National Healthcare Quality and Disparities Report
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- Adverse Events (1)
- Antibiotics (4)
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- Cancer: Skin Cancer (1)
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- Diagnostic Safety and Quality (1)
- Elderly (1)
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- Pain (1)
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- Patient Safety (2)
- Pneumonia (1)
- Practice Patterns (1)
- Prevention (1)
- Quality of Life (3)
- Racial and Ethnic Minorities (3)
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- (-) Skin Conditions (29)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 29 Research Studies DisplayedWurcel AG, Essien UR, Ortiz C
Variation by race in antibiotics prescribed for hospitalized patients with skin and soft tissue infections.
This cohort study examined antibiotics prescribed and variations by race among hospitalized patients with skin and soft tissue infections (SSTIs). A subanalysis of multisite, cross-sectional data collected through a national survey of acute care hospital groups within Vizient, Inc. considering adult inpatients treated for SSTIs was used. Of the 1242 adult inpatients included from 91 US hospitals, 45% were female, 18% were Black, and 69% were White with a mean age of 58 years. Penicillin allergy with hives was found in 23%, 19% with rash, and 18% with unknown effects, with allergy found more frequent in Black patients (23%) versus White (18%). Adjusting for multiple factors, White inpatients were at an increased risk of cefazolin use and decreased risk of clindamycin use compared with Black inpatients. Cefazolin use with less likely to be prescribed to Black inpatients than White inpatients and they were likely to be prescribed clindamycin. Cefazolin is considered a first-line SSTI treatment with clindamycin not recommended given frequent dosing and high potential for adverse effects including Clostridioides difficile infection (CDI). Although penicillin allergy is described as more prevalent among White patients, the authors observed an increased prevalence among Black inpatients compared with White inpatients treated for SSTI.
Citation: Wurcel AG, Essien UR, Ortiz C .
Variation by race in antibiotics prescribed for hospitalized patients with skin and soft tissue infections.
JAMA Netw Open 2021 Dec;4(12):e2140798. doi: 10.1001/jamanetworkopen.2021.40798..
Keywords: Antibiotics, Skin Conditions, Racial and Ethnic Minorities, Practice Patterns, Medication
Soper NS, Appukutty AJ, Paje D
Antibiotic overuse after discharge from medical short-stay units.
This study investigated antibiotic overuse after discharge from medical short-stay units (SSUs). This cross-sectional study included patients hospitalized in 2 different medical SSUs with a total of 40 beds at a single academic medical center. Eligible adults were discharged with an oral antibiotic from either SSU from May 2018 to September 2019. Of 100 patients discharged from SSUs with antibiotics, 47 had a skin and soft-tissue infection (SSTI), 22 pneumonia, 21 UTI, and 10 had “other” infections. Overall, 78 cases (78%) were defined as overuse, including 39 of 47 of those treated for SSTI, 17 of 21 for UTI, and 14 of 22 for pneumonia. The most common types of overuse were excess duration and guideline discordant selection. Examples of factors influencing overuse included consultant recommendations, miscalculation of duration, and the need for source control procedure.
AHRQ-funded; HS026530.
Citation: Soper NS, Appukutty AJ, Paje D .
Antibiotic overuse after discharge from medical short-stay units.
Nov;43(11):1689-92. doi: 10.1017/ice.2021.346..
Keywords: Antibiotics, Antimicrobial Stewardship, Medication, Pneumonia, Skin Conditions, Urinary Tract Infection (UTI), Respiratory Conditions, Hospital Discharge
Chovatiya R, Silverberg JI
Iatrogenic burden of atopic dermatitis.
The purpose of this study was to characterize the iatrogenic burden of atopic dermatitis (AD) and conduct a qualitative review of key areas that clinicians can address to minimize that burden. The researchers concluded that the multidimensional nature of AD requires a dynamic approach, and researcher recommendations included: encouraging providers to think strategically about the avoidance of itch triggers, slowly incorporating lifestyle changes, and highlighting step-up therapy when trigger avoidance becomes too burdensome for the patient. Out-of-pocket treatment costs should be incorporated into shared decision, polypharmacy should be minimized, and providers should incorporate evidence-based guidelines into their practices.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Iatrogenic burden of atopic dermatitis.
Dermatitis 2022 Nov-Dec;33(6s):S17-s23. doi: 10.1097/der.0000000000000799..
Keywords: Skin Conditions, Quality of Life
Chovatiya R, Begolka WS, Thibau IJ, R, Begolka WS, Thibau IJ
Impact and associations of atopic dermatitis out-of-pocket health care expenses in the United States.
The purpose of this study was to describe the impact and associations of out of pocket (OOP) health care expenses for atopic dermatitis (AD). The researchers administered a 25-question online survey to 113,502 National Eczema Association members aged 18 years or older. The study found that respondents with monthly OOP expenses over $200 were more likely to have increased AD severity, flares, health care provider visits, prescription polypharmacy, use of step-up therapy, frequent skin infections, and poorer disease control. Respondents with OOP yearly expenditures greater than $1000 had similar associations and additionally increased rates of comorbid asthma, allergic rhinitis, and anxiety/depression. A total of 64.6% of participants reported a harmful household financial impact of OOP expenses. Predictors of harmful impact included severe AD, comorbid asthma, 5 health care provider visits or more in a year, greater than $200 OOP monthly expenditures, and $1000 annual OOP expenditures or more. The study concluded that OOP expenses for AD are associated with increased disease severity and health care utilization and significantly impact household finances.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Begolka WS, Thibau IJ, R, Begolka WS, Thibau IJ .
Impact and associations of atopic dermatitis out-of-pocket health care expenses in the United States.
Dermatitis 2022 Nov-Dec;33(6s):S43-S51. doi: 10.1097/der.0000000000000795..
Keywords: Skin Conditions, Healthcare Costs
Chovatiya R, Begolka WS, Thibau IJ
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among Black individuals in the United States.
The purpose of this study was to explain the categories and impact of out-of-pocket (OOP) healthcare expenses associated with atopic dermatitis (AD) management among black individuals. The researchers administered a voluntary online survey to 113, 502 members of the National Eczema Association. 77.3% of respondents met the participation criteria of being U.S. residents, 18 years of age and older, and self-reporting that they had AD or were the primary caregivers of individuals with AD. The study found that Blacks (74.2%) vs. non-Blacks (63.3%) reported more OOP costs for prescription medications covered (65.1%) and not covered (46.5%), by insurance, emergency room visits (22.1% vs. 11.8%), and outpatient laboratory testing (33.3% vs. 21.8%,). There was a relationship between Black race and increased household financial impact from OOP expenses, and predictors of financial impact included minimally controlled AD, systemic therapy, greater than $200 monthly OOP expenses, and Medicaid. Blacks with Medicaid had greater odds of harmful financial impact than those of black race or with Medicaid alone. The researchers concluded that there is a relationship between Black race increased OOP costs for AD, with significant financial impact to the household.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Begolka WS, Thibau IJ .
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among Black individuals in the United States.
Arch Dermatol Res 2022 Oct;314(8):739-47. doi: 10.1007/s00403-021-02282-3..
Keywords: Skin Conditions, Healthcare Costs, Racial and Ethnic Minorities
Chovatiya R, Silverberg JI
Describe-ad: a novel classification framework for atopic dermatitis.
The purpose of this study was to develop a framework to standardize atopic dermatitis assessments based on a literature review and clinical experience. The researchers developed the DESCRIBE-AD framework to include both patient- and clinician-reported perspectives to effectively capture the clinical domains contributing to AD heterogeneity. DESCRIBE-AD includes assessments of Dermatitis morphology and phenotype, Evolution of disease, Symptom severity, Comorbid health disorders, Response to therapy, Intensity of lesions, Burden of disease, and Extent of lesions. The researchers conclude that DESCRIBE-AD can be utilized to better assess AD and guide treatment choices.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Describe-ad: a novel classification framework for atopic dermatitis.
J Am Acad Dermatol 2022 Sep;87(3):541-50. doi: 10.1016/j.jaad.2021.10.058..
Keywords: Skin Conditions
Chovatiya R, Silverberg JI
Evaluating the longitudinal course of atopic dermatitis: a review of the literature.
The purpose of this study was to better understand the longitudinal course of atopic dermatitis (AD) to improve clinical phenotyping and prognostication and improve personalized therapy recommendations. The researchers conducted a systematic literature review and meta-analysis of 46 studies to examine the current understanding of AD patterns over time and beyond childhood. The study found that 80% of childhood AD did not persist by 8 years of age and 5% by 20 years of age. Clinician-assessed severity showed a weaker association with persistence than patient-assessed severity. Persistent AD was related with intrinsic factors (severity, genetics, and atopic multimorbidity) and extrinsic (non-White race, Hispanic ethnicity, urban environment, and low income) factors. The researchers concluded that recognizing and incorporating the longitudinal course of AD is relevant for improved decision making in clinical practice and trials, and that future research should focus on the standardization of longitudinal course measures and their implementation alongside currently used measures for patient stratification and treatment.
AHRQ-funded; HS026385.
Citation: Chovatiya R, Silverberg JI .
Evaluating the longitudinal course of atopic dermatitis: a review of the literature.
J Am Acad Dermatol 2022 Sep;87(3):688-89. doi: 10.1016/j.jaad.2022.02.005..
Keywords: Skin Conditions
Manjunath J, Silverberg JI
Association of sleep disturbances with geriatric age in atopic dermatitis patients.
The purpose of this cross-sectional study was to investigate the association of geriatric age with atopic dermatitis (AD) severity and sleep disturbances (SD). Patients over the age of 18 seen at an eczema clinic were recruited and completed a self-administered questionnaire for encounters between 2014 and 2019. AD severity was assessed using the patient-oriented eczema measure (POEM), eczema area and severity index, Scoring AD (SCORAD), SCORAD-itch, investigator global assessment, and patient global assessment. The frequency of SD due to eczema was assessed using POEM. The impact of itching on the activity of falling asleep was assessed using 5 dimensions (5D) of itch. Fatigue was assessed using the patient-reported outcome measurement information system (PROMIS)-global health. Difficulty sleeping, falling asleep, and staying asleep was assessed using PROMIS-SD. The study found that geriatric AD patients had more profound SD, particularly staying asleep and fatigue, despite having AD severity similar to younger adult AD patients. The researchers concluded that future research is needed to understand why there is a difference between geriatric and non-geriatric patients as related to increased itching from atopic dermatitis and sleep disorders.
AHRQ-funded; HS023011.
Citation: Manjunath J, Silverberg JI .
Association of sleep disturbances with geriatric age in atopic dermatitis patients.
J Am Acad Dermatol 2022 Jul;87(1):206-08. doi: 10.1016/j.jaad.2021.07.039..
Keywords: Elderly, Sleep Problems, Skin Conditions
Cheng BT, Patel MS, Xu M
Timing of itch among children with atopic dermatitis.
The purpose of this study was to test the hypothesis that pediatric patients experience greater nighttime itch in atopic dermatitis. The primary study outcome was time of worst itch by parent report. Parents were asked “Over the past 7 days, what time of day or night was your child’s itch the worst?” They were able to select the hour of worst itch, with separate questions for weekdays versus weekend. Parents also rated their child’s itch intensity (range, 0-10; 10 = worst) during the morning, afternoon, evening, bedtime, and sleep. Data on when the child tried to sleep and how long it took to fall asleep were used to calculate time of sleep onset. Similarly, children ages 8 to 17 years were independently asked to self-report on time of worst itch, itch intensity at different times of day, and time of sleep onset. The researchers analyzed 240 parent-child dyads, with parent-proxy reported data from 60 infants (1-4 years), 120 children (5-12 years), and 60 adolescents (13-17 years) with AD and child self-reported data from all the children aged 8 to 17 years (n = 133). Most often, parent-proxy reported worst itch occurred at 7:00 PM during weekdays and 8:00 PM during weekends. Parents of older children aged 8 to 17 years old also reported worst itch at 7:00 PM during weekdays and 8:00 PM during weekends. Time of worst itch was consistent across age groups but delayed slightly as children grew older, likely owing to later bedtime. Parents of infants reported worst itch most frequently at 6:00 PM and 7:00 PM, children at 7:00 PM, and adolescents at 7:00 PM, 8:00 PM, and 10:00 PM. The researchers conclude that itch intensity by time of day might be explained by differences in skin and inflammatory circadian rhythms in childhood AD. Alternatively, evening rituals such as bathing, use of hot water and soap, and changing clothes may trigger itch. It also may be that children have more activities during the day to distract them from itch.
AHRQ-funded; HS023011.
Citation: Cheng BT, Patel MS, Xu M .
Timing of itch among children with atopic dermatitis.
Ann Allergy Asthma Immunol 2022 May;128(5):603-05. doi: 10.1016/j.anai.2022.01.042..
Keywords: Children/Adolescents, Skin Conditions
Cheng BT, Paller AS, Griffith JW
Burden and characteristics of skin pain among children with atopic dermatitis.
The purpose of this study was to determine clinical features and quality-of-life (QOL) burden associated with atopic dermatitis (AD)- induced skin pain in children. The researchers conducted a national cross-sectional survey of child-parent dyads with AD. Questions were administered to the parent proxy for all participants, and children 8 years and older completed a similar questionnaire adapted for self-report. The researchers surveyed 240 children with AD and parent dyads, including 60 infants (1-4 years) and 180 children (5-17 years). This cohort included 200 (83%) with moderate to very severe disease. The study reported that 111 of 240 participants (46%) had parent-proxy reported skin pain, and 59 of 133 children (44%) aged 8 to 17 years had self-reported skin pain. Children self-reported slightly greater pain intensity than did their parents. Pain intensity was associated with clinical skin features of bleeding, weeping/ oozing, cracking, itch frequency, and itch severity. Quality of life scores were also analyzed, with results indicating that skin pain was a significant factor in lower quality of life scores. The researchers concluded that intensity of skin pain in children was associated with significant decreases in quality of life.
AHRQ-funded; HS023011.
Citation: Cheng BT, Paller AS, Griffith JW .
Burden and characteristics of skin pain among children with atopic dermatitis.
J Allergy Clin Immunol Pract 2022 Apr;10(4):1104-06.e1. doi: 10.1016/j.jaip.2021.12.012..
Keywords: Children/Adolescents, Skin Conditions, Pain
Hong MR, Lei D, Yousaf M
A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis.
A prospective, dermatology practice-based study was performed of adults with atopic dermatitis. Using a Numeric Rating Scale (NRS), regression models were constructed to examine itch over time. In repeated-measures regression models, persistent NRS average-itch scores were associated with baseline NRS average-itch and food allergy. Persistent NRS worst-itch was associated with baseline worst-itch NRS and Medicaid insurance. Patients with atopic dermatitis had a heterogeneous longitudinal course with fluctuating and complex overlapping patterns of average- and worst-itch intensity, and frequency.
AHRQ-funded; HS023011.
Citation: Hong MR, Lei D, Yousaf M .
A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis.
Arch Dermatol Res 2022 Mar;314(2):141-49. doi: 10.1007/s00403-021-02214-1..
Keywords: Skin Conditions
Schwartzman G, Lei D, Ahmed A
Longitudinal course and phenotypes of health-related quality of life in adults with atopic dermatitis.
The real-world course of health-related quality of life (HRQoL) in atopic dermatitis (AD) is not well established. The aim of this prospective dermatology-practice based study was to examine predictors, longitudinal course and phenotypes of HRQoL in adult patients with AD. The investigators concluded that: patients with AD had a heterogeneous longitudinal course and distinct patterns of HRQoL; many patients had fluctuating HRQoL over time; and most patients with moderate to severe disease at baseline had persistent HRQoL impairment over time.
AHRQ-funded; HS023011.
Citation: Schwartzman G, Lei D, Ahmed A .
Longitudinal course and phenotypes of health-related quality of life in adults with atopic dermatitis.
Clin Exp Dermatol 2022 Feb;47(2):359-72. doi: 10.1111/ced.14948..
Keywords: Skin Conditions, Quality of Life
Zhou NY, Nili A, Blackwell CK
Parent report of sleep health and attention regulation in a cross-sectional study of infants and preschool-aged children with atopic dermatitis.
Older children with atopic dermatitis (AD) suffer from poor sleep and attention problems. However, until recently, the dearth of developmentally sensitive assessment tools impeded characterization in younger children. In this study the investigators aimed to characterize sleep and attention problems in young children with AD and identify modifiable factors. The investigators concluded that more severe AD correlates with poor sleep health and attention dysregulation.
AHRQ-funded; HS023011.
Citation: Zhou NY, Nili A, Blackwell CK .
Parent report of sleep health and attention regulation in a cross-sectional study of infants and preschool-aged children with atopic dermatitis.
Pediatr Dermatol 2022 Jan;39(1):61-68. doi: 10.1111/pde.14889..
Keywords: Children/Adolescents, Newborns/Infants, Sleep Problems, Skin Conditions
Greenhawt M, Shaker M
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
The authors sought to identify scenarios in which current early peanut introduction guidelines would be cost-effective. They found that the current screening approach to early peanut introduction could be cost-effective at a particular health utility for an in-clinic reaction, skin prick test sensitivity and specificity, and high baseline peanut allergy prevalence among high-risk infants. However, such conditions are unlikely to be plausible to achieve realistically. They recommend further research to define the health state utility associated with reaction location.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Shaker M .
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
JAMA Netw Open 2019 Dec 2;2(12):e1918041. doi: 10.1001/jamanetworkopen.2019.18041..
Keywords: Patient-Centered Outcomes Research, Newborns/Infants, Children/Adolescents, Respiratory Conditions, Skin Conditions, Screening, Healthcare Costs, Evidence-Based Practice, Guidelines
Quan VL, Erickson T, Daftary K
Atopic dermatitis across shades of skin.
This narrative review discussed key terminology related to atopic dermatitis (AD) across shades of skin, including modern definitions of 'race', 'ethnicity', and 'skin of color (SOC)'. Current literature describing disparities in AD prevalence, disease recognition, and burden was synthesized alongside data regarding genetic and immunologic findings across SOC populations. The authors highlighted key concomitant social determinants of health, including environmental factors, socioeconomic status, and access to care, within the context of these findings. They also discussed future efforts to move toward a more inclusive understanding of AD that encompasses all shades of skin and ensures equitable representation of diverse populations in high impact research.
AHRQ-funded; HS026385.
Citation: Quan VL, Erickson T, Daftary K .
Atopic dermatitis across shades of skin.
Am J Clin Dermatol 2023 Sep; 24(5):731-51. doi: 10.1007/s40257-023-00797-1..
Keywords: Skin Conditions, Racial and Ethnic Minorities
Montgomery KB, Holder AM, Burgan CM
Is it time for synoptic reporting in melanoma nodal surveillance ultrasonography?
Previous qualitative research has identified a potential gap between surgeons’ and radiologists’ awareness of Second Multicenter Selective Lymphadenectomy Trial (MSLT-II) criteria. The purpose of this study was to explore how these criteria have been adopted and reported outside of clinical trial settings or utilized by surgical teams when interpreting ultrasound results. The study found that of the 269 nodal ultrasounds performed in 78 patients, 81.0% reported normal findings versus 19% abnormal findings. Researchers indicated that only 15% of normal ultrasounds had one or more MSLT-II criteria reported versus 88.9% abnormal ultrasounds. While 37% of abnormal ultrasounds had only one MSLT-II criterion reported, 27.8% had two criteria and 24.1% had three criteria. Of the eight abnormal ultrasounds with biopsy recommendation, 75% had two or more MSLT-II criteria reported. Clinically actionable recommendations were provided in 94.9% of normal ultrasounds compared with 64.8% of abnormal ultrasounds.
AHRQ-funded; HS013852.
Citation: Montgomery KB, Holder AM, Burgan CM .
Is it time for synoptic reporting in melanoma nodal surveillance ultrasonography?
Ann Surg Oncol 2023 Sep; 30(9):5327-28. doi: 10.1245/s10434-023-13749-0..
Keywords: Cancer: Skin Cancer, Cancer, Skin Conditions, Imaging
Singam V, Rastogi S, Patel KR
The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.
Little is known about the mental health (MH) hospitalization among patients with acne and rosacea. The purpose of this study was to determine the MH disorders and cost burden associated with acne and rosacea. The investigators concluded that inpatients with acne or rosacea had increased odds of comorbid MH disorders. In particular, there was an increased number of hospital admissions secondary to a primary MH disorder with coexistent acne/rosacea. MH comorbidities were associated with considerable excess costs among inpatients with acne or rosacea.
AHRQ-funded; HS023011.
Citation: Singam V, Rastogi S, Patel KR .
The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.
Clin Exp Dermatol 2019 Oct;44(7):766-22. doi: 10.1111/ced.13919..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Behavioral Health, Hospitalization
Mower WR, Crisp JG, Krishnadasan A
Effect of initial bedside ultrasonography on emergency department skin and soft tissue infection management.
Researchers examined the utility of emergency department (ED) ultrasonography in treatment of skin and soft tissue infections. Study participants were ED patients with skin and soft tissue infections; the study also surveyed clinicians with regard to their pre-ultrasonography certainty about the presence or absence of an abscess, their planned management, post-ultrasonography findings, and actual management. The researchers found that ultrasonography rarely changed management when clinicians were certain about the presence or absence of an abscess. When clinicians were uncertain, ultrasonography changed drainage decisions in approximately one quarter of cases, of which most were appropriate.
AHRQ-funded; HS009699.
Citation: Mower WR, Crisp JG, Krishnadasan A .
Effect of initial bedside ultrasonography on emergency department skin and soft tissue infection management.
Ann Emerg Med 2019 Sep;74(3):372-80. doi: 10.1016/j.annemergmed.2019.02.002..
Keywords: Emergency Department, Imaging, Skin Conditions
Treister AD, Stefek H, Grimaldi D
Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography.
Atopic dermatitis (AD) is a prevalent, chronic, itchy skin condition. Children undergoing polysomnography (PSG) may coincidentally have AD. Many children with AD have sleep disturbances. This study aimed to characterize limb movements in children with AD and their effect on sleep. The investigators found altered PSG parameters in children with AD, suggesting that clinicians should consider the diagnosis when affected children undergo PSG.
AHRQ-funded; HS023011.
Citation: Treister AD, Stefek H, Grimaldi D .
Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography.
J Clin Sleep Med 2019 Aug 15;15(8):1107-13. doi: 10.5664/jcsm.7800..
Keywords: Children/Adolescents, Sleep Problems, Skin Conditions
Kates AE, Zimbric ML, Mitchell K
The impact of chlorhexidine gluconate on the skin microbiota of children and adults: a pilot study.
The authors examined the effect of chlorhexidine gluconate bathing on the skin microbiota of adult and pediatric patients. They observed no differences in pediatric patients, but multiple genera of bacteria were observed to be significantly less abundant in adults. They recommended further research to determine long-term impact.
AHRQ-funded; HS024039.
Citation: Kates AE, Zimbric ML, Mitchell K .
The impact of chlorhexidine gluconate on the skin microbiota of children and adults: a pilot study.
Am J Infect Control 2019 Aug;47(8):1014-16. doi: 10.1016/j.ajic.2019.01.024..
Keywords: Children/Adolescents, Skin Conditions, Healthcare-Associated Infections (HAIs), Prevention, Patient Safety
Blumenthal KG, Topaz M, Zhou L
Mining social media data to assess the risk of skin and soft tissue infections from allergen immunotherapy.
This study examined large social media databases including Facebook, Twitter, and Reddit to identify postings of rare incidents of contamination or infection from extracts for allergen immunotherapy (AIT). They used natural language processing (NLP) related to AIT from 2012 to 2016. They compared posts on adverse events for AIT compared to influenza vaccinations. The results showed that both types of posts are rare events.
AHRQ-funded; HS025375.
Citation: Blumenthal KG, Topaz M, Zhou L .
Mining social media data to assess the risk of skin and soft tissue infections from allergen immunotherapy.
J Allergy Clin Immunol 2019 Jul;144(1):129-34. doi: 10.1016/j.jaci.2019.01.029..
Keywords: Social Media, Skin Conditions, Adverse Events, Patient Safety, Vaccination, Risk
Ren Z, Laumann AE, Silverberg JI
Association of dermatomyositis with systemic and opportunistic infections in the United States.
This study examined whether dermatomyositis is associated with opportunistic and antibiotic-resistant infections. Data was analyzed from the Nationwide Inpatient Sample from 2002 to 2012 with a cross-sectional representative 20% sample of all hospitalizations in the US. There was an association found with serious infections in adults and children, with more associated with adults. Infections were found in the skin, bone, joints, brain, heart, lungs, and gastrointestinal system. Predictors of infections included non-white race/ethnicity, insurance status, history of long-term corticosteroid usage, Cushing’s syndrome, diabetes and cancer. This in turn caused higher odds, costs, and inpatient mortality from these infections.
AHRQ-funded; HS023011.
Citation: Ren Z, Laumann AE, Silverberg JI .
Association of dermatomyositis with systemic and opportunistic infections in the United States.
Arch Dermatol Res 2019 Jul;311(5):377-87. doi: 10.1007/s00403-019-01913-0..
Keywords: Antibiotics, Healthcare Cost and Utilization Project (HCUP), Infectious Diseases, Risk, Skin Conditions
Briscoe CC, Reich P, Fritz S
Staphylococcus aureus antibiotic susceptibility patterns in pediatric atopic dermatitis.
Researchers characterized Staphylococcus aureus strains recovered from pediatric atopic dermatitis patients with clinically apparent bacterial skin infections treated in an academic medical center. They conducted a five-year retrospective study to characterize the S aureus strains; patient demographics and dilute bleach bath usage were assessed to determine whether these factors were correlated with methicillin resistance. Culture results from the cohort were compared to those from pediatric patients presenting to a children's hospital emergency department with S aureus skin abscesses. The researchers concluded that first-generation cephalosporins remains an appropriate empiric therapy for most pediatric atopic dermatitis patients.
AHRQ-funded; HS021736; HS024269.
Citation: Briscoe CC, Reich P, Fritz S .
Staphylococcus aureus antibiotic susceptibility patterns in pediatric atopic dermatitis.
Pediatr Dermatol 2019 Jul;36(4):482-85. doi: 10.1111/pde.13867..
Keywords: Antibiotics, Children/Adolescents, Medication, Skin Conditions
Lee HH, Patel KR, Singam V
A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis.
This study analyzed the differences between childhood and adult-onset atopic dermatitis (AD). A systematic review was conducted using a range of online databases to find observational studies. A review was done of study title, abstract review, and data extraction. A pooled meta-analysis of the adult-onset AD was performed. A total of 25 studies met inclusion criteria. There were phenotypic differences across studies for adult-onset versus child-onset AD. This included higher rates of foot dermatitis and a personal history of atopy. It was found that 1 in 4 adults with AD report that it adult-onset.
AHRQ-funded; HS023011.
Citation: Lee HH, Patel KR, Singam V .
A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis.
J Am Acad Dermatol 2019 Jun;80(6):1526-32.e7. doi: 10.1016/j.jaad.2018.05.1241..
Keywords: Skin Conditions
Patel KR, Singam V, Vakharia pp
Measurement properties of three assessments of burden used in atopic dermatitis in adults.
The objectives of this study were to determine the content validity, construct validity, internal consistency, differential reporting, responsiveness, floor or ceiling effects and feasibility of the Dermatology Life Quality Index (DLQI), Itchy Quality of Life (ItchyQoL) and 5-dimensions (5-D) itch scales for assessing burden of AD in adults and to compare their performance.
AHRQ-funded; HS023011.
Citation: Patel KR, Singam V, Vakharia pp .
Measurement properties of three assessments of burden used in atopic dermatitis in adults.
Br J Dermatol 2019 May;180(5):1083-89. doi: 10.1111/bjd.17243..
Keywords: Skin Conditions, Healthcare Costs, Quality of Life