National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
AHRQ Research Studies Date
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 5 of 5 Research Studies DisplayedChilders CP, Childers KK, Maggard-Gibbons M
National estimates of genetic testing in women with a history of breast or ovarian cancer.
In the United States, 3.8 million women have a history of breast (BC) or ovarian cancer (OC). Up to 15 percent of cases are attributable to heritable mutations, which, if identified, provide critical knowledge for treatment and preventive care. This study found that fewer than one in five individuals with a history of BC or OC meeting select National Cancer Comprehensive Network criteria have undergone genetic testing.
AHRQ-funded; HS025079.
Citation: Childers CP, Childers KK, Maggard-Gibbons M .
National estimates of genetic testing in women with a history of breast or ovarian cancer.
J Clin Oncol 2017 Dec 1;35(34):3800-06. doi: 10.1200/jco.2017.73.6314.
.
.
Keywords: Cancer, Cancer: Breast Cancer, Cancer: Ovarian Cancer, Family Health and History, Genetics, Quality of Care, Screening, Women
Totten M, Ross T, Voskertchian A
Analysis of morphologically similar Staphylococcus aureus colonies for assessment of phenotypic and genotypic correlation.
In an effort to track and control the transmission of Staphylococcus aureus, patient isolates are saved for epidemiological studies (1–3). Study investigators often assume that colonies with the same morphology on the original culture plate represent the same clone. However, there is very limited literature to support this assumption. In this study, multiple S. aureus colonies were saved from a single culture plate and tested to determine their genotypes and susceptibility profiles.
AHRQ-funded; HS022872.
Citation: Totten M, Ross T, Voskertchian A .
Analysis of morphologically similar Staphylococcus aureus colonies for assessment of phenotypic and genotypic correlation.
J Clin Microbiol 2017 Jul;55(7):2285-86. doi: 10.1128/jcm.00402-17..
Keywords: Genetics, Infectious Diseases, Research Methodologies
Feldman S, Kasjanski R, Poposki J
Chronic airway inflammation provides a unique environment for B cell activation and antibody production.
This study sought to determine the mechanisms that drive B cell activation and antibody production during chronic airway inflammation. It found that nasal polyps contained significantly elevated frequencies of plasmablasts, especially those that expressed the extrafollicular marker Epstein-Barr virus-induced protein 2 (EBI2), but significantly fewer germinal centre (GC) B cells compared with tonsil.
AHRQ-funded; HS023011.
Citation: Feldman S, Kasjanski R, Poposki J .
Chronic airway inflammation provides a unique environment for B cell activation and antibody production.
Clin Exp Allergy 2017 Apr;47(4):457-66. doi: 10.1111/cea.12878.
.
.
Keywords: Chronic Conditions, Genetics, Respiratory Conditions
Harowicz MR, Robinson TJ, Dinan MA
Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset.
This study analyzed 305 patients with invasive breast cancer who had Oncotype DX recurrence scores (ODX RS) available. Five equations were selected that provide a surrogate measure of ODX by Klein (Magee equations 1-3), Gage et al., and Tang et al. Although commonly available surrogates for ODX appear to predict high-risk ODX RS, the study was unable to reliably rule out the presence of patients with intermediate-risk disease by ODX.
AHRQ-funded; HS022189.
Citation: Harowicz MR, Robinson TJ, Dinan MA .
Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset.
Breast Cancer Res Treat 2017 Feb;162(1):1-10. doi: 10.1007/s10549-016-4093-4.
.
.
Keywords: Cancer, Cancer: Breast Cancer, Genetics, Women
Taylor BD, Zheng X, Darville T
Whole-exome sequencing to identify novel biological pathways associated with infertility after pelvic inflammatory disease.
The researchers used whole-exome sequencing to identify biological pathways that may be associated with STI-related infertility. Pathway analysis revealed that focus genes were enriched in canonical pathways including, IL-1 signaling, P2Y purinergic receptor signaling, and bone morphogenic protein signaling. Targeted sequencing of biological pathways identified in this study may provide insight into STI-related infertility.
AHRQ-funded; HS008358.
Citation: Taylor BD, Zheng X, Darville T .
Whole-exome sequencing to identify novel biological pathways associated with infertility after pelvic inflammatory disease.
Sex Transm Dis 2017 Jan;44(1):35-41. doi: 10.1097/olq.0000000000000533.
.
.
Keywords: Genetics, Sexual Health, Women