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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedRomanelli RJ, Chung S, Pu J
Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes.
The purpose of this study was to quantify the effectiveness of early versus delayed initiation of metformin monotherapy on glycemic control (measured by change in HbA1c) and weight modification (change in body mass index [BMI]). It found that treatment with metformin earlier in the course of type 2 diabetes is associated with better glycemic control, more pronounced weight reduction, and a lower risk for therapy intensification than delayed treatment.
AHRQ-funded; HS019815.
Citation: Romanelli RJ, Chung S, Pu J .
Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes.
Diabetes Res Clin Pract 2015 Apr;108(1):170-8. doi: 10.1016/j.diabres.2014.12.019..
Keywords: Diabetes, Medication, Comparative Effectiveness, Obesity: Weight Management, Outcomes
McVay MA, Jeffreys AS, King HA
The relationship between pretreatment dietary composition and weight loss during a randomised trial of different diet approaches.
Identifying pretreatment dietary habits that are associated with weight-loss intervention outcomes could help guide individuals’ selection of weight-loss approach among competing options. This study concluded that selection of a weight-loss approach on the basis of pretreatment macronutrient intake is unlikely to improve weight outcomes at the end of a 1-year treatment.
AHRQ-funded; HS000079.
Citation: McVay MA, Jeffreys AS, King HA .
The relationship between pretreatment dietary composition and weight loss during a randomised trial of different diet approaches.
J Hum Nutr Diet 2015 Feb;28 Suppl 2:16-23. doi: 10.1111/jhn.12188..
Keywords: Nutrition, Obesity: Weight Management, Obesity, Outcomes, Comparative Effectiveness