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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
76 to 100 of 162 Research Studies DisplayedShah PD, Trogdon JG, Golden SD
Impact of pharmacists on access to vaccine providers: a geospatial analysis.
This study analyzed the impact of pharmacists on access to vaccines. The study concluded that pharmacists are more geographically dispersed across census tracts than primary care physicians. As a result, adding pharmacists to the workforce would increase the availability of vaccine providers in areas with inadequate primary care provider coverage.
AHRQ-funded; HS000032.
Citation: Shah PD, Trogdon JG, Golden SD .
Impact of pharmacists on access to vaccine providers: a geospatial analysis.
Milbank Q 2018 Sep;96(3):568-92. doi: 10.1111/1468-0009.12342.
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Keywords: Access to Care, Provider: Pharmacist, Vaccination
Shah PD, Calo WA, Marciniak MW
Support for pharmacist-provided HPV vaccination: national surveys of U.S. physicians and parents.
Cancer Epidemiol Biomarkers Prev 2018 Aug;27(8):970-78. doi: 10.1158/1055-9965.Epi-18-0380.
State laws about pharmacists providing human papillomavirus (HPV) vaccines vary considerably, limiting many pharmacists' ability to provide this important cancer prevention service. In this study, the investigators characterized physician and parent support for pharmacist-provided HPV vaccination for adolescents who are past due for vaccination. The authors concluded that to increase support for HPV vaccination services, pharmacists should raise awareness about their immunization training and standardize vaccination protocols that ensure coordination with primary care.
State laws about pharmacists providing human papillomavirus (HPV) vaccines vary considerably, limiting many pharmacists' ability to provide this important cancer prevention service. In this study, the investigators characterized physician and parent support for pharmacist-provided HPV vaccination for adolescents who are past due for vaccination. The authors concluded that to increase support for HPV vaccination services, pharmacists should raise awareness about their immunization training and standardize vaccination protocols that ensure coordination with primary care.
AHRQ-funded; HS000032.
Citation: Shah PD, Calo WA, Marciniak MW .
Support for pharmacist-provided HPV vaccination: national surveys of U.S. physicians and parents.
Cancer Epidemiol Biomarkers Prev 2018 Aug;27(8):970-78. doi: 10.1158/1055-9965.Epi-18-0380..
Keywords: Caregiving, Children/Adolescents, Infectious Diseases, Provider, Provider: Pharmacist, Provider: Physician, Vaccination
Daley MF, Narwaney KJ, Shoup JA
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Successful strategies are needed to address parental vaccine hesitancy, a significant public health issue. The study objective was to assess whether an Internet-based platform with vaccine information and interactive social media components improved parents' vaccine-related attitudes. The authors concluded that among vaccine-hesitant parents, an Internet-based intervention improved parents' attitudes about vaccines.
AHRQ-funded; HS021492.
Citation: Daley MF, Narwaney KJ, Shoup JA .
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Am J Prev Med 2018 Jul;55(1):44-54. doi: 10.1016/j.amepre.2018.04.010..
Keywords: Caregiving, Patient Safety, Social Media, Vaccination, Web-Based
Shah PD, Marciniak MW, Golden SD
Pharmacies versus doctors' offices for adolescent vaccination.
This study sought to understand the relative advantage of pharmacies compared to doctors' offices for delivering HPV vaccination to adolescents. The authors concluded that to be more appealing to parents as HPV vaccine providers, pharmacy providers within community and hospital settings should build on their relative advantage with respect to accessibility and enhance their appeal of their healthcare environment.
AHRQ-funded; HS000032.
Citation: Shah PD, Marciniak MW, Golden SD .
Pharmacies versus doctors' offices for adolescent vaccination.
Vaccine 2018 Jun 7;36(24):3453-59. doi: 10.1016/j.vaccine.2018.04.088..
Keywords: Children/Adolescents, Health Services Research (HSR), Ambulatory Care and Surgery, Provider: Pharmacist, Vaccination
Shay LA, Baldwin AS, Betts AC
Parent-provider communication of HPV vaccine hesitancy.
The authors of this study developed a typology characterizing parent-provider communication around the human papillomavirus (HPV) vaccine in order to assist providers in communicating more effectively with parents around HPV vaccine hesitancy. Visits with unvaccinated adolescents at six pediatric clinics in Dallas, Texas, in which parents were undecided about HPV vaccination, were audio-recorded. The parents’ verbal expression of hesitancy and whether the providers responded with acquiescence and/or persistence were qualitatively coded, and the frequency of parent and provider communication codes and same-day vaccination described. The results indicate that providers who engage hesitant parents and address their concerns can lead to same-day HPV vaccination, and that even parents who make assertive statements are amenable to influence by providers.
AHRQ-funded; HS022418.
Citation: Shay LA, Baldwin AS, Betts AC .
Parent-provider communication of HPV vaccine hesitancy.
Pediatrics 2018 Jun;141(6). doi: 10.1542/peds.2017-2312..
Keywords: Clinician-Patient Communication, Communication, Shared Decision Making, Infectious Diseases, Vaccination
Shoup JA, Narwaney KJ, Wagner NM
Social media vaccine websites: a comparative analysis of public and moderated websites.
This study examined vaccine social media (VSM) websites and compared expert moderated VSM websites to nonmoderated websites. Accuracy of information, vaccine stance, and tone was coded for 79 public blogs and discussion boards and 61 expert moderated VSM websites. The public VSM websites had a lot of inaccurate information and tended to have a negative stance towards vaccines. Expert moderated websites had a more civil tone, little to no inaccurate information and very little participant-to-participant interaction.
AHRQ-funded; HS021492.
Citation: Shoup JA, Narwaney KJ, Wagner NM .
Social media vaccine websites: a comparative analysis of public and moderated websites.
Health Educ Behav 2018 Jun;46(3):454-62. doi: 10.1177/1090198118818253..
Keywords: Education: Patient and Caregiver, Social Media, Vaccination
de Montigny S, Adamson BJS, Masse BR
Projected effectiveness and added value of HIV vaccination campaigns in South Africa: a modeling study.
Sci Rep 2018 Apr 17;8(1):6066. doi: 10.1038/s41598-018-24268-4.
In this paper, the authors estimated the potential epidemiological and economic impact of HIV vaccine campaigns compared to continuous vaccination, assuming that vaccine efficacy was transient and dependent on immune response. The investigators concluded that results suggested a partially effective HIV vaccine would have substantial impact on the HIV epidemic in South Africa and offer good value if priced less than $105 for a five-dose series. They suggested that vaccination campaigns every two years may offer greater value for money than continuous vaccination reaching the same coverage level.
In this paper, the authors estimated the potential epidemiological and economic impact of HIV vaccine campaigns compared to continuous vaccination, assuming that vaccine efficacy was transient and dependent on immune response. The investigators concluded that results suggested a partially effective HIV vaccine would have substantial impact on the HIV epidemic in South Africa and offer good value if priced less than $105 for a five-dose series. They suggested that vaccination campaigns every two years may offer greater value for money than continuous vaccination reaching the same coverage level.
AHRQ-funded; HS013853.
Citation: de Montigny S, Adamson BJS, Masse BR .
Projected effectiveness and added value of HIV vaccination campaigns in South Africa: a modeling study.
Sci Rep 2018 Apr 17;8(1):6066. doi: 10.1038/s41598-018-24268-4..
Keywords: Health Services Research (HSR), Healthcare Costs, Human Immunodeficiency Virus (HIV), Public Health, Vaccination
Wang SV, Abdurrob A, Spoendlin J
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addressed a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination.
AHRQ-funded; HS022193.
Citation: Wang SV, Abdurrob A, Spoendlin J .
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
Pharmacoepidemiol Drug Saf 2018 Apr;27(4):405-12. doi: 10.1002/pds.4399..
Keywords: Adverse Drug Events (ADE), Adverse Events, Children/Adolescents, Patient Safety, Vaccination
Shah PD, Calo WA, Marciniak MW
Service quality and parents' willingness to get adolescents HPV vaccine from pharmacists.
The researchers sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. They found that parents who went to independent pharmacies had lower willingness to get HPV vaccine from pharmacists compared to parents who went to chain pharmacies, but there was no difference in willingness for parents who went to clinic versus chain pharmacies.
AHRQ-funded; HS000032.
Citation: Shah PD, Calo WA, Marciniak MW .
Service quality and parents' willingness to get adolescents HPV vaccine from pharmacists.
Prev Med 2018 Apr;109:106-12. doi: 10.1016/j.ypmed.2018.01.002.
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Keywords: Children/Adolescents, Shared Decision Making, Infectious Diseases, Provider: Pharmacist, Vaccination
Shah MP, Lopman BA, Tate JE
AHRQ Author: Steiner CA
Use of Internet search data to monitor rotavirus vaccine impact in the United States, United Kingdom, and Mexico.
In this study, researchers aimed to study the correlation between internet query searches (IQS) for "rotavirus" and rotavirus disease activity in the United States, United Kingdom, and Mexico before and after introduction of rotavirus vaccine. They found positive correlation between the rotavirus IQS and laboratory reports in the United States and United Kingdom and between the rotavirus IQS and acute gastroenteritis hospitalizations in the United States and Mexico for all correlations.
AHRQ-authored.
Citation: Shah MP, Lopman BA, Tate JE .
Use of Internet search data to monitor rotavirus vaccine impact in the United States, United Kingdom, and Mexico.
J Pediatric Infect Dis Soc 2018 Feb 19;7(1):56-63. doi: 10.1093/jpids/pix004.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Vaccination, Web-Based
Szilagyi PG, Schaffer S, Rand CM
School-located influenza vaccinations for adolescents: a randomized controlled trial.
In this study, the investigators aimed to evaluate the effect of school-located influenza vaccination (SLIV) on adolescents' influenza vaccination rates. In 2015-2016, they performed a cluster-randomized trial of adolescent SLIV in middle/high schools. They concluded that SLIV in this community increased influenza vaccination rates among adolescents attending suburban schools.
AHRQ-funded; HS021163.
Citation: Szilagyi PG, Schaffer S, Rand CM .
School-located influenza vaccinations for adolescents: a randomized controlled trial.
J Adolesc Health 2018 Feb;62(2):157-63. doi: 10.1016/j.jadohealth.2017.09.021..
Keywords: Children/Adolescents, Education, Influenza, Prevention, Public Health, Vaccination
Anderson LJ, Shekelle P, Keeler E
The cost of interventions to increase influenza vaccination: a systematic review.
This study sought to systematically review economic evaluations of healthcare-based quality improvement interventions for improving influenza vaccination uptake among general populations and healthcare workers. The investigators concluded that quality improvement interventions for influenza vaccination involved per-enrollee costs that were similar to the cost of the vaccine itself ($11.78-$36.08/dose). They suggested that based on limited available evidence in general populations, quality improvement interventions may be cost saving to cost effective for the health system.
AHRQ-funded; HS022644.
Citation: Anderson LJ, Shekelle P, Keeler E .
The cost of interventions to increase influenza vaccination: a systematic review.
Am J Prev Med 2018 Feb;54(2):299-315. doi: 10.1016/j.amepre.2017.11.010..
Keywords: Healthcare Costs, Influenza, Quality Improvement, Vaccination
Pringle KD, Burke RM, Steiner CA
AHRQ Author: Steiner CA
Trends in rate of seizure-associated hospitalizations among children <5 years old before and after rotavirus vaccine introduction in the United Sates, 2000-2013.
Since rotavirus vaccine introduction, hospitalizations for treatment of acute gastroenteritis have decreased. Researchers assessed whether there has been an associated decrease in seizure-associated hospitalizations. Their analysis provides evidence for a decrease in seizure hospitalizations following rotavirus vaccine introduction in the United States, with the greatest impact in age groups with a high rotavirus-associated disease burden and during rotavirus infection season.
AHRQ-authored.
Citation: Pringle KD, Burke RM, Steiner CA .
Trends in rate of seizure-associated hospitalizations among children <5 years old before and after rotavirus vaccine introduction in the United Sates, 2000-2013.
J Infect Dis 2018 Jan 30;217(4):581-88. doi: 10.1093/infdis/jix589.
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Keywords: Adverse Drug Events (ADE), Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Vaccination
Greenhawt M, Turner PJ, Kelso JM
Administration of influenza vaccines to egg allergic recipients: a practice parameter update 2017.
The purpose of this practice parameter update is to review new data pertaining to the safety of influenza vaccines in egg allergic individuals and provide recommendations regarding annual influenza vaccination in egg allergic individuals. This focused practice parameter answers four questions.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Turner PJ, Kelso JM .
Administration of influenza vaccines to egg allergic recipients: a practice parameter update 2017.
Ann Allergy Asthma Immunol 2018 Jan;120(1):49-52. doi: 10.1016/j.anai.2017.10.020.
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Keywords: Adverse Drug Events (ADE), Guidelines, Prevention, Vaccination
Albright K, Hurley LP, Lockhart S
Attitudes about adult vaccines and reminder/recall in a safety net population.
The objective of this study was to determine patient perspectives on adult vaccines generally; attitudes about Tdap, pneumococcal polysaccharide (PPSV-23), and seasonal influenza vaccines specifically; and preferences for adult reminder/recall delivery.
AHRQ-funded; HS022648.
Citation: Albright K, Hurley LP, Lockhart S .
Attitudes about adult vaccines and reminder/recall in a safety net population.
Vaccine 2017 Dec 19;35(52):7292-96. doi: 10.1016/j.vaccine.2017.11.001..
Keywords: Influenza, Pneumonia, Vaccination, Prevention, Respiratory Conditions
Parker TC, Mohammed A, Leong T
Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia.
The purpose of this study was to determine possible disparities and socio-economic differences in RV vaccination rates. The study conclude that racial disparities and socio-economic differences are not determinants in rotavirus vaccination rates; however, age and ethnicity have an effect on RV vaccine status.
AHRQ-funded; HS024338.
Citation: Parker TC, Mohammed A, Leong T .
Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia.
Ethn Health 2017 Dec;22(6):585-95. doi: 10.1080/13557858.2016.1244744..
Keywords: Disparities, Health Status, Newborns/Infants, Social Determinants of Health, Vaccination
Erves JC, Mayo-Gamble TL, Hull PC
Adolescent participation in HPV vaccine clinical trials: are parents willing?
This study examined factors influencing parental willingness to consent to their adolescents' participation in HPV vaccine clinical trials and tested for possible racial differences. The authors assert that educating parents about the advantages of HPV vaccines for younger adolescents using low-literacy educational materials and building trust between parents and researchers may increase parental willingness to consent to adolescent participation in HPV vaccine clinical trials.
AHRQ-funded; HS022990.
Citation: Erves JC, Mayo-Gamble TL, Hull PC .
Adolescent participation in HPV vaccine clinical trials: are parents willing?
J Community Health 2017 Oct;42(5):894-901. doi: 10.1007/s10900-017-0331-x..
Keywords: Children/Adolescents, Research Methodologies, Vaccination
Leshem E, Tate JE, Steiner CA
AHRQ Author: Steiner. CA
National estimates of reductions in acute gastroenteritis-related hospitalizations and associated costs in US children after implementation of rotavirus vaccines.
The study compared acute gastroenteritis (AGE)-related hospitalization rates among children <5 years of age during the pre-rotavirus vaccine (2000-2006) and post-rotavirus vaccine (2008-2013) periods to estimate national reductions in AGE-related hospitalizations and associated costs.
AHRQ-authored
Citation: Leshem E, Tate JE, Steiner CA .
National estimates of reductions in acute gastroenteritis-related hospitalizations and associated costs in US children after implementation of rotavirus vaccines.
J Pediatric Infect Dis Soc 2017 Aug 17;7(3):257-60. doi: 10.1093/jpids/pix057..
Keywords: Children/Adolescents, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Vaccination
Lee BY, Haidari LA
The importance of vaccine supply chains to everyone in the vaccine world.
The study authors detail how vaccine supply chains may affect the work and decision making of ten examples of different members of the vaccine community: preclinical vaccinologists, vaccine clinical trialists, vaccine package designers, health care workers, epidemiologists and disease surveillance experts, policy makers, storage equipment manufacturers, other technology developers, information system specialists, and funders.
AHRQ-funded; HS023317.
Citation: Lee BY, Haidari LA .
The importance of vaccine supply chains to everyone in the vaccine world.
Vaccine 2017 Aug 16;35(35 Pt A):4475-79. doi: 10.1016/j.vaccine.2017.05.096..
Keywords: Shared Decision Making, Vaccination
McFarland M, Szasz TP, Zhou JY
Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
The primary goal of this study was to determine the vaccine-type (VT) serotype prevalence of nasopharyngeal (NP) pneumococcal colonization of children residing in the St. Louis, MO, USA metropolitan area following introduction of the 13-valent pneumococcal conjugate vaccine in 2010. It concluded that children in St. Louis exhibit a higher prevalence of VT serotypes among pneumococcal carriage isolates than has been reported in other areas in the US.
AHRQ-funded; HS021736; HS024269.
Citation: McFarland M, Szasz TP, Zhou JY .
Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
Vaccine 2017 Aug 3;35(34):4389-95. doi: 10.1016/j.vaccine.2017.06.047.
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Keywords: Vaccination, Children/Adolescents, Pneumonia, Infectious Diseases
Calo WA, Gilkey MB, Shah P
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
The researchers sought to examine parents' willingness to get human papillomavirus (HPV) vaccination for their children at pharmacies. Overall, their national survey found that 29 percent of parents would be willing to get HPV vaccine for their children at a pharmacy. Parental willingness was associated with believing that pharmacists are skilled at administering vaccines.
AHRQ-funded; HS000032.
Citation: Calo WA, Gilkey MB, Shah P .
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
Prev Med 2017 Jun;99:251-56. doi: 10.1016/j.ypmed.2017.02.003.
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Keywords: Children/Adolescents, Infectious Diseases, Provider: Pharmacist, Sexual Health, Vaccination
Lee BY, Wedlock PT, Haidari LA
Economic impact of thermostable vaccines.
Using simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India), and Niger, the researchers simulated replacing different existing vaccines with thermostable formulations and determined the resulting clinical and economic impact. They concluded that medical cost and productivity savings could outweigh even significant price premiums charged for thermostable formulations of vaccines, providing support for their use.
AHRQ-funded; HS023317.
Citation: Lee BY, Wedlock PT, Haidari LA .
Economic impact of thermostable vaccines.
Vaccine 2017 May 25;35(23):3135-42. doi: 10.1016/j.vaccine.2017.03.081.
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Keywords: Vaccination, Healthcare Costs
Brown T, Goldman SN, Persell SD
Development and evaluation of a patient education video promoting pneumococcal vaccination.
The researchers aimed to develop and refine a patient education video about pneumococcal polysaccharide vaccination (PPSV23) and to assess patient perceptions regarding video content and receipt of video during a clinic visit. They found that focus group participants had positive reactions to the video but suggested reducing the intensity of messages about pneumonia severity. Participants shown the revised video during a clinic visit perceived it to be easy to understand and informative.
AHRQ-funded; HS021141.
Citation: Brown T, Goldman SN, Persell SD .
Development and evaluation of a patient education video promoting pneumococcal vaccination.
Patient Educ Couns 2017 May;100(5):1024-27. doi: 10.1016/j.pec.2016.12.025.
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Keywords: Education: Patient and Caregiver, Health Promotion, Pneumonia, Vaccination
Adamson BJS, Carlson JJ, Kublin JG
The potential cost-effectiveness of pre-exposure prophylaxis combined with HIV vaccines in the United States.
This economic evaluation found that at current prices, pre-exposure prophylaxis (PrEP) was not cost-effective alone or in combination. A combination strategy had the greatest health benefit but was not cost-effective as compared to vaccination alone. Vaccine durability and PrEP drug prices were key drivers of cost-effectiveness.
AHRQ-funded; HS013853.
Citation: Adamson BJS, Carlson JJ, Kublin JG .
The potential cost-effectiveness of pre-exposure prophylaxis combined with HIV vaccines in the United States.
Vaccines 2017 May 24;5(2). doi: 10.3390/vaccines5020013.
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Keywords: Human Immunodeficiency Virus (HIV), Vaccination, Healthcare Costs, Prevention
Rao R, Schreiber B, Lee BY
Immunization supply chains: why they matter and how they are changing.
While considerable investments have been made over the past two decades to ensure that children and adults throughout the world have equitable access to safe and effective vaccines, comparatively few investments have been made to ensure that immunization products are safely and reliably managed and delivered from the point of arrival in a country to the many places where immunization services are provided. This editorial discusses the importance of immunization supply chains and describes how they are changing.
AHRQ-funded; HS023317.
Citation: Rao R, Schreiber B, Lee BY .
Immunization supply chains: why they matter and how they are changing.
Vaccine 2017 Apr 19;35(17):2103-04. doi: 10.1016/j.vaccine.2017.02.062..
Keywords: Vaccination