. 9.3% of participants reported pre-D1 SARS-CoV-2 infections and 9.3% reported breakthrough infections. The study found that 88.4% of adolescent SOTRs had positive antibody responses 1 month post-D3, an increase from 63–73% post-D2. 54.5% of participants with prior negative responses seroconverted and 100% with positive responses increased or remained at maximum titer. Titers remained stable 3 months post-D3. There were no vaccine-related adverse events and four breakthrough infections. The researchers concluded that although this was a convenience sample, the results suggest there is an antibody response benefit to a third SARS-CoV-2 vaccine in adolescent SOTRs.
AHRQ-funded; HS026510.
Citation: Qin CX, Auerbach SR, Charnaya O .
Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients.
Am J Transplant 2022 Oct;22(10):2481-83. doi: 10.1111/ajt.17085..
Keywords: Children/Adolescents, COVID-19, Vaccination, Transplantation
Butler T, Cummings LS, Purnell TS
The case for prioritizing diversity in the transplantation workforce to advance kidney health equity.
The authors of this article propose a more diverse transplant workforce to address the problem of kidney transplant inequity. Black patients are disproportionately affected by kidney failure and systemic barriers to kidney transplantation such as delayed referrals, which may be due to clinician bias. Workforce diversity would help to alleviate the harm of implicit biases.
AHRQ-funded; HS024600.
Citation: Butler T, Cummings LS, Purnell TS .
The case for prioritizing diversity in the transplantation workforce to advance kidney health equity.
J Am Soc Nephrol 2022 Oct; 33(10):1817-19. doi: 10.1681/asn.2022040429..
Keywords: Kidney Disease and Health, Transplantation, Workforce, Disparities, Racial and Ethnic Minorities
Israni AK, Schladt D, Bruin MJ
Deconstructing silos of knowledge around lung transplantation to support patients: a patient-specific search of scientific registry of transplant recipients data.
This article describes the development of the web site www.transplantcentersearch.org intended to support lung transplant patients by providing program-level data from the Scientific Registry of Transplant Recipients (SRTR) on each program in the United States. There is a high level of variation in selection criteria and although nearly half of recipients reside within 50 miles of their transplant program, >30% travel 100 miles or more. The web site allows patients to search for programs in the area of their choosing and receive information on the number of transplants and program factors that are most predictive of recipient survival after listing. Patients can also review information on recipients and donors at each program to further differentiate program options. This feature is patient-specific, allowing the patient to enter information about their clinical background and indicate general preferences for their treatment before receiving counts on recipients and donors matching their entries. The development of the site involved 2 phases. In Phase I the authors examined variations between programs using data on waitlist and transplant outcomes from the SRTR. Phase II involved interviews and focus groups with transplant candidates, recipients, and family members to gain insight into the decision-making process, barriers, and knowledge groups. In the future randomized trials will be conducted to evaluate the efficacy of the web site.
AHRQ-funded; HS026379.
Citation: Israni AK, Schladt D, Bruin MJ .
Deconstructing silos of knowledge around lung transplantation to support patients: a patient-specific search of scientific registry of transplant recipients data.
Transplantation 2022 Aug;106(8):1517-19. doi: 10.1097/tp.0000000000004051..
Keywords: Transplantation, Registries, Patient-Centered Outcomes Research, Evidence-Based Practice
Alvarado F, Cervantes CE, Crews DC
Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: a systematic review.
The purpose of this systematic qualitative review was to evaluate outcomes in Hispanic donors and examine how Hispanic ethnicity was presented. In October 2021, the researchers reviewed PubMed, EMBASE, and Scopus for studies, with 18 meeting the inclusion criteria. Across the studies, Hispanic donors ranged between 6% and 21% of the donor populations. The study found that Hispanic donors were not at increased risk for end-stage kidney disease, cardiovascular disease, non-pregnancy-related hospitalizations, overall perioperative surgical complications or post-donation mortality compared to non-Hispanic White donors. Also compared to non-Hispanic White donors, most studies showed Hispanic donors were at higher risk for diabetes mellitus following nephrectomy; however, mixed findings were observed regarding the risk for post-donation chronic kidney disease and hypertension. The researchers concluded that future studies should explain variation in health outcomes by considering and assessing differences within the Hispanic donor population.
AHRQ-funded; HS024600.
Citation: Alvarado F, Cervantes CE, Crews DC .
Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: a systematic review.
Am J Transplant 2022 Jul;22(7):1737-53. doi: 10.1111/ajt.17017..
Keywords: Transplantation, Kidney Disease and Health, Chronic Conditions, Racial and Ethnic Minorities, Disparities
Gonzales HM, Fleming JN, Gebregziabher M
A critical analysis of the specific pharmacist interventions and risk assessments during the 12-month TRANSAFE Rx randomized controlled trial.
The objective of this study was to describe frequency and types of interventions made during a pharmacist-led, mobile health-based intervention of high-risk kidney transplant (KTX) recipients and to assess impact on patient risk levels. Primary pharmacist intervention types were medication reconciliation, patient education, and medication changes. The authors concluded that pharmacist-led mHealth may enhance opportunities for interventions and mitigate risk levels in KTX recipients.
AHRQ-funded; HS023754.
Citation: Gonzales HM, Fleming JN, Gebregziabher M .
A critical analysis of the specific pharmacist interventions and risk assessments during the 12-month TRANSAFE Rx randomized controlled trial.
Ann Pharmacother 2022 Jun; 56(6):685-90. doi: 10.1177/10600280211044792..
Keywords: Provider: Pharmacist, Medication: Safety, Medication, Risk, Transplantation, Kidney Disease and Health, Adverse Drug Events (ADE), Medical Errors, Patient Safety
Wall SP, Castillo P, Shuchat Shaw F
Including medical footage and emotional content in organ donation educational videos for Latinx viewers.
The purpose of this 2 x 3 randomized controlled trial was to evaluate whether different types of videos shown in Latinx-owned barbershops and beauty salons affected deceased organ donor registration. Videos included medical footage of organ preservation and transplantation, as well as sad, uplifting, or unresolved stories. Impact was measured as it related to the impact of medical footage and storylines on three variables: registry enrollment, donation willingness and stage of change, and emotions. The study found that 14.8% of participants registered for deceased organ donation. Medical footage, sad, and unresolved stories did not differentially affect registration or willingness to donate organs. Compared to the uplifting story, the sad and unresolved stories increased sadness and decreased positive affect. The educational videos which included or excluded medical footage of organ preservation and transplantation and varying emotional levels of stories did not differentially affect registration. The researchers concluded that future work is necessary to analyze qualitative data that was collected with a subset of participants in order to report the qualitative reasons for participants' registration decisions.
AHRQ-funded; HS016482.
Citation: Wall SP, Castillo P, Shuchat Shaw F .
Including medical footage and emotional content in organ donation educational videos for Latinx viewers.
Health Educ Behav 2022 Jun;49(3):424-36. doi: 10.1177/10901981211022240..
Keywords: Transplantation, Education: Patient and Caregiver, Racial and Ethnic Minorities
Bowring MG, Massie AB, Schwarz KB
Survival benefit of split-liver transplantation for pediatric and adult candidates.
The patient and graft survival rates for split -liver transplantations (SLTs) among pediatric and adult recipients are similar to those of whole-liver transplantations (WLTs), yet SLTs are rarely used. The purpose of the study was to compare the survival benefit of accepting an offer of a splittable graft vs waiting for a subsequent offer. The researchers utilized data from the 2010 to 2018 Scientific Registry of Transplant Recipients (SRTR) on 1814 adult and 928 pediatric liver transplantation candidates ever offered a splittable graft, and compared the eventual mortality between patients who accepted vs declined an offer for an SLT. The study discovered that among adult candidates, acceptance of an SLT offer was associated with a 43% reduction in mortality, and within 1 year of declining an offer 39.3% received a WLT, and 7.9% died. In pediatric cases with a weight of less than or equal to 7 kilograms, acceptance of a split liver offer versus declining the offer was associated with a 63% reduction in mortality, and within 1 year of declining 45.8% received a WLT and 6.4% died. In the group of pediatric cases with weight greater than 7 kilograms there was no significant difference between acceptance of an SLT offer and decline. The study concluded that accepting an offer for SLT could significantly improve survival for adults and small children on the liver transplant waiting list.
AHRQ-funded; HS023876.
Citation: Bowring MG, Massie AB, Schwarz KB .
Survival benefit of split-liver transplantation for pediatric and adult candidates.
Liver Transpl 2022 Jun;28(6):969-82. doi: 10.1002/lt.26393..
Keywords: Children/Adolescents, Transplantation
Jacobson CE, Heximer A, Olmeda-Barrientos R
Language accessibility of liver transplantation center websites.
This research letter describes an analysis of language accessibility of liver transplantation center websites. The authors surveyed patient-facing educational websites of all 140 active, accredited US liver transplantation centers. Thirty-eight states and the District of Columbia had websites. Inclusion criteria was that they were using the Organ Procurement and Transplantation Network website. They analyzed each website for non-English content. Excluded were websites from Puerto Rico, as Spanish is the predominant governmental language. A total of 23 states had no transplant websites with online materials in a second language, and 34 sites (24.3%) had resources other than English on their website. California had the highest number of centers with resources in a language other than English, followed by Texas and New York. Spanish was the most common language available at 100% of sites that had resources other than English, followed by Arabic at 38.9% and Mandarin Chinese at 38.9%. A total of 108 different languages were represented among 10 state websites.
AHRQ-funded; HS000053.
Citation: Jacobson CE, Heximer A, Olmeda-Barrientos R .
Language accessibility of liver transplantation center websites.
Liver Transpl 2022 Apr; 28(4):722-24. doi: 10.1002/lt.26343..
Keywords: Transplantation, Clinician-Patient Communication, Communication, Health Information Technology (HIT), Health Literacy
Barreto EF, May HP, Schreier DJ
Development and feasibility of a multidisciplinary approach to AKI survivorship in care transitions: research letter.
The purpose of this study was to observe and describe the development and feasibility of a multidisciplinary approach to caring for acute kidney injury (AKI) survivors at care transitions (ACT). The studied population were adults with stage 3 AKI who were not discharging on dialysis and were established with a primary care provider at the authors’ academic medical center in the U.S. Preliminary data indicated that AKI survivors of interest could primarily be identified, educated, and followed up with using the multidisciplinary approach model, which also maximized the unique expertise of each team member. The authors concluded that this multidisciplinary ACT workflow supported by clinical decision support was feasible, scalable, and addressed gaps in existing care transition models.
AHRQ-funded; HS028060.
Citation: Barreto EF, May HP, Schreier DJ .
Development and feasibility of a multidisciplinary approach to AKI survivorship in care transitions: research letter.
Can J Kidney Health Dis 2022 Mar 6; 9:20543581221081258. doi: 10.1177/20543581221081258..
Keywords: Kidney Disease and Health, Transplantation, Transitions of Care
Kemme S, Yoeli D, Sundaram SS
Decreased access to pediatric liver transplantation during the COVID-19 pandemic.
The purpose of the study was to explore and understand the impact of the COVID-19 pandemic on nationwide pediatric liver transplants. The researchers compared data for transplant waiting list additions, removals, and liver transplants during pre-COVID-19 (March-November 2016-2019), early COVID-19 (March-May 2020), and late COVID-19 (June-November 2020). The study results showed a 38% decrease in liver transplantations during early COVID-19, recovering to pre-pandemic rates during late COVID-19. White children had a 30% decrease in overall liver transplantation, while non-White children had a 44% decrease in overall liver transplantation. Additions to the waiting list decreased 25% during COVID-19, with Black transplant candidates the most affected, and children spent longer on the waiting list during early COVID-19 compared to pre-COVID-19 (140 vs. 96 days). The study concluded that the COVID-19 pandemic decreased access to pediatric liver transplants, especially during early COVID-19. The researchers discussed that although the rate of pediatric liver transplants has resumed to pre-COVID-19 levels, racial disparities must be addressed.
AHRQ-funded; HS026510.
Citation: Kemme S, Yoeli D, Sundaram SS .
Decreased access to pediatric liver transplantation during the COVID-19 pandemic.
Pediatr Transplant 2022 Mar;26(2):e14162. doi: 10.1111/petr.14162..
Keywords: Children/Adolescents, COVID-19, Transplantation, Access to Care, Disparities
Gianaris K, Vargas GB, Johnson M
Perceived susceptibility to chronic kidney disease and hypertension self-management among Black and White live kidney donors.
This study examines the theory whether Black kidney donors are more likely than White donors to develop hypertension (HTN) and chronic kidney disease after donation. The authors ascertained electronic medical records and phone survey data from live donors enrolled in the multi-center Wellness and Health Outcomes of LivE Donors (WHOLE-Donor) Hypertension Care Study between May 2013 and April 2020. The study cohort included 318 US-based live kidney donors who developed post-donation HTN with 57.6% female, 78.9% White, 18.6% Black, and a mean age of 46.7 years. Donors with diabetes or who were older than 50 years reported being moderately or strongly concerned about kidney disease. A large majority (87%) reported taking at least one action to help control blood pressure, with no significant differences by sociodemographic factors. They found no substantial differences in perceived susceptibility to kidney disease among Black and White donors, despite published evidence that Black donors may experience greater risk of developing kidney disease than White donors.
AHRQ-funded; HS024600.
Citation: Gianaris K, Vargas GB, Johnson M .
Perceived susceptibility to chronic kidney disease and hypertension self-management among Black and White live kidney donors.
Ethn Dis 2022 Spring;32(2):101-08. doi: 10.18865/ed.32.2.101..
Keywords: Kidney Disease and Health, Chronic Conditions, Racial and Ethnic Minorities, Transplantation, Patient Self-Management, Blood Pressure
Qin CX, Auerbach SR, Charnaya O
Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients.
While many adult solid organ transplant recipients (SOTRs) have impaired antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, pediatric SOTRs’ response has not been assessed. In this article, the researchers reported the immunogenicity and safety of BNT162b2 mRNA vaccination in pediatric SOTRs.
AHRQ-funded; HS026510.
Citation: Qin CX, Auerbach SR, Charnaya O .
Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients.
Am J Transplant 2022 Feb;22(2):669-72. doi: 10.1111/ajt.16841..
Keywords: Children/Adolescents, Vaccination, COVID-19, Transplantation
Feldman AG, Marsh R, Kempe A
Barriers to pretransplant immunization: a qualitative interview study of pediatric solid organ transplant stakeholders.
Investigators described the experiences and beliefs of pediatric transplant stakeholders regarding factors that contribute to low pre-transplant immunization rates. Five central themes emerged: gaps in knowledge about timing and safety of pre-transplant immunizations; lack of communication, coordination, and follow-up between team members; lack of centralized immunization records; subspecialty clinics functioning as the medical home for transplant candidates, but not able to provide all needed immunizations; and differences between organ type in prioritization and completion of pre-transplant immunization. The authors recommended new tools to overcome these barriers and to increase immunization rates in transplant candidates.
AHRQ-funded; HS026510.
Citation: Feldman AG, Marsh R, Kempe A .
Barriers to pretransplant immunization: a qualitative interview study of pediatric solid organ transplant stakeholders.
J Pediatr 2020 Dec;227:60-68. doi: 10.1016/j.jpeds.2020.07.038..
Keywords: Children/Adolescents, Transplantation, Surgery, Healthcare Delivery, Healthcare Utilization
Feldman AG, Adams MA, Wachs ME
Successful non-directed living liver donor transplant for an infant with biliary atresia during the COVID-19 pandemic.
This case study describes a successful non-directed living liver donor transplant for an infant with biliary atresia that occurred during the COVID-19 pandemic. Careful preoperative planning was used to prevent infection pre- and post-cooperatively, and robust telehealth technology use both in and out of the hospital.
AHRQ-funded; HS026510.
Citation: Feldman AG, Adams MA, Wachs ME .
Successful non-directed living liver donor transplant for an infant with biliary atresia during the COVID-19 pandemic.
Pediatr Transplant 2020 Dec;24(8):e13816. doi: 10.1111/petr.13816..
Keywords: Newborns/Infants, COVID-19, Transplantation, Surgery, Case Study
Edwards GC, Shipe ME, Smith L
Exploring patient willingness to accept hepatitis C-infected kidneys for transplantation.
The objective of this study was to explore patient willingness to accept a kidney from Hepatitis C virus-infected donors compared to donors with active intravenous drug use and donors with longstanding diabetes and hypertension. Using electronic surveys, results showed that utilization of kidneys from Hepatitis C virus-infected donors to expand the donor pool appeared to be an acceptable option to patients.
AHRQ-funded; HS026122.
Citation: Edwards GC, Shipe ME, Smith L .
Exploring patient willingness to accept hepatitis C-infected kidneys for transplantation.
BMC Nephrol 2020 Nov 10;21(1):473. doi: 10.1186/s12882-020-02114-y..
Keywords: Hepatitis, Kidney Disease and Health, Transplantation
Kemme S, Sundaram SS, Curtis DJ
A community divided: post-transplant live vaccine practices among Society of Pediatric Liver Transplantation (SPLIT) centers.
The goal of this study was to assess current post-transplant live vaccine practices at individual pediatric liver transplant centers following the updated AST guidelines. Using email surveys with a 93% response rate, findings showed that only 29% of centers offered live vaccines post-transplant, with each center using different eligibility criteria for live vaccines. The main reasons for a center not offering post-transplant live vaccines were safety concerns and inability to reach group consensus.
AHRQ-funded; HS026510.
Citation: Kemme S, Sundaram SS, Curtis DJ .
A community divided: post-transplant live vaccine practices among Society of Pediatric Liver Transplantation (SPLIT) centers.
Pediatr Transplant 2020 Aug 26:e13804. doi: 10.1111/petr.13804..
Keywords: Children/Adolescents, Transplantation, Surgery, Vaccination, Practice Patterns
Shen NT, Bray J, Wahid NA
Evaluation of alcohol taxes as a public health opportunity to reduce liver transplant listings for alcohol-related liver disease.
Alcohol-related liver disease (ALD) is a leading indication for liver transplantation. In this study, the investigators evaluated alcohol taxes as a public health opportunity to reduce liver transplant listings for alcohol-related liver disease. The investigators concluded that transplant listings for ALD were directly associated with spirit consumption and inversely associated with spirits excise taxes. They indicate that these findings suggest a possible public health benefit of increasing excise taxes for spirits.
AHRQ-funded; HS000066.
Citation: Shen NT, Bray J, Wahid NA .
Evaluation of alcohol taxes as a public health opportunity to reduce liver transplant listings for alcohol-related liver disease.
Alcohol Clin Exp Res 2020 Nov;44(11):2307-15. doi: 10.1111/acer.14454..
Keywords: Alcohol Use, Policy, Transplantation
Mogul DB, Perito ER, Wood N
Impact of acuity circles on outcomes for pediatric liver transplant candidates.
In December 2018, UNOS approved an allocation scheme based on recipients' geographic distance from a deceased donor ("acuity circles"). Previous analyses suggested acuity circles (AC) would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. In this study, the investigators applied Scientific Registry of Transplant Recipients data from 2011-2016 towards the Liver Simulated Allocation Model (LSAM) to compare outcomes by age and illness severity for the UNOS-approved AC and the existing Donor Service Area (DSA)/Region-based allocation schemes.
AHRQ-funded; HS023876.
Citation: Mogul DB, Perito ER, Wood N .
Impact of acuity circles on outcomes for pediatric liver transplant candidates.
Transplantation 2020 Aug;104(8):1627-32. doi: 10.1097/tp.0000000000003079..
Keywords: Children/Adolescents, Transplantation, Outcomes, Patient-Centered Outcomes Research, Evidence-Based Practice, Registries, Surgery, Access to Care
Covarrubias K, Luo X, Massie A
Determinants of length of stay after pediatric liver transplantation.
In this study, the investigators sought to identify factors that were associated with LOS following pediatric (<18 years) liver transplantation in order to provide personalized counseling and discharge planning for recipients and their families. They concluded that while center-level practices accounted for substantial variation in LOS, consideration of donor and recipient factors could help clinicians provide more personalized counseling for families of pediatric liver transplant candidates.
AHRQ-funded; HS023876.
Citation: Covarrubias K, Luo X, Massie A .
Determinants of length of stay after pediatric liver transplantation.
Pediatr Transplant 2020 Jun;24(4):e13702. doi: 10.1111/petr.13702..
Keywords: Children/Adolescents, Transplantation
Brown CS, Wakam GK, Englesbe MJ
Increased-risk donors and solid organ transplantation: current practices and opportunities for improvement.
This study looked at recent developments in decision making for use of CDC-labeled increased-risk donor (IRD) use for solid organ transplantation. The implementation of nucleic acid testing for HIV and hepatitis C virus has resulted in decreasing risk of window-period infection often by an order of magnitude or more. However, surgeons still are hesitant to utilize IRD organs. The authors conclude that rate of transmission of window-period infection from IRD organs is exceptionally low and the harms regarding the increased risk classification outweigh the benefits for patients who need organ transplantation.
AHRQ-funded; HS000053.
Citation: Brown CS, Wakam GK, Englesbe MJ .
Increased-risk donors and solid organ transplantation: current practices and opportunities for improvement.
Curr Opin Organ Transplant 2020 Apr;25(2):139-43. doi: 10.1097/mot.0000000000000735..
Keywords: Transplantation, Surgery, Risk
Ingraham NE, Tignanelli CJ, Menk J
Pre- and peri-operative factors associated with chronic critical illness in liver transplant recipients.
This study examined whether patients with end-stage liver failure undergoing liver transplant would be at high risk for developing chronic critical illness (CCI). They looked at pre- and perioperative factors associated with CCI. This retrospective cohort study was performed at a large academic transplant center and included all adult liver transplant patients from 2011 to 2017. CCI was defined as the need for mechanical ventilation for seven days or more post-transplant. Recipients who had re-transplantation, acute rejection, or who died during transplant surgery were excluded. They identified 382 transplant recipients, and out of that cohort 45 (11.8%) developed CCI. Eight independent factors were associated with CCI including previous liver transplant, acute renal failure, frailty, lower albumin level, higher international normalized ratio, need for mechanical ventilation and higher systolic pulmonary artery pressure. A higher pre-transplant Model for End-Stage Liver Disease (MELD) score was associated with protection against CCI.
AHRQ-funded; HS026379.
Citation: Ingraham NE, Tignanelli CJ, Menk J .
Pre- and peri-operative factors associated with chronic critical illness in liver transplant recipients.
Surg Infect 2020 Apr;21(3):246-54. doi: 10.1089/sur.2019.192..
Keywords: Chronic Conditions, Transplantation, Surgery, Outcomes
Muzaale AD, Massie AB, Al Ammary F
Donor-recipient relationship and risk of ESKD in live kidney donors of varied racial groups.
Risk factors for kidney failure are the basis of live kidney donor candidate evaluation. In this retrospective cohort study, the investigators quantified risk for end-stage kidney disease (ESKD) by the biological relationship of the donor to the recipient, a risk factor that is not addressed by current clinical practice guidelines. The investigators found that marked differences in risk for ESKD across types of donor-recipient relationship were observed for Asian, black, and white donors.
AHRQ-funded; HS024600.
Citation: Muzaale AD, Massie AB, Al Ammary F .
Donor-recipient relationship and risk of ESKD in live kidney donors of varied racial groups.
Am J Kidney Dis 2020 Mar;75(3):333-41. doi: 10.1053/j.ajkd.2019.08.020..
Keywords: Transplantation, Kidney Disease and Health, Racial and Ethnic Minorities, Risk, Registries
Bowring MG, Massie AB, Chu NM
Projected 20- and 30-year outcomes for pediatric liver transplant recipients in the United States.
Researchers aimed to use national registry data and parametric models to project 20- and 30-year post-transplant outcomes for recently transplanted pediatric liver transplant (LT) recipients. Using Scientific Registry of Transplant Recipients data, they found that projected long-term outcomes for recently transplanted pediatric LT recipients are excellent, reflective of substantial improvements in medical care, and informative for physician-patient education and decision making in the current era.
AHRQ-funded; HS023876.
Citation: Bowring MG, Massie AB, Chu NM .
Projected 20- and 30-year outcomes for pediatric liver transplant recipients in the United States.
J Pediatr Gastroenterol Nutr 2020 Mar;70(3):356-63. doi: 10.1097/mpg.0000000000002592..
Keywords: Children/Adolescents, Transplantation, Patient-Centered Outcomes Research, Outcomes, Surgery, Registries, Evidence-Based Practice
Schaffhausen CR, Bruin MJ, Chu S
Tool to aid patients in selecting a liver transplant center.
Variations in candidate and donor acceptance criteria may influence access and mortality for liver transplantation. In this study, the investigators sought to understand how recipient and donor characteristics varied across centers and how patients interpreted this information. The data was then used to develop a tool to provide tailored information to candidates seeking a center.
AHRQ-funded; HS024527; HS026379.
Citation: Schaffhausen CR, Bruin MJ, Chu S .
Tool to aid patients in selecting a liver transplant center.
Liver Transpl 2020 Mar;26(3):337-48. doi: 10.1002/lt.25715..
Keywords: Transplantation, Shared Decision Making