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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedRuderman SA, Odden MC, Webel AR
Tobacco smoking and pack-years are associated with frailty among people with HIV.
This study examines the association of frailty with tobacco smoking and pack-years among people with HIV (PWH). The authors identified 8,608 PWH across 6 Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites who completed ≥2 patient-reported outcome assessments, including a frailty phenotype measuring unintentional weight loss, poor mobility, fatigue, and inactivity, scored 0-4. The authors measured smoking as baseline pack-years and time-updated never, former, or current use with cigarettes/day. They used Cox models to associate smoking with risk of incident frailty (score ≥3) and deterioration (frailty score increase by ≥2 points), adjusted for demographics, antiretroviral medication, and time-updated CD4 count. Mean follow-up period of PWH was 5.3 years, the mean age at baseline was 45 years, 15% were female, and 52% were non-White. At baseline, 60% reported current or former smoking and both were associated with higher incident frailty risk, as was higher pack-years. Current smoking (among younger PWH) and pack-years were associated with higher risk of deterioration, but not former smoking.
AHRQ-funded; HS026154.
Citation: Ruderman SA, Odden MC, Webel AR .
Tobacco smoking and pack-years are associated with frailty among people with HIV.
J Acquir Immune Defic Syndr 2023 Oct 1; 94(2):135-42. doi: 10.1097/qai.0000000000003242..
Keywords: Tobacco Use, Human Immunodeficiency Virus (HIV), Chronic Conditions, Health Status