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Search All Research Studies
Topics
- Antimicrobial Stewardship (2)
- Children/Adolescents (2)
- Critical Care (1)
- (-) Healthcare-Associated Infections (HAIs) (12)
- Hospitalization (1)
- Hospitals (1)
- Infectious Diseases (4)
- Intensive Care Unit (ICU) (2)
- Methicillin-Resistant Staphylococcus aureus (MRSA) (5)
- Neonatal Intensive Care Unit (NICU) (6)
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- Patient Safety (4)
- Prevention (5)
- Risk (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 12 of 12 Research Studies DisplayedSchuetz CR, Hogan PG, Reich PJ
Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates.
The purpose of this case-control study was to identify factors associated with development of symptomatic infection in infants colonized with methicillin-resistant Staphylococcus aureus (MRSA) in the Neonatal Intensive Care Unit (NICU). The investigators concluded that progression from MRSA colonization to symptomatic infection was associated with increased morbidity and may be mitigated through decolonization.
AHRQ-funded; HS021736; HS024269.
Citation: Schuetz CR, Hogan PG, Reich PJ .
Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates.
J Perinatol 2021 Jun;41(6):1285-92. doi: 10.1038/s41372-021-00944-8..
Keywords: Newborns/Infants, Neonatal Intensive Care Unit (NICU), Critical Care, Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs)
Milstone AM, Voskertchian A, Koontz DW
Effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the intensive care unit: a randomized clinical trial.
This study examined the effect of treating parents of neonates in the intensive care unit (NICUs) with intranasal mupirocin and topical chlorhexidine compared with a placebo treatment and whether it reduces transmission of Staphlyococcus aureus to their babies. A double-blind randomized trial was conducted at 2 tertiary NICUs in Baltimore, MD from November 2014 to December 2018. Parents were given intranasal treatments for 5 days. Of the intervention group 13 of 89 neonates acquired S aureus, and in the control group 29 of 101 neonates acquired S aureus with the same strain as their parents. The results showed a significant reduction in transmission.
AHRQ-funded; HS022872.
Citation: Milstone AM, Voskertchian A, Koontz DW .
Effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the intensive care unit: a randomized clinical trial.
JAMA 2020 Jan;323(4):295-386. doi: 10.1001/jama.2019.20785..
Keywords: Newborns/Infants, Intensive Care Unit (ICU), Healthcare-Associated Infections (HAIs), Infectious Diseases, Patient Safety, Prevention
Khamash DF, Mongodin EF, White JR
The association between the developing nasal microbiota of hospitalized neonates and Staphylococcus aureus colonization.
This research studied the association between hospitalized neonates who develop Staphylococcus aureus infections and nasal microbiota populations that preceded infection. Nares samples were obtained for neonates who were screened weekly for S. aureus. DNA was extracted and DNA of the bacterias were sequenced. It was found that controls and treated cases had a higher abundance of genes that contributed to the synthesis of natural antimicrobial compounds from several commensal bacterial types.
AHRQ-funded; HS022872.
Citation: Khamash DF, Mongodin EF, White JR .
The association between the developing nasal microbiota of hospitalized neonates and Staphylococcus aureus colonization.
Open Forum Infect Dis 2019 Apr;6(4):ofz062. doi: 10.1093/ofid/ofz062..
Keywords: Healthcare-Associated Infections (HAIs), Hospitalization, Hospitals, Infectious Diseases, Newborns/Infants
Akinboyo IC, Voskertchian A, Gorfu G
Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU.
In this single center retrospective cohort study, the investigators sought to examine neonatal risk factors associated with recurrent Staphylococcus aureus colonization and to determine the genetic relatedness of S. aureus strains cultured from neonates before and after decolonization.
AHRQ-funded; HS022872.
Citation: Akinboyo IC, Voskertchian A, Gorfu G .
Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU.
Infect Control Hosp Epidemiol 2018 Nov;39(11):1334-39. doi: 10.1017/ice.2018.223..
Keywords: Healthcare-Associated Infections (HAIs), Neonatal Intensive Care Unit (NICU), Newborns/Infants, Risk
Voskertchian A, Akinboyo IC, Colantuoni E
Association of an active surveillance and decolonization program on incidence of clinical cultures growing Staphylococcus aureus in the neonatal intensive care unit.
In this article, the authors discuss the association of an active surveillance and decolonization program on incidence of clinical cultures growing Staphylococcus aureus in the neonatal intensive care unit (NICU). They suggest that incorporating methicillin-susceptible S. aureus (MSSA) screening into a NICU’s infection control protocol may be an important step to reduce S. aureus infections in the vulnerable neonatal population.
AHRQ-funded; HS022872.
Citation: Voskertchian A, Akinboyo IC, Colantuoni E .
Association of an active surveillance and decolonization program on incidence of clinical cultures growing Staphylococcus aureus in the neonatal intensive care unit.
Infect Control Hosp Epidemiol 2018 Jul;39(7):882-84. doi: 10.1017/ice.2018.81..
Keywords: Healthcare-Associated Infections (HAIs), Healthcare-Associated Infections (HAIs), Infectious Diseases, Neonatal Intensive Care Unit (NICU), Newborns/Infants
Khamash DF, Voskertchian A, Milstone AM
Manipulating the microbiome: evolution of a strategy to prevent S. aureus disease in children.
Hospitalized infants have the highest rates of invasive Staphylococcus aureus disease of any population and infection control strategies such as decolonization have been insufficient. In this article, the authors review what is known about bacterial communities in the nasal cavity of infants and discuss how future microbiome studies may help identify novel interventions to protect high-risk infants from S. aureus disease.
AHRQ-funded; HS022872.
Citation: Khamash DF, Voskertchian A, Milstone AM .
Manipulating the microbiome: evolution of a strategy to prevent S. aureus disease in children.
J Perinatol 2018 Feb;38(2):105-09. doi: 10.1038/jp.2017.155..
Keywords: Healthcare-Associated Infections (HAIs), Infectious Diseases, Children/Adolescents, Prevention, Newborns/Infants, Patient Safety
Pierce R, Bryant K, Elward A
Bacterial infections in neonates following mupirocin-based MRSA decolonization: a multicenter cohort study.
This study characterized the risk of infection after MRSA decolonization with intranasal mupirocin. It concluded that in a multicentered cohort of MRSA-colonized neonates, mupirocin-based decolonization treatment appeared to decrease the risk of infection with select gram-positive organisms as intended, and the treatment was not significantly associated with risk of subsequent infections with organisms not covered by mupirocin's spectrum of activity.
AHRQ-funded; HS022872.
Citation: Pierce R, Bryant K, Elward A .
Bacterial infections in neonates following mupirocin-based MRSA decolonization: a multicenter cohort study.
Infect Control Hosp Epidemiol 2017 Aug;38(8):930-36. doi: 10.1017/ice.2017.108.
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Keywords: Healthcare-Associated Infections (HAIs), Methicillin-Resistant Staphylococcus aureus (MRSA), Newborns/Infants, Patient Safety
Pierce R, Lessler J, Popoola VO
Meticillin-resistant Staphylococcus aureus (MRSA) acquisition risk in an endemic neonatal intensive care unit with an active surveillance culture and decolonization programme.
The researchers measured the association between colonization pressure from decolonized and non-decolonized neonates and methicillin-resistant staphylococcus aureus (MRSA) and MRSA acquisition to inform use of this strategy for control of endemic MRSA. They concluded that untreated MRSA carriers were an important reservoir for transmission. Decolonized patients on contact isolation posed no detectable transmission threat, supporting the hypothesis that decolonization may reduce patient-to-patient transmission.
AHRQ-funded; HS022872.
Citation: Pierce R, Lessler J, Popoola VO .
Meticillin-resistant Staphylococcus aureus (MRSA) acquisition risk in an endemic neonatal intensive care unit with an active surveillance culture and decolonization programme.
J Hosp Infect 2017 Jan;95(1):91-97. doi: 10.1016/j.jhin.2016.10.022.
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Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Neonatal Intensive Care Unit (NICU), Prevention, Newborns/Infants
Reich PJ, Boyle MG, Hogan PG
Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge.
Methicillin-resistant Staphylococcus aureus (MRSA) infections cause significant morbidity and mortality in neonatal intensive care units (NICUs). The researchers characterized the clinical and molecular epidemiology of MRSA strains colonizing NICU patients. They found that community-acquired MRSA strains are prominent in the NICU and associated with distinct risk factors.
AHRQ-funded; HS021736; HS024269.
Citation: Reich PJ, Boyle MG, Hogan PG .
Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge.
Clin Microbiol Infect 2016 Jul;22(7):645.e1-8. doi: 10.1016/j.cmi.2016.04.013.
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Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Neonatal Intensive Care Unit (NICU), Patient Safety, Prevention, Antimicrobial Stewardship, Newborns/Infants, Healthcare-Associated Infections (HAIs)
Popoola VO, Colantuoni E, Suwantarat N
Active surveillance cultures and decolonization to reduce staphylococcus aureus infections in the neonatal intensive care unit.
The researchers examined the impact of methicillin-susceptible S. aureus (MSSA) decolonization on the incidence of MSSA infection and to measure the prevalence of mupirocin resistance. They found that active surveillance cultures and decolonization may be effective in decreasing S. aureus infections in NICUs.
AHRQ-funded; HS022872.
Citation: Popoola VO, Colantuoni E, Suwantarat N .
Active surveillance cultures and decolonization to reduce staphylococcus aureus infections in the neonatal intensive care unit.
Infect Control Hosp Epidemiol 2016 Apr;37(4):381-7. doi: 10.1017/ice.2015.316..
Keywords: Healthcare-Associated Infections (HAIs), Healthcare-Associated Infections (HAIs), Intensive Care Unit (ICU), Methicillin-Resistant Staphylococcus aureus (MRSA), Newborns/Infants
Cocoros NM, Kleinman K, Priebe GP
Ventilator-associated events in neonates and children--a new paradigm.
The objective of this study was to identify a pediatric ventilator-associated condition definition for use in neonates and children by exploring whether potential ventilator-associated condition definitions identify patients with worse outcomes. It found that pediatric patients with ventilator-associated conditions are at substantially higher risk for mortality and morbidity across ICUs, regardless of thresholds used.
AHRQ-funded; HS021636.
Citation: Cocoros NM, Kleinman K, Priebe GP .
Ventilator-associated events in neonates and children--a new paradigm.
Crit Care Med 2016 Jan;44(1):14-22. doi: 10.1097/ccm.0000000000001372.
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Keywords: Children/Adolescents, Healthcare-Associated Infections (HAIs), Healthcare-Associated Infections (HAIs), Newborns/Infants, Children/Adolescents
Milstone AM, Koontz DW, Voskertchian A
Treating parents to reduce NICU transmission of Staphylococcus aureus (TREAT PARENTS) trial: protocol of a multisite randomised, double-blind, placebo-controlled trial.
This study looks to measure the effect of treating parents with short course intranasal mupirocin and topical chlorhexidine antisepsis on acquisition of S. aureus colonisation and infection in neonates. The primary outcome will be neonatal acquisition of an S. aureus strain that is concordant to the parental baseline S. aureus strain.
AHRQ-funded; HS022872.
Citation: Milstone AM, Koontz DW, Voskertchian A .
Treating parents to reduce NICU transmission of Staphylococcus aureus (TREAT PARENTS) trial: protocol of a multisite randomised, double-blind, placebo-controlled trial.
BMJ Open 2015 Sep 09;5(9):e009274. doi: 10.1136/bmjopen-2015-009274.
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Keywords: Healthcare-Associated Infections (HAIs), Newborns/Infants, Antimicrobial Stewardship, Prevention, Neonatal Intensive Care Unit (NICU)