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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedJeffery AD, Werthman JA, Danesh V
Assess, prevent, and manage pain; both spontaneous awakening and breathing trials; choice of analgesia/sedation; delirium: assess, prevent, and manage; early mobility; family engagement and empowerment bundle implementation: quantifying the association of
This paper discusses a multicenter, exploratory, cross-sectional study to describe the physical environment factors of bundle-enhancing items and the association of physical environment with bundle adherence. The study included 10 medical and surgical ICUs in 6 academic medical centers. The cohort included adults with qualifying respiratory failure and/or septic shock. The interventions used were the Awakening, and Breathing trial Coordination, Delirium assessment/management, and Early mobility bundle as the recommended standard of care for randomized controlled trial patients. Primary outcome was adherence to the full bundle and the early mobility bundle component as identified from daily adherence documentation of 751 patient observations. Both unit- and patient-level factors such as unit size, a standard walker, and age were associated with increased or decreased adherence. Mechanical ventilation was always associated with decreased bundle adherence.
AHRQ-funded; HS026395.
Citation: Jeffery AD, Werthman JA, Danesh V .
Assess, prevent, and manage pain; both spontaneous awakening and breathing trials; choice of analgesia/sedation; delirium: assess, prevent, and manage; early mobility; family engagement and empowerment bundle implementation: quantifying the association of
Crit Care Explor 2021 Sep 14;3(9):e0525. doi: 10.1097/cce.0000000000000525..
Keywords: Critical Care, Intensive Care Unit (ICU), Care Management, Evidence-Based Practice
Huang C, Soleimani J, Herasevich S
Clinical characteristics, treatment, and outcomes of critically ill patients with COVID-19: a scoping review.
This scoping review of COVID-19 literature was done to synthesize clinical characteristics, treatment, and clinical outcomes among critically ill patients. The review was conducted between January 1-May 15, 2020 and identified high-quality clinical studies describing critically ill patients with a sample size of greater than 20 patients. Two reviewers independently reviewed all abstracts (2785 unique articles), full-text (218 articles), and abstracted data from 92 studies. Similarities for critically ill patients across all regions included a higher proportion of older males infected and with severe illness, high frequency of comorbidities (hypertension, diabetes, and cardiovascular disease), abnormal chest imaging findings, and death secondary to respiratory failures. Some differences in regions included newly identified complications (e.g. pulmonary embolism), and epidemiological risk factors (eg obesity), less chest computed tomography performed, and increased use of invasive mechanical ventilation in Europe and the US compared with Asia.
AHRQ-funded; HS026609.
Citation: Huang C, Soleimani J, Herasevich S .
Clinical characteristics, treatment, and outcomes of critically ill patients with COVID-19: a scoping review.
Mayo Clin Proc 2021 Jan;96(1):183-202. doi: 10.1016/j.mayocp.2020.10.022..
Keywords: COVID-19, Critical Care, Evidence-Based Practice