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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedWang SV, Verpillat P, Rassen JA
Transparency and reproducibility of observational cohort studies using large healthcare databases.
The researchers explored the extent to which published pharmacoepidemiologic studies using commercially available databases could be reproduced by other investigators. Based on a nonsystematic sample of 38 descriptive or comparative safety/effectiveness cohort studies, they concludedc that an essential component of transparent and reproducible databases is more complete reporting of study implementation.
AHRQ-funded; HS022193.
Citation: Wang SV, Verpillat P, Rassen JA .
Transparency and reproducibility of observational cohort studies using large healthcare databases.
Clin Pharmacol Ther 2016 Mar;99(3):325-32. doi: 10.1002/cpt.329..
Keywords: Health Information Technology (HIT), Data, Research Methodologies, Comparative Effectiveness
Holmes JH, Elliott TE, Brown JS
Clinical research data warehouse governance for distributed research networks in the USA: a systematic review of the literature.
The researchers reviewed the published, peer-reviewed literature on clinical research data warehouse governance in distributed research networks (DRNs). They determined that a peer-reviewed literature on data warehouse governance is emerging but is still sparse. Understanding of DRN data governance policies and procedures is limited but expected to change as more DRN projects disseminate their governance approaches.
AHRQ-funded; HS019912
Citation: Holmes JH, Elliott TE, Brown JS .
Clinical research data warehouse governance for distributed research networks in the USA: a systematic review of the literature.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):730-6. doi: 10.1136/amiajnl-2013-002370..
Keywords: Comparative Effectiveness, Data, Health Information Technology (HIT)
McGlynn EA, Lieu TA, Durham ML
Developing a data infrastructure for a learning health system: the PORTAL network.
The authors describe the Patient Outcomes Research To Advance Learning (PORTAL) network established by Kaiser Permanente and three other healthcare delivery systems. They discuss how PORTAL is enhancing its current capabilities by expanding the scope of the common data model and integrating the PCORnet PopMedNet platform across their research centers with the objective of conducting large-scale observational comparative effectiveness research across diverse clinical care settings.
AHRQ-funded; HS022143; HS019912
Citation: McGlynn EA, Lieu TA, Durham ML .
Developing a data infrastructure for a learning health system: the PORTAL network.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):596-601. doi: 10.1136/amiajnl-2014-002746..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Health Information Technology (HIT)
Ohno-Machado L, Agha Z, Bell DS
pSCANNER: patient-centered Scalable National Network for Effectiveness Research.
The authors describe the patient-centered Scalable National Network for Effectiveness Research (pSCANNER), which is part of the recently formed Patient-Centered Outcomes Research net (PCORnet). It is designed to be a stakeholder-governed federated network that uses a distributed architecture to integrate data from 3 existing networks covering over 21 million patients in all 50 States.
AHRQ-funded; HS019913
Citation: Ohno-Machado L, Agha Z, Bell DS .
pSCANNER: patient-centered Scalable National Network for Effectiveness Research.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):621-6. doi: 10.1136/amiajnl-2014-002751..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Health Information Technology (HIT)
Black JT, Romano PS, Sadeghi B
A remote monitoring and telephone nurse coaching intervention to reduce readmissions among patients with heart failure: study protocol for the Better
The objective of this randomized controlled comparative effectiveness study was to evaluate the effectiveness of a care transition intervention that included pre-discharge education about heart failure and post-discharge telephone nurse coaching combined with home telemonitoring of weight, blood pressure, heart rate, and symptoms in reducing all-cause 180-day hospital readmissions for older adults hospitalized with heart failure.
AHRQ-funded; HS019311.
Citation: Black JT, Romano PS, Sadeghi B .
A remote monitoring and telephone nurse coaching intervention to reduce readmissions among patients with heart failure: study protocol for the Better
Trials 2014 Apr 13;15:124. doi: 10.1186/1745-6215-15-124..
Keywords: Cardiovascular Conditions, Comparative Effectiveness, Health Information Technology (HIT), Heart Disease and Health, Hospital Readmissions, Telehealth, Transitions of Care
Ji Z, Jiang X, Wang S
Differentially private distributed logistic regression using private and public data.
The purpose of this study was to develop hybrid data mining models using both public and private data sets in a differentially private and distributed manner to achieve improved utility of the disclosed data. The researchers concluded that the logistic regression models built with their new algorithm based on both private and public datasets demonstrate better utility than models that trained on private or public datasets alone without sacrificing the rigorous privacy guarantee.
AHRQ-funded; HS019913
Citation: Ji Z, Jiang X, Wang S .
Differentially private distributed logistic regression using private and public data.
BMC Med Genomics 2014;7 Suppl 1:S14. doi: 10.1186/1755-8794-7-s1-s14.
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Keywords: Comparative Effectiveness, Data, Health Information Technology (HIT)