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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedAlrawashdeh M, Klompas M, Kimmel S
Epidemiology, outcomes, and trends of patients with sepsis and opioid-related hospitalizations in U.S. hospitals.
This study examined the epidemiology, outcomes, and trends of patients with sepsis and opioid-related hospitalizations in U.S. hospitals from January 2009 to September 2015. This retrospective cohort study looked at about 373 hospitals with a total of 6,715,286 hospitalizations. Using ICD-9 CM codes, 5.6% had sepsis, 1.9% had opioid-related hospitalizations, and 0.1% had both. Patients hospitalized with both diagnoses were younger and healthier, had more bloodstream infections from Gram-positive and fungal pathogens, and had lower in-hospital mortality rates. Of 1,803 patients with opioid-related hospitalizations who died in-hospital, 51.5% had sepsis. From 2009 to 2015, the proportion of sepsis hospitalizations that were opioid-related increased by 77%.
AHRQ-funded; HS025008.
Citation: Alrawashdeh M, Klompas M, Kimmel S .
Epidemiology, outcomes, and trends of patients with sepsis and opioid-related hospitalizations in U.S. hospitals.
Crit Care Med 2021 Dec;49(12):2102-11. doi: 10.1097/ccm.0000000000005141..
Keywords: Sepsis, Opioids, Hospitalization
Masonbrink AR, Harris M, Hall M
Safety events in children's hospitals during the COVID-19 pandemic.
The coronavirus disease 2019 (COVID-19) pandemic has impacted hospitals, potentially affecting quality and safety. The objective of this study was to compare pediatric hospitalization safety events during the pandemic versus previous years. The investigators concluded that postoperative sepsis rates increased among children hospitalized during COVID-19. They suggest that efforts are needed to improve safety of postoperative care for hospitalized children.
AHRQ-funded; HS024554; HS024592.
Citation: Masonbrink AR, Harris M, Hall M .
Safety events in children's hospitals during the COVID-19 pandemic.
Hosp Pediatr 2021 Jun;11(6):e95-e100. doi: 10.1542/hpeds.2020-004937..
Keywords: Children/Adolescents, COVID-19, Patient Safety, Sepsis, Adverse Events, Hospitalization, Hospitals, Inpatient Care, Infectious Diseases, Public Health
Kuye I, Anand V, Klompas M
Prevalence and clinical characteristics of patients with sepsis discharge diagnosis codes and short lengths of stay in U.S. hospitals.
The authors investigated the prevalence and clinical characteristics of patients diagnosed with sepsis in order to provide insight into how sepsis diagnoses are being applied as well as the breadth of illnesses encompassed by current sepsis definitions. In their study, they found that one in 10 patients who coded for sepsis were discharged alive within 3 days. Although most short-stay patients met systemic inflammatory response syndrome criteria, they met Sepsis-3 criteria less than half the time. These findings underscore the incomplete uptake of Sepsis-3 definitions, the breadth of illness severities encompassed by both traditional and new sepsis definitions, and the possibility that some patients with sepsis recover very rapidly.
AHRQ-funded; HS025008.
Citation: Kuye I, Anand V, Klompas M .
Prevalence and clinical characteristics of patients with sepsis discharge diagnosis codes and short lengths of stay in U.S. hospitals.
Crit Care Explor 2021 Mar;3(3):e0373. doi: 10.1097/cce.0000000000000373..
Keywords: Sepsis, Hospitalization