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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedAhmad FS, Ricket IM, Hammill BG BG
Computable phenotype implementation for a national, multicenter pragmatic clinical trial: lessons learned from ADAPTABLE.
This methods paper provides an overview of the development and implementation of a computable phenotype in ADAPTABLE (Aspirin Dosing: a Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness)--a pragmatic, randomized, open-label clinical trial testing the optimal dose of aspirin for secondary prevention of atherosclerotic cardiovascular disease events. Lessons learned included the following: the accuracy and utility of a computable phenotype are dependent on the quality of the source data; local validation and modification were required based on site factors; and sustained collaboration among a diverse team of researchers is needed during development and implementation. The ADAPTABLE computable phenotype served as an efficient method to recruit patients in a multisite pragmatic clinical trial.
AHRQ-funded; HS026385.
Citation: Ahmad FS, Ricket IM, Hammill BG BG .
Computable phenotype implementation for a national, multicenter pragmatic clinical trial: lessons learned from ADAPTABLE.
Circ Cardiovasc Qual Outcomes 2020 Jun;13(6):e006292. doi: 10.1161/circoutcomes.119.006292..
Keywords: Patient-Centered Outcomes Research, Research Methodologies, Heart Disease and Health, Cardiovascular Conditions
Roumie CL, Patel NJ, Munoz D
Design and outcomes of the Patient Centered Outcomes Research Institute coronary heart disease cohort study.
The objective was to electronically identify, recruit, and survey coronary heart disease (CHD) patients and describe their characteristics and willingness to participate in future research. The majority reported that their health was good or very good, while 40 percent reported that their general and physical health were fair or poor. A patient sample was provided with a trial summary which would randomize their aspirin dose; and 63 percent reported that they would consider participating.
AHRQ-funded; HS022990.
Citation: Roumie CL, Patel NJ, Munoz D .
Design and outcomes of the Patient Centered Outcomes Research Institute coronary heart disease cohort study.
Contemp Clin Trials Commun 2018 Jun;10:42-49. doi: 10.1016/j.conctc.2018.03.001.
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Keywords: Cardiovascular Conditions, Heart Disease and Health, Patient-Centered Outcomes Research, Research Methodologies