National Healthcare Quality and Disparities Report
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Search All Research Studies
AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (2)
- Adverse Events (2)
- Blood Thinners (4)
- Cardiovascular Conditions (11)
- Comparative Effectiveness (1)
- Elderly (1)
- Evidence-Based Practice (4)
- Guidelines (1)
- (-) Heart Disease and Health (15)
- Hospital Discharge (1)
- Medical Devices (1)
- Medicare (1)
- Medication (3)
- Mortality (2)
- Outcomes (3)
- Patient-Centered Healthcare (1)
- Patient-Centered Outcomes Research (8)
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- (-) Registries (15)
- Research Methodologies (1)
- Risk (3)
- Surgery (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 15 of 15 Research Studies DisplayedKelly JP, DeVore AD, Wu J
Rhythm control versus rate control in patients with atrial fibrillation and heart failure with preserved ejection fraction: insights from get with the guidelines-heart failure.
Researchers analyzed the Get With The Guidelines - Heart Failure (GWTG-HF) registry linked to Medicare claims data to describe current treatments for rate versus rhythm control and subsequent outcomes in patients with heart failure with preserved ejection fraction and atrial fibrillation. They found that rhythm control in patients aged 65 and older with heart failure with preserved ejection fraction and AF was associated with a lower risk of one-year all-cause mortality. They recommended future prospective randomized studies to explore this potential benefit.
AHRQ-funded; HS021092.
Citation: Kelly JP, DeVore AD, Wu J .
Rhythm control versus rate control in patients with atrial fibrillation and heart failure with preserved ejection fraction: insights from get with the guidelines-heart failure.
J Am Heart Assoc 2019 Dec 17;8(24):e011560. doi: 10.1161/jaha.118.011560.
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Keywords: Heart Disease and Health, Cardiovascular Conditions, Guidelines, Evidence-Based Practice, Registries, Patient-Centered Outcomes Research
Fanaroff AC, Vora AN, Chen AY
Hospital participation in clinical trials for patients with acute myocardial infarction: results from the National Cardiovascular Data Registry.
Using the nationwide Chest Pain-MI registry, the authors described the proportion of hospitals that enrolled patients with acute myocardial infarction (MI) in clinical trials from 2009 to 2014. They concluded that hospitals are becoming less likely to engage in clinical trials for patients with MI, and that patients admitted to hospitals that participated in clinical trials more often received guideline-adherent care and had better long-term outcomes.
AHRQ-funded; HS021092.
Citation: Fanaroff AC, Vora AN, Chen AY .
Hospital participation in clinical trials for patients with acute myocardial infarction: results from the National Cardiovascular Data Registry.
Am Heart J 2019 Aug;214:184-93. doi: 10.1016/j.ahj.2019.05.011..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Registries, Research Methodologies
Mentias A, Briasoulis A, Shantha G
Impact of heart failure type on thromboembolic and bleeding risk in patients with atrial fibrillation on oral anticoagulation.
Differential impact of heart failure (HF) category on thromboembolic and bleeding risk in atrial fibrillation (AF) patients on oral anticoagulation (OAC) is unknown. In this study, the investigators used Medicare data for beneficiaries with new AF diagnosed between 2011 and 2013 to identify patients with HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF), and no HF. The investigators concluded that in AF patients, HFrEF and HFpEF are both associated with higher risk of ischemic stroke, HF and AMI admissions, even after adjusting for OAC use, compared with patients without HF.
AHRQ-funded; HS023104.
Citation: Mentias A, Briasoulis A, Shantha G .
Impact of heart failure type on thromboembolic and bleeding risk in patients with atrial fibrillation on oral anticoagulation.
Am J Cardiol 2019 May 15;123(10):1649-53. doi: 10.1016/j.amjcard.2019.02.027..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Blood Thinners, Medication, Adverse Drug Events (ADE), Adverse Events, Risk, Elderly, Patient-Centered Healthcare, Registries
Inohara T, Kim S, Pieper K
B-type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation.
In this study, the investigators evaluated the association between B-type natriuretic peptide (BNP) levels and outcomes, including atrial fibrillation (AF) progression, composite outcome of major adverse cardiovascular or neurological events (MACNE) and major bleeding, via pooled logistic regression and Cox frailty models in Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II registry.
AHRQ-funded; HS021092.
Citation: Inohara T, Kim S, Pieper K .
B-type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation.
Heart 2019 Mar;105(5):370-77. doi: 10.1136/heartjnl-2018-313642..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Patient-Centered Outcomes Research, Outcomes, Registries
Alapati V, Tang F, Charlap E
Discharge heart rate after hospitalization for myocardial infarction and long-term mortality in 2 US registries.
In this study, researchers evaluated the association of discharge and admission heart rates with 3-year mortality. They concluded that a higher discharge heart rate after AMI was more strongly associated with 3-year mortality than a high heart rate at admissions.
AHRQ-funded; HS011282.
Citation: Alapati V, Tang F, Charlap E .
Discharge heart rate after hospitalization for myocardial infarction and long-term mortality in 2 US registries.
J Am Heart Assoc 2019 Feb 5;8(3):e010855. doi: 10.1161/jaha.118.010855..
Keywords: Cardiovascular Conditions, Hospital Discharge, Mortality, Heart Disease and Health, Registries
Calkins H, Gliklich RE, Leavy MB
Harmonized outcome measures for use in atrial fibrillation patient registries and clinical practice: endorsed by the Heart Rhythm Society Board of Trustees.
This study used AHRQ’s Outcome Measures Framework (OMF) to create standards so that different registries for atrial fibrillation (AF) can be linked and their data compared. One-hundred outcome measures from 13 different registries were curated and then harmonized according to OMF standards. Twenty measures were created to represent a minimum set of outcomes for research and clinical practice.
AHRQ-funded; 290201400004C.
Citation: Calkins H, Gliklich RE, Leavy MB .
Harmonized outcome measures for use in atrial fibrillation patient registries and clinical practice: endorsed by the Heart Rhythm Society Board of Trustees.
Heart Rhythm 2019 Jan;16(1):e3 - e16. doi: 10.1016/j.hrthm.2018.09.021..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Outcomes, Patient-Centered Outcomes Research, Registries
Desai NR, Parzynski CS, Krumholz HM
Patterns of institutional review of percutaneous coronary intervention appropriateness and the effect on quality of care and clinical outcomes.
The researchers sought to determine whether internal review of percutaneous coronary intervention (PCI) appropriateness using appropriate use criteria is associated with differences in procedural appropriateness, quality of care, and patient outcomes. They concluded that there was a modest association between procedural appropriateness and clinical outcomes and a similarly modest correlation between nonacute PCI volume and procedural appropriateness.
AHRQ-funded; HS023000
Citation: Desai NR, Parzynski CS, Krumholz HM .
Patterns of institutional review of percutaneous coronary intervention appropriateness and the effect on quality of care and clinical outcomes.
JAMA Intern Med. 2015 Dec;175(12):1988-90.
Keywords: Cardiovascular Conditions, Patient-Centered Outcomes Research, Heart Disease and Health, Registries
O'Brien EC, Simon DN, Thomas LE
The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.
The researchers sought to develop and validate a novel bleeding risk score using routinely available clinical information to predict major bleeding in a large, community-based in atrial fibrillation (AF) population. They concluded that their five-element ORBIT bleeding risk score had better ability to predict major bleeding in AF patients when compared with HAS-BLED and ATRIA risk scores.
AHRQ-funded; HS021092.
Citation: O'Brien EC, Simon DN, Thomas LE .
The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.
Eur Heart J 2015 Dec 7;36(46):3258-64. doi: 10.1093/eurheartj/ehv476.
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Keywords: Blood Thinners, Heart Disease and Health, Cardiovascular Conditions, Adverse Drug Events (ADE), Adverse Events, Risk, Registries, Patient-Centered Outcomes Research, Evidence-Based Practice
Kaplan RM, Irvin VL
AHRQ Author: Kaplan RM
Likelihood of null effects of large NHLBI clinical trials has increased over time.
This study explores whether the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased over time. It found that the number NHLBI trials reporting positive results declined after the year 2000. Prospective declaration of outcomes in RCTs, and the adoption of transparent reporting standards, as required by clinicaltrials.gov, may have contributed to the trend toward null findings.
AHRQ-authored
Citation: Kaplan RM, Irvin VL .
Likelihood of null effects of large NHLBI clinical trials has increased over time.
PLoS One 2015 Aug 5;10(8):e0132382. doi: 10.1371/journal.pone.0132382..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Registries
Qian F, Hannan EL, Pine M
Can adding laboratory values improve risk-adjustment mortality models using clinical percutaneous cardiac intervention registry data?
The authors predicted in-hospital/30-day mortality with and without appended laboratory data using New York's percutaneous coronary intervention registry data from 2008-2010. They found that adding laboratory data did not significantly improve the risk-adjustment mortality models' performance and did not dramatically change the quality assessment of hospitals.
AHRQ-funded; HS019965.
Citation: Qian F, Hannan EL, Pine M .
Can adding laboratory values improve risk-adjustment mortality models using clinical percutaneous cardiac intervention registry data?
J Invasive Cardiol 2015 Jul;27(7):E117-24.
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Keywords: Heart Disease and Health, Mortality, Registries, Risk
Bangalore S, Guo Y, Samadashvili Z
Everolimus eluting stents versus coronary artery bypass graft surgery for patients with diabetes mellitus and multivessel disease.
The researchers used data from the New York State registries to assess the comparative effectiveness of coronary artery bypass graft (CABG) when compared with percutaneous intervention (PCI) using everolimus eluting stents (EES) on short- and long-term cardiovascular outcomes. They found that PCI using EES, the latest generation stents, was associated with lower early risk of death and stroke when compared with CABG surgery.
AHRQ-funded; HS023683.
Citation: Bangalore S, Guo Y, Samadashvili Z .
Everolimus eluting stents versus coronary artery bypass graft surgery for patients with diabetes mellitus and multivessel disease.
Circ Cardiovasc Interv 2015 Jul;8(7):e002626. doi: 10.1161/circinterventions.115.002626..
Keywords: Patient-Centered Outcomes Research, Heart Disease and Health, Registries, Surgery
Holmqvist F, Simon D, Steinberg BA
Catheter ablation of atrial fibrillation in U.S. community practice--results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
The objective of the study was to describe the utilization of catheter ablation in a contemporary U.S. clinical practice and describe the characteristics and subsequent outcomes in patients undergoing AF ablation in community practice. It found that there were no clinically relevant differences in oral anticoagulation post-AF ablation or differences in outcomes in patients with or without previous AF catheter ablation.
AHRQ-funded; HS021092.
Citation: Holmqvist F, Simon D, Steinberg BA .
Catheter ablation of atrial fibrillation in U.S. community practice--results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
J Am Heart Assoc 2015 May;4(5):e001901. doi: 10.1161/jaha.115.001901..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Patient-Centered Outcomes Research, Registries, Evidence-Based Practice
Setoguchi SR, Warner Stevenson L, Stewart GC
Influence of healthy candidate bias in assessing clinical effectiveness for implantable cardioverter-defibrillators: cohort study of older patients with heart failure.
This study assessed the potential contribution of unmeasured general health status to patient selection in assessments of implantable cardioverter-defibrillator (ICD) therapy. In a group of heart failure patients, those who received ICD therapy were younger and had lower ejection fraction and more cardiac admissions to hospital but fewer non-cardiac admissions. The lower risks of measured outcomes likely reflect unmeasured differences in comorbidity and frailty.
AHRQ-funded; 29020050016I; HS017731
Citation: Setoguchi SR, Warner Stevenson L, Stewart GC .
Influence of healthy candidate bias in assessing clinical effectiveness for implantable cardioverter-defibrillators: cohort study of older patients with heart failure.
BMJ. 2014 May 8;348:g2866. doi: 10.1136/bmj.g2866..
Keywords: Medical Devices, Outcomes, Registries, Heart Disease and Health, Medicare
O'Brien EC, Holmes DN, Ansell JE
Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.
This study describes the frequencies of and factors associated with oral anticoagulation (OAC) contraindications in clinical practice for patients with atrial fibrillation (AF). Contraindications to OAC therapy among patients with AF are common but subjective. Many patients with reported contraindications were receiving OAC, suggesting that the perceived benefits outweighed the potential harm posed by the relative contraindication.
AHRQ-funded; HS021092
Citation: O'Brien EC, Holmes DN, Ansell JE .
Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.
Am Heart J. 2014 Apr;167(4):601-609.e1. doi: 10.1016/j.ahj.2013.12.014..
Keywords: Heart Disease and Health, Blood Thinners, Medication, Registries, Cardiovascular Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice, Practice Patterns
Eapen ZJ, Grau-Sepulveda MV, Fonarow GC
Prescribing warfarin at discharge for heart failure patients: findings from the Get With The Guidelines-Heart Failure Registry
The researchers used data from a heart failure (HF) registry to determine the prevalence and variation, as well as patient characteristics, in warfarin prescription among real-world HF population. They found that warfarin was prescribed at discharge for more than 1 out of 10 patients hospitalized for HF without evident indications or contraindications for anticoagulation.
AHRQ-funded; HS021092
Citation: Eapen ZJ, Grau-Sepulveda MV, Fonarow GC .
Prescribing warfarin at discharge for heart failure patients: findings from the Get With The Guidelines-Heart Failure Registry
Int J Cardiol. 2014 Mar 15;172(2):e322-3. doi: 10.1016/j.ijcard.2013.12.161..
Keywords: Heart Disease and Health, Registries, Comparative Effectiveness, Blood Thinners, Medication