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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 46 Research Studies DisplayedBachmann JM, Goggins KM, Nwosu SK
Perceived health competence predicts health behavior and health-related quality of life in patients with cardiovascular disease.
The authors sought to evaluate the effect of perceived health competence on health behavior and health-related quality of life. They found that perceived health competence was highly associated with health behaviors and health-related quality of life, while low perceived health competence was associated with a decrease in health-related quality of life between hospitalization and 90 days after discharge. They concluded that perceived health competence predicts health behavior and health-related quality of life in patients hospitalized with cardiovascular disease as well as change in health-related quality of life after discharge.
AHRQ-funded; HS022990.
Citation: Bachmann JM, Goggins KM, Nwosu SK .
Perceived health competence predicts health behavior and health-related quality of life in patients with cardiovascular disease.
Patient Educ Couns 2016 Dec;99(12):2071-79. doi: 10.1016/j.pec.2016.07.020.
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Keywords: Cardiovascular Conditions, Heart Disease and Health, Health Literacy, Patient Adherence/Compliance, Quality of Life
Brewer NT, DeFrank JT, Gilkey MB
Anticipated regret and health behavior: a meta-analysis.
The authors sought better understanding of anticipated regret's role in motivating health behaviors. They found that anticipated inaction regret has a stronger and more stable association with health behavior than previously thought and recommended giving greater attention to understanding how anticipated regret differs from similar constructs.
AHRQ-funded; HS021133.
Citation: Brewer NT, DeFrank JT, Gilkey MB .
Anticipated regret and health behavior: a meta-analysis.
Health Psychol 2016 Nov;35(11):1264-75. doi: 10.1037/hea0000294.
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Keywords: Behavioral Health, Patient Adherence/Compliance, Patient Self-Management
Carballo NJ, Alessi CA, Martin JL
Perceived effectiveness, self-efficacy, and social support for oral appliance therapy among older veterans with obstructive sleep apnea.
Adherence to oral appliance therapy may be influenced by patients' perceived effectiveness of the therapy, self-efficacy, and availability of social support. The researchers examined these perceptions among older adults with obstructive sleep apnea who were prescribed oral appliance therapy. They concluded that only about one third of older adults perceived it as an effective treatment, were confident about oral appliance use, and/or believed that they would receive needed support.
AHRQ-funded; HS024379.
Citation: Carballo NJ, Alessi CA, Martin JL .
Perceived effectiveness, self-efficacy, and social support for oral appliance therapy among older veterans with obstructive sleep apnea.
Clin Ther 2016 Nov;38(11):2407-15. doi: 10.1016/j.clinthera.2016.09.008.
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Keywords: Elderly, Patient Adherence/Compliance, Sleep Problems, Patient Self-Management
Tiruneh YM, Wilson IB
What time is it? Adherence to antiretroviral therapy in Ethiopia.
This study assessed adherence to antiretroviral therapy (ART) among people living with HIV/AIDS in Ethiopia and explored the sociocultural context in which they relate to their regimen requirements. Its findings indicate that study participants are highly adherent to dose but less adherent to dose schedule. Strict dose time instructions were reported as stressful and unrealistic.
AHRQ-funded; HS000011.
Citation: Tiruneh YM, Wilson IB .
What time is it? Adherence to antiretroviral therapy in Ethiopia.
AIDS Behav 2016 Nov;20(11):2662-73. doi: 10.1007/s10461-016-1322-0.
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Keywords: Patient Adherence/Compliance, Human Immunodeficiency Virus (HIV), Medication
Doll JA, Hellkamp AS, Goyal A
Treatment, outcomes, and adherence to medication regimens among dual Medicare-Medicaid-eligible adults with myocardial infarction.
The purpose of the study was to examine the association of dual-eligible status with clinical outcomes and adherence to medication regimens among older adults after MI. The investigators found that compared with Medicare-only patients, older adults with dual Medicare-Medicaid eligibility presenting with MI had superior rates of medication adherence but higher rates of postdischarge readmission and adverse cardiovascular outcomes.
AHRQ-funded; HS021092.
Citation: Doll JA, Hellkamp AS, Goyal A .
Treatment, outcomes, and adherence to medication regimens among dual Medicare-Medicaid-eligible adults with myocardial infarction.
JAMA Cardiol 2016 Oct 1;1(7):787-94. doi: 10.1001/jamacardio.2016.2724..
Keywords: Elderly, Medicaid, Medicare, Medication, Heart Disease and Health, Outcomes, Patient Adherence/Compliance
Albrecht JS, Park Y, Hur P
Adherence to maintenance medications among older adults with chronic obstructive pulmonary disease. the role of depression.
The objective of this study was to assess the impact of depression on COPD maintenance medication adherence among of Medicare beneficiaries newly diagnosed with COPD. Average monthly adherence to COPD maintenance medications was low, peaking at 57 percent in the month after first fill and decreasing to 35 percent within 6 months. In the adjusted regression model, depression was associated with decreased adherence to COPD maintenance medications.
AHRQ-funded; HS024560.
Citation: Albrecht JS, Park Y, Hur P .
Adherence to maintenance medications among older adults with chronic obstructive pulmonary disease. the role of depression.
Ann Am Thorac Soc 2016 Sep;13(9):1497-504. doi: 10.1513/AnnalsATS.201602-136OC.
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Keywords: Respiratory Conditions, Elderly, Medication, Patient Adherence/Compliance, Depression
Tajeu GS, Kent ST, Kronish IM
Trends in antihypertensive medication discontinuation and low adherence among Medicare beneficiaries initiating treatment from 2007 to 2012.
The authors analyzed a 5% sample of Medicare beneficiaries initiating antihypertensive medication between 2007 and 2012 to assess whether reductions occurred in discontinuation and low adherence. They found that low adherence decreased and was more common among racial/ethnic minorities, beneficiaries with Medicaid buy-in, and those with polypharmacy, and was less common among females, beneficiaries initiating antihypertensive medication with multiple classes or a 90-day prescription fill, with dementia, a history of stroke, and those who reached the Medicare Part D coverage gap in the previous year. They concluded that although low adherence has decreased, rates of discontinuation and low adherence remain high.
AHRQ-funded; HS024262.
Citation: Tajeu GS, Kent ST, Kronish IM .
Trends in antihypertensive medication discontinuation and low adherence among Medicare beneficiaries initiating treatment from 2007 to 2012.
Hypertension 2016 Sep;68(3):565-75. doi: 10.1161/hypertensionaha.116.07720.
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Keywords: Blood Pressure, Medication, Medicare, Patient Adherence/Compliance
Wu AC, Butler MG, Li L
Primary adherence to controller medications for asthma is poor.
The objective of this study was to compare real-world adherence, including both primary and secondary adherence, to the major controller regimens (inhaled corticosteroids (ICSs), leukotriene antagonists (LTRAs), or ICS/long-acting b-agonists (ICS/LABAs) in diverse, insured populations. It found that adherence to controller medications is poor and many patients do not ever fill prescriptions for controller medications. However, primary adherence to ICSs was better than to LTRAs and ICS/LABAs.
AHRQ-funded; HS019669.
Citation: Wu AC, Butler MG, Li L .
Primary adherence to controller medications for asthma is poor.
Ann Am Thorac Soc 2015 Feb;12(2):161-6. doi: 10.1513/AnnalsATS.201410-459OC..
Keywords: Asthma, Patient Adherence/Compliance, Medication, Comparative Effectiveness
Tiruneh YM, Galarraga O, Genberg B
Retention in care among HIV-infected adults in Ethiopia, 2005- 2011: a mixed-methods study.
This study assessed how well patients stay in care and explored factors associated with retention in the context of an initial antiretroviral therapy (ART) rollout at a teaching hospital in Addis Ababa, Ethiopia. The researchers found that fear of stigma, care dissatisfaction, use of holy water, and economic constraints discouraged retention in care, while social support and restored health and functional ability motivated retention.
AHRQ-funded; HS000011.
Citation: Tiruneh YM, Galarraga O, Genberg B .
Retention in care among HIV-infected adults in Ethiopia, 2005- 2011: a mixed-methods study.
PLoS One 2016 Jun 7;11(6):e0156619. doi: 10.1371/journal.pone.0156619.
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Keywords: Medication, Human Immunodeficiency Virus (HIV), Patient Adherence/Compliance
Curtis JR, Bharat A, Chen L
Agreement between rheumatologist and patient-reported adherence to methotrexate in a US rheumatoid arthritis registry.
To determine the extent to which methotrexate (MTX) adherence is overestimated by rheumatologists, the researchers deployed an Internet survey to patients with rheumatoid arthritis (RA) participating in a US registry. They found that MTX use was misclassified for 13-20 percent of patients, mainly because of 1 or more missed doses rather than overt discontinuation. Clinicians should be aware of suboptimal adherence when assessing MTX response.
AHRQ-funded; HS018517.
Citation: Curtis JR, Bharat A, Chen L .
Agreement between rheumatologist and patient-reported adherence to methotrexate in a US rheumatoid arthritis registry.
J Rheumatol 2016 Jun;43(6):1027-9. doi: 10.3899/jrheum.151136.
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Keywords: Arthritis, Patient Adherence/Compliance, Medication, Registries
Heerman WJ, Wallston KA, Osborn CY
Food insecurity is associated with diabetes self-care behaviours and glycaemic control.
The objective of the study was to examine the association between food insecurity, diabetes self-care and glycaemic control. It concluded that there was a high rate of food insecurity in a sample of patients with Type 2 diabetes who were of low socio-economic status. Food insecurity was associated with less adherence to recommended self-care behaviours and worse glycaemic control.
AHRQ-funded; HS022990.
Citation: Heerman WJ, Wallston KA, Osborn CY .
Food insecurity is associated with diabetes self-care behaviours and glycaemic control.
Diabet Med 2016 Jun;33(6):844-50. doi: 10.1111/dme.12896.
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Keywords: Diabetes, Nutrition, Patient Adherence/Compliance, Patient-Centered Outcomes Research, Patient Self-Management
Osborn CY, Mayberry LS, Kim JM
Medication adherence may be more important than other behaviours for optimizing glycaemic control among low-income adults.
The authors sought to identify which behaviors are most important for HbA1c among low-socioeconomic status patients with type 2 diabetes mellitus. They found that only medication adherence was significantly associated with lower HbA1c after adjusting for the other self-care behaviours and further adjusting for demographic and diabetes characteristics. They suggested that focused efforts to improve medication adherence among low-socioeconomic status patient populations may improve glycemic control.
AHRQ-funded; HS022990.
Citation: Osborn CY, Mayberry LS, Kim JM .
Medication adherence may be more important than other behaviours for optimizing glycaemic control among low-income adults.
J Clin Pharm Ther 2016 Jun;41(3):256-9. doi: 10.1111/jcpt.12360.
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Keywords: Diabetes, Low-Income, Medication, Patient Adherence/Compliance, Patient-Centered Outcomes Research
Kahwati L, Viswanathan M, Golin CE
Identifying configurations of behavior change techniques in effective medication adherence interventions: a qualitative comparative analysis.
The researchers aimed to extend the results from an existing systematic review of interventions to improve medication adherence by using qualitative comparative analysis (QCA) to identify necessary or sufficient configurations of behavior change techniques among effective interventions. They were able to identify seven configurations of behavior change techniques sufficient for improving adherence, which together accounted for 26 (76 percent) of the effective studies.
AHRQ-funded; HS022563.
Citation: Kahwati L, Viswanathan M, Golin CE .
Identifying configurations of behavior change techniques in effective medication adherence interventions: a qualitative comparative analysis.
Syst Rev 2016 May 4;5:83. doi: 10.1186/s13643-016-0255-z.
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Keywords: Medication, Patient Adherence/Compliance, Research Methodologies, Comparative Effectiveness, Behavioral Health
Kahwati L, Jacobs S, Kane H
Using qualitative comparative analysis in a systematic review of a complex intervention.
The objective of this study was to describe in detail and examine the suitability of using qualitative comparative analysis (QCA) within the context of a systematic review. It concluded that QCA was suitable for use within a systematic review of medication adherence interventions and offered insights beyond the single dimension stratifications used in the original completed review.
AHRQ-funded; HS022563.
Citation: Kahwati L, Jacobs S, Kane H .
Using qualitative comparative analysis in a systematic review of a complex intervention.
Syst Rev 2016 May 4;5:82. doi: 10.1186/s13643-016-0256-y.
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Keywords: Medication, Patient Adherence/Compliance, Research Methodologies, Comparative Effectiveness, Behavioral Health
Johnson KB, Patterson BL, Ho YX
The feasibility of text reminders to improve medication adherence in adolescents with asthma.
The goal of this study was to assess the impact of MyMediHealth (MMH) - a website and a short messaging service (SMS)-based reminder system - on medication adherence and perceived self-efficacy in adolescents with asthma. The investigators found that MMH was associated with improved medication adherence, perceived quality of life, and self-efficacy.
AHRQ-funded; HS018168.
Citation: Johnson KB, Patterson BL, Ho YX .
The feasibility of text reminders to improve medication adherence in adolescents with asthma.
J Am Med Inform Assoc 2016 May;23(3):449-55. doi: 10.1093/jamia/ocv158..
Keywords: Asthma, Children/Adolescents, Health Information Technology (HIT), Medication, Patient Adherence/Compliance
Faridi KF, Peterson ED, McCoy LA
Timing of first postdischarge follow-up and medication adherence after acute myocardial infarction.
The investigators sought to determine whether earlier outpatient follow-up after acute myocardial infarction (AMI) is associated with higher rates of medication adherence. They found that delayed outpatient follow-up beyond the first 6 weeks after AMI is associated with worse short-term and long-term patient medication adherence. They concluded that medication adherence is modifiable via improved care transitions.
AHRQ-funded; HS021092.
Citation: Faridi KF, Peterson ED, McCoy LA .
Timing of first postdischarge follow-up and medication adherence after acute myocardial infarction.
JAMA Cardiol 2016 May 1;1(2):147-55. doi: 10.1001/jamacardio.2016.0001.
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Keywords: Hospital Discharge, Medication, Heart Disease and Health, Patient Adherence/Compliance, Patient-Centered Healthcare
Farris KB, Salgado TM, Aneese N
Effect of clinical and attitudinal characteristics on obtaining comprehensive medication reviews.
The researchers sought to quantify the association between attitudinal and clinical factors with intention and predict future behavior to obtain a comprehensive medication reviews (CMR) among Medicare Part D beneficiaries. They found that worrying about medications doing more harm than good, number of pharmacies where participants obtained their medications from, number of medications, and number of medical conditions predicted intention to obtain a CMR.
AHRQ-funded; HS018353.
Citation: Farris KB, Salgado TM, Aneese N .
Effect of clinical and attitudinal characteristics on obtaining comprehensive medication reviews.
J Manag Care Spec Pharm 2016 Apr;22(4):388-95. doi: 10.18553/jmcp.2016.22.4.388.
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Keywords: Medication, Medicare, Elderly, Medication: Safety, Patient Adherence/Compliance
Lyles CR, Seligman HK, Parker MM
Financial strain and medication adherence among diabetes patients in an integrated health care delivery system: The Diabetes Study of Northern California (DISTANCE).
The researchers examined self-reported financial strain in relation to pharmacy utilization adherence data. Their analysis of survey, administrative, and electronic medical data from Kaiser Permanente Northern California found that 8 percent and 9 percent reported general and medication-specific financial strain. In adjusted models, general strain was significantly associated with primary nonadherence and refilling late and medication-specific strain was ssociated with primary nonadherence.
AHRQ-funded; HS022408.
Citation: Lyles CR, Seligman HK, Parker MM .
Financial strain and medication adherence among diabetes patients in an integrated health care delivery system: The Diabetes Study of Northern California (DISTANCE).
Health Serv Res 2016 Apr;51(2):610-24. doi: 10.1111/1475-6773.12346.
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Keywords: Diabetes, Medication, Patient Adherence/Compliance, Healthcare Costs, Healthcare Delivery
Lyles CR, Sarkar U, Schillinger D
Refilling medications through an online patient portal: consistent improvements in adherence across racial/ethnic groups.
The researchers evaluated longitudinal changes in statin adherence to determine whether racial/ethnic minorities initiating use of the online refill function in patient portals had similar changes over time compared with whites. Their examination of a retrospective cohort of diabetes patients who were existing patient portal users found that all racial/ethnic minority groups had poorer baseline statin adherence compared with whites.
AHRQ-funded; HS022408.
Citation: Lyles CR, Sarkar U, Schillinger D .
Refilling medications through an online patient portal: consistent improvements in adherence across racial/ethnic groups.
J Am Med Inform Assoc 2016 Apr;23(e1):e28-e33. doi: 10.1093/jamia/ocv126.
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Keywords: Medication, Web-Based, Patient Adherence/Compliance, Electronic Health Records (EHRs), Racial and Ethnic Minorities
McMahon LF, Tipimeni R, Chopra V
Health system loyalty programs: An innovation in customer care and service.
Loyalty programs could empower patients to manage their health in new and innovative ways while enhancing the business model for health systems. The authors argue that by providing both better appreciation/customer service and high-quality technical care, loyalty programs may offer a new way to attract and retain patients within a health system.
AHRQ-funded; HS022835.
Citation: McMahon LF, Tipimeni R, Chopra V .
Health system loyalty programs: An innovation in customer care and service.
JAMA 2016 Mar 1;315(9):863-4. doi: 10.1001/jama.2015.19463..
Keywords: Healthcare Delivery, Patient Experience, Primary Care, Patient Self-Management, Patient Adherence/Compliance
Dauw CA, Yi Y, Bierlein MJ
Medication nonadherence and effectiveness of preventive pharmacological therapy for kidney stones.
To examine the impact that medication nonadherence has on the secondary prevention of kidney stones, the researchers compared clinical health outcomes between patients who adhered to their regimen and those who did not. They found that the frequency of emergency department visits, hospitalization and surgery for stone disease was significantly lower among adherent patients.
AHRQ-funded; HS020927.
Citation: Dauw CA, Yi Y, Bierlein MJ .
Medication nonadherence and effectiveness of preventive pharmacological therapy for kidney stones.
J Urol 2016 Mar;195(3):648-52. doi: 10.1016/j.juro.2015.10.082.
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Keywords: Medication, Patient Adherence/Compliance, Kidney Disease and Health, Prevention
Flickinger TE, Saha S, Roter D
Clinician empathy is associated with differences in patient-clinician communication behaviors and higher medication self-efficacy in HIV care.
The researchers examined associations of clinicians' empathy with patient-clinician communication behaviors, patients' rating of care, and medication self-efficacy. They found that clinicians in the highest vs. lowest empathy tertile engaged in less explicitly emotional talk, while clinicians in the middle vs. lowest engaged in more positive talk, more questions, and more patient activating talk, while patients of higher empathy clinicians disclosed more psychosocial and biomedical information. They further found that patients of clinicians in both the middle and highest (vs. lowest) empathy tertiles had greater odds of reporting highest medication self-efficacy.
AHRQ-funded; HS013903.
Citation: Flickinger TE, Saha S, Roter D .
Clinician empathy is associated with differences in patient-clinician communication behaviors and higher medication self-efficacy in HIV care.
Patient Educ Couns 2016 Feb;99(2):220-6. doi: 10.1016/j.pec.2015.09.001.
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Keywords: Communication, Human Immunodeficiency Virus (HIV), Medication, Patient Adherence/Compliance, Clinician-Patient Communication
Lafata JE, Karter AJ, O'Connor PJ
Medication adherence does not explain black-white differences in cardiometabolic risk factor control among insured patients with diabetes.
The researchers examined whether medication adherence, controlling for treatment intensification, could explain differences in risk factor control between black and white patients with diabetes. They found poorer medication adherence among black patients than white patients. They concluded that medication adherence failed to explain observed racial differences in the achievement of HbA1c, LDL-C, and SBP control among insured patients with diabetes.
AHRQ-funded; HS019859.
Citation: Lafata JE, Karter AJ, O'Connor PJ .
Medication adherence does not explain black-white differences in cardiometabolic risk factor control among insured patients with diabetes.
J Gen Intern Med 2016 Feb;31(2):188-95. doi: 10.1007/s11606-015-3486-0.
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Keywords: Cardiovascular Conditions, Diabetes, Medication, Patient Adherence/Compliance, Racial and Ethnic Minorities
Kwan BM, Sills MR, Graham D
Stakeholder engagement in a patient-reported outcomes (PRO) measure implementation: a report from the SAFTINet Practice-based Research Network (PBRN).
The objective is to demonstrate the use of stakeholder engagement in implementation of patient-reported outcome (PRO) measures. It concluded that stakeholder engagement appeared useful for promoting PRO measure implementation in clinical practice, in a way that met the needs of both researchers and clinical practice stakeholders.
AHRQ-funded; HS019908.
Citation: Kwan BM, Sills MR, Graham D .
Stakeholder engagement in a patient-reported outcomes (PRO) measure implementation: a report from the SAFTINet Practice-based Research Network (PBRN).
J Am Board Fam Med 2016 Jan-Feb;29(1):102-15. doi: 10.3122/jabfm.2016.01.150141.
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Keywords: Practice-Based Research Network (PBRN), Patient-Centered Outcomes Research, Comparative Effectiveness, Patient Adherence/Compliance, Evidence-Based Practice
Gatwood J, Balkrishnan R, Erickson SR
The impact of tailored text messages on health beliefs and medication adherence in adults with diabetes: a randomized pilot study.
The purpose of this pilot study was to test the effectiveness of tailored text messages focusing on improving medication adherence and health beliefs in adults with diabetes. It found that declines in medication adherence were observed in both groups over time but no significant differences were observed between groups or from baseline to the end of the active study period.
AHRQ-funded; HS021976.
Citation: Gatwood J, Balkrishnan R, Erickson SR .
The impact of tailored text messages on health beliefs and medication adherence in adults with diabetes: a randomized pilot study.
Res Social Adm Pharm 2016 Jan-Feb;12(1):130-40. doi: 10.1016/j.sapharm.2015.04.007.
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Keywords: Diabetes, Medication, Patient Adherence/Compliance, Health Information Technology (HIT), Clinician-Patient Communication