National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
AHRQ Research Studies Date
Topics
- Behavioral Health (4)
- Blood Pressure (2)
- Blood Thinners (1)
- Cancer (1)
- Cancer: Breast Cancer (1)
- Cancer: Lung Cancer (1)
- Cancer: Ovarian Cancer (1)
- Cardiovascular Conditions (1)
- Care Management (1)
- Case Study (1)
- Central Line-Associated Bloodstream Infections (CLABSI) (1)
- Children/Adolescents (2)
- Chronic Conditions (1)
- Clinical Decision Support (CDS) (1)
- Communication (4)
- Comparative Effectiveness (4)
- Complementary and Alternative Medicine (1)
- Decision Making (2)
- Diagnostic Safety and Quality (1)
- Education: Continuing Medical Education (2)
- Elderly (1)
- Emergency Department (1)
- (-) Evidence-Based Practice (29)
- Family Health and History (1)
- Genetics (1)
- (-) Guidelines (29)
- Healthcare-Associated Infections (HAIs) (2)
- Health Information Technology (HIT) (1)
- Health Promotion (3)
- Health Services Research (HSR) (1)
- Heart Disease and Health (1)
- Human Immunodeficiency Virus (HIV) (1)
- Imaging (1)
- Implementation (5)
- Intensive Care Unit (ICU) (1)
- Kidney Disease and Health (1)
- Long-Term Care (1)
- Medication (5)
- Nursing Homes (1)
- Opioids (1)
- Outcomes (1)
- Pain (1)
- Patient-Centered Outcomes Research (1)
- Patient Safety (2)
- Policy (1)
- Practice Patterns (1)
- Pressure Ulcers (1)
- Prevention (4)
- Primary Care (1)
- Quality Improvement (3)
- Quality of Care (4)
- Research Methodologies (3)
- Risk (1)
- Screening (5)
- Simulation (1)
- Sleep Problems (1)
- Social Media (1)
- Surgery (1)
- Tools & Toolkits (1)
- Training (2)
- Trauma (1)
- U.S. Preventive Services Task Force (USPSTF) (7)
- Women (1)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 29 Research Studies DisplayedProbst MA, Dayan PS, Raja AS
Knowledge translation and barriers to imaging optimization in the emergency department: a research agenda.
This article outlines a research agenda to promote the dissemination and implementation (also known as knowledge translation) of evidence-based interventions for emergency department (ED) imaging, i.e., clinical pathways, clinical decision instruments, and clinical practice guidelines. A multidisciplinary group of stakeholders held online and telephone discussions over a 6-month period culminating at the 2015 Academic Emergency Medicine consensus conference. They were able to identify four overarching research questions.
AHRQ-funded; HS023498.
Citation: Probst MA, Dayan PS, Raja AS .
Knowledge translation and barriers to imaging optimization in the emergency department: a research agenda.
Acad Emerg Med 2015 Dec;22(12):1455-64. doi: 10.1111/acem.12830.
.
.
Keywords: Emergency Department, Evidence-Based Practice, Health Services Research (HSR), Guidelines, Imaging, Implementation
Grossman DC, Elder RW
Aligning the work of two U.S. Task Forces on behavioral counseling recommendations.
This paper highlights the collaboration and alignment between topics and recommendations related to behavioral counseling interventions from the U.S. Preventive Services Task Force (USPSTF) and Community Preventive Services Task Force (CPSTF). It also explores opportunities for greater alignment between the two Task Forces and compares and contrasts the groups and their current approaches to making recommendations that involve behavioral counseling interventions.
AHRQ-funded; 290201000004I.
Citation: Grossman DC, Elder RW .
Aligning the work of two U.S. Task Forces on behavioral counseling recommendations.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S174-83. doi: 10.1016/j.amepre.2015.06.003.
.
.
Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Health Promotion, U.S. Preventive Services Task Force (USPSTF)
Curry SJ, McNellis RJ
AHRQ Author: McNellis RJ
Behavioral counseling in primary care: perspectives in enhancing the evidence base.
This article introduces a special issue containing eight articles that were written for a behavioral counseling interventions (BCI) Expert Forum convened in November 2013 by the US Preventive Services Task Force. The authors briefly discuss each of the papers. The forum brought together experienced behavioral counseling researchers, senior leaders in NIH and CDC, members of the USPSTF, and senior members of the AHRQ team supporting the USPSTF.
AHRQ-authored.
Citation: Curry SJ, McNellis RJ .
Behavioral counseling in primary care: perspectives in enhancing the evidence base.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S125-8. doi: 10.1016/j.amepre.2015.06.004..
Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, U.S. Preventive Services Task Force (USPSTF)
Curry SJ, Whitlock EP
Behavioral counseling interventions expert forum: overview and primer on U.S. Preventive Services Task Force methods.
In November 2013, the U.S. Preventive Services Task Force convened an expert forum on behavioral counseling interventions. The forum brought together NIH, CDC, and AHRQ leaders, leading behavioral counseling researchers, and members of the U.S. preventive Services Task Force to discuss issues related to optimizing evidence-based behavioral counseling recommendations. This paper provides an overview of the methods used by the Task Force to develop counseling recommendations.
AHRQ-funded; 290201000004I.
Citation: Curry SJ, Whitlock EP .
Behavioral counseling interventions expert forum: overview and primer on U.S. Preventive Services Task Force methods.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S129-37. doi: 10.1016/j.amepre.2015.04.017.
.
.
Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Prevention, U.S. Preventive Services Task Force (USPSTF)
Alcantara C, Klesges LM, Resnicow K
Enhancing the evidence for behavioral counseling: a perspective from the society of behavioral medicine.
The members of the Society of Behavioral Medicine (SBM)-a multidisciplinary scientific organization committed to improving population health through behavior change- review the USPSTF mandate and current recommendations for behavioral counseling interventions and provide a perspective for the future that calls for concerted and coordinated efforts among SBM, USPSTF, and other organizations invested in the rapid and wider uptake of beneficial, feasible, and referable primary care-focused behavioral counseling interventions.
AHRQ-funded; 290201000004I.
Citation: Alcantara C, Klesges LM, Resnicow K .
Enhancing the evidence for behavioral counseling: a perspective from the society of behavioral medicine.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S184-93. doi: 10.1016/j.amepre.2015.05.015.
.
.
Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Health Promotion, Primary Care, U.S. Preventive Services Task Force (USPSTF)
Mussa FF
Screening for abdominal aortic aneurysm.
Consensus exists across guidelines on one-time screening of elderly men to detect and treat abdominal aortic aneurysm (AAA) larger than 5.5 cm. However, the recommendations regarding other age groups, imaging intervals for small AAAs, inclusion of women, and cost-effectiveness have not been universally adopted. As many countries are considering the initiation of an AAA screening program, this is an overview on the current status of such programs.
AHRQ-funded; HS019473.
Citation: Mussa FF .
Screening for abdominal aortic aneurysm.
J Vasc Surg 2015 Sep;62(3):774-8. doi: 10.1016/j.jvs.2015.05.035..
Keywords: Screening, Evidence-Based Practice, Guidelines
Narayanaswami P, Gronseth G, Dubinsky R
The impact of social media on dissemination and implementation of clinical practice guidelines: a longitudinal observational study.
The researchers’ aim was to develop and evaluate an innovative dissemination strategy by adding social media-based dissemination methods to traditional methods for the clinical practice guidelines (CPGs) “Complementary and alternative medicine in multiple sclerosis.” They found that social media-based dissemination methods did not confer additional benefit over print-, email-, and Internet-based methods in increasing CPG awareness and changing intent in physicians or patients.
AHRQ-funded; HS022004.
Citation: Narayanaswami P, Gronseth G, Dubinsky R .
The impact of social media on dissemination and implementation of clinical practice guidelines: a longitudinal observational study.
J Med Internet Res 2015 Aug 13;17(8):e193. doi: 10.2196/jmir.4414..
Keywords: Communication, Complementary and Alternative Medicine, Evidence-Based Practice, Guidelines, Social Media, Implementation
Wang D, Le XH, Luque AE
Identifying effective approaches for dissemination of clinical evidence--correlation analyses on promotional activities and usage of a guideline-driven interactive case simulation tool in a statewide HIV-HCV-STD clinical education program.
The investigators analyzed correlations between promotional activities and usage of a guideline-driven interactive case simulation tool (ICST) for insomnia screening and treatment in a statewide HIV-HCV-STD clinical education program. They found that promotional activities were strongly correlated with the number of audience as well as the intensity of use of the target resource, with strong correlations identified between the sending of email newsletters and the intensity of resource use by promotion recipients, by new users, and through the most convenient access channel associated with the promotion.
AHRQ-funded; HS022057.
Citation: Wang D, Le XH, Luque AE .
Identifying effective approaches for dissemination of clinical evidence--correlation analyses on promotional activities and usage of a guideline-driven interactive case simulation tool in a statewide HIV-HCV-STD clinical education program.
Stud Health Technol Inform 2015;216:515-9.
.
.
Keywords: Human Immunodeficiency Virus (HIV), Education: Continuing Medical Education, Simulation, Guidelines, Evidence-Based Practice, Health Promotion, Screening, Sleep Problems, Training
Morrato EH, Rabin B, Proctor J
Bringing it home: expanding the local reach of dissemination and implementation training via a university-based workshop.
The Colorado Research in Implementation Science Program (CRISP) developed and delivered an introductory D&I workshop adapted from national programs to extend training reach and foster a local learning community for D&I. This paper describes the context of the local training environment, findings from a pre-workshop needs assessment survey, training design and structure, and post-workshop evaluation. Lessons learned may inform others intending to develop local D&I training workshop.
AHRQ-funded; HS021138.
Citation: Morrato EH, Rabin B, Proctor J .
Bringing it home: expanding the local reach of dissemination and implementation training via a university-based workshop.
Implement Sci 2015 Jul 4;10:94. doi: 10.1186/s13012-015-0281-6..
Keywords: Communication, Education: Continuing Medical Education, Evidence-Based Practice, Guidelines, Quality of Care, Quality Improvement, Training, Implementation
Tjia J, Field T, Mazor K
Dissemination of evidence-based antipsychotic prescribing guidelines to nursing homes: a cluster randomized trial.
This study evaluated the effectiveness of efforts to translate and disseminate evidence-based guidelines about atypical antipsychotic use to nursing homes (NHs). It found that RE-AIM indicators suggest some success in disseminating the toolkit and differences in reach, adoption, and implementation according to dissemination strategy but no measurable effect on antipsychotic prescribing trends.
AHRQ-funded; HS019351.
Citation: Tjia J, Field T, Mazor K .
Dissemination of evidence-based antipsychotic prescribing guidelines to nursing homes: a cluster randomized trial.
J Am Geriatr Soc 2015 Jul;63(7):1289-98. doi: 10.1111/jgs.13488..
Keywords: Communication, Evidence-Based Practice, Guidelines, Long-Term Care, Medication, Nursing Homes, Practice Patterns, Tools & Toolkits, Implementation
Simonov M, Pittiruti M, Rickard CM
Navigating venous access: a guide for hospitalists.
The authors provided an in-depth summary of the relevant anatomical considerations, physical characteristics, advantages, and disadvantages of venous access devices commonly used in the hospital setting in order to improve the safety and share the science of vascular access with frontline clinicians.
AHRQ-funded; HS022835.
Citation: Simonov M, Pittiruti M, Rickard CM .
Navigating venous access: a guide for hospitalists.
J Hosp Med 2015 Jul;10(7):471-8. doi: 10.1002/jhm.2335.
.
.
Keywords: Evidence-Based Practice, Guidelines, Patient Safety
Chenoweth CE, Hines SC, Hall KK
Variation in infection prevention practices in dialysis facilities: results from the national opportunity to improve infection control in ESRD (End-Stage Renal Disease) project.
The purpose of this study was to observe patient care across hemodialysis facilities enrolled in the National Opportunity to Improve Infection Control in ESRD (end-stage renal disease) (NOTICE) project in order to evaluate adherence to evidence-based practices aimed at prevention of infection. The researchers found considerable variation in infection control practices across enrolled facilities. Overall adherence to recommended practices was 68 percent (range, 45 percent–92 percent) across all facilities.
AHRQ-authored; AHRQ-funded; 290200600022I.
Citation: Chenoweth CE, Hines SC, Hall KK .
Variation in infection prevention practices in dialysis facilities: results from the national opportunity to improve infection control in ESRD (End-Stage Renal Disease) project.
Infect Control Hosp Epidemiol 2015 Jul;36(7):802-6. doi: 10.1017/ice.2015.55..
Keywords: Kidney Disease and Health, Evidence-Based Practice, Guidelines, Healthcare-Associated Infections (HAIs), Prevention
O'Brien EC, Kim S, Hess PL
Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation.
Researchers assessed the potential effect of a new guideline for atrial fibrillation (AF) by comparing the proportion of patients with AF recommended for oral anticoagulation (OAC) under the 2011 and 2014 guidelines. They found that two-thirds of patients with AF who were previously not recommended for OAC are newly recommended under the 2014 guideline. They advised future studies evaluating longitudinal changes in anticoagulation treatment patterns and outcomes among patients reclassified by the new guidelines.
AHRQ-funded; HS021092.
Citation: O'Brien EC, Kim S, Hess PL .
Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation.
JAMA Intern Med 2015 May;175(5):848-50. doi: 10.1001/jamainternmed.2015.13.
.
.
Keywords: Heart Disease and Health, Blood Thinners, Guidelines, Medication, Cardiovascular Conditions, Evidence-Based Practice, Patient-Centered Outcomes Research
Abdelsattar ZM, Reames BN, Regenbogen SE
Critical evaluation of the scientific content in clinical practice guidelines.
The researchers sought to critically evaluate clinical practice guidelines (CPGs) on the basis of their overall development quality, the evidence base used to synthesize recommendations, and the scientific agreement between CPGs on key processes of care. They concluded that there is significant variation in CPG development processes, with associated differences in scientific content and interpretation of evidence, resulting in conflicting recommendations.
AHRQ-funded: HS000053.
Citation: Abdelsattar ZM, Reames BN, Regenbogen SE .
Critical evaluation of the scientific content in clinical practice guidelines.
Cancer 2015 Mar 1;121(5):783-9. doi: 10.1002/cncr.29124..
Keywords: Care Management, Evidence-Based Practice, Guidelines, Quality of Care
Nadpara PA, Madhavan SS, Tworek C
Guideline-concordant lung cancer care and associated health outcomes among elderly patients in the United States.
This study comprehensively evaluates the variations in guideline-concordant lung cancer care among elderly in the US. It found that less than half of all patients (44.7 percent) received guideline-concordant care in the study population. The likelihood of receiving guideline-concordant care significantly decreased with increasing age, non-white race, higher comorbidity score, and lower income.
AHRQ-funded; HS018622.
Citation: Nadpara PA, Madhavan SS, Tworek C .
Guideline-concordant lung cancer care and associated health outcomes among elderly patients in the United States.
J Geriatr Oncol 2015 Mar;6(2):101-10. doi: 10.1016/j.jgo.2015.01.001..
Keywords: Cancer: Lung Cancer, Elderly, Guidelines, Outcomes, Evidence-Based Practice
Mabry-Hernandez I, Chu K
AHRQ Author: Mabry-Hernandez I
Screening for primary hypertension in children and adolescents.
This article presents a case study about a 14-year-old black adolescent who presents for a routine school physical examination. Her mother tells you that she and her husband have hypertension, and they worry about their daughter’s blood pressure. She asks you whether her child should be periodically checked for high blood pressure. The case study was coordinated with the AHRQ-administered US Preventive Services Task Force and published online on the American Academy of Family Practice website.
Citation: Mabry-Hernandez I, Chu K .
Screening for primary hypertension in children and adolescents.
Am Fam Physician 2015 Feb 15;91(4):257-8..
Keywords: U.S. Preventive Services Task Force (USPSTF), Children/Adolescents, Blood Pressure, Screening, Evidence-Based Practice, Guidelines, Prevention, Case Study
Piper MA, Evans CV, Burda BU
Diagnostic and predictive accuracy of blood pressure screening methods with consideration of rescreening intervals: a systematic review for the U.S. Preventive Services Task Force.
The purpose of this paper is to update a systematic review on the benefits and harms of screening for high BP in adults and to summarize evidence on rescreening intervals and diagnostic and predictive accuracy of different BP methods for cardiovascular events. It concluded that evidence supports ambulatory blood pressure monitoring as the reference standard for confirming elevated office BP screening results to avoid misdiagnosis and overtreatment of persons with isolated clinic hypertension.
AHRQ-funded; 290201200151I.
Citation: Piper MA, Evans CV, Burda BU .
Diagnostic and predictive accuracy of blood pressure screening methods with consideration of rescreening intervals: a systematic review for the U.S. Preventive Services Task Force.
Ann Intern Med 2015 Feb 3;162(3):192-204. doi: 10.7326/m14-1539..
Keywords: U.S. Preventive Services Task Force (USPSTF), Blood Pressure, Diagnostic Safety and Quality, Screening, Evidence-Based Practice, Guidelines
Patel MB, Humble SS, Cullinane DC
Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma.
The authors’ aims were to perform a systematic review and to develop evidence-based recommendations that might be used to direct decision making in the removal of a cervical collar from adult obtunded blunt trauma patients. In conclusion, they conditionally recommended cervical collar removal after a negative high-quality C-spine CT scan result alone.
AHRQ-funded; HS017952.
Citation: Patel MB, Humble SS, Cullinane DC .
Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma.
J Trauma Acute Care Surg 2015 Feb;78(2):430-41. doi: 10.1097/ta.0000000000000503..
Keywords: Comparative Effectiveness, Evidence-Based Practice, Guidelines, Trauma, Decision Making
Scheife RT, Hines LE, Boyce RD
Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support.
An expert workgroup developed recommendations by consensus for systematic evaluation of evidence for DDIs from the scientific literature, drug product labeling, and regulatory documents. It concluded that evidence-based clinical decision support for drug–drug interactions (DDIs) requires consistent application of transparent and systematic methods to evaluate the evidence.
AHRQ-funded; HS021826; HS019461.
Citation: Scheife RT, Hines LE, Boyce RD .
Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support.
Drug Saf 2015 Feb;38(2):197-206. doi: 10.1007/s40264-014-0262-8..
Keywords: Clinical Decision Support (CDS), Guidelines, Evidence-Based Practice, Comparative Effectiveness
Moher D, Shamseer L, Clarke M
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.
The aim of PRISMA-P 2015 is to improve the quality of systematic review protocols, similar to the impact achieved by other reporting guidelines. PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. This Statement paper summarizes the development of the guideline and presents the PRISMA-P checklist.
AHRQ-funded; 290200710059I.
Citation: Moher D, Shamseer L, Clarke M .
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.
Syst Rev 2015 Jan 1;4:1. doi: 10.1186/2046-4053-4-1..
Keywords: Evidence-Based Practice, Research Methodologies, Guidelines
Simianu VV, Bastawrous AL, Farrokhi ET
Addressing the appropriateness of elective colon resection for diverticulitis: a report from the SCOAP CERTAIN collaborative.
The aim of this study was to assess the clinician-reported indications for elective colectomy and describe trends in the number of prior episodes of diverticulitis. It found an increase in the proportion of cases that met expert-established guidelines for appropriate surgery, but nearly 1 in 3 still do not meet established criteria.
AHRQ-funded; HS020025
Citation: Simianu VV, Bastawrous AL, Farrokhi ET .
Addressing the appropriateness of elective colon resection for diverticulitis: a report from the SCOAP CERTAIN collaborative.
Ann Surg. 2014 Sep;260(3):533-8; discussion 38-9. doi: 10.1097/sla.0000000000000894..
Keywords: Decision Making, Surgery, Evidence-Based Practice, Guidelines
Kealey E, Scholle SH, Byron SC
Quality concerns in antipsychotic prescribing for youth: a review of treatment guidelines.
The authors reviewed treatment guidelines relevant to 7 quality concepts for appropriate use and management of youth on antipsychotics.They found that all 7 quality concepts were strongly endorsed by 1 or more guidelines, and 2 or more guidelines assigned their highest strength of recommendation ratings to 6 of the 7 concepts. Two guidelines rated evidence, providing high strength of evidence for 2 quality concepts.
AHRQ-funded; HS020503.
Citation: Kealey E, Scholle SH, Byron SC .
Quality concerns in antipsychotic prescribing for youth: a review of treatment guidelines.
Acad Pediatr 2014 Sep-Oct;14(5 Suppl):S68-75. doi: 10.1016/j.acap.2014.05.009.
.
.
Keywords: Evidence-Based Practice, Children/Adolescents, Guidelines, Quality of Care, Medication
Padula WV, Mishra MK, Makic MB
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
The purpose of this paper is to enhance the learner’s competence with knowledge about a framework of quality improvement (QI) interventions to implement evidence-based practices for pressure ulcer (PrU) prevention. The best-practice framework offers a reference point to initiating a bundle of QI interventions in support of evidence-based practices. Hospitals and clinicians tasked with quality improvement efforts can use this framework to problem-solve PrU prevention and other critical issues.
AHRQ-funded; HS023710.
Citation: Padula WV, Mishra MK, Makic MB .
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
Adv Skin Wound Care 2014 Jun;27(6):280-4; quiz 85-6. doi: 10.1097/01.ASW.0000450703.87099.5b..
Keywords: Quality Improvement, Patient Safety, Evidence-Based Practice, Pressure Ulcers, Guidelines
Camp KM, Parisi MA, Acosta PB
AHRQ Author: Chang CS
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
An NIH State-of-the-Science Conference was convened in 2012 to address new findings, particularly the use of the medication sapropterin to treat some individuals with phenylketonuria (PKU), and to develop a research agenda. An AHRQ Evidence-based Practice Center conducted a systematic review of adjuvant treatments for PKU and presented its conclusions at the conference. New drugs that are safe, efficacious, and impact a larger proportion of individuals with PKU are needed. The identification of a research agenda has facilitated the development of clinical practice guidelines by professional organizations and serves as a model for other inborn errors of metabolism.
AHRQ-authored.
Citation: Camp KM, Parisi MA, Acosta PB .
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
Mol Genet Metab 2014 Jun;112(2):87-122. doi: 10.1016/j.ymgme.2014.02.013.
.
.
Keywords: Comparative Effectiveness, Evidence-Based Practice, Guidelines, Medication, Research Methodologies
Nelson HD, Pappas M, Zakher B
Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the U.S. Preventive Services Task Force recommendation.
This systematic review was done in support of the U.S. Preventive Services Task Force (USPSTF) updated recommendation on the benefit and harms of risk assessment, genetic testing, and genetic counseling for BRCA-related cancer in women. A systematic review was done on literature from 2004 to July 30, 2013 from MEDLINE, PsycINFO, the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Health Technology Assessment, Scopus, and reference lists. Data on the participants, study design, analysis, follow-up, and results was extracted and a second investigator confirmed key data. The studies were rated on study quality and applicability. The analysis found women with high-risk for breast cancer had decreased risk of breast cancer by 85% to 100% by having a mastectomy, and risk of mortality by 81% to 100% compared to women without surgery. There was also a lower risk of breast and ovarian cancer after having salpingo-oopherectomy surgery.
AHRQ-funded; 290200710057
Citation: Nelson HD, Pappas M, Zakher B .
Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the U.S. Preventive Services Task Force recommendation.
Ann Intern Med 2014 Feb 18;160(4):255-66. doi: 10.7326/m13-1684..
Keywords: U.S. Preventive Services Task Force (USPSTF), Cancer: Breast Cancer, Cancer: Ovarian Cancer, Cancer, Genetics, Screening, Prevention, Guidelines, Evidence-Based Practice, Women, Risk, Family Health and History