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Search All Research Studies
AHRQ Research Studies Date
Topics
- Cardiovascular Conditions (1)
- Children/Adolescents (1)
- Community-Acquired Infections (1)
- (-) Comparative Effectiveness (9)
- Data (4)
- Electronic Health Records (EHRs) (2)
- (-) Health Information Technology (HIT) (9)
- Heart Disease and Health (1)
- Hospital Readmissions (1)
- Patient-Centered Outcomes Research (4)
- Pneumonia (1)
- Registries (1)
- Research Methodologies (1)
- System Design (1)
- Telehealth (1)
- Transitions of Care (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 9 of 9 Research Studies DisplayedSimon KC, Tideman S, Hillman L
Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design.
The purpose of this study was to demonstrate the feasibility of pragmatic clinical trials comparing the effectiveness of treatments using the electronic medical record (EMR) and an adaptive assignment design. The authors suggest that the demonstration of successful pragmatic clinical trials based on a customized EMR and adaptive design is an important next step in achieving personalized medicine and provides a framework for future studies of comparative effectiveness.
AHRQ-funded; HS024057.
Citation: Simon KC, Tideman S, Hillman L .
Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design.
JAMIA Open 2018 Jul;1(1):99-106. doi: 10.1093/jamiaopen/ooy017..
Keywords: Comparative Effectiveness, Electronic Health Records (EHRs), Health Information Technology (HIT), Research Methodologies, System Design
Ong TC, Kahn MG, Kwan BM
Dynamic-ETL: a hybrid approach for health data extraction, transformation and loading.
The researchers designed and implemented a health data transformation and loading approach, which we refer to as Dynamic ETL (Extraction, Transformation and Loading) (D-ETL), that automates part of the process through use of scalable, reusable and customizable code. Their results showed that ETL rule composition methods and the D-ETL engine offer a scalable solution for health data transformation via automatic query generation to harmonize source datasets.
AHRQ-funded; HS019908; HS022956.
Citation: Ong TC, Kahn MG, Kwan BM .
Dynamic-ETL: a hybrid approach for health data extraction, transformation and loading.
BMC Med Inform Decis Mak 2017 Sep 13;17(1):134. doi: 10.1186/s12911-017-0532-3.
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Keywords: Comparative Effectiveness, Data, Electronic Health Records (EHRs), Health Information Technology (HIT), Patient-Centered Outcomes Research
Ong T, Pradhananga R, Holve E
A framework for classification of electronic health data extraction-transformation-loading challenges in data network participation.
The researchers conducted key-informant interviews with data partner representatives to survey the Extract, Transform, Load (ETL) process challenges faced in clinical data research networks (CDRNs) and registries. The paper concluded that overcoming ETL technical challenges requires significant investments in a broad array of information technologies and human resources. Identifying these technical obstacles can inform optimal resource allocation to minimize the barriers and cost of entry for new data partners into extant networks, which in turn can expand data networks' inclusiveness and diversity.
AHRQ-funded; HS019564.
Citation: Ong T, Pradhananga R, Holve E .
A framework for classification of electronic health data extraction-transformation-loading challenges in data network participation.
eGEMS 2017 Jun 13;5(1):10. doi: 10.5334/egems.222..
Keywords: Comparative Effectiveness, Data, Health Information Technology (HIT), Patient-Centered Outcomes Research, Registries
Meystre S, Gouripeddi R, Tieder J
Enhancing comparative effectiveness research with automated pediatric pneumonia detection in a multi-institutional clinical repository: a PHIS+ pilot study.
The aim of this study was to develop an automated, scalable, and accurate method to determine the presence or absence of pneumonia in children using chest imaging reports. It found that, when compared with each of the domain experts manually annotating these reports, the new Natural Language Processing (NLP) application developed by the researchers allowed for significantly higher sensitivity (.71 vs .527) and similar positive predictive value and specificity.
AHRQ-funded; HS019862.
Citation: Meystre S, Gouripeddi R, Tieder J .
Enhancing comparative effectiveness research with automated pediatric pneumonia detection in a multi-institutional clinical repository: a PHIS+ pilot study.
J Med Internet Res 2017 May 15;19(5):e162. doi: 10.2196/jmir.6887.
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Keywords: Children/Adolescents, Community-Acquired Infections, Comparative Effectiveness, Health Information Technology (HIT), Pneumonia
Holmes JH, Elliott TE, Brown JS
Clinical research data warehouse governance for distributed research networks in the USA: a systematic review of the literature.
The researchers reviewed the published, peer-reviewed literature on clinical research data warehouse governance in distributed research networks (DRNs). They determined that a peer-reviewed literature on data warehouse governance is emerging but is still sparse. Understanding of DRN data governance policies and procedures is limited but expected to change as more DRN projects disseminate their governance approaches.
AHRQ-funded; HS019912
Citation: Holmes JH, Elliott TE, Brown JS .
Clinical research data warehouse governance for distributed research networks in the USA: a systematic review of the literature.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):730-6. doi: 10.1136/amiajnl-2013-002370..
Keywords: Comparative Effectiveness, Data, Health Information Technology (HIT)
McGlynn EA, Lieu TA, Durham ML
Developing a data infrastructure for a learning health system: the PORTAL network.
The authors describe the Patient Outcomes Research To Advance Learning (PORTAL) network established by Kaiser Permanente and three other healthcare delivery systems. They discuss how PORTAL is enhancing its current capabilities by expanding the scope of the common data model and integrating the PCORnet PopMedNet platform across their research centers with the objective of conducting large-scale observational comparative effectiveness research across diverse clinical care settings.
AHRQ-funded; HS022143; HS019912
Citation: McGlynn EA, Lieu TA, Durham ML .
Developing a data infrastructure for a learning health system: the PORTAL network.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):596-601. doi: 10.1136/amiajnl-2014-002746..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Health Information Technology (HIT)
Ohno-Machado L, Agha Z, Bell DS
pSCANNER: patient-centered Scalable National Network for Effectiveness Research.
The authors describe the patient-centered Scalable National Network for Effectiveness Research (pSCANNER), which is part of the recently formed Patient-Centered Outcomes Research net (PCORnet). It is designed to be a stakeholder-governed federated network that uses a distributed architecture to integrate data from 3 existing networks covering over 21 million patients in all 50 States.
AHRQ-funded; HS019913
Citation: Ohno-Machado L, Agha Z, Bell DS .
pSCANNER: patient-centered Scalable National Network for Effectiveness Research.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):621-6. doi: 10.1136/amiajnl-2014-002751..
Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Health Information Technology (HIT)
Black JT, Romano PS, Sadeghi B
A remote monitoring and telephone nurse coaching intervention to reduce readmissions among patients with heart failure: study protocol for the Better
The objective of this randomized controlled comparative effectiveness study was to evaluate the effectiveness of a care transition intervention that included pre-discharge education about heart failure and post-discharge telephone nurse coaching combined with home telemonitoring of weight, blood pressure, heart rate, and symptoms in reducing all-cause 180-day hospital readmissions for older adults hospitalized with heart failure.
AHRQ-funded; HS019311.
Citation: Black JT, Romano PS, Sadeghi B .
A remote monitoring and telephone nurse coaching intervention to reduce readmissions among patients with heart failure: study protocol for the Better
Trials 2014 Apr 13;15:124. doi: 10.1186/1745-6215-15-124..
Keywords: Cardiovascular Conditions, Comparative Effectiveness, Health Information Technology (HIT), Heart Disease and Health, Hospital Readmissions, Telehealth, Transitions of Care
Ji Z, Jiang X, Wang S
Differentially private distributed logistic regression using private and public data.
The purpose of this study was to develop hybrid data mining models using both public and private data sets in a differentially private and distributed manner to achieve improved utility of the disclosed data. The researchers concluded that the logistic regression models built with their new algorithm based on both private and public datasets demonstrate better utility than models that trained on private or public datasets alone without sacrificing the rigorous privacy guarantee.
AHRQ-funded; HS019913
Citation: Ji Z, Jiang X, Wang S .
Differentially private distributed logistic regression using private and public data.
BMC Med Genomics 2014;7 Suppl 1:S14. doi: 10.1186/1755-8794-7-s1-s14.
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Keywords: Comparative Effectiveness, Data, Health Information Technology (HIT)