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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedMovahedi F, Kanwar MK, Antaki JF
Timelines of adverse event journeys of LVAD patients.
The objective of this study was to investigate the timelines of adverse events (AEs) in the INTERMACS database to obtain insights into the "AE journeys" of left ventricular assist device (LVAD) patients. The characteristics of the timelines were investigated via six descriptive research questions. The analysis revealed time-related characteristics and patterns of the AE journey after LVAD, including the most common time of occurrences, duration, and time intervals between AEs. The authors concluded that the INTERMACS Event dataset is a valuable resource for research about the timeline of AE journeys of LVAD patients and noted that future studies should consider the time-related characteristics of the dataset to choose an appropriate scope of time and time granularity.
AHRQ-funded; HS027784.
Citation: Movahedi F, Kanwar MK, Antaki JF .
Timelines of adverse event journeys of LVAD patients.
Artif Organs 2023 Oct; 47(10):1604-12. doi: 10.1111/aor.14596..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Adverse Events, Medical Devices
Mao J, Sedrakyan A, Sun T
Assessing adverse event reports of hysteroscopic sterilization device removal using natural language processing.
This study’s objective was to develop an annotation model to develop natural language processing (NLP) to device adverse event reports and to implement the model to evaluate the most frequently experienced events among women reporting a sterilization device removal. Adverse event reports from the Manufacturer and User Facility Device Experience database from January 2005 to June 2018 were included. The authors used an iterative process to develop an annotation model that extracts six categories of desired information and applied the annotation model to train an NLP algorithm. A total of 16,535 reports of device removal were analyzed with the most frequently reported patient and device events being abdominal/pelvic/genital pain (79.6%) and device dislocation/migration (19.2%), respectively. A total of 7,932 patients reported an additional sterilization procedure of a hysterectomy or salpingectomy. One-fifth of the cases that had device removal timing specified reported a removal 7 years after original insertion.
AHRQ-funded; HS026291.
Citation: Mao J, Sedrakyan A, Sun T .
Assessing adverse event reports of hysteroscopic sterilization device removal using natural language processing.
Pharmacoepidemiol Drug Saf 2022 Apr;31(4):442-51. doi: 10.1002/pds.5402..
Keywords: Adverse Events, Surgery, Medical Devices, Patient Safety
Steinberg BA, Al-Khatib SM, Edwards R
Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials.
The researchers aimed to determine if the benefit of implantable cardioverter-defibrillators (ICDs) is modulated by medical comorbidity. They concluded that patients with extensive comorbid medical illnesses may experience less benefit from primary prevention ICDs than those with less comorbidity, and that implantation should be carefully considered in sick patients. They recommended further study of ICDs in medically complex patients.
AHRQ-funded; HS018505.
Citation: Steinberg BA, Al-Khatib SM, Edwards R .
Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials.
JACC Heart Fail 2014 Dec;2(6):623-9. doi: 10.1016/j.jchf.2014.06.007.
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Keywords: Adverse Events, Heart Disease and Health, Medical Devices, Patient-Centered Outcomes Research