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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedParekh TM, Bhatia S, Cherrington A
Factors influencing decline in quality of life in smokers without airflow obstruction: the COPDGene study.
This study looked at factors influencing decline in quality of life (QoL) in smokers without airflow obstruction using participants from the COPDGene study, a multicenter, longitudinal US study designed to determine genetic determinants of chronic obstructive pulmonary disease (COPD). The authors hypothesized that exacerbations and changes in exacerbation status would predict QoL decline among normal spirometry and Preserved Ratio Impaired Spirometry (PRISm) populations. They enrolled study subjects from Phase 1 of COPDGene and performed multivariable logistic regression models to determine independent predictors of decline in quality of life. Independent predictors of QoL deterioration included current smoking, higher exacerbation frequency, and a change from infrequent to frequent exacerbation status in both groups.
AHRQ-funded; HS023009.
Citation: Parekh TM, Bhatia S, Cherrington A .
Factors influencing decline in quality of life in smokers without airflow obstruction: the COPDGene study.
Respir Med 2020 Jan;161:105820. doi: 10.1016/j.rmed.2019.105820..
Keywords: Respiratory Conditions, Chronic Conditions, Tobacco Use, Quality of Life
Ware JE, Gandek B, Kulasekaran A
Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States.
The researchers evaluated the psychometric properties of German- and English-language versions of survey scales representing both types of measures in samples of current and former smokers. They concluded that German- and English-language Tobacco Quality of Life Impact Tool (TQOLIT) surveys have comparable and satisfactory psychometric properties. Cross-sectional tests, including correlations with four biomarkers, support the validity of the new smoking-specific measures for use in studies of otherwise healthy smokers.
AHRQ-funded; HS023117.
Citation: Ware JE, Gandek B, Kulasekaran A .
Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States.
Health Qual Life Outcomes 2015 Aug 16;13:128. doi: 10.1186/s12955-015-0316-3..
Keywords: Quality of Life, Tobacco Use