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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedMazi PB, Olsen MA, Stwalley D
Attributable mortality of Candida bloodstream infections in the modern era: a propensity score analysis.
The purpose of this retrospective cohort study was to quantify the mortality attributed to Candida bloodstream infections (BSI). The researchers identified 626 adult patients with Candida BSI that were frequency-matched with 6269 control patients with similar candida BSI risk-factors. The study found that the 90-day crude mortality rate was 42.4% for Candida BSI cases and 17.1% for frequency matched controls. After propensity score-matching, the attributable risk difference for 90-day mortality was 28.4% with hazard ratio (HR) of 2.12. In the stratified analysis, the 90-day mortality risk was highest in patients in the lowest risk quintile to develop Candida BSI. Patients in this lowest risk quintile accounted for 61% of the untreated patients with Candida BSI. Sixty-nine percent of untreated patients died versus 35% of treated patients.
AHRQ-funded; HS019455.
Citation: Mazi PB, Olsen MA, Stwalley D .
Attributable mortality of Candida bloodstream infections in the modern era: a propensity score analysis.
Clin Infect Dis 2022 Sep 29;75(6):1031-36. doi: 10.1093/cid/ciac004..
Keywords: Infectious Diseases, Mortality, Sepsis
Cimiotti JP, Becker ER, Li Y
Association of registered nurse staffing with mortality risk of Medicare beneficiaries hospitalized with sepsis.
The purpose of this cross-sectional study was to determine if registered nurse workload was related with mortality in Medicare beneficiaries admitted to an acute care hospital with sepsis. The researchers evaluated the records of Medicare beneficiaries ages 65 to 99 years with a primary diagnosis of sepsis that was present on admission to 1 of 1958 nonfederal, general acute care hospitals that had data on CMS SEP-1 scores and registered nurse workload. Researchers utilized 2018 data from the American Hospital Association Annual Survey, CMS Hospital Compare, and Medicare claims. The patient outcome of interest was mortality within 60 days of admission. The study found that 702,140 Medicare beneficiaries with a mean age of 78.2 years, 51% of whom were women, had a diagnosis of sepsis. In a multivariable regression model, each additional registered nurse hour per patient day (HPPD) was associated with a 3% decrease in the odds of 60-day mortality. The researchers concluded that hospitals which provide more registered nurse hours of care could possibly decrease the likelihood of mortality in Medicare beneficiaries with sepsis.
AHRQ-funded; HS026232.
Citation: Cimiotti JP, Becker ER, Li Y .
Association of registered nurse staffing with mortality risk of Medicare beneficiaries hospitalized with sepsis.
JAMA Health Forum 2022 May;3(5):e221173. doi: 10.1001/jamahealthforum.2022.1173..
Keywords: Sepsis, Mortality, Provider: Nurse, Nursing, Workforce