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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedHallas J, Pottegard A, Wang S
Persistent user bias in case-crossover studies in pharmacoepidemiology.
The authors aimed to assess the occurrence of an upward-biased odds ratio of studying chronic medication exposure and to evaluate whether it is remedied by including a control group. They found that, in case-crossover studies of medications, contamination by persistent users confers a moderate bias upward, which is partly remedied by using a control group.
AHRQ-funded; HS022193.
Citation: Hallas J, Pottegard A, Wang S .
Persistent user bias in case-crossover studies in pharmacoepidemiology.
Am J Epidemiol 2016 Nov 15;184(10):761-69. doi: 10.1093/aje/kww079.
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Keywords: Medication, Research Methodologies
Goedken AM, Lund BC, Cook EA
Application of a framework for determining number of drugs.
The purpose of the study was to propose a framework and illustrate how that framework can be used to create and succinctly describe various approaches to counting the number of drugs used by patients and to examine the impact of varying individual components of the framework on the resulting drug count.
AHRQ-funded; HS018381.
Citation: Goedken AM, Lund BC, Cook EA .
Application of a framework for determining number of drugs.
BMC Res Notes 2016 May 13;9:272. doi: 10.1186/s13104-016-2076-5.
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Keywords: Medication, Research Methodologies, Heart Disease and Health, Medicare
Kahwati L, Viswanathan M, Golin CE
Identifying configurations of behavior change techniques in effective medication adherence interventions: a qualitative comparative analysis.
The researchers aimed to extend the results from an existing systematic review of interventions to improve medication adherence by using qualitative comparative analysis (QCA) to identify necessary or sufficient configurations of behavior change techniques among effective interventions. They were able to identify seven configurations of behavior change techniques sufficient for improving adherence, which together accounted for 26 (76 percent) of the effective studies.
AHRQ-funded; HS022563.
Citation: Kahwati L, Viswanathan M, Golin CE .
Identifying configurations of behavior change techniques in effective medication adherence interventions: a qualitative comparative analysis.
Syst Rev 2016 May 4;5:83. doi: 10.1186/s13643-016-0255-z.
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Keywords: Medication, Patient Adherence/Compliance, Research Methodologies, Comparative Effectiveness, Behavioral Health
Kahwati L, Jacobs S, Kane H
Using qualitative comparative analysis in a systematic review of a complex intervention.
The objective of this study was to describe in detail and examine the suitability of using qualitative comparative analysis (QCA) within the context of a systematic review. It concluded that QCA was suitable for use within a systematic review of medication adherence interventions and offered insights beyond the single dimension stratifications used in the original completed review.
AHRQ-funded; HS022563.
Citation: Kahwati L, Jacobs S, Kane H .
Using qualitative comparative analysis in a systematic review of a complex intervention.
Syst Rev 2016 May 4;5:82. doi: 10.1186/s13643-016-0256-y.
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Keywords: Medication, Patient Adherence/Compliance, Research Methodologies, Comparative Effectiveness, Behavioral Health
Wong AF, Pielmeier U, Haug PJ
An in silico method to identify computer-based protocols worthy of clinical study: an insulin infusion protocol use case.
In this paper, the authors compared two existing computer-based insulin infusion protocols: eProtocol-insulin from Utah, USA, and Glucosafe from Denmark. They concluded that preclinical in silico comparison analytical framework allows rapid and inexpensive identification of computer-based protocol care strategies that justify expensive and burdensome clinical trials.
AHRQ-funded; HS006594.
Citation: Wong AF, Pielmeier U, Haug PJ .
An in silico method to identify computer-based protocols worthy of clinical study: an insulin infusion protocol use case.
J Am Med Inform Assoc 2016 Mar;23(2):283-8. doi: 10.1093/jamia/ocv067.
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Keywords: Health Information Technology (HIT), Medication, Research Methodologies
Hennessy S, Leonard CE, Gagne JJ
Pharmacoepidemiologic methods for studying the health effects of drug-drug interactions.
A drug-drug interaction (DDI) occurs when one or more drugs affect the pharmacokinetics (the body's effect on the drug) and/or pharmacodynamics (the drug's effect on the body) of one or more other drugs. This article discusses aspects of pharmacoepidemiologic research designs that are particularly salient to the design and interpretation of pharmacoepidemiologic studies of DDIs.
AHRQ-funded; HS023898; HS023122.
Citation: Hennessy S, Leonard CE, Gagne JJ .
Pharmacoepidemiologic methods for studying the health effects of drug-drug interactions.
Clin Pharmacol Ther 2016 Jan;99(1):92-100. doi: 10.1002/cpt.277..
Keywords: Medication: Safety, Research Methodologies, Medication