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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 5 of 5 Research Studies DisplayedSlatnick LR, Thornhill D, Deakyne Davies
Disseminated intravascular coagulation is an independent predictor of adverse outcomes in children in the emergency department with suspected sepsis.
The purpose of this study was to evaluate the impact of early disseminated intravascular coagulation (DIC) on illness severity in children using a database of emergency department ED encounters for children with suspected sepsis, in view of similar associations in adults. The investigators concluded that a DIC score of ≥3 was an independent predictor for both vasopressor use and mortality in this pediatric cohort, distinct from the adult overt DIC score cutoff of ≥5.
AHRQ-funded; HS025696.
Citation: Slatnick LR, Thornhill D, Deakyne Davies .
Disseminated intravascular coagulation is an independent predictor of adverse outcomes in children in the emergency department with suspected sepsis.
J Pediatr 2020 Oct;225:198-206.e2. doi: 10.1016/j.jpeds.2020.06.022..
Keywords: Children/Adolescents, Emergency Department, Sepsis, Adverse Events, Mortality, Patient Safety, Outcomes
Williams CN, Eriksson CO, Kirby A
Hospital mortality and functional outcomes in pediatric neurocritical care.
Pediatric neurocritical care (PNCC) outcomes research is scarce. In this study, the investigators aimed to expand knowledge about outcomes in PNCC by evaluating death and changes in Functional Status Scale (FSS) from baseline among PNCC diagnoses. The investigators concluded that PNCC patients had high rates of death and new disability at discharge, varying significantly between PNCC diagnoses. Multiple domains of disability were affected, underscoring the ongoing multidisciplinary health care needs of survivors.
AHRQ-funded; HS022981.
Citation: Williams CN, Eriksson CO, Kirby A .
Hospital mortality and functional outcomes in pediatric neurocritical care.
Hosp Pediatr 2019 Dec;9(12):958-66. doi: 10.1542/hpeds.2019-0173..
Keywords: Children/Adolescents, Newborns/Infants, Intensive Care Unit (ICU), Critical Care, Neurological Disorders, Mortality, Hospitals, Inpatient Care, Outcomes, Patient-Centered Outcomes Research
Spees LP, Martin PL, Kurtzberg J
Reduction in mortality after umbilical cord blood transplantation in children over a 20-year period (1995-2014).
Infections and graft-versus-host disease (GVHD) have historically resulted in high mortality among children undergoing umbilical cord blood transplantation (UCBT). However, recent advances in clinical practice have likely improved outcomes of these patients. In this paper, the authors report on a retrospective cohort study, they conducted, of children (<18years of age) undergoing UCBT at Duke University between January 1, 1995 and December 31, 2014.
AHRQ-funded; HS000032.
Citation: Spees LP, Martin PL, Kurtzberg J .
Reduction in mortality after umbilical cord blood transplantation in children over a 20-year period (1995-2014).
Biol Blood Marrow Transplant 2019 Apr;25(4):756-63. doi: 10.1016/j.bbmt.2018.11.018..
Keywords: Children/Adolescents, Mortality, Outcomes
Wilkes JJ, Hennessy S, Xiao R
Volume-outcome relationships in pediatric acute lymphoblastic leukemia: association between hospital pediatric and pediatric oncology volume with mortality and intensive care resources during initial therapy.
Researchers investigated if inpatient hospital volume influences outcomes. The objective of their study was to evaluate the relationship between inpatient pediatric and pediatric oncology volume and mortality and intensive care resources (ICU care). It concluded that induction mortality was low and that there was no inverse relationship between volume and mortality or ICU care.
AHRQ-funded; HS023419.
Citation: Wilkes JJ, Hennessy S, Xiao R .
Volume-outcome relationships in pediatric acute lymphoblastic leukemia: association between hospital pediatric and pediatric oncology volume with mortality and intensive care resources during initial therapy.
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):404-10.e1. doi: 10.1016/j.clml.2016.04.016.
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Keywords: Cancer, Children/Adolescents, Hospitalization, Mortality, Outcomes
Cauley RP, Potanos K, Fullington N
Pulmonary support on day of life 30 is a strong predictor of increased 1 and 5-year morbidity in survivors of congenital diaphragmatic hernia.
The researchers aimed to determine if the degree of pulmonary support (PS) on day of life 30 (DOL-30) could be a simple cross-institutional tool for identifying those patients with a higher risk of long-term morbidity. They found that PS on DOL-30 is a strong independent predictor of morbidity at 1 and 5-years and may be used as a simple prognostic tool to identify high-risk infants.
AHRQ-funded; HS019485.
Citation: Cauley RP, Potanos K, Fullington N .
Pulmonary support on day of life 30 is a strong predictor of increased 1 and 5-year morbidity in survivors of congenital diaphragmatic hernia.
J Pediatr Surg 2015 May;50(5):849-55. doi: 10.1016/j.jpedsurg.2014.12.007..
Keywords: Children/Adolescents, Mortality, Outcomes