National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (1)
- Adverse Events (1)
- (-) Anxiety (20)
- Asthma (1)
- Behavioral Health (17)
- Cancer (2)
- Cancer: Breast Cancer (1)
- Cancer: Prostate Cancer (1)
- Children/Adolescents (7)
- Chronic Conditions (3)
- COVID-19 (2)
- (-) Depression (20)
- Diagnostic Safety and Quality (3)
- Domestic Violence (1)
- Elderly (1)
- Electronic Health Records (EHRs) (1)
- Emergency Department (1)
- Evidence-Based Practice (1)
- Family Health and History (1)
- Health Information Technology (HIT) (2)
- Health Services Research (HSR) (1)
- Implementation (2)
- Injuries and Wounds (1)
- Medication (2)
- Men's Health (1)
- Neurological Disorders (2)
- Outcomes (2)
- Pain (1)
- Patient-Centered Healthcare (1)
- Patient-Centered Outcomes Research (5)
- Patient Safety (1)
- Primary Care (2)
- Public Health (1)
- Quality Improvement (1)
- Quality of Care (1)
- Quality of Life (2)
- Research Methodologies (1)
- Respiratory Conditions (2)
- Screening (3)
- Shared Decision Making (1)
- Tobacco Use (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 20 of 20 Research Studies DisplayedTitus AR, Mezuk B, Hirschtick JL
Patterns and predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in Michigan.
Researchers examined the intersection of demographic, economic, and illness-related predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in Michigan. Data were taken from a population-based survey of Michigan adults who experienced a COVID-19 diagnosis prior to August 2020. Results indicated that relative risks for experiencing poor mental health outcomes varied by race/ethnicity, sex, age, and income. Symptom severity was associated with a higher burden of comorbid depressive/anxiety symptoms. "Long COVID" was associated with all outcomes. The researchers concluded that because of overlapping risk factors, integrated approaches to treating depressive/anxiety symptoms among COVID-19 survivors is warranted.
AHRQ-funded; HS026120.
Citation: Titus AR, Mezuk B, Hirschtick JL .
Patterns and predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in Michigan.
Soc Psychiatry Psychiatr Epidemiol 2023 Jul; 58(7):1099-108. doi: 10.1007/s00127-023-02453-9..
Keywords: COVID-19, Depression, Anxiety, Behavioral Health
Ortiz D, Perkins AJ, Fuchita M
Pre-existing anxiety and depression in injured older adults: an under-recognized comorbidity with major health implications.
The purpose of this retrospective post-hoc analysis study was to evaluate variations in baseline depression and anxiety screenings between older injured patients with pre-existing diagnoses and those without. Data from the Trauma Medical Home, a multicenter randomized controlled trial was used for analysis. The study found that almost 50% of the patients screened positive for at least mild depressive symptoms as measured by the Patient Health Questionnaire-9, and 41% of the patients screened positive for at least mild anxiety symptoms as measured by the Generalized Anxiety Disorder Scale. Female patients with a history of concurrent anxiety and depression, greater injury severity scores, and higher Charlson scores were more likely to have mild anxiety at the baseline assessment. Patients with a history of depression only, a prior history of depression and concurrent anxiety, and higher Charlson scores (greater medical comorbidity) were more likely to have experienced at least mild depression at the time of hospital discharge after traumatic injury.
AHRQ-funded; HS026390.
Citation: Ortiz D, Perkins AJ, Fuchita M .
Pre-existing anxiety and depression in injured older adults: an under-recognized comorbidity with major health implications.
Ann Surg Open 2022 Dec; 3(4):e217. doi: 10.1097/as9.0000000000000217..
Keywords: Elderly, Anxiety, Depression, Behavioral Health, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Injuries and Wounds
Richmond J, Sanderson M, Shrubsole MJ
Psychosocial impact of COVID-19 among adults in the southeastern United States.
The authors investigated factors associated with depressive and anxiety symptoms during the COVID-19 pandemic. Using data from the Southern Community Cohort Study (SCCS), their results overall suggested that individuals in fair/poor health, living alone, and/or experiencing decreased physical activity and vegetable/fruit consumption have higher risk of depressive and anxiety symptoms. They recommended clinical and public health interventions to support individuals experiencing depression and anxiety during the COVID-19 pandemic.
AHRQ-funded; HS026122.
Citation: Richmond J, Sanderson M, Shrubsole MJ .
Psychosocial impact of COVID-19 among adults in the southeastern United States.
Prev Med 2022 Oct;163:107191. doi: 10.1016/j.ypmed.2022.107191..
Keywords: COVID-19, Anxiety, Depression, Behavioral Health, Public Health
Munger Clary HM, Croxton RD, Snively BM
Neurologist prescribing versus psychiatry referral: examining patient preferences for anxiety and depression management in a symptomatic epilepsy clinic sample.
The objective of this study was to determine patient preference for anxiety and/or depression prescribing by neurologists versus psychiatry referral among an adult epilepsy clinic sample of symptomatic patients. Findings showed that most patients indicated a preference for neurologists to prescribe for anxiety or depression symptoms in the epilepsy clinic. Care models involving neurologist prescribing for anxiety and depression symptoms merit further investigation and potential adoption in clinical practice.
AHRQ-funded; HS025723.
Citation: Munger Clary HM, Croxton RD, Snively BM .
Neurologist prescribing versus psychiatry referral: examining patient preferences for anxiety and depression management in a symptomatic epilepsy clinic sample.
Epilepsy Behav 2021 Jan;114(Pt A):107543. doi: 10.1016/j.yebeh.2020.107543..
Keywords: Anxiety, Depression, Behavioral Health, Neurological Disorders
Liu FF, Lew A, Andes E
Implementation strategies for depression and anxiety screening in a pediatric cystic fibrosis center: a quality improvement project.
The objective of this study was to share key strategies that led to successful mental health screening (MHS) implementation in one pediatric cystic fibrosis center and to report implementation and screening outcomes. Results showed that leveraging coproduction to address stakeholder needs led to successful implementation of a sustainable MHS process.
AHRQ-funded; HS026393.
Citation: Liu FF, Lew A, Andes E .
Implementation strategies for depression and anxiety screening in a pediatric cystic fibrosis center: a quality improvement project.
Pediatr Pulmonol 2020 Dec;55(12):3328-36. doi: 10.1002/ppul.24951..
Keywords: Children/Adolescents, Respiratory Conditions, Chronic Conditions, Depression, Anxiety, Behavioral Health, Screening, Implementation, Quality Improvement, Quality of Care, Diagnostic Safety and Quality
Radovic A, Odenthal K, Flores AT
Prescribing technology to increase uptake of depression treatment in primary care: a pre-implementation focus group study of SOVA (Supporting Our Valued Adolescents).
Supporting Our Valued Adolescents (SOVA) is a web-based technology intervention designed to increase depression and anxiety treatment uptake by adolescents in the context of an anonymous peer community with an accompanying website for parents. With a goal of informing the design of a hybrid effectiveness-implementation randomized controlled trial, we conducted a pre-implementation study in two primary care practices to guide implementation strategy development. We conducted focus groups with primary care providers (PCPs) at three different timepoints with PCPs (14 total) from two community practices.
AHRQ-funded; HS022989.
Citation: Radovic A, Odenthal K, Flores AT .
Prescribing technology to increase uptake of depression treatment in primary care: a pre-implementation focus group study of SOVA (Supporting Our Valued Adolescents).
J Clin Psychol Med Settings 2020 Dec;27(4):766-82. doi: 10.1007/s10880-019-09669-5.
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Keywords: Children/Adolescents, Depression, Anxiety, Behavioral Health, Primary Care, Health Information Technology (HIT), Implementation
Erim DO, Bennett AV, Gaynes BN
Associations between prostate cancer-related anxiety and health-related quality of life.
This study followed prostate cancer patients who were enrolled in the cohort study North Cancer Prostate Cancer Comparative Effectiveness & Survivorship Study (NC ProCess) from January 2011 and June 2013. A 1-year follow-up survey was done to assess prostate cancer-related anxiety (PCRA) in the cohort. The researchers were interested in the association between PCRA and health-related quality of life (HRQOL). The risk of probable depression was significantly higher in participants with clinically significant PCRA compared with those without it.
AHRQ-funded; 29020050040I.
Citation: Erim DO, Bennett AV, Gaynes BN .
Associations between prostate cancer-related anxiety and health-related quality of life.
Cancer Med 2020 Jun;9(12):4467-73. doi: 10.1002/cam4.3069..
Keywords: Cancer: Prostate Cancer, Cancer, Anxiety, Quality of Life, Men's Health, Patient-Centered Outcomes Research, Depression, Evidence-Based Practice
Munger Clary HM, Croxton RD, Allan J
Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic.
This study assessed the willingness of epilepsy patients positively screened for anxiety and/or depression to participate in a research study. A total of 199 patients screened positively during a routine epilepsy screening visit and 154 (77.4%) opted-in for further research assessment. Nearly half of those 199 individuals were already being treated for anxiety and/or depression, with 46.7% receiving neither antidepressants or therapy. Higher depression scores and current treatment were independently associated with opting in. One-quarter reported a past psychiatric hospitalization, but only half of those individuals were currently receiving mental health specialty care.
AHRQ-funded; HS025723.
Citation: Munger Clary HM, Croxton RD, Allan J .
Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic.
Epilepsy Behav 2020 Mar;104(Pt A):106907. doi: 10.1016/j.yebeh.2020.106907..
Keywords: Anxiety, Depression, Behavioral Health, Neurological Disorders, Chronic Conditions, Screening, Diagnostic Safety and Quality, Health Services Research (HSR), Research Methodologies
Bardach NS, Neel C, Kleinman LC
Depression, anxiety, and emergency department use for asthma.
This study examined whether pediatric patients with asthma who use the emergency department (ED) experience increased depression and anxiety in the same way that adult asthma patients do. Out of 65,342 patients identified from the Massachusetts All-Payer Claims Database for 2014 to 2015 who had ED visits, 24.7% had a diagnosis of anxiety, depression, or both. Asthma rates were shown to be higher than those of patients who had no diagnosis of anxiety or depression.
AHRQ-funded; HS025297; HS020518.
Citation: Bardach NS, Neel C, Kleinman LC .
Depression, anxiety, and emergency department use for asthma.
Pediatrics 2019 Oct;144(4). doi: 10.1542/peds.2019-0856..
Keywords: Asthma, Depression, Anxiety, Children/Adolescents, Emergency Department, Behavioral Health
Adrian M, Jenness JL, Kuehn KS
Emotion regulation processes linking peer victimization to anxiety and depression symptoms in adolescence.
This study examined emotional regulation processes linked to anxiety and depression symptoms in adolescents experiencing peer victimization. A total of 287 adolescents aged 16-17 years were recruited in three urban centers in the United States. They completed baseline and follow-up assessments 4 months apart. Three models of emotion regulation were evaluated using confirmatory factor analysis. Difficulties with emotion regulation were associated with increased depression in adolescents experiencing peer victimization and increased anxiety associated with cognitive regulation difficulties.
AHRQ-funded; HS022982.
Citation: Adrian M, Jenness JL, Kuehn KS .
Emotion regulation processes linking peer victimization to anxiety and depression symptoms in adolescence.
Dev Psychopathol 2019 Aug;31(3):999-1009. doi: 10.1017/s0954579419000543..
Keywords: Anxiety, Depression, Children/Adolescents, Behavioral Health
Iyer AS, Holm KE, Bhatt SP
Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - a cross sectional analysis of the COPDGene cohort.
This study compared the frequency of anxiety/depressive symptoms of current and former smokers with and without COPD and their use of anxiolytic-hypnotics/antidepressants. A cohort of 5331 current/former smokers were surveyed. About 25% of smokers with and without COPD had anxiety/depressive symptoms. Unmedicated smokers tended to be African American, male, have no health insurance, have severe-very severe COPD and higher respiratory symptoms/exacerbation history.
AHRQ-funded; HS023009; HS013852.
Citation: Iyer AS, Holm KE, Bhatt SP .
Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - a cross sectional analysis of the COPDGene cohort.
J Psychosom Res 2019 Mar;118:18-26. doi: 10.1016/j.jpsychores.2019.01.002..
Keywords: Anxiety, Medication, Respiratory Conditions, Depression, Behavioral Health, Anxiety, Tobacco Use
Graham AK, Minc A, Staab E
Validation of the computerized adaptive test for mental health in primary care.
This study compared the use of a computerized assessment tool with paper questionnaires to diagnose major depressive disorder (MDD) and general anxiety disorder (GAD). It was found that the majority of patients in the study preferred the computerized adaptive testing tool. Diagnostic accuracy of the tool was similar or higher than many of the traditional screening methods.
AHRQ-funded; HS000078.
Citation: Graham AK, Minc A, Staab E .
Validation of the computerized adaptive test for mental health in primary care.
Ann Fam Med 2019 Jan;17(1):23-30. doi: 10.1370/afm.2316..
Keywords: Anxiety, Depression, Diagnostic Safety and Quality, Behavioral Health, Primary Care, Screening
Blumenthal KG, Li Y, Acker WW
Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression.
In this study, the authors used electronic health record (EHR) data to describe prevalences of MDIS and MDAS and to examine associations with anxiety and depression. The investigators concluded that: 1.) while 6% of patients had MDIS, only 1% had MDAS; 2.) MDIS was associated with both anxiety and depression; 3.) patients with both anxiety and depression had an almost twofold increased odds of MDIS; 4.) MDAS was associated with a 40% increased odds of depression, but there was no significant association with anxiety.
AHRQ-funded; HS022728.
Citation: Blumenthal KG, Li Y, Acker WW .
Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression.
Allergy 2018 Oct;73(10):2012-23. doi: 10.1111/all.13440..
Keywords: Adverse Drug Events (ADE), Adverse Events, Anxiety, Depression, Electronic Health Records (EHRs), Health Information Technology (HIT), Medication, Behavioral Health, Patient Safety
Rhoten BA, Murphy BA, Dietrich MS
Depressive symptoms, social anxiety, and perceived neck function in patients with head and neck cancer.
This study examined the relationships of depressive symptoms and social anxiety with perceived neck function in patients treated for head and neck cancer. Significant associations were found between membership in the neck disability index trajectories and membership in the longitudinal patterns of depressive symptoms and social anxiety. The investigators concluded that impaired physical function and psychological distress are intertwined for patients with head and neck cancer long after completing treatment.
AHRQ-funded; HS022990.
Citation: Rhoten BA, Murphy BA, Dietrich MS .
Depressive symptoms, social anxiety, and perceived neck function in patients with head and neck cancer.
Head Neck 2018 Jul;40(7):1443-52. doi: 10.1002/hed.25129..
Keywords: Anxiety, Cancer, Depression, Behavioral Health
McKernan LC, Walsh CG, Reynolds WS
Psychosocial co-morbidities in Interstitial cystitis/bladder pain syndrome (IC/BPS): a systematic review.
Psychosocial factors amplify symptoms of Interstitial Cystitis (IC/BPS). While psychosocial self-management is efficacious in other pain conditions, its impact on an IC/BPS population has rarely been studied. The objective of this review was to learn the prevalence and impact of psychosocial factors on IC/BPS, assess baseline psychosocial characteristics, and offer recommendations for assessment and treatment.
AHRQ-funded; HS022990.
Citation: McKernan LC, Walsh CG, Reynolds WS .
Psychosocial co-morbidities in Interstitial cystitis/bladder pain syndrome (IC/BPS): a systematic review.
Neurourol Urodyn 2018 Mar;37(3):926-41. doi: 10.1002/nau.23421..
Keywords: Pain, Anxiety, Depression, Behavioral Health, Patient-Centered Outcomes Research, Outcomes, Chronic Conditions
McBride NM, Johnco C, Salloum A
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
This study examined the incidence of suicidal thoughts and behaviors in youth with anxiety before initiating cognitive behavioral therapy, as well as the emergence of suicidal thoughts and behaviors during treatment. Findings suggest that the assessment of suicidality at a single time-point and from one informant is not sufficient to identify at-risk youth. Ongoing assessment of suicidal risk during treatment is important in this population.
AHRQ-funded; HS018665.
Citation: McBride NM, Johnco C, Salloum A .
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
Child Psychiatry Hum Dev 2017 Oct;48(5):705-13. doi: 10.1007/s10578-016-0696-6..
Keywords: Anxiety, Behavioral Health, Children/Adolescents, Depression
Garber J, Brunwasser SM, Zerr AA
Treatment and prevention of depression and anxiety in youth: test of cross-over effects.
The present meta-analytic review examined whether interventions for children and adolescents that explicitly targeted either anxiety or depression showed treatment specificity or also impacted the other outcome (i.e. cross-over effects). Anxiety prevention studies (n = 14) significantly affected anxious, but not depressive symptoms, indicating no cross-over effect of anxiety prevention trials on depression. For depression prevention studies (n = 15), the effects were not significant for either depressive or anxiety symptoms, although the effect was significantly larger for depressive than for anxious symptoms.
AHRQ-funded; HS022990.
Citation: Garber J, Brunwasser SM, Zerr AA .
Treatment and prevention of depression and anxiety in youth: test of cross-over effects.
Depress Anxiety 2016 Oct;33(10):939-59. doi: 10.1002/da.22519.
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Keywords: Anxiety, Children/Adolescents, Depression, Patient-Centered Outcomes Research
Fernandes-Taylor S, Adesoye T, Bloom JR
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
This review examines recent literature on the psychosocial needs of and interventions for young women. It focuses on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. It concluded that shared decision-making, balancing body image, fear of recurrence, and recommended treatment, and palliative care for metastasis are essential research priorities for the clinical setting.
AHRQ-funded; HS023395.
Citation: Fernandes-Taylor S, Adesoye T, Bloom JR .
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
Curr Opin Support Palliat Care 2015 Sep;9(3):279-84. doi: 10.1097/spc.0000000000000161..
Keywords: Anxiety, Cancer: Breast Cancer, Shared Decision Making, Depression, Quality of Life
Mooney TK, Gibbons MB, Gallop R
Psychotherapy credibility ratings: patient predictors of credibility and the relation of credibility to therapy outcome.
The researchers examined the relation between credibility ratings for adult psychotherapies and various patient factors as well as the relation between credibility ratings and subsequent symptom change. Their findings indicate that patient beliefs after a brief exposure to treatment may influence symptom improvement. Age and education may influence the patient’s beliefs about the credibility of a treatment.
AHRQ-funded; HS022124.
Citation: Mooney TK, Gibbons MB, Gallop R .
Psychotherapy credibility ratings: patient predictors of credibility and the relation of credibility to therapy outcome.
Psychother Res 2014;24(5):565-77. doi: 10.1080/10503307.2013.847988..
Keywords: Anxiety, Depression, Behavioral Health, Outcomes, Patient-Centered Outcomes Research
Gilbert AL, Bauer NS, Carroll AE
Child exposure to parental violence and psychological distress associated with delayed milestones.
The researchers examined the association between parental report of intimate partner violence (IPV) and parental psychological distress (PPD) with child attainment of developmental milestones. They found that parental report of both IPV and PPD during the first 72 months of a child’s life is significantly associated with developmental milestone failure across all 4 developmental domains and within the domains of language, personal-social, and gross motor development.
AHRQ-funded; HS017939; HS018453.
Citation: Gilbert AL, Bauer NS, Carroll AE .
Child exposure to parental violence and psychological distress associated with delayed milestones.
Pediatrics 2013 Dec;132(6):e1577-83. doi: 10.1542/peds.2013-1020..
Keywords: Children/Adolescents, Domestic Violence, Family Health and History, Depression, Anxiety, Behavioral Health