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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedAsti L, Hopley C, Avelis C
The potential clinical and economic value of a human papillomavirus primary screening test that additionally identifies genotypes 31, 45, 51, and 52 individually.
This study looked at the potential clinical and economic value of a human papillomavirus (HPV) primary screening test that additionally identified genotypes 31,45,51, and 52 along with genotypes 16 and 18. The authors developed a Markov model of the HPV disease course and evaluated the clinical and economic value of HPV primary screening with Onclarity. Currently HPV primary screening results in 25,194 invasive procedures and 48 invasive cervical cancer (ICC) cases per 100,000 women. Screening with extended genotyping and later screening women with certain genotypes averted 903 to 3163 invasive procedures and results in 0 to 3 more ICC cases compared with current primary screening tests. Extended genotyping was cost effective when costing $75 and cost saving when costing $43. When the probabilities of disease progression increased 2-4 times, it was not cost-effective because it resulted in more ICC cases and accrued fewer quality-adjusted life-years.
AHRQ-funded; HS023317.
Citation: Asti L, Hopley C, Avelis C .
The potential clinical and economic value of a human papillomavirus primary screening test that additionally identifies genotypes 31, 45, 51, and 52 individually.
Sex Transm Dis 2021 May;48(5):370-80. doi: 10.1097/olq.0000000000001327.
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Keywords: Sexual Health, Infectious Diseases, Screening, Diagnostic Safety and Quality, Genetics, Cancer: Cervical Cancer, Cancer, Women
Taylor BD, Totten PA, Astete SG
Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.
Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). This study determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID). The investigators concluded that host gene variants in TLR2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical PID.
AHRQ-funded; HS008358.
Citation: Taylor BD, Totten PA, Astete SG .
Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.
Am J Reprod Immunol 2018 Feb;79(2). doi: 10.1111/aji.12804..
Keywords: Genetics, Sexual Health, Women
Taylor BD, Zheng X, Darville T
Whole-exome sequencing to identify novel biological pathways associated with infertility after pelvic inflammatory disease.
The researchers used whole-exome sequencing to identify biological pathways that may be associated with STI-related infertility. Pathway analysis revealed that focus genes were enriched in canonical pathways including, IL-1 signaling, P2Y purinergic receptor signaling, and bone morphogenic protein signaling. Targeted sequencing of biological pathways identified in this study may provide insight into STI-related infertility.
AHRQ-funded; HS008358.
Citation: Taylor BD, Zheng X, Darville T .
Whole-exome sequencing to identify novel biological pathways associated with infertility after pelvic inflammatory disease.
Sex Transm Dis 2017 Jan;44(1):35-41. doi: 10.1097/olq.0000000000000533.
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Keywords: Genetics, Sexual Health, Women