National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
251 to 261 of 261 Research Studies DisplayedGauguet S, Ahmed AA, Zhou J
Group A streptococcal bacteremia without a source is associated with less severe disease in children.
The authors analyzed characteristics of 86 Group A streptococcal bacteremia cases at Boston Children's Hospital from 1992 to 2012. They found that children with bacteremia without a source (30% of cases) were less likely to have severe disease than children with focal infections.
AHRQ-funded; HS013908.
Citation: Gauguet S, Ahmed AA, Zhou J .
Group A streptococcal bacteremia without a source is associated with less severe disease in children.
Pediatr Infect Dis J 2015 Apr;34(4):447-9. doi: 10.1097/inf.0000000000000587.
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Keywords: Children/Adolescents, Hospitalization, Infectious Diseases, Outcomes
Linder JA
Sore throat: avoid overcomplicating the uncomplicated.
In this editorial, the author described issues involving sore throat diagnosis and delineated various points concerning an article within the same journal issue, concluding that physicians should remember that the prevalence of group A streptococcus in adults with a sore throat is approximately 10%; and that they should use the Centor scoring criteria; selectively use rapid antigen-detection testing; limit antibiotic treatment to patients most likely to have group A streptococcus; and most of the time when prescribing antibiotics, use penicillin.
AHRQ-funded; HS018419.
Citation: Linder JA .
Sore throat: avoid overcomplicating the uncomplicated.
Ann Intern Med 2015 Feb 17;162(4):311-2. doi: 10.7326/m14-2899.
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Keywords: Antibiotics, Diagnostic Safety and Quality, Infectious Diseases, Medication, Pneumonia, Respiratory Conditions, Practice Patterns
Bartsch SM, Gorham K, Lee BY
The cost of an Ebola case.
The researchers developed a mathematical model to estimate the cost of an Ebola virus disease (EVD) case from the provider and societal perspectives in the three most affected countries of Guinea, Liberia, and Sierra Leone. Their model estimates the total societal cost of an EVD case with full recovery ranges from $480 to $912, while that of an EVD case not surviving ranges from $5,929 to $18,929, varying by age and country.
AHRQ-funded; HS023317.
Citation: Bartsch SM, Gorham K, Lee BY .
The cost of an Ebola case.
Pathog Glob Health 2015 Feb;109(1):4-9. doi: 10.1179/2047773214y.0000000169..
Keywords: Healthcare Costs, Mortality, Public Health, Infectious Diseases
Pitzer VE, Viboud C, Alonso WJ
AHRQ Author: Steiner CA
Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States.
The authors examined the association between environmental variables and state-specific measures of respiratory syncytial virus (RSV) seasonality. They found that states with low mean vapor pressure and the largest seasonal variation in potential evapotranspiration tended to experience biennial patterns of RSV activity, with alternating years of "early-big" and "late-small" epidemics. Their results successfully connected environmental drivers to the epidemic dynamics of RSV; however, the results do not fully explain why RSV activity begins in Florida, one of the warmest states, when RSV is a winter-seasonal pathogen.
AHRQ-authored.
Citation: Pitzer VE, Viboud C, Alonso WJ .
Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States.
PLoS Pathog 2015 Jan;11(1):e1004591. doi: 10.1371/journal.ppat.1004591.
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Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Infectious Diseases, Respiratory Conditions
Matthews Pillemer F, Blendon RJ, Zaslavsky AM
Predicting support for non-pharmaceutical interventions during infectious outbreaks: a four region analysis.
Non-pharmaceutical interventions (NPIs) such as quarantines and face masks are socially and economically disruptive, and usually require compliance by a significant proportion of the population to be effective. The researchers investigated the predictors of NPI support in Hong Kong, Singapore, Taiwan, and the United States. They found NPI support varies widely by region, possibly because of cultural variation and prior experience.
AHRQ-funded; HS000055; HS017587.
Citation: Matthews Pillemer F, Blendon RJ, Zaslavsky AM .
Predicting support for non-pharmaceutical interventions during infectious outbreaks: a four region analysis.
Disasters 2015 Jan;39(1):125-45. doi: 10.1111/disa.12089..
Keywords: Public Health, Prevention, Infectious Diseases, Emergency Preparedness
Rosenman MB, Szucs KA, Finnell SM
Nascent regional system for alerting infection preventionists about patients with multidrug-resistant gram-negative bacteria: implementation and initial results.
The authors sought to build and to begin evaluating a regional automated system to notify infection preventionists (IPs) when a patient with a history of gram-negative rod multidrug-resistant organism (GNRMDRO) is admitted to an emergency department (ED) or inpatient setting. They found it feasible to create a regional microbiology-based alert system and observed substantial crossover between institutions. They concluded that this system, if it contributes to timely isolation, may help reduce the spread of GNRMDROs.
AHRQ-funded; HS020014.
Citation: Rosenman MB, Szucs KA, Finnell SM .
Nascent regional system for alerting infection preventionists about patients with multidrug-resistant gram-negative bacteria: implementation and initial results.
Infect Control Hosp Epidemiol 2014 Oct;35 Suppl 3:S40-7. doi: 10.1086/677833.
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Keywords: Emergency Department, Infectious Diseases, Inpatient Care, Patient Safety, Prevention
Jacobs JH, Viboud C, Tchetgen ET
AHRQ Author: Steiner C
The association of meningococcal disease with influenza in the United States, 1989-2009.
The purpose of this paper is to quantify the fraction of meningococcal disease attributable to influenza. The authors found that, over 20 years, 12.8% of meningococcal disease can be attributable to influenza in the preceding weeks with H3N2 accounting for 5.2%, H1N1 4.3%, B 3.0%, and pH1N1 0.2%. They concluded that influenza vaccination could provide protection, particularly in young children where the meningococcal disease vaccine is not recommended or protective against the most common serogroup.
AHRQ-authored.
Citation: Jacobs JH, Viboud C, Tchetgen ET .
The association of meningococcal disease with influenza in the United States, 1989-2009.
PLoS One 2014 Sep 29;9(9):e107486. doi: 10.1371/journal.pone.0107486.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Infectious Diseases, Influenza
Kappagoda S, Ioannidis JP
Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.
The purpose of this review was to analyze evidence from randomized controlled trials (RCTs) on the prevention and control of neglected tropical diseases (NTDs) and to identify areas where evidence is lacking. The most studied diseases were geohelminth infection (51 RCTs) and leishmaniasis (46 RCTs). Vaccines, chemoprophylaxis and interventions targeting insect vectors were evaluated in 113, 99 and 39 RCTs, respectively. Few addressed how best to deliver preventive chemotherapy.
AHRQ-funded; HS000028.
Citation: Kappagoda S, Ioannidis JP .
Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.
Bull World Health Organ 2014 May;92(5):356-66c. doi: 10.2471/blt.13.129601..
Keywords: Prevention, Infectious Diseases, Evidence-Based Practice
Harris AD, Pineles L, Belton B
Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial.
Antibiotic-resistant bacteria are associated with increased patient morbidity and mortality. It is unknown whether wearing gloves and gowns for all patient contact in the intensive care unit (ICU) decreases acquisition of antibiotic-resistant bacteria. The purpose of this study was to assess whether wearing gloves and gowns for all patient contact in the ICU decreases acquisition of methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) compared with usual care.
AHRQ-funded; HS018111; 290200600015.
Citation: Harris AD, Pineles L, Belton B .
Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial.
JAMA 2013 Oct 16;310(15):1571-80. doi: 10.1001/jama.2013.277815..
Keywords: Patient Safety, Healthcare-Associated Infections (HAIs), Methicillin-Resistant Staphylococcus aureus (MRSA), Infectious Diseases, Intensive Care Unit (ICU), Hospitals, Prevention, Critical Care
Steinberg JP, Denham ME, Zimring C
https://www.researchgate.net/publication/276382905/download
The role of the hospital environment in the prevention of healthcare-associated infections by contact transmission.
The authors describe the role of the hospital environment in the spread of pathogens by direct and indirect contact. In addition, the prevention of transmission through interventions involving the built environment is discussed. They conclude that enhanced environmental cleaning including touchless technologies and self-cleaning surfaces can reduce environmental contamination and may prevent infections.
AHRQ-funded; 290201000024I.
Citation: Steinberg JP, Denham ME, Zimring C .
The role of the hospital environment in the prevention of healthcare-associated infections by contact transmission.
HERD 2013 Oct;7(1 suppl):46-73..
Keywords: Healthcare-Associated Infections (HAIs), Infectious Diseases, Hospitals, Prevention, Patient Safety
Huang SS, Septimus E, Kleinman K
Targeted versus universal decolonization to prevent ICU infection.
In this pragmatic, cluster-randomized trial the authors compared targeted versus universal decolonization of patients in intensive care units (ICUs) as strategies for preventing health care-associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). They found that in routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen.
AHRQ-funded; 290201000008I.
Citation: Huang SS, Septimus E, Kleinman K .
Targeted versus universal decolonization to prevent ICU infection.
N Engl J Med 2013 Jun 13;368(24):2255-65. doi: 10.1056/NEJMoa1207290..
Keywords: Comparative Effectiveness, Infectious Diseases, Healthcare-Associated Infections (HAIs), Methicillin-Resistant Staphylococcus aureus (MRSA), Intensive Care Unit (ICU), Patient-Centered Healthcare, Patient Safety, Prevention