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Search All Research Studies
Topics
- Brain Injury (1)
- Cardiovascular Conditions (1)
- Children/Adolescents (2)
- Critical Care (1)
- Evidence-Based Practice (1)
- Intensive Care Unit (ICU) (2)
- Mortality (1)
- (-) Neurological Disorders (4)
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- (-) Risk (4)
- Sleep Problems (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 4 of 4 Research Studies DisplayedLuther M, Poppert Cordts KM, Williams CN
Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery.
This is a systematic review to quantify sleep wake disturbances (SWD) after pediatric traumatic brain injury (TBI). These SWD can place children at risk for worse outcomes since sleep is needed for brain development and healing after injury. They also evaluated interventions for SWD and the association between SWD and other post-traumatic outcomes. Literature was searched from 1999-2019 evaluating sleep or fatigue in children hospitalized for TBI. Two independent reviewers assessed quality of the studies using the Newcastle-Ottowa Score for observational studies. Out of 966 identified articles, 126 full text articles were reviewed and 24 studies were included. Studies showed at least 20% of children with TBI had some degree of SWD including trouble falling or staying asleep, fatigue, daytime fatigue, and nightmares. SWD was negatively correlated with cognitive, behavioral, and quality of life outcomes. There was moderate-high risk of bias for all studies due to small sample size and lack of validated or objective SWD measures.
AHRQ-funded; HS022981.
Citation: Luther M, Poppert Cordts KM, Williams CN .
Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery.
Sleep 2020 Oct;43(10):zsaa083. doi: 10.1093/sleep/zsaa083..
Keywords: Children/Adolescents, Sleep Problems, Brain Injury, Neurological Disorders, Trauma, Risk, Patient-Centered Outcomes Research, Outcomes, Quality of Life, Evidence-Based Practice
Hartman ME, Williams CN, Hall TA
Post-intensive-care syndrome for the pediatric neurologist.
The investigators are working to create awareness and help mitigate post-intensive-care syndrome in pediatric patients who had experienced primary neurological injury and also help their parents and siblings. In this paper they review current knowledge regarding post-intensive-care syndrome in pediatrics and its risk factors. They describe their experience establishing Pediatric Neurocritical Care Recovery Programs at two large academic centers. They also provide a battery of validated tests to identify and manage the different aspects of post-intensive-care syndrome in pediatrics.
AHRQ-funded; HS022981.
Citation: Hartman ME, Williams CN, Hall TA .
Post-intensive-care syndrome for the pediatric neurologist.
Pediatr Neurol 2020 Jul;108:47-53. doi: 10.1016/j.pediatrneurol.2020.02.003..
Keywords: Children/Adolescents, Neurological Disorders, Intensive Care Unit (ICU), Critical Care, Risk
Andrews PS, Wang S, Perkins AJ
Relationship between intensive care unit delirium severity and 2-year mortality and health care utilization.
Critical care patients with delirium are at an increased risk of functional decline and mortality long term. The objective of this study was to determine the relationship between delirium severity in the intensive care unit and mortality and acute health care utilization within 2 years after hospital discharge. The investigators concluded that increased delirium severity and days of delirium or coma were associated with higher mortality risk 2 years after discharge.
AHRQ-funded; P30 HS024384.
Citation: Andrews PS, Wang S, Perkins AJ .
Relationship between intensive care unit delirium severity and 2-year mortality and health care utilization.
Am J Crit Care 2020 Jul 1;29(4):311-17. doi: 10.4037/ajcc2020498..
Keywords: Intensive Care Unit (ICU), Neurological Disorders, Mortality, Risk
Kole MJ, Shea P, Albrecht JS
Utility of the Hijdra sum score in predicting risk of aneurysm in patients with subarachnoid hemorrhage: a single-center experience with 550 patients.
This study’s objective was to generate a model to assist in predicting risk of aneurysm in patients with subarachnoid hemorrhage (SAH). A retrospective cohort study was conducted of all patients 18 years and older admitted to a single center from March 2008 to March 2018 with non-traumatic SAH (n = 550). Risk factors examined included female sex, higher modified Fisher or Hijdra score, nonperimesencephalic location, presence of intracerebral hemorrhage, World Federation of Neurological Societies (WFNS) score ≥3, need for cerebrospinal fluid diversion on admission, and history of tobacco use. Greater modified Fisher, greater Hijdra score, WFNS ≥3, and hydrocephalus present on admission presented a significantly greater risk of an aneurysm. The authors concluded a simple scoring tool based on patient sex, SAH location and SAH burden can assist in predicting the presence of an aneurysm in patients with nontraumatic SAH.
AHRQ-funded; HS024560.
Citation: Kole MJ, Shea P, Albrecht JS .
Utility of the Hijdra sum score in predicting risk of aneurysm in patients with subarachnoid hemorrhage: a single-center experience with 550 patients.
Neurosurgery 2020 Jun;86(6):783-91. doi: 10.1093/neuros/nyz346.
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Keywords: Cardiovascular Conditions, Neurological Disorders, Risk