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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 24 of 24 Research Studies DisplayedKaplan J, Somohano VC, Zaccari B
Randomized controlled trials of mind-body interventions for posttraumatic stress disorder: a systematic review.
This systematic review examined strength of evidence for use of mind-body interventions (MBIs), including mindfulness-based interventions (MiBIs), meditation- and mantra-based interventions (MMIs), and movement-based interventions (MoBIs) for treatment of post-traumatic stress disorder (PTSD). The authors used the AHRQ-funded evidence tables for the PTSD-Repository to identify relevant studies and assess the risk of bias. The search was conducted between June 2018 and June 2022 using a number of relevant databases. They found 26 randomized controlled trials that met their inclusion criteria. Strength of evidence was rated as low for MiBIs and MMIs, largely due to contradicting results, inconsistent use of active versus passive comparators, and high risk of bias. It was rated as moderate for MoBIs due to individual studies consistently favoring the intervention and a relatively large number of studies and participants. Only two of the included studies had objective outcome measures.
AHRQ-funded; HS026370.
Citation: Kaplan J, Somohano VC, Zaccari B .
Randomized controlled trials of mind-body interventions for posttraumatic stress disorder: a systematic review.
Front Psychol 2024 Jan 24; 14:1219296. doi: 10.3389/fpsyg.2023.1219296.
Keywords: Complementary and Alternative Medicine, Behavioral Health
Alford CM, Wahlquist AE, Sterba KR
A quality improvement study on the feasibility and potential benefits of a yogic breathing program for cancer survivors and caregivers during treatment in a lodging facility.
This study assessed the acceptability and feasibility of a yogic breathing program in cancer patients and caregivers during the treatment period, and then investigated whether it provided any benefits. The authors designed a 20-minute yogic breathing regimen and introduced them to all-site cancer patients and their caregivers during the cancer treatment period at a lodging facility, Hope Lodge in Charleston, SC. The classes were advertised via intercom, displays, and word of mouth. Participants were taught five different breathing exercises. After completion of the exercises in a single session, a self-reported quality improvement questionnaire was administered assessing sociodemographic/clinical factors, expectations about the session, and ratings of satisfaction with the session. There were 52 participants who provided feedback during the nine months of the collection period, with patients and caregivers in almost equal numbers. The findings indicated that yogic breathing is acceptable to patients and caregivers and may alleviate key symptoms from cancer treatment, in particular stress. The lodging facility continues to offer weekly yogic breathing sessions to their patients conducted by Hope Lodge volunteers trained by the study team.
AHRQ-funded; HS024533.
Citation: Alford CM, Wahlquist AE, Sterba KR .
A quality improvement study on the feasibility and potential benefits of a yogic breathing program for cancer survivors and caregivers during treatment in a lodging facility.
Brain Behav Immun Integr 2023 Jul; 3. doi: 10.1016/j.bbii.2023.100019..
Keywords: Complementary and Alternative Medicine, Cancer, Quality of Life
McDonagh MS, Morasco BJ, Wagner J
Cannabis-based products for chronic pain : a systematic review.
Researchers sought to evaluate the benefits and harms of cannabinoids for chronic pain. They found that oral, synthetic cannabis products with high THC-to-CBD ratios and sublingual, extracted cannabis products with comparable THC-to-CBD ratios may be associated with short-term improvements in chronic pain and increased risk for dizziness and sedation.
AHRQ-funded; 75Q80120D00006.
Citation: McDonagh MS, Morasco BJ, Wagner J .
Cannabis-based products for chronic pain : a systematic review.
Ann Intern Med 2022 Aug;175(8):1143-53. doi: 10.7326/m21-4520.
AHRQ-funded; 75Q80120D00006..
AHRQ-funded; 75Q80120D00006..
Keywords: Pain, Chronic Conditions, Complementary and Alternative Medicine, Treatments, Evidence-Based Practice
Sun K, Szymonifka J, Tian H
Association of traditional Chinese medicine use with adherence to prescribed Western rheumatic medications among Chinese American patients: a cross-sectional survey.
Chinese Americans are a fast-growing immigrant group with worse rheumatic disease outcomes compared to white populations and frequently use traditional Chinese medicine (TCM). Whether TCM use is associated with lower adherence to Western rheumatic medications is unknown. The purpose of this study was to examine adherence to Western medications for systemic rheumatic diseases in the Chinese American immigrant population and its association with TCM use.
Citation: Sun K, Szymonifka J, Tian H .
Association of traditional Chinese medicine use with adherence to prescribed Western rheumatic medications among Chinese American patients: a cross-sectional survey.
Arthritis Care Res 2020 Oct;72(10):1474-80. doi: 10.1002/acr.24031..
Keywords: Medication, Complementary and Alternative Medicine, Patient Adherence/Compliance, Racial and Ethnic Minorities, Arthritis, Chronic Conditions
Sun K, Szymonifka J, Tian H
Is traditional Chinese medicine use associated with worse patient-reported outcomes among Chinese American rheumatology patients?
Chinese Americans are a fast-growing immigrant group with more severe rheumatic disease manifestations than whites and often a strong cultural preference for traditional Chinese medicine (TCM). In this study, the investigators aimed to examine TCM use patterns and association with patient-reported outcomes (PRO) among Chinese American rheumatology patients. The investigators concluded that among these Chinese American rheumatology patients, TCM users had worse PRO in many physical and mental health domains.
AHRQ-funded; HS000066.
Citation: Sun K, Szymonifka J, Tian H .
Is traditional Chinese medicine use associated with worse patient-reported outcomes among Chinese American rheumatology patients?
J Rheumatol 2019 Dec;46(12):1634-39. doi: 10.3899/jrheum.181148..
Keywords: Complementary and Alternative Medicine, Racial and Ethnic Minorities, Outcomes
Befus DR, Hull S
Nonpharmacological self-management of migraine across social locations: an equity-oriented, qualitative analysis.
The authors conducted focus groups to explore patients’ desires and recommendations for migraine clinicians and researchers. They identified 4 themes: a more holistic, collaborative, long-term treatment approach; medication as a short-term solution; high personal and economic costs of medication; and desire for more information about and access to natural approaches. The authors concluded that holistic and integrative approaches were preferred over medication as long-term migraine management strategies; however, people in marginalized social locations, while disproportionately disabled by migraine, did not feel as comfortable accessing integrative approaches through currently available channels.
AHRQ-funded; HS0224430.
Citation: Befus DR, Hull S .
Nonpharmacological self-management of migraine across social locations: an equity-oriented, qualitative analysis.
Glob Adv Health Med 2019 Jun 13;8:2164956119858034. doi: 10.1177/2164956119858034..
Keywords: Care Management, Chronic Conditions, Complementary and Alternative Medicine, Neurological Disorders, Patient Self-Management
Duvall SW, Lindly O, Zuckerman K
Ethical implications for providers regarding cannabis use in children with autism spectrum disorders.
In this paper, the authors present commentary on the ethical implications of cannabis use in children with autism spectrum disorder and severe self-harm behaviors. They discuss ethical analysis that includes harm reduction, health concerns, and information sharing.
AHRQ-funded; HS000063.
Citation: Duvall SW, Lindly O, Zuckerman K .
Ethical implications for providers regarding cannabis use in children with autism spectrum disorders.
Pediatrics 2019 Feb;143(2). doi: 10.1542/peds.2018-0558..
Keywords: Autism, Children/Adolescents, Complementary and Alternative Medicine, Neurological Disorders
Khan SH, Kitsis M, Golovyan D
Effects of music intervention on inflammatory markers in critically ill and post-operative patients: a systematic review of the literature.
This systematic review was conducted to determine if music has a beneficial effect on inflammatory biomarkers in intensive care and post-operative patients. After screening, a total of 26 studies were identified for review and 14 were selected for inclusion. Only seven studies showed a significant decrease in cortisol levels. Three of the studies had a low risk of bias, but 11 studies had a high risk. None of the studies had a high level of evidence.
AHRQ-funded; HS024384.
Citation: Khan SH, Kitsis M, Golovyan D .
Effects of music intervention on inflammatory markers in critically ill and post-operative patients: a systematic review of the literature.
Heart Lung 2018 Sep - Oct;47(5):489-96. doi: 10.1016/j.hrtlng.2018.05.015..
Keywords: Complementary and Alternative Medicine, Intensive Care Unit (ICU), Surgery
Lindly OJ, Thorburn S, Heisler K
Parents' use of complementary health approaches for young children with autism spectrum disorder.
Researchers conducted a study to better understand factors influencing parents' decision to use complementary health approaches (CHA) for children with autism spectrum disorder (ASD). CHA use was negatively associated with older child age and positively associated with parents' belief ASD has major consequences and medication use. Nine themes help explain these results.
AHRQ-funded; HS000063.
Citation: Lindly OJ, Thorburn S, Heisler K .
Parents' use of complementary health approaches for young children with autism spectrum disorder.
J Autism Dev Disord 2018 May;48(5):1803-18. doi: 10.1007/s10803-017-3432-6.
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Keywords: Autism, Children/Adolescents, Complementary and Alternative Medicine, Shared Decision Making, Disabilities
Lindly O, Thorburn S, Zuckerman K
Use and nondisclosure of complementary health approaches among US children with developmental disabilities.
The researchers aimed to profile the use and nondisclosure of complementary health approaches (CHAs) among US children with developmental disabilities (DDs). They found that nearly one-quarter (23 percent) of US children with DDs used CHAs. Among those with a personal health provider, 42 percent of parents did not disclose some or all CHAs used to the child's provider.
AHRQ-funded; HS000063.
Citation: Lindly O, Thorburn S, Zuckerman K .
Use and nondisclosure of complementary health approaches among US children with developmental disabilities.
J Dev Behav Pediatr 2018 Apr;39(3):217-27. doi: 10.1097/dbp.0000000000000536.
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Keywords: Children/Adolescents, Complementary and Alternative Medicine, Shared Decision Making, Disabilities
Spatz ES, Wang Y, Beckman AL
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
This study examined the use of traditional Chinese medicine (TCM) in patients admitted for acute myocardial infarction (AMI) in China during the first 24 hours of hospitalization. The data came from the China Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction. A chart review was done of randomly sampled patients in 2001, 2006 and 2011 in 162 Western medicine hospitals across China. Nearly all (99%) hospitals used some form of TCM, with Salvia miltiorrhiza being the most commonly prescribed. This TCM treatment (and others) was used intravenously and use has increased over the span of the study, despite lack of evidence of benefit or harm.
AHRQ-funded; HS023000.
Citation: Spatz ES, Wang Y, Beckman AL .
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
Circ Cardiovasc Qual Outcomes 2018 Mar;11(3):e004190. doi: 10.1161/circoutcomes.117.004190..
Keywords: Adverse Events, Cardiovascular Conditions, Complementary and Alternative Medicine, Heart Disease and Health, Hospitals, Mortality, Outcomes, Patient-Centered Outcomes Research, Patient Safety, Practice Patterns, Risk
Senders A, Borgatti A, Hanes D
Association between pain and mindfulness in multiple sclerosis: a cross-sectional survey.
The objective of this study was to evaluate the association between pain interference and trait mindfulness in people with multiple sclerosis (MS). The results suggest a clinically significant association between mindfulness and pain interference in MS and support further exploration of mindfulness-based interventions in the management of MS-related pain.
AHRQ-funded; HS017582.
Citation: Senders A, Borgatti A, Hanes D .
Association between pain and mindfulness in multiple sclerosis: a cross-sectional survey.
Int J MS Care 2018 Jan-Feb;20(1):28-34. doi: 10.7224/1537-2073.2016-076.
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Keywords: Chronic Conditions, Chronic Conditions, Complementary and Alternative Medicine, Neurological Disorders, Patient-Centered Outcomes Research
Asher GN, Gartlehner G, Gaynes BN
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
The objective of this study was to report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). The investigators indicated that although they found little difference in the comparative efficacy of most CAM therapies or exercise and SGAs, the overall poor quality of the available evidence base tempers any conclusions that they might draw from those trials.
AHRQ-funded; 290201200008I.
Citation: Asher GN, Gartlehner G, Gaynes BN .
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
Journal Altern Complement Med 2017 Dec;23(12):907-19. doi: 10.1089/acm.2016.0261..
Keywords: Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Evidence-Based Practice, Behavioral Health
Lapham GT, Lee AK, Caldeiro RM
Frequency of cannabis use among primary care patients in Washington state.
This study describes the prevalence and frequency of past-year cannabis use among primary care patients assessed for use during a primary care visit. The study concluded that cannabis use was common in adult primary care patients, especially among younger patients and those with behavioral health conditions. Results highlight the need for primary care approaches to address cannabis use.
AHRQ-funded; HS023173.
Citation: Lapham GT, Lee AK, Caldeiro RM .
Frequency of cannabis use among primary care patients in Washington state.
J Am Board Fam Med 2017 Nov/Dec;30(6):795-805. doi: 10.3122/jabfm.2017.06.170062..
Keywords: Complementary and Alternative Medicine, Primary Care, Practice Patterns
Handley MA, Quan J, Chao MT
Use of complementary health approaches among diverse primary care patients with type 2 diabetes and association with cardiometabolic outcomes: from the SF Bay Collaborative Research Network (SF Bay CRN).
The purpose of this study is to describe use of complementary health approaches (CHAs) among patients with type 2 diabetes, and independent associations between CHA use and Hemoglobin A1c (A1C) and lower-density lipoprotein (LDL) cholesterol. The study concluded that CHA use is common among patients with type 2 diabetes and may be associated with poor cardiometabolic control and medication adherence.
AHRQ-funded; HS022561.
Citation: Handley MA, Quan J, Chao MT .
Use of complementary health approaches among diverse primary care patients with type 2 diabetes and association with cardiometabolic outcomes: from the SF Bay Collaborative Research Network (SF Bay CRN).
J Am Board Fam Med 2017 Sep-Oct;30(5):624-31. doi: 10.3122/jabfm.2017.05.170030..
Keywords: Heart Disease and Health, Complementary and Alternative Medicine, Diabetes, Outcomes, Patient Self-Management
Gartlehner G, Gaynes BN, Amick HR
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
This evidence report compared the benefits and harms of second-generation antidepressants and psychological, complementary and alternative medicine (CAM), and exercise treatments as first- and second-step interventions for adults with acute major depressive disorder (MDD). It concluded tht, given their similar efficacy, cognitive behavioral therapy and antidepressants are both viable choices for initial treatment of MDD.
AHRQ-funded.
Citation: Gartlehner G, Gaynes BN, Amick HR .
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
Ann Intern Med 2016 Mar 1;164(5):331-41. doi: 10.7326/m15-1813.
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Keywords: Medication, Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Behavioral Health
Chao MT, Handley MA, Quan J
Disclosure of complementary health approaches among low income and racially diverse safety net patients with diabetes.
The authors identified sociodemographic and communication factors associated with disclosure of complementary health approaches to providers by low-income patients with diabetes. Disclosure was associated with language concordance, physicians' interpersonal communication scores, shared decision making, and explanatory-type communication.
AHRQ-funded; HS020684; HS017261; HS022561.
Citation: Chao MT, Handley MA, Quan J .
Disclosure of complementary health approaches among low income and racially diverse safety net patients with diabetes.
Patient Educ Couns 2015 Nov;98(11):1360-6. doi: 10.1016/j.pec.2015.06.011.
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Keywords: Low-Income, Diabetes, Complementary and Alternative Medicine, Racial and Ethnic Minorities, Healthcare Delivery
Narayanaswami P, Gronseth G, Dubinsky R
The impact of social media on dissemination and implementation of clinical practice guidelines: a longitudinal observational study.
The researchers’ aim was to develop and evaluate an innovative dissemination strategy by adding social media-based dissemination methods to traditional methods for the clinical practice guidelines (CPGs) “Complementary and alternative medicine in multiple sclerosis.” They found that social media-based dissemination methods did not confer additional benefit over print-, email-, and Internet-based methods in increasing CPG awareness and changing intent in physicians or patients.
AHRQ-funded; HS022004.
Citation: Narayanaswami P, Gronseth G, Dubinsky R .
The impact of social media on dissemination and implementation of clinical practice guidelines: a longitudinal observational study.
J Med Internet Res 2015 Aug 13;17(8):e193. doi: 10.2196/jmir.4414..
Keywords: Communication, Complementary and Alternative Medicine, Evidence-Based Practice, Guidelines, Social Media, Implementation
Kim HS, Anderson JD, Saghafi O
Cyclic vomiting presentations following marijuana liberalization in Colorado.
This paper's primary objective was to determine the prevalence of patients presenting with cyclic vomiting before and after the liberalization of medical marijuana in Colorado in 2009. Its secondary objective was to describe the odds of marijuana use among cyclic vomiting visits in these same time periods. The researchers found that the prevalence of cyclic vomiting presentations nearly doubled after the liberalization of medical marijuana, with said patients more likely to endorse marijuana use.
AHRQ-funded; HS000078.
Citation: Kim HS, Anderson JD, Saghafi O .
Cyclic vomiting presentations following marijuana liberalization in Colorado.
Acad Emerg Med 2015 Jun;22(6):694-9. doi: 10.1111/acem.12655.
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Keywords: Adverse Drug Events (ADE), Complementary and Alternative Medicine, Emergency Medical Services (EMS), Policy, Substance Abuse
Chao MT, Abercrombie PD, Nakagawa S
Prevalence and use of complementary health approaches among women with chronic pelvic pain in a prospective cohort study.
The aim of this study was to examine the prevalence of and factors associated with use of complementary health approaches among women with chronic pelvic pain (CPP). It found that just over 51 percent of the women with CPP who used complementary health approaches had more optimal health-related quality of life, as measured by the Pelvic Problem Impact Questionnaire.
AHRQ-funded; HS011657; HS07373; HS09478.
Citation: Chao MT, Abercrombie PD, Nakagawa S .
Prevalence and use of complementary health approaches among women with chronic pelvic pain in a prospective cohort study.
Pain Med 2015 Feb;16(2):328-40. doi: 10.1111/pme.12585..
Keywords: Chronic Conditions, Women, Complementary and Alternative Medicine, Quality of Life
Jacoby VL, Jacoby A, Learman LA
Use of medical, surgical and complementary treatments among women with fibroids.
This study examined the use of medical management, uterus-preserving surgery, and complementary treatments among women with uterine fibroids. It found that uterus-preserving fibroid surgery is effective, but many symptomatic women can be successfully treated with nonsurgical management, including complementary and alternative therapy.
AHRQ-funded; HS011657; HS07373; HS09478.
Citation: Jacoby VL, Jacoby A, Learman LA .
Use of medical, surgical and complementary treatments among women with fibroids.
Eur J Obstet Gynecol Reprod Biol 2014 Nov;182:220-5. doi: 10.1016/j.ejogrb.2014.09.004..
Keywords: Care Management, Complementary and Alternative Medicine, Medication, Surgery, Treatments, Women
Bannuru RR, Flavin NE, Vaysbrot E
High-energy extracorporeal shock-wave therapy for treating chronic calcific tendinitis of the shoulder: a systematic review.
Calcific and noncalcific tendinitis of the shoulder can be unresponsive to conventional therapies. Extracorporeal shock-wave therapy (ESWT) has been suggested as an alternative treatment. The purpose of this study was to assess the efficacy of ESWT in patients with calcific and noncalcific tendinitis. The investigators found that high-energy ESWT was effective for improving pain and shoulder function in chronic calcific shoulder tendinitis and can result in complete resolution of calcifications.
AHRQ-funded; HS017960.
Citation: Bannuru RR, Flavin NE, Vaysbrot E .
High-energy extracorporeal shock-wave therapy for treating chronic calcific tendinitis of the shoulder: a systematic review.
Ann Intern Med 2014 Apr 15;160(8):542-9. doi: 10.7326/m13-1982..
Keywords: Chronic Conditions, Comparative Effectiveness, Complementary and Alternative Medicine, Patient-Centered Outcomes Research
Bannuru RR, Flavin NE, Vaysbrot E
High-energy extracorporeal shock-wave therapy for treating chronic calcific tendinitis of the shoulder: a systematic review.
Calcific and noncalcific tendinitis of the shoulder can be unresponsive to conventional therapies. Extracorporeal shock-wave therapy (ESWT) has been suggested as an alternative treatment. The purpose of this study was to assess the efficacy of ESWT in patients with calcific and noncalcific tendinitis. The investigators found that high-energy ESWT was effective for improving pain and shoulder function in chronic calcific shoulder tendinitis and can result in complete resolution of calcifications.
AHRQ-funded; HS017960.
Citation: Bannuru RR, Flavin NE, Vaysbrot E .
High-energy extracorporeal shock-wave therapy for treating chronic calcific tendinitis of the shoulder: a systematic review.
Ann Intern Med 2014 Apr 15;160(8):542-9. doi: 10.7326/m13-1982..
Keywords: Chronic Conditions, Comparative Effectiveness, Complementary and Alternative Medicine, Patient-Centered Outcomes Research
Goyal M, Singh S, Sibinga EM
Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.
Many people meditate to reduce psychological stress and stress-related health problems. To counsel people appropriately, clinicians need to know what the evidence says about the health benefits of meditation. The objective of this study was to determine the efficacy of meditation programs in improving stress-related outcomes (anxiety, depression, stress/distress, positive mood, mental health-related quality of life, attention, substance use, eating habits, sleep, pain, and weight) in diverse adult clinical populations.
AHRQ-funded; 290200710061.
Citation: Goyal M, Singh S, Sibinga EM .
Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.
JAMA Intern Med 2014 Mar;174(3):357-68. doi: 10.1001/jamainternmed.2013.13018..
Keywords: Behavioral Health, Complementary and Alternative Medicine, Evidence-Based Practice