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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedRoberts JE, Campbell JI, Gauvreau K
Differentiating multisystem inflammatory syndrome in children: a single-centre retrospective cohort study.
This study’s objective was to identify clinical and laboratory findings that distinguished multisystem inflammatory syndrome in children (MIS-C) from febrile illnesses in which MIS-C was considered but ultimately excluded, and to examine the diseases that most often mimicked MIS-C in a tertiary medical center. All children who were hospitalized at the author’s center with fever were evaluated for MIS-C and were compared for clinical signs and symptoms, SARS-CoV-2 status, and laboratory studies between those with and without MIS-C. The authors identified 50 confirmed MIS-C cases (MIS-C(+)) and 68 children evaluated for, but ultimately not diagnosed with, MIS-C (MIS-C(-)). Symptoms of conjunctivitis, abdominal pain, fatigue, hypoxaemia, tachypnoea and hypotension at presentation were significantly more common among MIS-C(+) patients, with MIS-C(+) and MIS-C(-) patients having similar elevations in C-reactive protein (CRP), but were differentiated by thrombocytopenia, lymphopenia, and elevated ferritin, neutrophil/lymphocyte ratio, BNP and troponin. Children hospitalized with MIS-C were older, more likely to present with conjunctivitis, oral mucosa changes, abdominal pain and hypotension, and had higher neutrophil/lymphocyte ratios and lower platelet counts.
AHRQ-funded; HS000063.
Citation: Roberts JE, Campbell JI, Gauvreau K .
Differentiating multisystem inflammatory syndrome in children: a single-centre retrospective cohort study.
Arch Dis Child 2022 Mar; 107(3):e3. doi: 10.1136/archdischild-2021-322290..
Keywords: Children/Adolescents, COVID-19, Chronic Conditions, Diagnostic Safety and Quality