National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- Antibiotics (1)
- Children/Adolescents (5)
- Diagnostic Safety and Quality (2)
- Evidence-Based Practice (2)
- Healthcare-Associated Infections (HAIs) (1)
- Healthcare Cost and Utilization Project (HCUP) (2)
- Healthcare Costs (2)
- Health Services Research (HSR) (2)
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- Long-Term Care (1)
- Nursing Homes (1)
- Obesity (1)
- Outcomes (2)
- Patient-Centered Outcomes Research (2)
- Patient Safety (2)
- Quality of Life (2)
- Research Methodologies (3)
- (-) Skin Conditions (13)
- Sleep Problems (2)
- Treatments (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 13 of 13 Research Studies DisplayedVakharia PP, Chopra R, Silverberg NB
Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review.
The objective of this systematic review was to assess the efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts. The investigators found that topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric molluscum contagiosum with good tolerability and safety.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Silverberg NB .
Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review.
Am J Clin Dermatol 2018 Dec;19(6):791-803. doi: 10.1007/s40257-018-0375-4..
Keywords: Evidence-Based Practice, Skin Conditions, Treatments
Felix HC, Bradway C, Bird TM
Safety of obese persons in nursing homes.
This paper discusses the emergence of obese persons as a vulnerable group in the nursing home community. The authors discuss the special needs of this population including that obese residents require special protocols, trained staff, and appropriately sized equipment to prevent and treat skin breakdown.
AHRQ-funded; HS025703.
Citation: Felix HC, Bradway C, Bird TM .
Safety of obese persons in nursing homes.
Med Care 2018 Dec;56(12):1032-34. doi: 10.1097/mlr.0000000000000997..
Keywords: Long-Term Care, Obesity, Nursing Homes, Patient Safety, Skin Conditions
Kwa MC, Silverberg JI, Ardalan K
Inpatient burden of juvenile dermatomyositis among children in the United States.
The purpose of this study was to determine the prevalence and risk factors for hospitalization with juvenile dermatomyositis and assess inpatient burden of juvenile dermatomyositis (JDM). The study authors found that JDM contributes to both increased length of hospitalization and inpatient cost of care. Non-Medicaid government insurance was associated with higher rates of hospitalization for JDM while Hispanic and other non-white racial/ethnic groups demonstrated increased length of stay and cost of care.
AHRQ-funded; HS023011.
Citation: Kwa MC, Silverberg JI, Ardalan K .
Inpatient burden of juvenile dermatomyositis among children in the United States.
Pediatr Rheumatol Online J 2018 Nov 13;16(1):70. doi: 10.1186/s12969-018-0286-1..
Keywords: Children/Adolescents, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Skin Conditions
Thorlacius L, Ingram JR, Villumsen B
A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process.
This article describes the outcome of six stakeholder groups participating in a Delphi process to create a core outcomes set (COS) for hidradenitis suppurative (HS) research. Five anonymous e-Delphi rounds and four face-to-face consensus meetings were conducted. A total of 41 patients and 52 healthcare professionals (HCPs) from 19 countries and 4 continents participated. The consensus adopted included five domains were approved: disease course, physical signs, HS-specific quality of life, pain, and global assessments.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Ingram JR, Villumsen B .
A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process.
Br J Dermatol 2018 Sep;179(3):642-50. doi: 10.1111/bjd.16672..
Keywords: Skin Conditions, Health Services Research (HSR), Research Methodologies, Quality of Life
Li JC, Fishbein A, Singam V
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
The aim of this prospective online questionnaire-based study was to determine the relationship between atopic dermatitis (AD) severity, sleep disturbance (SD), and sleep-related impairment (SRI). The investigators concluded that their study suggests that SD and SRI are common in adults with AD, particularly those with severe diseases. They suggest that sleep disturbances and SRI should be considered when assessing burden of AD and therapeutic decisions.
AHRQ-funded; HS023011.
Citation: Li JC, Fishbein A, Singam V .
Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: a cross-sectional study.
Dermatitis 2018 Sep/Oct;29(5):270-77. doi: 10.1097/der.0000000000000401..
Keywords: Skin Conditions, Sleep Problems
Silverberg JI, Vakharia PP, Chopra R
Phenotypical differences of childhood- and adult-onset atopic dermatitis.
This prospective study of adult- versus childhood-onset atopic dermatitis (AD) analyzed phenotypical differences with 356 adults with AD. In that sample, 41.9% reported adult-onset, with 24.4% after the age of 50. Adult-onset was associated with being born outside the US, but not sex, race/ethnicity, current smoking status, or alcohol consumption. Most adult-onset AD was associated with a high probability of lesions on for the hands and/or head/neck.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Vakharia PP, Chopra R .
Phenotypical differences of childhood- and adult-onset atopic dermatitis.
J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1306-12. doi: 10.1016/j.jaip.2017.10.005.
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Keywords: Skin Conditions, Children/Adolescents
Owen JL, Vakharia PP, Silverberg JI
The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis.
Recent systematic reviews have suggested that allergic contact dermatitis (ACD) is a significant clinical problem in both children and adults with atopic dermatitis (AD). The authors review the clinical scenarios where patch testing is indicated in AD. In addition, they review the contraindications, preferred patch-testing series, pitfalls, and challenges determining the relevance of positive patch-test reactions in AD patients.
AHRQ-funded; HS023011.
Citation: Owen JL, Vakharia PP, Silverberg JI .
The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis.
Am J Clin Dermatol 2018 Jun;19(3):293-302. doi: 10.1007/s40257-017-0340-7.
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Keywords: Diagnostic Safety and Quality, Skin Conditions
Vakharia PP, Chopra R, Sacotte R
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Several patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, such as the Patient-Oriented Eczema Measure (POEM), while others pertain to itch, for example the numerical rating scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatological disease in general, for example the Dermatology Life Quality Index (DLQI). The purpose of this study was to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQoL and 5-D itch scale for use in adults with AD.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Br J Dermatol 2018 Apr;178(4):925-30. doi: 10.1111/bjd.16078..
Keywords: Outcomes, Patient-Centered Outcomes Research, Quality of Life, Skin Conditions
Thorlacius L, Garg A, Ingram JR
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
This article describes the outcome of two in-person consensus meetings to create a core outcomes set (COS) for hidradenitis suppurative (HS) research. Forty-one individuals from 13 countries and 4 continents were included. The list of items discussed had been developed from patient interviews, a systematic literature review and a healthcare professional survey. Nine items were excluded and seven domains were approved which included: disease course, physical signs, HS-specific quality of life, satisfaction, symptoms, pain and global assessments.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Garg A, Ingram JR .
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
Br J Dermatol 2018 Mar;178(3):715-21. doi: 10.1111/bjd.16093..
Keywords: Evidence-Based Practice, Health Services Research (HSR), Outcomes, Research Methodologies, Skin Conditions
Hsu DY, Shinkai K, Silverberg JI
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
This study used data from the Nationwide Inpatient Sample 2002-2012 to determine incidence, risk factors, comorbidities, costs, length of stay, and mortality in hospitalized children with Eczema herpeticum (EH). A higher risk was associated with younger age and non-white ethnicity (Asian in particular). However there was less frequency of hospitalization associated with lower income quartiles. The mortality incidence was 0.1%.
AHRQ-funded; HS023011.
Citation: Hsu DY, Shinkai K, Silverberg JI .
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
J Invest Dermatol 2018 Feb;138(2):265-72. doi: 10.1016/j.jid.2017.08.039..
Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Healthcare Costs, Hospitalization, Skin Conditions
Fishbein AB, Mueller K, Kruse L
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
The researchers sought to characterize sleep in a cohort of children with moderate-to-severe atopic dermatitis (AD) and to determine methods for assessment of sleep disturbance. In nineteen patients and nineteen controls, they found that patients with AD experienced wake after sleep onset (WASO) for 103 plus or minus 55 minutes as compared with 50 plus or minus 27 minutes in the controls. They had a higher frequency of restless sleep, daytime sleepiness, difficulty falling back to sleep at night, and teacher-reported daytime sleepiness. They concluded that children with moderate-to-severe AD experience more WASO and lower sleep efficiency than healthy controls but similar bedtime and wake time, sleep duration, and sleep onset latency.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Mueller K, Kruse L .
Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study.
J Am Acad Dermatol 2018 Feb;78(2):336-41. doi: 10.1016/j.jaad.2017.08.043.
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Keywords: Children/Adolescents, Children/Adolescents, Skin Conditions, Sleep Problems
Vakharia PP, Chopra R, Silverberg JI
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
This study sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally. The results highlighted the lack of uniformity and documentation of atopic dermatitis diagnostic criteria in randomized controlled trials for atopic dermatitis. The investigators recommended harmonizing the diagnostic criteria for atopic dermatitis in future randomized controlled trials.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Silverberg JI .
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
Am J Clin Dermatol 2018 Feb;19(1):15-22. doi: 10.1007/s40257-017-0299-4..
Keywords: Diagnostic Safety and Quality, Patient-Centered Outcomes Research, Research Methodologies, Skin Conditions
Hogan PG, Rodriguez M, Spenner AM
Impact of systemic antibiotics on staphylococcus aureus colonization and recurrent skin infection.
This study found that systemic antibiotics, as part of acute skin and soft tissue infection (SSTI) management in conjunction with incision and drainage, impacted S. aureus colonization, thus contributing to a decreased incidence of recurrent SSTI. The mechanism by which clindamycin differentially affects colonization and recurrent SSTI compared to trimethoprim-sulfamethoxazole (TMP-SMX) warrants further study.
AHRQ-funded; HS021736; HS024269.
Citation: Hogan PG, Rodriguez M, Spenner AM .
Impact of systemic antibiotics on staphylococcus aureus colonization and recurrent skin infection.
Clin Infect Dis 2018 Jan 6;66(2):191-97. doi: 10.1093/cid/cix754.
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Keywords: Antibiotics, Children/Adolescents, Healthcare-Associated Infections (HAIs), Patient Safety, Skin Conditions