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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 32 Research Studies DisplayedShover CL, Rosen A, Mata J
Engaging same-day peer ambassadors to increase coronavirus disease 2019 vaccination among people experiencing unsheltered homelessness in Los Angeles County: a hybrid feasibility-evaluation study.
This study’s goal was to evaluate the feasibility and acceptability of engaging unhoused peer ambassadors (PAs) in COVID-19 vaccination efforts to reach people experiencing unsheltered homelessness in Los Angeles County. A total of 117 PAs were enrolled at 103 events, participating for an average of 2 hours. Findings showed that 197 additional people were vaccinated over 167 PA hours, accounting for >25% of all vaccines given at these events, indicating that recruiting same-day unhoused PAs is a feasible, acceptable, and preliminarily effective technique to increase COVID-19 vaccination in unsheltered settings.
AHRQ-funded; HS026407.
Citation: Shover CL, Rosen A, Mata J .
Engaging same-day peer ambassadors to increase coronavirus disease 2019 vaccination among people experiencing unsheltered homelessness in Los Angeles County: a hybrid feasibility-evaluation study.
J Infect Dis 2022 Oct 7;226(suppl 3):S346-s52. doi: 10.1093/infdis/jiac291..
Keywords: COVID-19, Vaccination, Vulnerable Populations, Public Health
Glenn BA, Nonzee NJ, Herrmann AK
Impact of a multi-level, multi-component, system intervention on HPV vaccination in a federally qualified health center.
This paper evaluates the effectiveness of a multi-component, system-level intervention to improve human papillomavirus (HPV) vaccination rates in Federally Qualified Health Center (FQHC) clinics. The eight participating clinics were randomly assigned to study condition (four intervention, four usual care) that serve a primarily low-income Latino population. The intervention included parent reminders for HPV vaccine series completion, provider training, clinic-level audit and feedback, and workflow modifications to reduce missed opportunities for vaccination. The authors compared HPV vaccination rates among patients, ages 11 to 17 during a 12-month preintervention period and a 15-month intervention period. There was a greater increase in vaccination completion rates among boys, but not girls.
AHRQ-funded; HS000046.
Citation: Glenn BA, Nonzee NJ, Herrmann AK .
Impact of a multi-level, multi-component, system intervention on HPV vaccination in a federally qualified health center.
Cancer Epidemiol Biomarkers Prev 2022 Oct 4;31(10):1952-58. doi: 10.1158/1055-9965.Epi-22-0156..
Keywords: Infectious Diseases, Sexual Health, Vaccination
Qin CX, Auerbach SR, Charnaya O
Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients.
The purpose of this observational cohort study was to assess whether a third SARS-CoV-2 vaccine would improve immunogenicity in adolescent solid organ transplant recipients (SOTRs), and to report the antibody response and safety of a third mRNA vaccine dose (D3) in adolescent SOTRs. Forty-two participants received three BNT162b2 doses and one received three mRNA-1273 doses. Participants were 6-13 years from transplant (median 10 [IQR]), and heart transplant was the most common procedure, in 41.9% of the participants. 9.3% of participants reported pre-D1 SARS-CoV-2 infections and 9.3% reported breakthrough infections. The study found that 88.4% of adolescent SOTRs had positive antibody responses 1 month post-D3, an increase from 63–73% post-D2. 54.5% of participants with prior negative responses seroconverted and 100% with positive responses increased or remained at maximum titer. Titers remained stable 3 months post-D3. There were no vaccine-related adverse events and four breakthrough infections. The researchers concluded that although this was a convenience sample, the results suggest there is an antibody response benefit to a third SARS-CoV-2 vaccine in adolescent SOTRs.
AHRQ-funded; HS026510.
Citation: Qin CX, Auerbach SR, Charnaya O .
Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients.
Am J Transplant 2022 Oct;22(10):2481-83. doi: 10.1111/ajt.17085..
Keywords: Children/Adolescents, COVID-19, Vaccination, Transplantation
Khorasani S, Zubiago J, Carreiro J
Influenza vaccination in Massachusetts jails: a mixed-methods analysis.
The objectives of this study were to survey health administrators in Massachusetts county jails about institutional influenza vaccine policies and practices and estimate influenza vaccination rates in Massachusetts jails from 2013 to 2020. Findings showed that influenza vaccination rates in Massachusetts jails were low, and delivery practices in jails varied. The authors noted that lack of influenza vaccinations in jails is a gap in health care that needs to be prioritized, especially considering the current COVID-19 pandemic. They suggested that further investigations for effective and equitable vaccination in this population should involve people who are incarcerated and people who make influenza vaccine policies in jails.
AHRQ-funded; HS026008.
Citation: Khorasani S, Zubiago J, Carreiro J .
Influenza vaccination in Massachusetts jails: a mixed-methods analysis.
Public Health Rep 2022 Sep-Oct;137(5):936-43. doi: 10.1177/00333549211041659..
Keywords: Influenza, Vaccination, Respiratory Conditions
Banerji A, Norton AE, Blumenthal KG
Rapid progress in our understanding of COVID-19 vaccine allergy: a cause for optimism, not hesitancy.
This paper is a review of current understanding of COVID-19 vaccine allergy. Rapid progress has been made over the past several years in large part due to important research efforts from individuals in the allergy community. Better data has shown safety of repeat vaccination despite an initial reaction. The review ran from December 2020 through early 2022.
AHRQ-funded; HS026395; HS025375
Citation: Banerji A, Norton AE, Blumenthal KG .
Rapid progress in our understanding of COVID-19 vaccine allergy: a cause for optimism, not hesitancy.
J Allergy Clin Immunol 2022 Jul;150(1):12-16. doi: 10.1016/j.jaci.2022.03.023..
Keywords: COVID-19, Vaccination, Adverse Drug Events (ADE), Adverse Events
Huppert J
AHRQ Author: Huppert J
Adolescents with vulvar ulcers: COVID-19 disease, COVID-19 vaccines, and the value of case reports.
The author indicates that there are too few cases reporting aphthosis after COVID disease or COVID-19 vaccination to infer a statistical association, but that case reports are a valuable source of rich details about conditions that are difficult to study with more rigorous designs and can be synthesized to help guide medical care. She recommends that it is time for a high-quality systematic review of vulvar aphthosis in order for clinicians to incorporate the existing evidence into decision-making and best care for patients.
AHRQ-authored.
Citation: Huppert J .
Adolescents with vulvar ulcers: COVID-19 disease, COVID-19 vaccines, and the value of case reports.
J Pediatr Adolesc Gynecol 2022 Apr;35(2):109-11. doi: 10.1016/j.jpag.2022.01.006..
Keywords: Children/Adolescents, COVID-19, Vaccination, Research Methodologies
Chu DK, Abrams EM, Golden BK
Risk of second allergic reaction to SARS-CoV-2 vaccines: a systematic review and meta-analysis.
The purpose of this systematic review and meta-analysis of case studies and case reports was to assess the risk of severe immediate allergic reactions to a second dose of SARS-CoV-2 mRNA vaccine in people who experienced an immediate allergic reaction to the first dose. The researchers evaluated the World Health Organization Global Coronavirus database, Web of Science, MEDLINE, and Embase from the date of inception through October 4th, 2021. The main outcomes and measures were a risk of severe immediate allergic reaction and repeated severe immediate allergic reactions with a second vaccine dose. The study found that among 22 studies of SARS-CoV-2 mRNA vaccines, 1366 individuals had immediate allergic reactions to their first vaccination. Of these, 87.8% were women with a mean age of 46.1 years. Six patients developed severe immediate allergic reactions after their second vaccination, 232 developed mild symptoms, and 1360 tolerated the dose. Among 78 persons with severe immediate allergic reactions to their first SARS-CoV-2 mRNA vaccination, 4 people had a second severe immediate reaction, and 15 had non-severe symptoms. There were no deaths. The study concluded that in a supervised setting equipped to manage severe allergic reactions, revaccination of individuals with an immediate allergic reaction to a first SARS-CoV-2 mRNA vaccine dose can be safe.
AHRQ-funded; HS026395.
Citation: Chu DK, Abrams EM, Golden BK .
Risk of second allergic reaction to SARS-CoV-2 vaccines: a systematic review and meta-analysis.
JAMA Intern Med 2022 Apr;182(4):376-85. doi: 10.1001/jamainternmed.2021.8515..
Keywords: COVID-19, Vaccination, Risk, Evidence-Based Practice, Patient-Centered Outcomes Research
Choi K, Becerra-Culqui T, Bhakta B
Parent intentions to vaccinate children with autism spectrum disorder against COVID-19.
This study’s purpose was to investigate associations between parent vaccine confidence and intentions to have their child with autism vaccinated with the COVID-19 vaccine. A cross-sectional, web-based survey of 332 parents of children with autism spectrum disorder who were members of an integrated healthcare system in Southern California was conducted from May to July 2021. Approximately 35% of parents were going to vaccinate their child against COVID-19. Positive vaccine beliefs, healthcare provider trust, or parent vaccination status were associated with intention to vaccinate.
AHRQ-funded; HS026407.
Citation: Choi K, Becerra-Culqui T, Bhakta B .
Parent intentions to vaccinate children with autism spectrum disorder against COVID-19.
J Pediatr Nurs 2022 Mar-Apr;63:108-10. doi: 10.1016/j.pedn.2021.11.019..
Keywords: Children/Adolescents, COVID-19, Vaccination, Autism, Chronic Conditions
Qin CX, Auerbach SR, Charnaya O
Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients.
While many adult solid organ transplant recipients (SOTRs) have impaired antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, pediatric SOTRs’ response has not been assessed. In this article, the researchers reported the immunogenicity and safety of BNT162b2 mRNA vaccination in pediatric SOTRs.
AHRQ-funded; HS026510.
Citation: Qin CX, Auerbach SR, Charnaya O .
Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients.
Am J Transplant 2022 Feb;22(2):669-72. doi: 10.1111/ajt.16841..
Keywords: Children/Adolescents, Vaccination, COVID-19, Transplantation
Bastani R, Glenn BA, Singhal R
Increasing HPV vaccination among low-income, ethnic minority adolescents: effects of a multicomponent system intervention through a county health department hotline.
The human papillomavirus (HPV) vaccine has cancer prevention benefits, yet low uptake. The purpose of the study was to evaluate an intervention intended to improve vaccine uptake in low-income, ethnic minority adolescents using a telephone hotline to seek county health department services. The researchers recruited participants through randomization of health department hotline callers who were caregivers of never-vaccinated adolescents aged 11-17. The intervention included multi-lingual print and telephone education and personalized referral to a low cost or free provider of vaccines. Participants completed baseline, 3-month, and 9-month telephone surveys. The study found that by the end of the 9-month follow up period, the HPV vaccination rates had increased, however there were no differences between the intervention (45%) and control (42%) groups. The researchers also observed significant improvements in perceived HPV knowledge, perceived HPV risk, and barriers to vaccination. The study concluded that the county hotline intervention did not produce a greater increase in HPV vaccine rates in the intervention group than the group without the intervention. The study authors recommend that future studies should evaluate interventions which are more intensive and address accessing and using services in complex, safety net settings. The authors also noted that because 44% of unvaccinated adolescents in both the intervention and control groups received at least one dose of the vaccine during the study period, investigators of future studies should be aware of the potential priming effects of participation in the study, which may impact the results of interventions.
AHRQ-funded; HS000046.
Citation: Bastani R, Glenn BA, Singhal R .
Increasing HPV vaccination among low-income, ethnic minority adolescents: effects of a multicomponent system intervention through a county health department hotline.
Cancer Epidemiol Biomarkers Prev 2022 Jan;31(1):175-82. doi: 10.1158/1055-9965.Epi-20-1578..
Keywords: Children/Adolescents, Vaccination, Low-Income, Racial and Ethnic Minorities, Sexual Health, Prevention
Koo G, Anvari S, Friedman DL
mRNA COVID-19 vaccine safety in patients with previous immediate hypersensitivity to pegaspargase.
The authors sought to understand the safety of PEG2000-containing mRNA COVID vaccines in patients who reported a label of immediate pegaspargase hypersensitivity. They found that all 19 studied patients tolerated their first dose of Pfizer-BioNTech SARS-CoV-2 vaccine with no symptoms. Subsequently, all 19 patients tolerated their second doses uneventfully as well.
AHRQ-funded; HS026395.
Citation: Koo G, Anvari S, Friedman DL .
mRNA COVID-19 vaccine safety in patients with previous immediate hypersensitivity to pegaspargase.
J Allergy Clin Immunol Pract 2022 Jan;10(1):322-25. doi: 10.1016/j.jaip.2021.09.051..
Keywords: COVID-19, Vaccination
Albright K, Hurley LP, Lockhart S
Attitudes about adult vaccines and reminder/recall in a safety net population.
The objective of this study was to determine patient perspectives on adult vaccines generally; attitudes about Tdap, pneumococcal polysaccharide (PPSV-23), and seasonal influenza vaccines specifically; and preferences for adult reminder/recall delivery.
AHRQ-funded; HS022648.
Citation: Albright K, Hurley LP, Lockhart S .
Attitudes about adult vaccines and reminder/recall in a safety net population.
Vaccine 2017 Dec 19;35(52):7292-96. doi: 10.1016/j.vaccine.2017.11.001..
Keywords: Influenza, Pneumonia, Vaccination, Prevention, Respiratory Conditions
Parker TC, Mohammed A, Leong T
Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia.
The purpose of this study was to determine possible disparities and socio-economic differences in RV vaccination rates. The study conclude that racial disparities and socio-economic differences are not determinants in rotavirus vaccination rates; however, age and ethnicity have an effect on RV vaccine status.
AHRQ-funded; HS024338.
Citation: Parker TC, Mohammed A, Leong T .
Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia.
Ethn Health 2017 Dec;22(6):585-95. doi: 10.1080/13557858.2016.1244744..
Keywords: Disparities, Health Status, Newborns/Infants, Social Determinants of Health, Vaccination
Erves JC, Mayo-Gamble TL, Hull PC
Adolescent participation in HPV vaccine clinical trials: are parents willing?
This study examined factors influencing parental willingness to consent to their adolescents' participation in HPV vaccine clinical trials and tested for possible racial differences. The authors assert that educating parents about the advantages of HPV vaccines for younger adolescents using low-literacy educational materials and building trust between parents and researchers may increase parental willingness to consent to adolescent participation in HPV vaccine clinical trials.
AHRQ-funded; HS022990.
Citation: Erves JC, Mayo-Gamble TL, Hull PC .
Adolescent participation in HPV vaccine clinical trials: are parents willing?
J Community Health 2017 Oct;42(5):894-901. doi: 10.1007/s10900-017-0331-x..
Keywords: Children/Adolescents, Research Methodologies, Vaccination
Leshem E, Tate JE, Steiner CA
AHRQ Author: Steiner. CA
National estimates of reductions in acute gastroenteritis-related hospitalizations and associated costs in US children after implementation of rotavirus vaccines.
The study compared acute gastroenteritis (AGE)-related hospitalization rates among children <5 years of age during the pre-rotavirus vaccine (2000-2006) and post-rotavirus vaccine (2008-2013) periods to estimate national reductions in AGE-related hospitalizations and associated costs.
AHRQ-authored
Citation: Leshem E, Tate JE, Steiner CA .
National estimates of reductions in acute gastroenteritis-related hospitalizations and associated costs in US children after implementation of rotavirus vaccines.
J Pediatric Infect Dis Soc 2017 Aug 17;7(3):257-60. doi: 10.1093/jpids/pix057..
Keywords: Children/Adolescents, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Vaccination
Lee BY, Haidari LA
The importance of vaccine supply chains to everyone in the vaccine world.
The study authors detail how vaccine supply chains may affect the work and decision making of ten examples of different members of the vaccine community: preclinical vaccinologists, vaccine clinical trialists, vaccine package designers, health care workers, epidemiologists and disease surveillance experts, policy makers, storage equipment manufacturers, other technology developers, information system specialists, and funders.
AHRQ-funded; HS023317.
Citation: Lee BY, Haidari LA .
The importance of vaccine supply chains to everyone in the vaccine world.
Vaccine 2017 Aug 16;35(35 Pt A):4475-79. doi: 10.1016/j.vaccine.2017.05.096..
Keywords: Shared Decision Making, Vaccination
McFarland M, Szasz TP, Zhou JY
Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
The primary goal of this study was to determine the vaccine-type (VT) serotype prevalence of nasopharyngeal (NP) pneumococcal colonization of children residing in the St. Louis, MO, USA metropolitan area following introduction of the 13-valent pneumococcal conjugate vaccine in 2010. It concluded that children in St. Louis exhibit a higher prevalence of VT serotypes among pneumococcal carriage isolates than has been reported in other areas in the US.
AHRQ-funded; HS021736; HS024269.
Citation: McFarland M, Szasz TP, Zhou JY .
Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
Vaccine 2017 Aug 3;35(34):4389-95. doi: 10.1016/j.vaccine.2017.06.047.
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Keywords: Vaccination, Children/Adolescents, Pneumonia, Infectious Diseases
Calo WA, Gilkey MB, Shah P
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
The researchers sought to examine parents' willingness to get human papillomavirus (HPV) vaccination for their children at pharmacies. Overall, their national survey found that 29 percent of parents would be willing to get HPV vaccine for their children at a pharmacy. Parental willingness was associated with believing that pharmacists are skilled at administering vaccines.
AHRQ-funded; HS000032.
Citation: Calo WA, Gilkey MB, Shah P .
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
Prev Med 2017 Jun;99:251-56. doi: 10.1016/j.ypmed.2017.02.003.
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Keywords: Children/Adolescents, Infectious Diseases, Provider: Pharmacist, Sexual Health, Vaccination
Lee BY, Wedlock PT, Haidari LA
Economic impact of thermostable vaccines.
Using simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India), and Niger, the researchers simulated replacing different existing vaccines with thermostable formulations and determined the resulting clinical and economic impact. They concluded that medical cost and productivity savings could outweigh even significant price premiums charged for thermostable formulations of vaccines, providing support for their use.
AHRQ-funded; HS023317.
Citation: Lee BY, Wedlock PT, Haidari LA .
Economic impact of thermostable vaccines.
Vaccine 2017 May 25;35(23):3135-42. doi: 10.1016/j.vaccine.2017.03.081.
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Keywords: Vaccination, Healthcare Costs
Brown T, Goldman SN, Persell SD
Development and evaluation of a patient education video promoting pneumococcal vaccination.
The researchers aimed to develop and refine a patient education video about pneumococcal polysaccharide vaccination (PPSV23) and to assess patient perceptions regarding video content and receipt of video during a clinic visit. They found that focus group participants had positive reactions to the video but suggested reducing the intensity of messages about pneumonia severity. Participants shown the revised video during a clinic visit perceived it to be easy to understand and informative.
AHRQ-funded; HS021141.
Citation: Brown T, Goldman SN, Persell SD .
Development and evaluation of a patient education video promoting pneumococcal vaccination.
Patient Educ Couns 2017 May;100(5):1024-27. doi: 10.1016/j.pec.2016.12.025.
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Keywords: Education: Patient and Caregiver, Health Promotion, Pneumonia, Vaccination
Adamson BJS, Carlson JJ, Kublin JG
The potential cost-effectiveness of pre-exposure prophylaxis combined with HIV vaccines in the United States.
This economic evaluation found that at current prices, pre-exposure prophylaxis (PrEP) was not cost-effective alone or in combination. A combination strategy had the greatest health benefit but was not cost-effective as compared to vaccination alone. Vaccine durability and PrEP drug prices were key drivers of cost-effectiveness.
AHRQ-funded; HS013853.
Citation: Adamson BJS, Carlson JJ, Kublin JG .
The potential cost-effectiveness of pre-exposure prophylaxis combined with HIV vaccines in the United States.
Vaccines 2017 May 24;5(2). doi: 10.3390/vaccines5020013.
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Keywords: Human Immunodeficiency Virus (HIV), Vaccination, Healthcare Costs, Prevention
Rao R, Schreiber B, Lee BY
Immunization supply chains: why they matter and how they are changing.
While considerable investments have been made over the past two decades to ensure that children and adults throughout the world have equitable access to safe and effective vaccines, comparatively few investments have been made to ensure that immunization products are safely and reliably managed and delivered from the point of arrival in a country to the many places where immunization services are provided. This editorial discusses the importance of immunization supply chains and describes how they are changing.
AHRQ-funded; HS023317.
Citation: Rao R, Schreiber B, Lee BY .
Immunization supply chains: why they matter and how they are changing.
Vaccine 2017 Apr 19;35(17):2103-04. doi: 10.1016/j.vaccine.2017.02.062..
Keywords: Vaccination
Haidari LA, Brown ST, Wedlock P
When are solar refrigerators less costly than on-grid refrigerators: a simulation modeling study.
Gavi the Vaccine Alliance recommends solar refrigerators for vaccine storage in areas with less than eight hours of electricity per day, and World Health Organization guidelines are more conservative. This study investigated whether solar refrigerators provide value where electrical outages are less frequent. It identified the frequency and duration at which electrical outages need to occur for solar refrigerators to provide savings in total cost per dose administered over electric refrigerators at different solar refrigerator prices.
AHRQ-funded; HS023317.
Citation: Haidari LA, Brown ST, Wedlock P .
When are solar refrigerators less costly than on-grid refrigerators: a simulation modeling study.
Vaccine 2017 Apr 19;35(17):2224-28. doi: 10.1016/j.vaccine.2016.11.103.
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Keywords: Healthcare Costs, Medication, Vaccination
Iroh Tam PY, Thielen BK, Obaro SK
Childhood pneumococcal disease in Africa - a systematic review and meta-analysis of incidence, serotype distribution, and antimicrobial susceptibility.
This study provided updated estimates of the incidence, serotype distribution, and antimicrobial susceptibility profile of Streptococcus pneumoniae causing disease in Africa. It concluded that, although the incidence of invasive pneumococcal disease (IPD) in young children in Africa is substantial, currently available conjugate vaccines are estimated to cover the majority of invasive disease-causing pneumococcal serotypes.
AHRQ-funded; HS020666.
Citation: Iroh Tam PY, Thielen BK, Obaro SK .
Childhood pneumococcal disease in Africa - a systematic review and meta-analysis of incidence, serotype distribution, and antimicrobial susceptibility.
Vaccine 2017 Apr 4;35(15):1817-27. doi: 10.1016/j.vaccine.2017.02.045.
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Keywords: Children/Adolescents, Infectious Diseases, Medication, Pneumonia, Vaccination
Haidari LA, Brown ST, Constenla D
Geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in Mozambique.
Researchers developed the Strategic Integrated Geo-temporal Mapping Application) to determine the potential economic impact of HPV immunization in Mozambique. If each health center covers a catchment area with a 5-km radius, then 40 percent of the target population could be reached to prevent 50 cases, 178 disability-adjusted life years, and US $202,854 in health care costs and lost productivity.
AHRQ-funded; HS023317.
Citation: Haidari LA, Brown ST, Constenla D .
Geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in Mozambique.
Sex Transm Dis 2017 Apr;44(4):222-26. doi: 10.1097/olq.0000000000000574.
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Keywords: Cancer, Healthcare Costs, Infectious Diseases, Sexual Health, Vaccination