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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedMorrow EL, Mayberry LS, Duff MC
The growing gap: a study of sleep, encoding, and consolidation of new words in chronic traumatic brain injury.
Evidence from neuroscience emphasizes sleep as a crucial support for longitudinal memory and word learning. In numerous lab-based word learning experiments, participants encode and then retrieve new words within the same session. Single session designs are not adequate for capturing the full word learning process. Single session studies also inhibit exploration of the role of behavioral and lifestyle factors such as sleep in supporting longitudinal word learning. Adults with a history of traumatic brain injury (TBI), who experience challenges in the memory systems that support word learning and report related sleep disturbance, provide a unique opportunity to explore linkages between memory, sleep, and word learning. The purpose of this study was to evaluate longitudinal word learning and the influence of sleep on short- and long-term word recall in 50 adults with chronic moderate-severe traumatic brain injury (TBI) and 50 demographically matched neurotypical peers. Participants took part in the study over a two week period in their homes in an attempt to capture the process of real-world word learning and to measure sleep within normal living conditions. The study found that participants with TBI demonstrated a deficit in word learning that started at encoding, continued across time, and increased over the course of the week. The gap in performance between groups was greater at the 1-week post-test than the immediate post-test. Participants with and without TBI recalled more words when they slept after learning.
AHRQ-funded; HS026122.
Citation: Morrow EL, Mayberry LS, Duff MC .
The growing gap: a study of sleep, encoding, and consolidation of new words in chronic traumatic brain injury.
Neuropsychologia 2023 Jun 6; 184:108518. doi: 10.1016/j.neuropsychologia.2023.108518..
Keywords: Brain Injury, Chronic Conditions, Sleep Problems, Trauma
Johnson BN, McKernan L
Co-occurring trauma and non-suicidal self-injury among people with chronic pain: a systematic review.
The authors conducted a systematic review on the intersection of trauma, chronic pain, and non-suicidal self-injury (NSSI). They found that self-harm rates varied across studies, though appeared elevated among patients with chronic pain, and childhood trauma was linked to this co-occurrence. Further, causal links between trauma, NSSI, and pain were proposed, highlighting the need for a comprehensive theoretical model. They recommended assessing for childhood trauma when treating patients with chronic pain and querying regarding NSSI when patients present with indicators of NSSI risk and to treat or refer such patients to specialized treatment.
AHRQ-funded; HS022990.
Citation: Johnson BN, McKernan L .
Co-occurring trauma and non-suicidal self-injury among people with chronic pain: a systematic review.
Curr Pain Headache Rep 2021 Nov 11;25(11):70. doi: 10.1007/s11916-021-00984-x..
Keywords: Trauma, Behavioral Health, Chronic Conditions
Johnson BN, Lumley MA, Cheavens JS
Exploring the links among borderline personality disorder symptoms, trauma, and pain in patients with chronic pain disorders.
The authors compared study participants high or low on borderline personality disorder (BPD) symptoms on patterns of pain experience and types of child and adult traumas. They found that BPD symptoms were associated with increased clinical severity among patients with chronic pain as well as a unique manifestation of pain experiencing. Childhood trauma of all types is associated with chronic pain and BPD co-occurrence. They recommended that researchers and clinicians assess for BPD in people with chronic pain to enhance conceptual models of the transaction between these disorders and to improve clinical care.
AHRQ-funded; HS022990.
Citation: Johnson BN, Lumley MA, Cheavens JS .
Exploring the links among borderline personality disorder symptoms, trauma, and pain in patients with chronic pain disorders.
J Psychosom Res 2020 Aug;135:110164. doi: 10.1016/j.jpsychores.2020.110164..
Keywords: Behavioral Health, Trauma, Pain, Chronic Conditions
Kim J, Engelberg RA, Downey L
Predictors of advance care planning documentation in patients with underlying chronic illness who died of traumatic injury.
This study examined predictors of advance care planning (ACP) in patients with underlying chronic illness who died of traumatic injury. Death records and electronic health records were used to identify decedents with chronic life-limiting illness who died between 2010 and 2015. Only 22% of decedents at ACP documentation at the time of their traumatic injury. Patients who were older, had more chronic illnesses and more nonsurgical hospitalizations were more likely to have completed ACP documentation in the year before injury. After injury, only 4% completed ACP documentation who did not have it before.
AHRQ-funded; HS022982.
Citation: Kim J, Engelberg RA, Downey L .
Predictors of advance care planning documentation in patients with underlying chronic illness who died of traumatic injury.
J Pain Symptom Manage 2019 Nov;58(5):857-63.e1. doi: 10.1016/j.jpainsymman.2019.07.015..
Keywords: Patient-Centered Healthcare, Trauma, Chronic Conditions
McKernan LC, Johnson BN, Crofford LJ
Posttraumatic stress symptoms mediate the effects of trauma exposure on clinical indicators of central sensitization in patients with chronic pain.
This study examines the relationship between posttraumatic stress disorder (PTSD) and chronic pain involving central sensitization (CS). A sample of 202 patients (79% female) with chronic pain filled out surveys describing their trauma exposure, current PTSD symptoms, experiential avoidance and 3 manifestations of CS which are widespread pain, greater pain severity, and polysomatic symptom reporting. All 3 clinical indicators of CS were significantly associated with trauma exposure and PTSD symptoms. Further investigation is needed on the mediating effect of current PTSD symptoms.
AHRQ-funded; HS022990.
Citation: McKernan LC, Johnson BN, Crofford LJ .
Posttraumatic stress symptoms mediate the effects of trauma exposure on clinical indicators of central sensitization in patients with chronic pain.
Clin J Pain 2019 May;35(5):385-93. doi: 10.1097/ajp.0000000000000689..
Keywords: Chronic Conditions, Behavioral Health, Pain, Trauma