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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedChovatiya R, Silverberg JI
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
The purpose of this study was to determine whether chronic inflammatory skin disease (CISD) is associated with herpes zoster (HZ). Data from the Nationwide Inpatient Sample 2002-2012 were analyzed. Findings showed that many CISDs are associated with increased hospitalization for HZ, even below the ages recommended for HZ vaccination. Recommendations included additional studies to establish CISD-specific vaccination guidelines.
AHRQ-funded; HS023011.
Citation: Chovatiya R, Silverberg JI .
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
J Am Acad Dermatol 2021 Dec;85(6):1437-45. doi: 10.1016/j.jaad.2019.12.073..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Chronic Conditions
Cheng BT, Fishbein AB, Silverberg JI
Mental health symptoms and functional impairment in children with atopic dermatitis.
This study sought to determine the prevalence and predictors of social and behavioral symptoms and functional impairment among US children with atopic dermatitis (AD). Using MEPS data 1996-2015, findings showed that AD was associated with behavioral and functional impairment, similar to psoriasis and other common chronic conditions.
AHRQ-funded; HS023011.
Citation: Cheng BT, Fishbein AB, Silverberg JI .
Mental health symptoms and functional impairment in children with atopic dermatitis.
Dermatitis 2021 Sep-Oct;32(5):353-61. doi: 10.1097/der.0000000000000680..
Keywords: Children/Adolescents, Skin Conditions, Chronic Conditions, Behavioral Health
Fishbein AB, Lin B, Beaumont J
Nocturnal movements in children with atopic dermatitis have a timing pattern: a case-control study.
This case-control study compared nocturnal movements in children with atopic dermatitis (AD) with a control non-AD group. The study looked at nocturnal motor activity due to itch in children age 6 to 17 years with moderate-to-severe AD. The mean age of children with AD was 11.0 plus or minus 3.2 years, and without AD 11.5 plus or minute 3.3 years with the majority (65%) male. The AD scoring scale SCORAD was used to define moderate to severe AD. A home activity monitor, actigraphy and a sleep diary for 3 to 7 nights was used to monitor nocturnal movements and sleep. Activity counts were averaged across nights. Bouts of nocturnal activity increased in children with AD versus the controls between 1 and 6 hours after sleep onset. Nocturnal scratch activity peaks at 3 hours. Although AD patients were instructed to avoid oral antihistamine during the study, 5 patients took an antihistamine on some nights. Results showed no significant difference with respect to movement in the patients that took antihistamine some nights and not others. Timing of the nocturnal scratch behavior could potentially be targeted for treatment.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Lin B, Beaumont J .
Nocturnal movements in children with atopic dermatitis have a timing pattern: a case-control study.
J Am Acad Dermatol 2021 Aug;85(2):474-76. doi: 10.1016/j.jaad.2018.04.020..
Keywords: Children/Adolescents, Skin Conditions, Chronic Conditions
Lee S, Rastogi S, Hsu DY
Association of bullous pemphigoid and comorbid health conditions: a case-control study.
Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality. The purpose of the study was to identify the comorbid health conditions of bullous pemphigoid. The investigators concluded bullous pemphigoid patients needed screening for comorbid health conditions even though treatment options did not seem to be associated with these comorbidities.
AHRQ-funded; HS023011.
Citation: Lee S, Rastogi S, Hsu DY .
Association of bullous pemphigoid and comorbid health conditions: a case-control study.
Arch Dermatol Res 2021 Jul;313(5):327-32. doi: 10.1007/s00403-020-02100-2..
Keywords: Skin Conditions, Chronic Conditions
Chovatiya R, Lei D, Ahmed A
Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: a prospective observational study.
The purpose of this study was to determine the characteristics, associations, burden, and course of patients with atopic dermatitis (AD) using combined itch and lesional severity. Findings showed that combined itch and lesional severity seem to describe unique AD phenotypes. Recommendations included further studies to confirm these findings and to understand the optimal treatments for these groups.
AHRQ-funded; HS023011.
Citation: Chovatiya R, Lei D, Ahmed A .
Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: a prospective observational study.
Ann Allergy Asthma Immunol 2021 Jul;127(1):83-90.e2. doi: 10.1016/j.anai.2021.03.019..
Keywords: Skin Conditions, Chronic Conditions
Kirby JS, Hereford B, Thorlacius L
Validation of global item for assessing impact on quality of life of patients with Hidradenitis suppurativa.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease. The HS core outcome set calls for a patient global assessment (PtGA). The objective of this study was to assess the validity, reliability and responsiveness of a candidate single-item PtGA for HS-specific health-related quality of life (HRQoL). The investigators concluded that the single-item PtGA exhibited reliability, validity and responsiveness in assessing HS-specific HRQoL in HS, making it a good provisional tool for HS clinical research.
AHRQ-funded; HS024585.
Citation: Kirby JS, Hereford B, Thorlacius L .
Validation of global item for assessing impact on quality of life of patients with Hidradenitis suppurativa.
Br J Dermatol 2021 Apr;184(4):681-87. doi: 10.1111/bjd.19344..
Keywords: Skin Conditions, Quality of Life, Chronic Conditions