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AHRQ Research Studies Date
Topics
- Blood Clots (1)
- Children/Adolescents (5)
- Chronic Conditions (2)
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- COVID-19 (2)
- Diagnostic Safety and Quality (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedStarnes LS, Starnes JR, Stopczynski T
Clinical prediction model: multisystem inflammatory syndrome in children versus Kawasaki disease.
This study aimed to develop a prediction model to differentiate between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD). Using retrospective and prospective cohort data, a logistic regression model was developed, incorporating factors such as age, laboratory values, and clinical indicators. The model showed excellent discrimination (AUC 0.96) and calibration. It offers potential usefulness in aiding the diagnosis of MIS-C but requires further validation.
AHRQ-funded; HS026122.
Citation: Starnes LS, Starnes JR, Stopczynski T .
Clinical prediction model: multisystem inflammatory syndrome in children versus Kawasaki disease.
J Hosp Med 2024 Mar; 19(3):175-84. doi: 10.1002/jhm.13290.
Keywords: Children/Adolescents, Respiratory Conditions, COVID-19, Chronic Conditions
Steuart R, Pan AY, Woolums A
Respiratory culture growth and 3-years lung health outcomes in children with bronchopulmonary dysplasia and tracheostomies.
The goal of this cohort study is to determine the long-term effects of pathogenic identification on respiratory cultures in children. The study included infants and children with BPD and tracheostomies. The cohort study conclusions suggest that respiratory pathogens including P. aeruginosa may not promote long-term respiratory dysfunction, but identification of P. aeruginosa may delay decannulation.
AHRQ-funded; HS025138.
Citation: Steuart R, Pan AY, Woolums A .
Respiratory culture growth and 3-years lung health outcomes in children with bronchopulmonary dysplasia and tracheostomies.
Pediatr Pulmonol 2024 Feb; 59(2):300-13. doi: 10.1002/ppul.26746..
Keywords: Children/Adolescents, Respiratory Conditions, Outcomes
Geanacopoulos AT, Neuman MI, Michelson KA
Cost of pediatric pneumonia episodes with or without chest radiography.
Researchers sought to assess the costs of community-acquired pneumonia (CAP) episodes with and without chest radiograph (CXR) among children discharged from the pediatric emergency department. Their retrospective cohort study used data from the Healthcare Cost and Utilization Project State ED and Inpatient Databases on children aged 3 months to 18 years with CAP in eight states from 2014 to 2019. The results indicated that use of CXR for CAP diagnosis is associated with lower costs when considering the subsequent provision of care among patients who need additional health care after initial emergency department discharge.
AHRQ-funded; HS026503; HS000063.
Citation: Geanacopoulos AT, Neuman MI, Michelson KA .
Cost of pediatric pneumonia episodes with or without chest radiography.
Hosp Pediatr 2024 Feb; 14(2):146-52. doi: 10.1542/hpeds.2023-007506.
Keywords: Healthcare Cost and Utilization Project (HCUP), Children/Adolescents, Pneumonia, Respiratory Conditions, Community-Acquired Infections
Gyftopoulos S, Simon E, Swartz JL
Efficacy and impact of a multimodal intervention on CT pulmonary angiography ordering behavior in the emergency department.
The objective of this study was to evaluate the efficacy of a multimodal intervention to reduce overutilization of computed tomography pulmonary angiography (CTPA) for suspected pulmonary embolism in the emergency department. Results indicated that guideline concordance increased significantly after intervention. The authors concluded that their success in increasing guideline concordance demonstrated the efficacy of a mixed-methods, human-centered approach to behavior change; however, given that neither of the secondary outcomes improved, the results may demonstrate potential limitations to the guidelines directing the ordering of CTPA studies.
AHRQ-funded; HS024376.
Citation: Gyftopoulos S, Simon E, Swartz JL .
Efficacy and impact of a multimodal intervention on CT pulmonary angiography ordering behavior in the emergency department.
J Am Coll Radiol 2024 Feb; 21(2):309-18. doi: 10.1016/j.jacr.2023.02.033.
Keywords: Emergency Department, Respiratory Conditions, Imaging, Diagnostic Safety and Quality, Blood Clots
Melton K, Liu J, Sadeghi H
Predictors of transition outcomes in cystic fibrosis: analysis of National Patient Registry and CF RISE (Responsibility. Independence. Self-care. Education) data.
This retrospective cohort study’s goal was to identify predictors of transition outcomes in cystic fibrosis (CF) patients aged 16-25 years who transitioned to adult care from 2013 to 2019. The authors used data from the CF Foundation Patient Registry and the web-based transition program CF RISE (Responsibility. Independence. Self-care. Education). They modeled change in forced expiratory volume in 1 second % predicted and weight using linear regression fit with generalized estimating equations. Predictor variables included gap in care (time between last pediatric and first adult outpatient visit), transition program engagement, and sociodemographic and medical factors. Among 12,420 adolescents and young adults, 3876 transitioned to adult care with a median gap in care of 7.6 months. Patients from CF centers that have greater rates of CF RISE engagement had improved lung function and weight at their first adult outpatient visit. Patients with coverage on a parent's insurance plan and absence of CF complications predicted increased lung function. Sinus disease and history of a nonlung transplant predicted increased weight. Comorbid diabetes mellitus and gaps in care greater than 3 months predicted decreased lung function with longer gaps in care associated with greater decrease. Care gaps of 6 to 9 months predicted decreased weight. Other control variables including baseline forced expiratory volume in 1 second and weight, and exacerbation status were also statistically significant.
AHRQ-funded; HS000063.
Citation: Melton K, Liu J, Sadeghi H .
Predictors of transition outcomes in cystic fibrosis: analysis of National Patient Registry and CF RISE (Responsibility. Independence. Self-care. Education) data.
J Pediatr 2024 Feb; 265:113812. doi: 10.1016/j.jpeds.2023.113812.
Keywords: Chronic Conditions, Respiratory Conditions, Children/Adolescents, Transitions of Care
Jurlina A, Maul T, Hunsaker P
Changes in bronchiolitis characteristics during the COVID-19 pandemic: a description of pediatric emergency department visits in a community hospital, 2019-2021.
The purpose of this retrospective, cross-sectional study was to describe changes in bronchiolitis characteristics in pediatric emergency department patients in a community hospital during the COVID-19 pandemic. The researchers conducted the study with children with bronchiolitis aged 1 to 24 months during an ED visit between 2019 and 2021. The study found that bronchiolitis cases decreased by 75% from 2019 to 2020 and rose back to prepandemic levels by 2021. Radiographs, steroids, and bronchodilators decreased during the study period. Laboratory studies, viral testing, antibiotic use, and respiratory support were unchanged. The decrease in steroids and bronchodilators was related to a clinical pathway that discouraged their use. Respiratory support remained unchanged.
AHRQ-funded; HS026393.
Citation: Jurlina A, Maul T, Hunsaker P .
Changes in bronchiolitis characteristics during the COVID-19 pandemic: a description of pediatric emergency department visits in a community hospital, 2019-2021.
Clin Pediatr 2024 Jan; 63(1):73-79. doi: 10.1177/00099228231208941..
Keywords: COVID-19, Respiratory Conditions, Children/Adolescents, Emergency Department