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Search All Research Studies
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- Children/Adolescents (4)
- Chronic Conditions (1)
- Comparative Effectiveness (1)
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- Outcomes (4)
- (-) Patient-Centered Outcomes Research (16)
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- (-) Skin Conditions (16)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 16 of 16 Research Studies DisplayedFishbein AB, Lor J, Penedo FJ
Patient-reported outcomes for measuring sleep disturbance in pediatric atopic dermatitis: cross-sectional study of the patient reported outcomes measurement information system pediatric sleep measures and actigraphy.
The purposes of this cross-sectional study were to test the Patient-Reported Outcomes Measurement Information System (PROMIS) sleep measures in pediatric atopic dermatitis (AD) and to develop an algorithm to screen, evaluate, and intervene to reduce sleep disturbances. Participants were children with AD aged 5 to 17 and one parent who completed sleep, itch, and AD-specific questionnaires. Clinicians assessed disease severity. PROMIS sleep disturbance parent proxy reliability was high and was differentiated among Patient-Oriented Eczema Measure (POEM)-determined disease severity groups. The authors concluded that sleep disturbance in pediatric AD should be screened using the POEM sleep question, and further assessment using the PROMIS sleep disturbance measure or objective sleep monitoring if it is needed.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Lor J, Penedo FJ .
Patient-reported outcomes for measuring sleep disturbance in pediatric atopic dermatitis: cross-sectional study of the patient reported outcomes measurement information system pediatric sleep measures and actigraphy.
J Am Acad Dermatol 2023 Feb; 88(2):348-56. doi: 10.1016/j.jaad.2020.05.138..
Keywords: Children/Adolescents, Sleep Problems, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lai Cella, D D
Reliability and meaningful change of the Patient-Reported Outcomes Measurement Information System(®) Itch Questionnaire (PIQ) item banks in adults with atopic dermatitis.
The Patient-Reported Outcomes Measurement Information System Itch Questionnaire (PIQ), includes a suite of patient-reported outcome measures to assess the burden of itch in adults. In this study, the investigators sought to determine the smallest detectable change (SDC), threshold for meaningful improvement and test–retest reliability of PIQ item banks for assessing the burden of itch in adult AD.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lai Cella, D D .
Reliability and meaningful change of the Patient-Reported Outcomes Measurement Information System(®) Itch Questionnaire (PIQ) item banks in adults with atopic dermatitis.
Br J Dermatol 2021 Aug;185(2):438-39. doi: 10.1111/bjd.20066..
Keywords: Skin Conditions, Patient-Centered Outcomes Research, Outcomes, Diagnostic Safety and Quality
Silverberg JI, Lei D, Yousaf M
What are the best endpoints for eczema area and severity index and scoring atopic dermatitis in clinical practice? A prospective observational study.
This prospective observational study’s objective was to determine the minimal important changes (MICs) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis (SCORAD) across all severities of atopic dermatitis (AD). Questionnaires and evaluation by a dermatologist (n =826) were used to determine the MIC of percentage and absolute improvement of EASI and SCORAD scores in adults and children. Absolute MICs for EASI, SCORAD, and O-SCORAD varied by baseline severity and EASI 50, SCORAD 35 and O-SCORAD 35 were meaningful percentage MICs regardless of baseline AD severity.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
What are the best endpoints for eczema area and severity index and scoring atopic dermatitis in clinical practice? A prospective observational study.
Br J Dermatol 2021 May;184(5):888-95. doi: 10.1111/bjd.19457..
Keywords: Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lei D, Yousaf M
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
This study’s goal was to determine the measurement properties of the product of validated Investigator’s Global Assessment for AD and body surface area (vIGA*BSA) for atopic dermatitis (AD) severity. The authors performed a prospective practice-based study using questionnaires and evaluation by a dermatologist (n = 653). The vIGA*BSA can also be divided into six categories (vIGA*cBSA: 0%/0.1, <10%/10, <30%/30, <50%/50, <70%/70 and <90%/90-100%)). The assessment was compared with other rating scales such as SCORAD, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, ItchyOOL, PROMISE Sleep Disturbance, and sleep-related impairment. Scores showed good convergent and discriminant validity, reliability, responsiveness and interpretability in adults and children with AD.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
J Eur Acad Dermatol Venereol 2021 Jan;35(1):180-87. doi: 10.1111/jdv.16846..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lei D, Yousaf M
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
This study looked at the measurement properties of the Rajka-Langeland severity score for atopic dermatitis (AD) in children and adults and compared it with other clinician-reported outcomes. The study used questionnaires and evaluation by a dermatologist (n = 427). Rajka-Langeland had good concurrent validity with the Eczema Area and Severity Index and body surface area; good convergent validity with the numeric rating scale average-itch and worst-itch, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, Patient Reported Outcomes Measurement Information System Itch Questionnaire in adults and/or children; fair discriminant validity for patient- and physician reported global AD severity; good responsive to change of severity of AD and itch; and good reliability, internal consistency; with no floor or ceiling effects.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
Br J Dermatol 2021 Jan;184(1):87-95. doi: 10.1111/bjd.19159..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Hong MR, Lei D, Yousaf M
A real-world study of the longitudinal course of adult atopic dermatitis severity in clinical practice.
This study examined the longitudinal course of adult atopic dermatitis (AD) severity in clinical practice. Dermatology patients were assessed at approximately 6,12, 18, and 24 months by the scoring systems Eczema Area and Severity Index (EASI) and objective-Scoring Atopic Dermatitis (objective-SCORAD). At any visit, 36.2% of cases were scored as moderate, and 18.2% were severe. Among those patients, 25% and 18.6% continued to have moderate or severe scores at 1 or more follow-up visits for EASI, and 22.6% and 24.5% moderate or severe objective-SCORAD scores respectively. Many patients had fluctuating severity scores over time and a minority had persistently moderate or severe lesions over time, and most of those patients were unable to achieve persistent lesional clearance.
AHRQ-funded; HS023011.
Citation: Hong MR, Lei D, Yousaf M .
A real-world study of the longitudinal course of adult atopic dermatitis severity in clinical practice.
Ann Allergy Asthma Immunol 2020 Dec;125(6):686-92.e3. doi: 10.1016/j.anai.2020.07.005.
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Keywords: Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lai JS, Patel KR
Measurement properties of the Patient-Reported Outcomes Information System (PROMIS(®) ) Itch Questionnaire: itch severity assessments in adults with atopic dermatitis.
This study evaluated the validity of numeric rating scales (NRS) and verbal rating scales (VRS) for itch and itch frequency for assessing itch severity in atopic dermatitis (AD). The authors evaluated the Patient-Reported Outcomes Information System (PROMIS(®) ) Itch Questionnaire (PIQ) - itch severity assessment, including multiple NRS, VRS and frequency of itch assessments, in adults with AD and compared their performance. The evaluation involved self-administered questionnaires and skin examinations performed in 410 patients with AD (aged 18-90 years) in a dermatology practice setting. PIQ NRS, VRS and frequency of itch had good content validity, strong correlations with one another and weak-to-moderate correlations with patient-oriented eczema measure (POEM), Eczema Area and Severity Index (EASI), objective SCORing AD (SCORAD) and Dermatology Life Quality Index (DLQI) and very good discriminant validity.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lai JS, Patel KR .
Measurement properties of the Patient-Reported Outcomes Information System (PROMIS(®) ) Itch Questionnaire: itch severity assessments in adults with atopic dermatitis.
Br J Dermatol 2020 Nov;183(5):891-98. doi: 10.1111/bjd.18978..
Keywords: Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice, Outcomes
Silverberg JI, Lei D, Yousaf M
Comparison of Patient-Oriented Eczema Measure and Patient-Oriented Scoring Atopic Dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis: a validation study.
Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM). The purpose of this study was to examine the measurement properties of PO-SCORAD and compare them with those of POEM. The investigators concluded that PO-SCORAD and POEM had good construct and cross-cultural validity, reliability, and responsiveness in adults with AD and were feasible for use in clinical trials and practice.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Comparison of Patient-Oriented Eczema Measure and Patient-Oriented Scoring Atopic Dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis: a validation study.
Ann Allergy Asthma Immunol 2020 Jul;125(1):78-83. doi: 10.1016/j.anai.2020.03.006..
Keywords: Skin Conditions, Research Methodologies, Patient-Centered Outcomes Research
Kirby JS, Butt M, King T
Severity and Area Score for Hidradenitis (SASH): a novel outcome measurement for hidradenitis suppurativa.
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease with a large impact on patients' health-related quality of life. However, reliable and consistent outcome measures to assess body surface area (BSA) of HS have not been established. The objectives of this study were to develop and assess the reliability and validity of a novel outcome instrument for assessment of HS BSA in a clinical trial setting.
AHRQ-funded; HS024585.
Citation: Kirby JS, Butt M, King T .
Severity and Area Score for Hidradenitis (SASH): a novel outcome measurement for hidradenitis suppurativa.
Br J Dermatol 2020 Apr;182(4):940-48. doi: 10.1111/bjd.18244..
Keywords: Skin Conditions, Chronic Conditions, Patient-Centered Outcomes Research, Outcomes
Lei D, Yousaf M, Janmohamed SR
Validation of four single-item patient-reported assessments of sleep in adult atopic dermatitis patients.
The purpose of this study was to assess the measurement properties of sleep-related items from the Patient-Oriented Eczema Measure (POEM), SCORing AD (SCORAD), 5-dimensions of itch (5D), and Itch-Related Quality of Life (ItchyQOL) in adults with atopic dermatitis (AD). Results showed modest overlap and weak to moderate concordance of responses to the different assessments. The researchers conclude that sleep-related items from POEM, SCORAD, 5D, and ItchyQOL showed good validity and responsiveness to monitor sleep disturbances in adult AD patients.
AHRQ-funded; HS023011.
Citation: Lei D, Yousaf M, Janmohamed SR .
Validation of four single-item patient-reported assessments of sleep in adult atopic dermatitis patients.
Ann Allergy Asthma Immunol 2020 Mar;124(3):261-66. doi: 10.1016/j.anai.2019.12.002..
Keywords: Sleep Problems, Skin Conditions, Quality of Life, Patient-Centered Outcomes Research
Greenhawt M, Shaker M
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
The authors sought to identify scenarios in which current early peanut introduction guidelines would be cost-effective. They found that the current screening approach to early peanut introduction could be cost-effective at a particular health utility for an in-clinic reaction, skin prick test sensitivity and specificity, and high baseline peanut allergy prevalence among high-risk infants. However, such conditions are unlikely to be plausible to achieve realistically. They recommend further research to define the health state utility associated with reaction location.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Shaker M .
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
JAMA Netw Open 2019 Dec 2;2(12):e1918041. doi: 10.1001/jamanetworkopen.2019.18041..
Keywords: Patient-Centered Outcomes Research, Newborns/Infants, Children/Adolescents, Respiratory Conditions, Skin Conditions, Screening, Healthcare Costs, Evidence-Based Practice, Guidelines
Vakharia PP, Chopra R, Sacotte R
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Several patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, such as the Patient-Oriented Eczema Measure (POEM), while others pertain to itch, for example the numerical rating scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatological disease in general, for example the Dermatology Life Quality Index (DLQI). The purpose of this study was to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQoL and 5-D itch scale for use in adults with AD.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Br J Dermatol 2018 Apr;178(4):925-30. doi: 10.1111/bjd.16078..
Keywords: Outcomes, Patient-Centered Outcomes Research, Quality of Life, Skin Conditions
Vakharia PP, Chopra R, Silverberg JI
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
This study sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally. The results highlighted the lack of uniformity and documentation of atopic dermatitis diagnostic criteria in randomized controlled trials for atopic dermatitis. The investigators recommended harmonizing the diagnostic criteria for atopic dermatitis in future randomized controlled trials.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Silverberg JI .
Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials.
Am J Clin Dermatol 2018 Feb;19(1):15-22. doi: 10.1007/s40257-017-0299-4..
Keywords: Diagnostic Safety and Quality, Patient-Centered Outcomes Research, Research Methodologies, Skin Conditions
Chopra R, Vakharia PP, Sacotte R
Efficacy of bleach baths in reducing severity of atopic dermatitis: a systematic review and meta-analysis.
This study sought to determine the efficacy of bleach vs water baths at decreasing atopic dermatitis (AD) severity. In pooled analyses, there were no significant differences observed between bleach vs water baths at 4 weeks vs baseline for the Eczema Area and Severity Index. Although bleach baths are effective in decreasing AD severity, they do not appear to be more effective than water baths alone.
AHRQ-funded; HS023011.
Citation: Chopra R, Vakharia PP, Sacotte R .
Efficacy of bleach baths in reducing severity of atopic dermatitis: a systematic review and meta-analysis.
Ann Allergy Asthma Immunol 2017 Nov;119(5):435-40. doi: 10.1016/j.anai.2017.08.289.
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Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Skin Conditions
Greenhawt M, Fleischer DM, Chan ES
LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction.
This study explored relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race. It concluded that increasing peanut wheal size predicted peanut tolerance only in the avoidance arm. Peanut introduction between 6 and 11 months of age was associated with the highest rates of peanut tolerance, questioning the 'urgency' of introduction before 6 months.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Fleischer DM, Chan ES .
LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction.
Allergy 2017 Aug;72(8):1254-60. doi: 10.1111/all.13100.
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Keywords: Evidence-Based Practice, Nutrition, Skin Conditions, Patient-Centered Outcomes Research
Kwa MC, Ardalan K, Laumann AE
Validation of International Classification of Diseases codes for the epidemiologic study of dermatomyositis.
The authors assessed the validity of using ICD-9-CM code 710.3 to identify adult patients with dermatomyositis in outpatient and inpatient settings. They found that one or more occurrences of ICD-9 code 710.3 is insufficient to support the diagnosis of dermatomyositis in the outpatient setting, but that ICD-9 710.3 codes appear to be valid in the inpatient setting.
AHRQ-funded; HS023011.
Citation: Kwa MC, Ardalan K, Laumann AE .
Validation of International Classification of Diseases codes for the epidemiologic study of dermatomyositis.
Arthritis Care Res 2017 May;69(5):753-57. doi: 10.1002/acr.23010.
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Keywords: Diagnostic Safety and Quality, Patient-Centered Outcomes Research, Skin Conditions