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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedFeldman AG, Beaty BL, Ferrolino Ja
Safety and immunogenicity of live viral vaccines in a multicenter cohort of pediatric transplant recipients.
This study’s objective was to determine the safety and immunogenicity of live vaccines in pediatric liver and kidney transplant recipients. This cohort study included 281 children, of which 270 had received a liver transplant, 9 a kidney transplant, and 2 were liver-kidney transplant recipients. None of the children included had completed their primary measles-mumps-rubella (MMR) and varicella-zoster virus (VZV) vaccine series and/or had displayed nonprotective serum antibody levels at enrollment between January 1, 2002, and February 28, 2023. Safety data was collected after these transplant recipients had received 1 to 3 doses or MMR vaccine and/or 1 to 3 doses of VZV vaccine. The median time from transplant to enrollment was 6.3 years, with the median age at first posttransplant vaccine 8.9 years. The majority of children developed protective antibodies following vaccination (107 of 149 varicella, 130 of 152 measles, 100 of 120 mumps, and 124 of 125 rubella). One year post vaccination, the majority of children who initially mounted protective antibodies maintained this protection (34 of 44 varicella, 45 of 49 measles, 35 of 42 mumps, 51 of 54 rubella). Five children developed varicella, all of which resolved within 1 week, and there were no cases of measles or rubella and no episodes or graft rejection within 1 month of vaccination. There was also no association between antibody response and immunosuppression level at the time of vaccination.
AHRQ-funded; HS026510.
Citation: Feldman AG, Beaty BL, Ferrolino Ja .
Safety and immunogenicity of live viral vaccines in a multicenter cohort of pediatric transplant recipients.
JAMA Netw Open 2023 Oct; 6(10):e2337602. doi: 10.1001/jamanetworkopen.2023.37602..
Keywords: Children/Adolescents, Vaccination, Transplantation
Bahakel H, Feldman AG, Danziger-Isakov L
Immunization of solid organ transplant candidates and recipients: a 2022 update.
The authors discussed the dissemination and implementation of up-to-date vaccine recommendations to aid primary care providers and multi-disciplinary transplant team members taking care of solid organ transplant patients. Key recommendations included: All age-appropriate vaccines should be administered pretransplant; nonimmune liver and kidney transplant recipients on low-dose immunosuppression can be given live vaccines posttransplant under careful medical observation; immunizations should be a prioritized part of pre- and posttransplant care.
AHRQ-funded; HS026510.
Citation: Bahakel H, Feldman AG, Danziger-Isakov L .
Immunization of solid organ transplant candidates and recipients: a 2022 update.
Infect Dis Clin North Am 2023 Sep; 37(3):427-41. doi: 10.1016/j.idc.2023.03.004..
Keywords: Vaccination, Transplantation