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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedLee AK, Rawlings AM, Lee CJ
Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study.
In this study, the investigators aimed to evaluate the link between severe hypoglycaemia and domain-specific cognitive decline, smaller brain volumes and dementia in adults with type 2 diabetes. The investigators concluded that their results demonstrated a strong link between severe hypoglycaemia and poor cognitive outcomes, suggesting a need for discussion of appropriate diabetes treatments for high-risk older adults.
AHRQ-funded; HS018542.
Citation: Lee AK, Rawlings AM, Lee CJ .
Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study.
Diabetologia 2018 Sep;61(9):1956-65. doi: 10.1007/s00125-018-4668-1..
Keywords: Dementia, Diabetes, Elderly, Neurological Disorders, Risk
Parker WF, Georges RJ, Gao YN
Association between groundwater lithium and the diagnosis of bipolar disorder and dementia in the United States.
This study examined the association between groundwater lithium and the diagnoses of bipolar disorder and dementia in the United States, with adjustment for local health care resources and demographics. Data on groundwater lithium concentrations was collected by the US Geological Survey, and diagnoses were identified from inpatient hospital, long-term care, and other therapy claims files from several sources. The results of the study indicate that, in spite of the substantial variations in groundwater lithium exposure, no significant association between exposure and the risk of bipolar disorder or dementia after adjustment for county-level demographics and health care resource was found. The authors note that therapeutic lithium doses are orders of magnitude larger than groundwater lithium concentrations, which makes a true causal relationship between groundwater lithium and mental health dubious.
AHRQ-funded; HS000084.
Citation: Parker WF, Georges RJ, Gao YN .
Association between groundwater lithium and the diagnosis of bipolar disorder and dementia in the United States.
JAMA Psychiatry 2018 Jul;75(7):751-54. doi: 10.1001/jamapsychiatry.2018.1020..
Keywords: Dementia, Behavioral Health, Neurological Disorders, Risk
Jutkowitz E, MacLehose RF, Gaugler JE
Risk factors associated with cognitive, functional, and behavioral trajectories of newly diagnosed dementia patients.
This study examined the effect of sociodemographic and clinical risk factors on cognitive, functional, and behavioral declines in incident dementia patients. Age of onset, region of residence, and history of hypertension and psychiatric problems predicted behaviors at diagnosis. Cognition explained changes in behavior. Sociodemographic characteristics and clinical comorbidities predicted cognitive and functional changes. Only cognitive status explained behavioral decline.
AHRQ-funded; HS024165.
Citation: Jutkowitz E, MacLehose RF, Gaugler JE .
Risk factors associated with cognitive, functional, and behavioral trajectories of newly diagnosed dementia patients.
J Gerontol A Biol Sci Med Sci 2017 Feb;72(2):251-58. doi: 10.1093/gerona/glw079.
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Keywords: Dementia, Elderly, Behavioral Health, Neurological Disorders, Risk, Social Determinants of Health