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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedGoyette P, Boucher G, Mallon D
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Studies in inflammatory bowel diseases (IBD) have indicated that multiple independent associations exist at human leukocyte antigen (HLA) and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, the researchers performed high-density single nucleotide polymorphism (SNP) typing of the major histocompatibility complex in >32,000 individuals with IBD.
AHRQ-funded; HS021747.
Citation: Goyette P, Boucher G, Mallon D .
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Nat Genet 2015 Feb;47(2):172-9. doi: 10.1038/ng.3176..
Keywords: Chronic Conditions, Genetics, Digestive Disease and Health
Norman JM, Handley SA, Baldridge MT
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
The researchers show that the enteric virome is abnormal in Crohn's disease (CD) and ulcerative colitis (UC) patients. Their data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. They conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
AHRQ-funded; HS021747.
Citation: Norman JM, Handley SA, Baldridge MT .
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Cell 2015 Jan 29;160(3):447-60. doi: 10.1016/j.cell.2015.01.002.
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Keywords: Digestive Disease and Health, Chronic Conditions
Liu TC, Gao F, McGovern DP
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.
The researchers sought to develop Paneth cell phenotype as a prognostic biomarker in Crohn’s disease by additional characterization building on their earlier research. Specifically, they examined the effects of disease activity, phenotype duration, and the minimal crypt number that would allow for accurate Paneth cell phenotyping. They demonstrated that Paneth cell phenotypes are not affected either by disease activity or by exposure to therapeutic agents.
AHRQ-funded; HS021747.
Citation: Liu TC, Gao F, McGovern DP .
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.
Inflamm Bowel Dis 2014 Apr;20(4):646-51. doi: 10.1097/01.MIB.0000442838.21040.d7..
Keywords: Chronic Conditions, Digestive Disease and Health