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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedLei DK, Yousaf M, Janmohamed SR
Validation of patient-reported outcomes information system sleep disturbance and sleep-related impairment in adults with atopic dermatitis.
This study examined the measurement properties of the Patient-Reported Outcomes Measurement System (PROMIS) Sleep Disturbance (SD) and Sleep-Related Impairment (SRI) questionnaires to assess sleep disturbances in adults with atopic dermatitis (AD). The authors performed a prospective dermatology-practice-based study using questionnaires and evaluation by a dermatologist (n=420). Both questionnaires showed good construct validity, internal consistency, and feasibility to assess sleep in patients with AD.
AHRQ-funded; HS023011.
Citation: Lei DK, Yousaf M, Janmohamed SR .
Validation of patient-reported outcomes information system sleep disturbance and sleep-related impairment in adults with atopic dermatitis.
Br J Dermatol 2020 Nov;183(5):875-82. doi: 10.1111/bjd.18920..
Keywords: Sleep Problems, Skin Conditions
Lei D, Yousaf M, Janmohamed SR
Validation of four single-item patient-reported assessments of sleep in adult atopic dermatitis patients.
The purpose of this study was to assess the measurement properties of sleep-related items from the Patient-Oriented Eczema Measure (POEM), SCORing AD (SCORAD), 5-dimensions of itch (5D), and Itch-Related Quality of Life (ItchyQOL) in adults with atopic dermatitis (AD). Results showed modest overlap and weak to moderate concordance of responses to the different assessments. The researchers conclude that sleep-related items from POEM, SCORAD, 5D, and ItchyQOL showed good validity and responsiveness to monitor sleep disturbances in adult AD patients.
AHRQ-funded; HS023011.
Citation: Lei D, Yousaf M, Janmohamed SR .
Validation of four single-item patient-reported assessments of sleep in adult atopic dermatitis patients.
Ann Allergy Asthma Immunol 2020 Mar;124(3):261-66. doi: 10.1016/j.anai.2019.12.002..
Keywords: Sleep Problems, Skin Conditions, Quality of Life, Patient-Centered Outcomes Research
McKenzie C, Paller AS, Fishbein A
Association between the longitudinal course of AD, sleep disturbance, and overall health in US children.
Atopic dermatitis (AD) is a chronic inflammatory skin disease impacting 13% of children in the United States. It is associated with sleep disturbances. In this paper the investigators sought to examine the associations of AD onset, AD persistence, and comorbid atopic conditions with sleep disturbance and overall health in childhood. This study added to previous studies by demonstrating that comorbid atopy and AD course, particularly early-onset and more persistent AD, were associated with sleep disturbance.
AHRQ-funded; HS023011.
Citation: McKenzie C, Paller AS, Fishbein A .
Association between the longitudinal course of AD, sleep disturbance, and overall health in US children.
J Allergy Clin Immunol Pract 2020 Feb;8(2):812-14.e1. doi: 10.1016/j.jaip.2019.08.027..
Keywords: Children/Adolescents, Sleep Problems, Skin Conditions
Li JC, Fishbein A, Singam V
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
The aim of this prospective online questionnaire-based study was to determine the relationship between atopic dermatitis (AD) severity, sleep disturbance (SD), and sleep-related impairment (SRI). The investigators concluded that their study suggests that SD and SRI are common in adults with AD, particularly those with severe diseases. They suggest that sleep disturbances and SRI should be considered when assessing burden of AD and therapeutic decisions.
AHRQ-funded; HS023011.
Citation: Li JC, Fishbein A, Singam V .
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
Dermatitis 2018 Sep/Oct;29(5):270-77. doi: 10.1097/der.0000000000000401..
Keywords: Skin Conditions, Sleep Problems
Fishbein AB, Mueller K, Kruse L
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
The researchers sought to characterize sleep in a cohort of children with moderate-to-severe atopic dermatitis (AD) and to determine methods for assessment of sleep disturbance. In nineteen patients and nineteen controls, they found that patients with AD experienced wake after sleep onset (WASO) for 103 plus or minus 55 minutes as compared with 50 plus or minus 27 minutes in the controls. They had a higher frequency of restless sleep, daytime sleepiness, difficulty falling back to sleep at night, and teacher-reported daytime sleepiness. They concluded that children with moderate-to-severe AD experience more WASO and lower sleep efficiency than healthy controls but similar bedtime and wake time, sleep duration, and sleep onset latency.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Mueller K, Kruse L .
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
J Am Acad Dermatol 2018 Feb;78(2):336-41. doi: 10.1016/j.jaad.2017.08.043.
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Keywords: Children/Adolescents, Children/Adolescents, Skin Conditions, Sleep Problems