National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
AHRQ Research Studies Date
Topics
- Antibiotics (3)
- Antimicrobial Stewardship (1)
- Children/Adolescents (8)
- Diagnostic Safety and Quality (2)
- Elderly (1)
- Evidence-Based Practice (2)
- Healthcare-Associated Infections (HAIs) (1)
- Healthcare Cost and Utilization Project (HCUP) (2)
- Healthcare Costs (4)
- Health Services Research (HSR) (2)
- Hospital Discharge (1)
- Hospitalization (2)
- Long-Term Care (1)
- Medication (2)
- Newborns/Infants (1)
- Nursing Homes (1)
- Obesity (1)
- Outcomes (2)
- Pain (1)
- Patient-Centered Outcomes Research (2)
- Patient Safety (2)
- Pneumonia (1)
- Practice Patterns (1)
- Quality of Life (4)
- Racial and Ethnic Minorities (2)
- Research Methodologies (3)
- Respiratory Conditions (1)
- (-) Skin Conditions (26)
- Sleep Problems (4)
- Treatments (1)
- Urinary Tract Infection (UTI) (1)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 26 Research Studies DisplayedWurcel AG, Essien UR, Ortiz C
Variation by race in antibiotics prescribed for hospitalized patients with skin and soft tissue infections.
This cohort study examined antibiotics prescribed and variations by race among hospitalized patients with skin and soft tissue infections (SSTIs). A subanalysis of multisite, cross-sectional data collected through a national survey of acute care hospital groups within Vizient, Inc. considering adult inpatients treated for SSTIs was used. Of the 1242 adult inpatients included from 91 US hospitals, 45% were female, 18% were Black, and 69% were White with a mean age of 58 years. Penicillin allergy with hives was found in 23%, 19% with rash, and 18% with unknown effects, with allergy found more frequent in Black patients (23%) versus White (18%). Adjusting for multiple factors, White inpatients were at an increased risk of cefazolin use and decreased risk of clindamycin use compared with Black inpatients. Cefazolin use with less likely to be prescribed to Black inpatients than White inpatients and they were likely to be prescribed clindamycin. Cefazolin is considered a first-line SSTI treatment with clindamycin not recommended given frequent dosing and high potential for adverse effects including Clostridioides difficile infection (CDI). Although penicillin allergy is described as more prevalent among White patients, the authors observed an increased prevalence among Black inpatients compared with White inpatients treated for SSTI.
Citation: Wurcel AG, Essien UR, Ortiz C .
Variation by race in antibiotics prescribed for hospitalized patients with skin and soft tissue infections.
JAMA Netw Open 2021 Dec;4(12):e2140798. doi: 10.1001/jamanetworkopen.2021.40798..
Keywords: Antibiotics, Skin Conditions, Racial and Ethnic Minorities, Practice Patterns, Medication
Soper NS, Appukutty AJ, Paje D
Antibiotic overuse after discharge from medical short-stay units.
This study investigated antibiotic overuse after discharge from medical short-stay units (SSUs). This cross-sectional study included patients hospitalized in 2 different medical SSUs with a total of 40 beds at a single academic medical center. Eligible adults were discharged with an oral antibiotic from either SSU from May 2018 to September 2019. Of 100 patients discharged from SSUs with antibiotics, 47 had a skin and soft-tissue infection (SSTI), 22 pneumonia, 21 UTI, and 10 had “other” infections. Overall, 78 cases (78%) were defined as overuse, including 39 of 47 of those treated for SSTI, 17 of 21 for UTI, and 14 of 22 for pneumonia. The most common types of overuse were excess duration and guideline discordant selection. Examples of factors influencing overuse included consultant recommendations, miscalculation of duration, and the need for source control procedure.
AHRQ-funded; HS026530.
Citation: Soper NS, Appukutty AJ, Paje D .
Antibiotic overuse after discharge from medical short-stay units.
Nov;43(11):1689-92. doi: 10.1017/ice.2021.346..
Keywords: Antibiotics, Antimicrobial Stewardship, Medication, Pneumonia, Skin Conditions, Urinary Tract Infection (UTI), Respiratory Conditions, Hospital Discharge
Chovatiya R, Silverberg JI
Iatrogenic burden of atopic dermatitis.
The purpose of this study was to characterize the iatrogenic burden of atopic dermatitis (AD) and conduct a qualitative review of key areas that clinicians can address to minimize that burden. The researchers concluded that the multidimensional nature of AD requires a dynamic approach, and researcher recommendations included: encouraging providers to think strategically about the avoidance of itch triggers, slowly incorporating lifestyle changes, and highlighting step-up therapy when trigger avoidance becomes too burdensome for the patient. Out-of-pocket treatment costs should be incorporated into shared decision, polypharmacy should be minimized, and providers should incorporate evidence-based guidelines into their practices.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Iatrogenic burden of atopic dermatitis.
Dermatitis 2022 Nov-Dec;33(6s):S17-s23. doi: 10.1097/der.0000000000000799..
Keywords: Skin Conditions, Quality of Life
Chovatiya R, Begolka WS, Thibau IJ, R, Begolka WS, Thibau IJ
Impact and associations of atopic dermatitis out-of-pocket health care expenses in the United States.
The purpose of this study was to describe the impact and associations of out of pocket (OOP) health care expenses for atopic dermatitis (AD). The researchers administered a 25-question online survey to 113,502 National Eczema Association members aged 18 years or older. The study found that respondents with monthly OOP expenses over $200 were more likely to have increased AD severity, flares, health care provider visits, prescription polypharmacy, use of step-up therapy, frequent skin infections, and poorer disease control. Respondents with OOP yearly expenditures greater than $1000 had similar associations and additionally increased rates of comorbid asthma, allergic rhinitis, and anxiety/depression. A total of 64.6% of participants reported a harmful household financial impact of OOP expenses. Predictors of harmful impact included severe AD, comorbid asthma, 5 health care provider visits or more in a year, greater than $200 OOP monthly expenditures, and $1000 annual OOP expenditures or more. The study concluded that OOP expenses for AD are associated with increased disease severity and health care utilization and significantly impact household finances.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Begolka WS, Thibau IJ, R, Begolka WS, Thibau IJ .
Impact and associations of atopic dermatitis out-of-pocket health care expenses in the United States.
Dermatitis 2022 Nov-Dec;33(6s):S43-S51. doi: 10.1097/der.0000000000000795..
Keywords: Skin Conditions, Healthcare Costs
Chovatiya R, Begolka WS, Thibau IJ
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among Black individuals in the United States.
The purpose of this study was to explain the categories and impact of out-of-pocket (OOP) healthcare expenses associated with atopic dermatitis (AD) management among black individuals. The researchers administered a voluntary online survey to 113, 502 members of the National Eczema Association. 77.3% of respondents met the participation criteria of being U.S. residents, 18 years of age and older, and self-reporting that they had AD or were the primary caregivers of individuals with AD. The study found that Blacks (74.2%) vs. non-Blacks (63.3%) reported more OOP costs for prescription medications covered (65.1%) and not covered (46.5%), by insurance, emergency room visits (22.1% vs. 11.8%), and outpatient laboratory testing (33.3% vs. 21.8%,). There was a relationship between Black race and increased household financial impact from OOP expenses, and predictors of financial impact included minimally controlled AD, systemic therapy, greater than $200 monthly OOP expenses, and Medicaid. Blacks with Medicaid had greater odds of harmful financial impact than those of black race or with Medicaid alone. The researchers concluded that there is a relationship between Black race increased OOP costs for AD, with significant financial impact to the household.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Begolka WS, Thibau IJ .
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among Black individuals in the United States.
Arch Dermatol Res 2022 Oct;314(8):739-47. doi: 10.1007/s00403-021-02282-3..
Keywords: Skin Conditions, Healthcare Costs, Racial and Ethnic Minorities
Chovatiya R, Silverberg JI
Describe-ad: a novel classification framework for atopic dermatitis.
The purpose of this study was to develop a framework to standardize atopic dermatitis assessments based on a literature review and clinical experience. The researchers developed the DESCRIBE-AD framework to include both patient- and clinician-reported perspectives to effectively capture the clinical domains contributing to AD heterogeneity. DESCRIBE-AD includes assessments of Dermatitis morphology and phenotype, Evolution of disease, Symptom severity, Comorbid health disorders, Response to therapy, Intensity of lesions, Burden of disease, and Extent of lesions. The researchers conclude that DESCRIBE-AD can be utilized to better assess AD and guide treatment choices.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Describe-ad: a novel classification framework for atopic dermatitis.
J Am Acad Dermatol 2022 Sep;87(3):541-50. doi: 10.1016/j.jaad.2021.10.058..
Keywords: Skin Conditions
Chovatiya R, Silverberg JI
Evaluating the longitudinal course of atopic dermatitis: a review of the literature.
The purpose of this study was to better understand the longitudinal course of atopic dermatitis (AD) to improve clinical phenotyping and prognostication and improve personalized therapy recommendations. The researchers conducted a systematic literature review and meta-analysis of 46 studies to examine the current understanding of AD patterns over time and beyond childhood. The study found that 80% of childhood AD did not persist by 8 years of age and 5% by 20 years of age. Clinician-assessed severity showed a weaker association with persistence than patient-assessed severity. Persistent AD was related with intrinsic factors (severity, genetics, and atopic multimorbidity) and extrinsic (non-White race, Hispanic ethnicity, urban environment, and low income) factors. The researchers concluded that recognizing and incorporating the longitudinal course of AD is relevant for improved decision making in clinical practice and trials, and that future research should focus on the standardization of longitudinal course measures and their implementation alongside currently used measures for patient stratification and treatment.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Evaluating the longitudinal course of atopic dermatitis: a review of the literature.
J Am Acad Dermatol 2022 Sep;87(3):688-89. doi: 10.1016/j.jaad.2022.02.005..
Keywords: Skin Conditions
Manjunath J, Silverberg JI
Association of sleep disturbances with geriatric age in atopic dermatitis patients.
The purpose of this cross-sectional study was to investigate the association of geriatric age with atopic dermatitis (AD) severity and sleep disturbances (SD). Patients over the age of 18 seen at an eczema clinic were recruited and completed a self-administered questionnaire for encounters between 2014 and 2019. AD severity was assessed using the patient-oriented eczema measure (POEM), eczema area and severity index, Scoring AD (SCORAD), SCORAD-itch, investigator global assessment, and patient global assessment. The frequency of SD due to eczema was assessed using POEM. The impact of itching on the activity of falling asleep was assessed using 5 dimensions (5D) of itch. Fatigue was assessed using the patient-reported outcome measurement information system (PROMIS)-global health. Difficulty sleeping, falling asleep, and staying asleep was assessed using PROMIS-SD. The study found that geriatric AD patients had more profound SD, particularly staying asleep and fatigue, despite having AD severity similar to younger adult AD patients. The researchers concluded that future research is needed to understand why there is a difference between geriatric and non-geriatric patients as related to increased itching from atopic dermatitis and sleep disorders.
AHRQ-funded; HS023011.
Citation: Manjunath J, Silverberg JI .
Association of sleep disturbances with geriatric age in atopic dermatitis patients.
J Am Acad Dermatol 2022 Jul;87(1):206-08. doi: 10.1016/j.jaad.2021.07.039..
Keywords: Elderly, Sleep Problems, Skin Conditions
Cheng BT, Patel MS, Xu M
Timing of itch among children with atopic dermatitis.
The purpose of this study was to test the hypothesis that pediatric patients experience greater nighttime itch in atopic dermatitis. The primary study outcome was time of worst itch by parent report. Parents were asked “Over the past 7 days, what time of day or night was your child’s itch the worst?” They were able to select the hour of worst itch, with separate questions for weekdays versus weekend. Parents also rated their child’s itch intensity (range, 0-10; 10 = worst) during the morning, afternoon, evening, bedtime, and sleep. Data on when the child tried to sleep and how long it took to fall asleep were used to calculate time of sleep onset. Similarly, children ages 8 to 17 years were independently asked to self-report on time of worst itch, itch intensity at different times of day, and time of sleep onset. The researchers analyzed 240 parent-child dyads, with parent-proxy reported data from 60 infants (1-4 years), 120 children (5-12 years), and 60 adolescents (13-17 years) with AD and child self-reported data from all the children aged 8 to 17 years (n = 133). Most often, parent-proxy reported worst itch occurred at 7:00 PM during weekdays and 8:00 PM during weekends. Parents of older children aged 8 to 17 years old also reported worst itch at 7:00 PM during weekdays and 8:00 PM during weekends. Time of worst itch was consistent across age groups but delayed slightly as children grew older, likely owing to later bedtime. Parents of infants reported worst itch most frequently at 6:00 PM and 7:00 PM, children at 7:00 PM, and adolescents at 7:00 PM, 8:00 PM, and 10:00 PM. The researchers conclude that itch intensity by time of day might be explained by differences in skin and inflammatory circadian rhythms in childhood AD. Alternatively, evening rituals such as bathing, use of hot water and soap, and changing clothes may trigger itch. It also may be that children have more activities during the day to distract them from itch.
AHRQ-funded; HS023011.
Citation: Cheng BT, Patel MS, Xu M .
Timing of itch among children with atopic dermatitis.
Ann Allergy Asthma Immunol 2022 May;128(5):603-05. doi: 10.1016/j.anai.2022.01.042..
Keywords: Children/Adolescents, Skin Conditions
Cheng BT, Paller AS, Griffith JW
Burden and characteristics of skin pain among children with atopic dermatitis.
The purpose of this study was to determine clinical features and quality-of-life (QOL) burden associated with atopic dermatitis (AD)- induced skin pain in children. The researchers conducted a national cross-sectional survey of child-parent dyads with AD. Questions were administered to the parent proxy for all participants, and children 8 years and older completed a similar questionnaire adapted for self-report. The researchers surveyed 240 children with AD and parent dyads, including 60 infants (1-4 years) and 180 children (5-17 years). This cohort included 200 (83%) with moderate to very severe disease. The study reported that 111 of 240 participants (46%) had parent-proxy reported skin pain, and 59 of 133 children (44%) aged 8 to 17 years had self-reported skin pain. Children self-reported slightly greater pain intensity than did their parents. Pain intensity was associated with clinical skin features of bleeding, weeping/ oozing, cracking, itch frequency, and itch severity. Quality of life scores were also analyzed, with results indicating that skin pain was a significant factor in lower quality of life scores. The researchers concluded that intensity of skin pain in children was associated with significant decreases in quality of life.
AHRQ-funded; HS023011.
Citation: Cheng BT, Paller AS, Griffith JW .
Burden and characteristics of skin pain among children with atopic dermatitis.
J Allergy Clin Immunol Pract 2022 Apr;10(4):1104-06.e1. doi: 10.1016/j.jaip.2021.12.012..
Keywords: Children/Adolescents, Skin Conditions, Pain
Hong MR, Lei D, Yousaf M
A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis.
A prospective, dermatology practice-based study was performed of adults with atopic dermatitis. Using a Numeric Rating Scale (NRS), regression models were constructed to examine itch over time. In repeated-measures regression models, persistent NRS average-itch scores were associated with baseline NRS average-itch and food allergy. Persistent NRS worst-itch was associated with baseline worst-itch NRS and Medicaid insurance. Patients with atopic dermatitis had a heterogeneous longitudinal course with fluctuating and complex overlapping patterns of average- and worst-itch intensity, and frequency.
AHRQ-funded; HS023011.
Citation: Hong MR, Lei D, Yousaf M .
A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis.
Arch Dermatol Res 2022 Mar;314(2):141-49. doi: 10.1007/s00403-021-02214-1..
Keywords: Skin Conditions
Schwartzman G, Lei D, Ahmed A
Longitudinal course and phenotypes of health-related quality of life in adults with atopic dermatitis.
The real-world course of health-related quality of life (HRQoL) in atopic dermatitis (AD) is not well established. The aim of this prospective dermatology-practice based study was to examine predictors, longitudinal course and phenotypes of HRQoL in adult patients with AD. The investigators concluded that: patients with AD had a heterogeneous longitudinal course and distinct patterns of HRQoL; many patients had fluctuating HRQoL over time; and most patients with moderate to severe disease at baseline had persistent HRQoL impairment over time.
AHRQ-funded; HS023011.
Citation: Schwartzman G, Lei D, Ahmed A .
Longitudinal course and phenotypes of health-related quality of life in adults with atopic dermatitis.
Clin Exp Dermatol 2022 Feb;47(2):359-72. doi: 10.1111/ced.14948..
Keywords: Skin Conditions, Quality of Life
Zhou NY, Nili A, Blackwell CK
Parent report of sleep health and attention regulation in a cross-sectional study of infants and preschool-aged children with atopic dermatitis.
Older children with atopic dermatitis (AD) suffer from poor sleep and attention problems. However, until recently, the dearth of developmentally sensitive assessment tools impeded characterization in younger children. In this study the investigators aimed to characterize sleep and attention problems in young children with AD and identify modifiable factors. The investigators concluded that more severe AD correlates with poor sleep health and attention dysregulation.
AHRQ-funded; HS023011.
Citation: Zhou NY, Nili A, Blackwell CK .
Parent report of sleep health and attention regulation in a cross-sectional study of infants and preschool-aged children with atopic dermatitis.
Pediatr Dermatol 2022 Jan;39(1):61-68. doi: 10.1111/pde.14889..
Keywords: Children/Adolescents, Newborns/Infants, Sleep Problems, Skin Conditions
Vakharia PP, Chopra R, Silverberg NB
Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review.
The objective of this systematic review was to assess the efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts. The investigators found that topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric molluscum contagiosum with good tolerability and safety.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Silverberg NB .
Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review.
Am J Clin Dermatol 2018 Dec;19(6):791-803. doi: 10.1007/s40257-018-0375-4..
Keywords: Evidence-Based Practice, Skin Conditions, Treatments
Felix HC, Bradway C, Bird TM
Safety of obese persons in nursing homes.
This paper discusses the emergence of obese persons as a vulnerable group in the nursing home community. The authors discuss the special needs of this population including that obese residents require special protocols, trained staff, and appropriately sized equipment to prevent and treat skin breakdown.
AHRQ-funded; HS025703.
Citation: Felix HC, Bradway C, Bird TM .
Safety of obese persons in nursing homes.
Med Care 2018 Dec;56(12):1032-34. doi: 10.1097/mlr.0000000000000997..
Keywords: Long-Term Care, Obesity, Nursing Homes, Patient Safety, Skin Conditions
Kwa MC, Silverberg JI, Ardalan K
Inpatient burden of juvenile dermatomyositis among children in the United States.
The purpose of this study was to determine the prevalence and risk factors for hospitalization with juvenile dermatomyositis and assess inpatient burden of juvenile dermatomyositis (JDM). The study authors found that JDM contributes to both increased length of hospitalization and inpatient cost of care. Non-Medicaid government insurance was associated with higher rates of hospitalization for JDM while Hispanic and other non-white racial/ethnic groups demonstrated increased length of stay and cost of care.
AHRQ-funded; HS023011.
Citation: Kwa MC, Silverberg JI, Ardalan K .
Inpatient burden of juvenile dermatomyositis among children in the United States.
Pediatr Rheumatol Online J 2018 Nov 13;16(1):70. doi: 10.1186/s12969-018-0286-1..
Keywords: Children/Adolescents, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Skin Conditions
Thorlacius L, Ingram JR, Villumsen B
A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process.
This article describes the outcome of six stakeholder groups participating in a Delphi process to create a core outcomes set (COS) for hidradenitis suppurative (HS) research. Five anonymous e-Delphi rounds and four face-to-face consensus meetings were conducted. A total of 41 patients and 52 healthcare professionals (HCPs) from 19 countries and 4 continents participated. The consensus adopted included five domains were approved: disease course, physical signs, HS-specific quality of life, pain, and global assessments.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Ingram JR, Villumsen B .
A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process.
Br J Dermatol 2018 Sep;179(3):642-50. doi: 10.1111/bjd.16672..
Keywords: Skin Conditions, Health Services Research (HSR), Research Methodologies, Quality of Life
Li JC, Fishbein A, Singam V
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
The aim of this prospective online questionnaire-based study was to determine the relationship between atopic dermatitis (AD) severity, sleep disturbance (SD), and sleep-related impairment (SRI). The investigators concluded that their study suggests that SD and SRI are common in adults with AD, particularly those with severe diseases. They suggest that sleep disturbances and SRI should be considered when assessing burden of AD and therapeutic decisions.
AHRQ-funded; HS023011.
Citation: Li JC, Fishbein A, Singam V .
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
Dermatitis 2018 Sep/Oct;29(5):270-77. doi: 10.1097/der.0000000000000401..
Keywords: Skin Conditions, Sleep Problems
Silverberg JI, Vakharia PP, Chopra R
Phenotypical differences of childhood- and adult-onset atopic dermatitis.
This prospective study of adult- versus childhood-onset atopic dermatitis (AD) analyzed phenotypical differences with 356 adults with AD. In that sample, 41.9% reported adult-onset, with 24.4% after the age of 50. Adult-onset was associated with being born outside the US, but not sex, race/ethnicity, current smoking status, or alcohol consumption. Most adult-onset AD was associated with a high probability of lesions on for the hands and/or head/neck.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Vakharia PP, Chopra R .
Phenotypical differences of childhood- and adult-onset atopic dermatitis.
J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1306-12. doi: 10.1016/j.jaip.2017.10.005.
.
.
Keywords: Skin Conditions, Children/Adolescents
Owen JL, Vakharia PP, Silverberg JI
The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis.
Recent systematic reviews have suggested that allergic contact dermatitis (ACD) is a significant clinical problem in both children and adults with atopic dermatitis (AD). The authors review the clinical scenarios where patch testing is indicated in AD. In addition, they review the contraindications, preferred patch-testing series, pitfalls, and challenges determining the relevance of positive patch-test reactions in AD patients.
AHRQ-funded; HS023011.
Citation: Owen JL, Vakharia PP, Silverberg JI .
The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis.
Am J Clin Dermatol 2018 Jun;19(3):293-302. doi: 10.1007/s40257-017-0340-7.
.
.
Keywords: Diagnostic Safety and Quality, Skin Conditions
Vakharia PP, Chopra R, Sacotte R
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Several patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, such as the Patient-Oriented Eczema Measure (POEM), while others pertain to itch, for example the numerical rating scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatological disease in general, for example the Dermatology Life Quality Index (DLQI). The purpose of this study was to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQoL and 5-D itch scale for use in adults with AD.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Br J Dermatol 2018 Apr;178(4):925-30. doi: 10.1111/bjd.16078..
Keywords: Outcomes, Patient-Centered Outcomes Research, Quality of Life, Skin Conditions
Thorlacius L, Garg A, Ingram JR
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
This article describes the outcome of two in-person consensus meetings to create a core outcomes set (COS) for hidradenitis suppurative (HS) research. Forty-one individuals from 13 countries and 4 continents were included. The list of items discussed had been developed from patient interviews, a systematic literature review and a healthcare professional survey. Nine items were excluded and seven domains were approved which included: disease course, physical signs, HS-specific quality of life, satisfaction, symptoms, pain and global assessments.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Garg A, Ingram JR .
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
Br J Dermatol 2018 Mar;178(3):715-21. doi: 10.1111/bjd.16093..
Keywords: Evidence-Based Practice, Health Services Research (HSR), Outcomes, Research Methodologies, Skin Conditions
Hsu DY, Shinkai K, Silverberg JI
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
This study used data from the Nationwide Inpatient Sample 2002-2012 to determine incidence, risk factors, comorbidities, costs, length of stay, and mortality in hospitalized children with Eczema herpeticum (EH). A higher risk was associated with younger age and non-white ethnicity (Asian in particular). However there was less frequency of hospitalization associated with lower income quartiles. The mortality incidence was 0.1%.
AHRQ-funded; HS023011.
Citation: Hsu DY, Shinkai K, Silverberg JI .
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
J Invest Dermatol 2018 Feb;138(2):265-72. doi: 10.1016/j.jid.2017.08.039..
Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Healthcare Costs, Hospitalization, Skin Conditions
Fishbein AB, Mueller K, Kruse L
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
The researchers sought to characterize sleep in a cohort of children with moderate-to-severe atopic dermatitis (AD) and to determine methods for assessment of sleep disturbance. In nineteen patients and nineteen controls, they found that patients with AD experienced wake after sleep onset (WASO) for 103 plus or minus 55 minutes as compared with 50 plus or minus 27 minutes in the controls. They had a higher frequency of restless sleep, daytime sleepiness, difficulty falling back to sleep at night, and teacher-reported daytime sleepiness. They concluded that children with moderate-to-severe AD experience more WASO and lower sleep efficiency than healthy controls but similar bedtime and wake time, sleep duration, and sleep onset latency.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Mueller K, Kruse L .
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
J Am Acad Dermatol 2018 Feb;78(2):336-41. doi: 10.1016/j.jaad.2017.08.043.
.
.
Keywords: Children/Adolescents, Children/Adolescents, Skin Conditions, Sleep Problems
Vakharia PP, Chopra R, Silverberg JI
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
This study sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally. The results highlighted the lack of uniformity and documentation of atopic dermatitis diagnostic criteria in randomized controlled trials for atopic dermatitis. The investigators recommended harmonizing the diagnostic criteria for atopic dermatitis in future randomized controlled trials.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Silverberg JI .
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
Am J Clin Dermatol 2018 Feb;19(1):15-22. doi: 10.1007/s40257-017-0299-4..
Keywords: Diagnostic Safety and Quality, Patient-Centered Outcomes Research, Research Methodologies, Skin Conditions